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1. 发明专利

IL272271D0 Therapeutic agent for fibrosis 未知
公开(公告)号：IL272271D0
公开(公告)日：2020-03-31
申请号：IL27227120
申请日：2020-01-27
申请人： KYORIN SEIYAKU KK , KAZUHISA NAKAO , JUNICHI ISHIYAMA , WATARU ICHIKAWA , ATSUSHI MASUI , YUNIKE AKASAKA , HIDEKAZU TOYOFUKU , AYA HONDA
发明人： KAZUHISA NAKAO , JUNICHI ISHIYAMA , WATARU ICHIKAWA , ATSUSHI MASUI , YUNIKE AKASAKA , HIDEKAZU TOYOFUKU , AYA HONDA
摘要： Disclosed is a phosphorylation inhibitor of SMAD2/3 protein or a therapeutic agent for fibrosis which contains as an active ingredient, a nucleic acid that suppresses NEK6 (NIMA-related serine/threonine kinase 6) gene expression.

2. 发明授权

US08361709B2 Method of producing tooth, set of teeth, and method of producing tissue 有权
标题翻译：产生牙齿，牙齿组合的方法和生产组织的方法
公开(公告)号：US08361709B2
公开(公告)日：2013-01-29
申请号：US11921233
申请日：2006-05-30
申请人： Takashi Tsuji , Kazuhisa Nakao
发明人： Takashi Tsuji , Kazuhisa Nakao
IPC分类号： C12Q1/68 , A01N1/00 , C12N5/00
CPC分类号： C12N5/0062 , A61K35/12 , A61L27/3813 , A61L27/3834 , A61L27/3865 , A61L27/3886 , A61L2430/12 , C12N5/0627 , C12N5/0654 , C12N2502/097 , C12N2533/54
摘要： A first cell mass substantially containing only either one of mesenchymal cells or epithelial cells and a second cell mass substantially containing only the other one of the cells are positioned in contact with each other inside a support carrier which can maintain a condition of cell contact; and cultured to obtain a tooth having a specific cell placement. Preferably, after the culturing, the support carrier having both cell masses is cultured with kidney cells.
摘要翻译：基本上仅含有间充质细胞或上皮细胞中的任一种的第一细胞团和基本上仅含有另一个细胞的第二细胞团彼此定位在可保持细胞接触状态的载体载体内彼此接触; 并培养以获得具有特定细胞放置的牙齿。优选培养后，将具有两个细胞块的载体载体与肾细胞一起培养。

3. 发明授权

US06378983B1 Digital prepress system 失效
标题翻译：数字印前系统
公开(公告)号：US06378983B1
公开(公告)日：2002-04-30
申请号：US09644297
申请日：2000-08-23
申请人： Shinichi Ito , Kazuhisa Nakao , Kozi Tokunaga
发明人： Shinichi Ito , Kazuhisa Nakao , Kozi Tokunaga
IPC分类号： B41J201
CPC分类号： B41C1/12 , B41M2205/16 , G03F3/108
摘要： A digital prepress system capable of preparing an excellent proof sheet free from the wrong conversion of characters and double procedure of trapping processing, having little color difference of images between the proof sheet and the regular printed matters and imparting no impression that proofreading paper and regular printing paper are different in the color tone, feeling of gloss and the like. This invention provides a digital prepress system wherein digital data are processed on a unit of Raster image processor and data obtained therefrom are transferred to a planographic print output unit and an ink jet printer to generate a planographic print and a proof sheet respectively, said ink jet printer includes a device for preparing said proof sheet to make ink jet recording on a proofreading paper having a color difference of 2 or less and a gloss difference of 75° specular gloss in an absolute value of 15 or less as compared with regular printing paper according to the provisions of JIS 28730, with the basis weight different from that of regular printing paper by a range between −10 to +50%.
摘要翻译：一种数字印前系统，能够制作出不会错误的字符转换和双重处理过程的优秀校样，校样纸和普通印刷品之间的图像差异小，校正纸和普通打印不会产生印象纸的色调，光泽感等不同。本发明提供了一种数字印前系统，其中数字数据在光栅图像处理器的单元上被处理，并且从其获得的数据被传送到平版印刷输出单元和喷墨打印机以分别产生平版印刷和校样片，所述喷墨打印机包括一种用于制备所述校样片的装置，用于在普通打印纸上与普通打印纸相比，在具有2或更小的色差和75°镜面光泽度的校正纸上进行喷墨记录，绝对值为15或更小符合JIS 28730的规定，其定量印刷纸的基重与-10至+ 50％之间的范围不同。

