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1. 发明授权

US5285780A Pacemaker with improved pulse detection 失效
标题翻译：起搏器具有改进的脉搏检测
公开(公告)号：US5285780A
公开(公告)日：1994-02-15
申请号：US797889
申请日：1991-11-26
申请人： Takashi Tsuji , Masayuki Horikawa
发明人： Takashi Tsuji , Masayuki Horikawa
IPC分类号： A61N1/37 , A61N1/362
CPC分类号： A61N1/3704
摘要： Disclosed is a pacemaker having an output circuit which is set to a high impedance when the potential of the input signal transmitted through the input-output terminal is within a predetermined range, and is set to a low impedance when the potential of the signal is outside of the range. Therefore, the time when the input to an R wave detection circuit must be stopped due to the after potential becomes extremely short and the failure of detection of an R wave decreases and, further, there are no rapid fluctuations in the potential arising due to the on-off operation of the switch. Further, the pacemaker of the invention may include a pulse lowering circuit for inputting a lowering pulse to the R wave detecting circuit so that the pacing pulse and the following after potential can't be detected as the R wave of the electrical activity of the heart.
摘要翻译：公开了一种具有输出电路的起搏器，当通过输入 - 输出端子传输的输入信号的电位在预定范围内时，输出电路被设置为高阻抗，并且当信号的电位在外部时被设置为低阻抗的范围。因此，R波检测电路的输入必须由于后置电位而停止的时间变得非常短，并且R波检测的失败降低，并且还不会由于开关的开 - 关操作。此外，本发明的起搏器可以包括用于向R波检测电路输入降低脉冲的脉冲降低电路，使得起搏脉冲和随后的电位不能被检测为心脏的电活动的R波。

2. 发明授权

US5154169A Pacing unit with catheter holder 失效
标题翻译：带CATHETER HOLDER的PACING单元
公开(公告)号：US5154169A
公开(公告)日：1992-10-13
申请号：US667929
申请日：1991-03-12
申请人： Shinichi Miyata , Kiyoshi Takagi , Takashi Tsuji , Masayuki Horikawa , Takashi Kawabata
发明人： Shinichi Miyata , Kiyoshi Takagi , Takashi Tsuji , Masayuki Horikawa , Takashi Kawabata
IPC分类号： A61N1/05 , A61N1/362 , A61N1/372 , A61N1/375
CPC分类号： A61N1/056 , A61N1/3752
摘要： A pacing unit is disclosed. The pacing unit incorporates a catheter with pacing electrodes and leads extending from the pacing electrodes through the body of the catheter, a catheter holder for holding the catheter, and a pacer. Into the pacer, the connector plugs of the leads are plugged with the catheter holder fixedly attached to the pacer by interlocking means consisting of members fitting in respect to each other.
摘要翻译：披露起搏单位起搏单元包括具有起搏电极的导管和从起搏电极穿过导管的主体延伸的导管，用于保持导管的导管保持器和起搏器。引导件的连接器插头插入导管支架，导管支架通过由相对于彼此配合的部件组成的互锁装置固定地连接到推杆上。

3. 发明授权

US5356427A Catheter for temporary pacing and pacemaker 失效
标题翻译：导管用于临时起搏和起搏器
公开(公告)号：US5356427A
公开(公告)日：1994-10-18
申请号：US63068
申请日：1993-05-20
申请人： Shinichi Miyata , Takashi Kawabata , Kiyoshi Takagi , Masaru Miyahara , Takashi Tsuji , Shigeto Yoshida , Masayuki Horikawa , Fumiharu Iwai
发明人： Shinichi Miyata , Takashi Kawabata , Kiyoshi Takagi , Masaru Miyahara , Takashi Tsuji , Shigeto Yoshida , Masayuki Horikawa , Fumiharu Iwai
IPC分类号： A61N1/05 , A61N1/362 , A61N1/365 , A61N1/04
CPC分类号： A61N1/0565 , A61N1/3625 , A61N1/365
摘要： A temporary pacing catheter having an integrally attached temporary pacemaker function is disclosed. The pacemaker integrally built in this catheter for temporary pacing has a very small size and can be fixed to the body of a patient, and therefore, the patient can be transferred conveniently. Furthermore, if this catheter is packaged in the sterilized condition, problems or another's help required for the connection of the catheter to the pacemaker and the like operations in the conventional technique can be avoided, and therefore, the packaged catheter is suitably used for an emergency treatment. Moreover, if a balloon is attached and arranged so that when the balloon is inflated, the balloon envelopes an electrode at the distal end, the catheter can be caused to flow in the heart and blood vessel safely and promptly.
摘要翻译：公开了具有整体安装的临时起搏器功能的临时起搏导管。整体构建在该导管中用于临时起搏的起搏器具有非常小的尺寸并且可以固定到患者的身体，因此可以方便地转移患者。此外，如果该导管被包装在灭菌状态，则可以避免在常规技术中将导管连接到起搏器和类似操作所需的问题或其它帮助，因此，封装的导管适合用于紧急情况治疗。此外，如果气囊被附接并布置成使得当气囊膨胀时，气囊包围在远端的电极，则可以使导管安全且及时地流过心脏和血管。