4. 发明授权

US08927284B2 Method for producing tooth 有权
标题翻译：牙齿生产方法
公开(公告)号：US08927284B2
公开(公告)日：2015-01-06
申请号：US13146029
申请日：2010-01-14
申请人： Takashi Tsuji , Kazuhisa Nakao
发明人： Takashi Tsuji , Kazuhisa Nakao
IPC分类号： C12N5/02 , A61L27/38
CPC分类号： A61L27/3886 , A61L27/3804 , A61L27/3865
摘要： A method for producing a tooth having a desired length in one direction includes the steps of: placing a first cell aggregate and a second cell aggregate in the inside of a support while bringing the first and the second cell aggregates into close contact with each other; and culturing the first and the second cell aggregates in the inside of the support, in which the first cell aggregate is composed of one of mesenchymal cells or epithelial cells and the second cell aggregate is composed of the other, and the size of the tooth is controlled by adjusting the length of contact between the first cell aggregate and the second cell aggregate in one direction.
摘要翻译：一种在一个方向上具有期望长度的牙齿的制造方法包括以下步骤：将第一细胞聚集体和第二细胞聚集体放置在支撑体的内部，同时使第一和第二细胞聚集体彼此紧密接触; 并且在第一细胞集合体由间充质细胞或上皮细胞之一构成的载体内部培养第一和第二细胞聚集体，第二细胞集合体由另一个组成，并且牙齿的尺寸为通过在一个方向上调节第一细胞聚集体和第二细胞聚集体之间的接触长度来控制。

5. 发明申请

US20130089827A1 Methods For Manufacturing A Regenerated Tooth Unit 审中-公开
标题翻译：再生牙齿单元制造方法
公开(公告)号：US20130089827A1
公开(公告)日：2013-04-11
申请号：US13638963
申请日：2011-03-15
申请人： Takashi Tsuji , Kazuhisa Nakao , Masamitsu Oshima
发明人： Takashi Tsuji , Kazuhisa Nakao , Masamitsu Oshima
IPC分类号： A61C13/08 , A61D5/00
CPC分类号： A61D5/00 , A61C13/08 , A61L27/24 , A61L27/38 , A61L27/3813 , A61L27/3834 , A61L27/3886 , A61L2430/12
摘要： A method for manufacturing a regenerated tooth unit comprising a step of disposing and culturing a regenerated tooth germ inside a spacer in vivo in the body of a mammal is provided, wherein said spacer is configured so as to enable prevention of said regenerated tooth germ being extended to more than the maximum tolerance; and configured such that the regenerated tooth germ disposed inside is communicatable with the exterior of the spacer.
摘要翻译：一种再生牙齿单元的制造方法，其特征在于，具备在哺乳动物的体内将间隔物内的再生牙胚配置于培养体内的步骤，其特征在于，所述间隔件构成为能够防止所述再生牙胚延伸超过最大容差; 并且构造成使得设置在内部的再生牙胚可以与间隔件的外部通信。

6. 发明授权

US08771931B2 Perfusion culture method and perfusion culture device for organ or tissue 有权
标题翻译：灌注培养法和器官或组织灌注培养装置
公开(公告)号：US08771931B2
公开(公告)日：2014-07-08
申请号：US13574855
申请日：2011-01-25
申请人： Takashi Tsuji , Kazuhisa Nakao
发明人： Takashi Tsuji , Kazuhisa Nakao
IPC分类号： A01N1/00
CPC分类号： A01N1/0247 , C12M21/08 , C12M29/10
摘要： Disclosed are a perfusion culture method and a perfusion culture device whereby a perfusate can be delivered to all parts of an organ or tissue so that the organ or tissue can be preserved while sufficiently maintaining the function thereof. Specifically disclosed is a method for perfusion culture of an organ or tissue removed from a mammal, said organ or tissue having been removed together with a second organ or tissue connected to the aforesaid organ or tissue in vivo, which comprises a step for fixing said second organ or tissue so as to hang the aforesaid organ or tissue and a step for perfusing blood vessels in the aforesaid organ or tissue with a perfusate.
摘要翻译：公开了一种灌注培养方法和灌注培养装置，其中灌注液可以递送到器官或组织的所有部分，使得可以在充分保持其功能的同时保存器官或组织。具体公开了一种用于从哺乳动物，所述器官或组织移除的器官或组织的灌注培养的方法，所述器官或组织与连接到所述前述器官或组织的体内的第二器官或组织一起被去除，其包括用于固定所述第二器官或组织，以悬挂上述器官或组织，以及用灌注液灌注前述器官或组织中的血管的步骤。

7. 发明申请

US20130109093A1 Method of Producing Tooth, Set of Teeth, and Method of Producing Tissue 有权
标题翻译：牙齿，牙齿的生产方法和生产组织的方法
公开(公告)号：US20130109093A1
公开(公告)日：2013-05-02
申请号：US13718749
申请日：2012-12-18
申请人： Takashi TSUJI , Kazuhisa NAKAO
发明人： Takashi TSUJI , Kazuhisa NAKAO
IPC分类号： C12N5/00
CPC分类号： C12N5/0062 , A61K35/12 , A61L27/3813 , A61L27/3834 , A61L27/3865 , A61L27/3886 , A61L2430/12 , C12N5/0627 , C12N5/0654 , C12N2502/097 , C12N2533/54
摘要： A first cell mass substantially containing only either one of mesenchymal cells or epithelial cells and a second cell mass substantially containing only the other one of the cells are positioned in contact with each other inside a support carrier which can maintain a condition of cell contact; and cultured to obtain a tooth having a specific cell placement. Preferably, after the culturing, the support carrier having both cell masses is cultured with kidney cells.
摘要翻译：基本上仅含有间充质细胞或上皮细胞中的任一种的第一细胞团和基本上仅含有另一个细胞的第二细胞团彼此定位在可保持细胞接触状态的载体载体内彼此接触; 并培养以获得具有特定细胞放置的牙齿。优选培养后，将具有两个细胞块的载体载体与肾细胞一起培养。

8. 发明申请

US20130017533A1 Perfusion Culture Method and Perfusion Culture Device for Organ or Tissue 有权
标题翻译：灌注培养方法和器官或组织灌注培养装置
公开(公告)号：US20130017533A1
公开(公告)日：2013-01-17
申请号：US13574855
申请日：2011-01-25
申请人： Takashi Tsuji , Kazuhisa Nakao
发明人： Takashi Tsuji , Kazuhisa Nakao
IPC分类号： A01N1/02 , C12M3/00
CPC分类号： A01N1/0247 , C12M21/08 , C12M29/10
摘要： Disclosed are a perfusion culture method and a perfusion culture device whereby a perfusate can be delivered to all parts of an organ or tissue so that the organ or tissue can be preserved while sufficiently maintaining the function thereof. Specifically disclosed is a method for perfusion culture of an organ or tissue removed from a mammal, said organ or tissue having been removed together with a second organ or tissue connected to the aforesaid organ or tissue in vivo, which comprises a step for fixing said second organ or tissue so as to hang the aforesaid organ or tissue and a step for perfusing blood vessels in the aforesaid organ or tissue with a perfusate.
摘要翻译：公开了一种灌注培养方法和灌注培养装置，其中灌注液可以递送到器官或组织的所有部分，使得可以在充分保持其功能的同时保存器官或组织。具体公开了一种用于从哺乳动物，所述器官或组织移除的器官或组织的灌注培养的方法，所述器官或组织与连接到所述前述器官或组织的体内的第二器官或组织一起被除去，其包括用于固定所述第二器官或组织，以悬挂上述器官或组织，以及用灌注液灌注前述器官或组织中的血管的步骤。

9. 发明申请

US20110306135A1 METHOD FOR PRODUCING TOOTH 有权
标题翻译：生产牙科的方法
公开(公告)号：US20110306135A1
公开(公告)日：2011-12-15
申请号：US13146029
申请日：2010-01-14
申请人： Takashi Tsuji , Kazuhisa Nakao
发明人： Takashi Tsuji , Kazuhisa Nakao
IPC分类号： C12N5/077
CPC分类号： A61L27/3886 , A61L27/3804 , A61L27/3865
摘要： A method for producing a tooth having a desired length in one direction includes the steps of: placing a first cell aggregate and a second cell aggregate in the inside of a support while bringing the first and the second cell aggregates into close contact with each other; and culturing the first and the second cell aggregates in the inside of the support, in which the first cell aggregate is composed of one of mesenchymal cells or epithelial cells and the second cell aggregate is composed of the other, and the size of the tooth is controlled by adjusting the length of contact between the first cell aggregate and the second cell aggregate in one direction.
摘要翻译：一种在一个方向上具有期望长度的牙齿的制造方法包括以下步骤：将第一细胞聚集体和第二细胞聚集体放置在支撑体的内部，同时使第一和第二细胞聚集体彼此紧密接触; 并且在第一细胞集合体由间充质细胞或上皮细胞之一构成的载体内部培养第一和第二细胞聚集体，第二细胞集合体由另一个组成，并且牙齿的尺寸为通过在一个方向上调节第一细胞聚集体和第二细胞聚集体之间的接触长度来控制。

10. 发明授权

US08679755B2 Method of producing tooth, set of teeth, and method of producing tissue 有权
标题翻译：产生牙齿，牙齿组合的方法和生产组织的方法
公开(公告)号：US08679755B2
公开(公告)日：2014-03-25
申请号：US13718749
申请日：2012-12-18
申请人： Takashi Tsuji , Kazuhisa Nakao
发明人： Takashi Tsuji , Kazuhisa Nakao
IPC分类号： C12Q1/68 , C12N11/18 , C12N5/00
CPC分类号： C12N5/0062 , A61K35/12 , A61L27/3813 , A61L27/3834 , A61L27/3865 , A61L27/3886 , A61L2430/12 , C12N5/0627 , C12N5/0654 , C12N2502/097 , C12N2533/54
摘要： A first cell mass substantially containing only either one of mesenchymal cells or epithelial cells and a second cell mass substantially containing only the other one of the cells are positioned in contact with each other inside a support carrier which can maintain a condition of cell contact; and cultured to obtain a tooth having a specific cell placement. Preferably, after the culturing, the support carrier having both cell masses is cultured with kidney cells.
摘要翻译：基本上仅含有间充质细胞或上皮细胞中的任一种的第一细胞团和基本上仅含有另一个细胞的第二细胞团彼此定位在可保持细胞接触状态的载体载体内彼此接触; 并培养以获得具有特定细胞放置的牙齿。优选培养后，将具有两个细胞块的载体载体与肾细胞一起培养。

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