4. 发明授权

US5099839A Catheter for temporary pacing 失效
标题翻译：临时管道导管
公开(公告)号：US5099839A
公开(公告)日：1992-03-31
申请号：US445673
申请日：1989-11-27
申请人： Shinichi Miyata , Takashi Kawabata , Kiyoshi Takagi , Masaru Miyahara , Takashi Tsuji , Shigeto Yoshida , Masayuki Horikawa , Fumiharu Iwai
发明人： Shinichi Miyata , Takashi Kawabata , Kiyoshi Takagi , Masaru Miyahara , Takashi Tsuji , Shigeto Yoshida , Masayuki Horikawa , Fumiharu Iwai
IPC分类号： A61N1/05 , A61N1/362 , A61N1/365
CPC分类号： A61N1/0565 , A61N1/3625 , A61N1/365
摘要： A temporary pacing catheter having an integrally attached temporary pacemaker function is disclosed. The pacemaker integrally built in this catheter for temporary pacing has a very small size and can be fixed to the body of a patient, and therefore, the patient can be transferred conveniently. Furthermore, if this catheter is packaged in the sterilized conditions, problems or another's help required for the connection of the catheter to the pacemaker and the like operations in the conventional technique can be avoided, and therefore, the packaged catheter is suitably used for an emergency treatment. Moreover, if a balloon is attached and arranged so that when the balloon is inflated, the balloon envelopes an electrode at the distal end, the catheter can be caused to flow in the heart and blood vessel safely and promptly.
摘要翻译：公开了具有整体安装的临时起搏器功能的临时起搏导管。整体构建在该导管中用于临时起搏的起搏器具有非常小的尺寸并且可以固定到患者的身体，因此可以方便地转移患者。此外，如果该导管被包装在消毒条件下，可以避免常规技术中将导管连接到起搏器和类似操作所需的问题或其它帮助，因此，封装的导管适用于紧急情况治疗。此外，如果气囊被附接并布置成使得当气囊膨胀时，气囊包围在远端的电极，则可以使导管安全且及时地流过心脏和血管。

5. 发明授权

US08426588B2 Phenylalanine derivatives 有权
标题翻译：苯丙氨酸衍生物
公开(公告)号：US08426588B2
公开(公告)日：2013-04-23
申请号：US13524318
申请日：2012-06-15
申请人： Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
发明人： Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
IPC分类号： C07D253/08
CPC分类号： C07D239/22 , C07D239/54 , C07D239/78 , C07D239/80 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D265/26 , C07D285/16 , C07D285/24 , C07D401/12 , C07D471/04 , C07D475/02 , C07D487/04 , Y02P20/582
摘要： Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译：指定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗活性。它们被用作关于α4整联蛋白的各种疾病的治疗剂。

6. 发明授权

US08361709B2 Method of producing tooth, set of teeth, and method of producing tissue 有权
标题翻译：产生牙齿，牙齿组合的方法和生产组织的方法
公开(公告)号：US08361709B2
公开(公告)日：2013-01-29
申请号：US11921233
申请日：2006-05-30
申请人： Takashi Tsuji , Kazuhisa Nakao
发明人： Takashi Tsuji , Kazuhisa Nakao
IPC分类号： C12Q1/68 , A01N1/00 , C12N5/00
CPC分类号： C12N5/0062 , A61K35/12 , A61L27/3813 , A61L27/3834 , A61L27/3865 , A61L27/3886 , A61L2430/12 , C12N5/0627 , C12N5/0654 , C12N2502/097 , C12N2533/54
摘要： A first cell mass substantially containing only either one of mesenchymal cells or epithelial cells and a second cell mass substantially containing only the other one of the cells are positioned in contact with each other inside a support carrier which can maintain a condition of cell contact; and cultured to obtain a tooth having a specific cell placement. Preferably, after the culturing, the support carrier having both cell masses is cultured with kidney cells.
摘要翻译：基本上仅含有间充质细胞或上皮细胞中的任一种的第一细胞团和基本上仅含有另一个细胞的第二细胞团彼此定位在可保持细胞接触状态的载体载体内彼此接触; 并培养以获得具有特定细胞放置的牙齿。优选培养后，将具有两个细胞块的载体载体与肾细胞一起培养。

7. 发明申请

US20120253041A1 NEW PHENYLALANINE DERIVATIVES 有权
标题翻译：新的苯乙烯胺衍生物
公开(公告)号：US20120253041A1
公开(公告)日：2012-10-04
申请号：US13524318
申请日：2012-06-15
申请人： Shingo MAKINO , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
发明人： Shingo MAKINO , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
IPC分类号： C07D253/08
CPC分类号： C07D239/22 , C07D239/54 , C07D239/78 , C07D239/80 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D265/26 , C07D285/16 , C07D285/24 , C07D401/12 , C07D471/04 , C07D475/02 , C07D487/04 , Y02P20/582
摘要： Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译：指定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。它们被用作关于α4整联蛋白的各种疾病的治疗剂。

8. 发明申请

US20120047586A9 POLYPEPTIDE HAVING ENHANCED EFFECTOR FUNCTION 审中-公开
标题翻译：具有增强效应功能的多肽
公开(公告)号：US20120047586A9
公开(公告)日：2012-02-23
申请号：US12739480
申请日：2008-10-23
申请人： Takashi Tsuji , Yasuhiro Kajihara , Katsunari Tezuka , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai
发明人： Takashi Tsuji , Yasuhiro Kajihara , Katsunari Tezuka , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai
IPC分类号： C12P21/02 , C07H21/04 , A01H5/00 , C12N5/10 , A01K67/00 , C07K16/28 , C12N15/63
CPC分类号： C07K16/00 , A61K38/00 , C07K16/2887 , C07K2317/72 , C07K2317/732 , C07K2319/30 , C07K2319/33
摘要： Disclosed is a polypeptide having an enhanced effector function. Specifically disclosed are: a polypeptide having a modified Fc region; a nucleic acid encoding the polypeptide; a vector carrying the nucleic acid; a host cell or a host organism harboring the vector; a pharmaceutical composition comprising the polypeptide; a method for producing the polypeptide; a method for enhancing the effector function of an antibody; and a method for producing a cell capable of producing an antibody having a high effector function.
摘要翻译：公开了具有增强的效应子功能的多肽。具体公开的是：具有修饰的Fc区的多肽; 编码该多肽的核酸; 携带核酸的载体; 携带载体的宿主细胞或宿主生物体; 包含该多肽的药物组合物; 一种生产该多肽的方法; 用于增强抗体的效应子功能的方法; 以及能够产生具有高效应功能的抗体的细胞的制备方法。

9. 发明授权

US07732861B2 Trench MOS type silicon carbide semiconductor device 有权
标题翻译：沟槽MOS型碳化硅半导体器件
公开(公告)号：US07732861B2
公开(公告)日：2010-06-08
申请号：US12461713
申请日：2009-08-21
申请人： Takashi Tsuji
发明人： Takashi Tsuji
IPC分类号： H01L21/336 , H01L29/788
CPC分类号： H01L29/7813 , H01L21/047 , H01L29/0623 , H01L29/0696 , H01L29/0878 , H01L29/1608 , H01L29/41766 , H01L29/66068
摘要： A trench MOS type SiC semiconductor device includes a first conductivity semiconductor substrate, a first conductivity drift layer on the substrate, a second conductivity base layer on the drift layer, a first conductivity source layer on the base layer, a stripe shaped trench reaching from the surface of the source layer to the drift layer and having a gate electrode via a gate oxide film, a second conductivity layer on the bottom of the trench, and a second conductivity type region thereon on across-the-width side walls of at least one end of the trench, electrically coupling the second conductivity layer with the base layer. The device allows a low on-resistance without newly forming an electrode connected to the second conductivity layer even in the case of a device in which the second conductivity layer has to be grounded.
摘要翻译：沟槽MOS型SiC半导体器件包括第一导电半导体衬底，衬底上的第一电导率漂移层，漂移层上的第二导电性基底层，基底层上的第一导电源层，源极层的表面到漂移层，并且通过栅极氧化膜具有栅电极，在沟槽的底部具有第二导电层，并且在其上的至少一个的宽度侧壁上的第二导电类型区域沟槽的端部，将第二导电层与基底层电耦合。即使在第二导电层必须接地的装置的情况下，该装置也允许低导通电阻而不新形成连接到第二导电层的电极。

10. 发明申请

US20100129771A1 METHOD FOR PRODUCTION OF TOOTH, AND TOOTH PRODUCED BY THE METHOD 失效
标题翻译：用于生产牙齿的方法，以及通过该方法生产的牙齿
公开(公告)号：US20100129771A1
公开(公告)日：2010-05-27
申请号：US12528936
申请日：2008-02-28
申请人： Takashi Tsuji , Nobuo Sakuragawa
发明人： Takashi Tsuji , Nobuo Sakuragawa
IPC分类号： A61C13/225 , C12N5/077
CPC分类号： A61L27/22 , A61L27/3813 , A61L27/3834 , A61L27/3865 , A61L27/3891 , A61L2430/12 , C12N5/0654 , C12N2502/097 , C12N2506/025
摘要： Disclosed is a method for producing a tooth, which comprises the steps of: positioning a first cell mass substantially comprising either one of amniotic mesenchymal cells or epithelial cells, and a second cell mass substantially comprising the other one in the inside of a support carrier while keeping them in close contact with each other without being mixed together; and culturing the first and second cell masses in the inside of the support carrier.
摘要翻译：公开了一种生产牙齿的方法，其包括以下步骤：将基本上包含羊膜间充质细胞或上皮细胞之一的第一细胞群和基本上包含另一种的第二细胞团定位在载体载体的内部，同时保持彼此紧密接触而不混合在一起; 并且在支撑载体的内部培养第一和第二细胞块。

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