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1. 发明授权

US06391315B1 Vaccine for inhibiting and preventing induced staphylococcus infection, isolated antigens used therein, and isolated antibodies induced thereby 失效
标题翻译：用于抑制和预防诱导的葡萄球菌感染的疫苗，其中使用的分离的抗原以及由此诱导的分离的抗体
公开(公告)号：US06391315B1
公开(公告)日：2002-05-21
申请号：US08509630
申请日：1995-07-31
申请人： Takashi Takahashi , Takeji Sasaki , Yuzuru Iwai , Takashi Hashimoto
发明人： Takashi Takahashi , Takeji Sasaki , Yuzuru Iwai , Takashi Hashimoto
IPC分类号： A61K39085
CPC分类号： C07K16/18 , A61K38/00 , A61K39/085
摘要： An antigenic composition is derived from surface extracted protein of cell wall surfaces and the culture supernatant extract of Staphylococci. The strain is highly virulent and &bgr; hemolytic on blood agar plate. They are mixed and purified by ion exchange and gel filtration column chromatography. This preparation method can be used in all Gram-positive bacilli. The antigens, having molecular weight of about 10,000-70,000 are certain kinds of glycoprotein comprising proteins (ca. 10-20%) and carbohydrates (ca. 75-90%). They are extracted from the cells with the use of a hypertonic buffer solution of pH 6.5-8.5 at a temperature below the denaturing point of the antigenic protein, and are salted out with ammonium sulfate (ca. 65-85%). The culture supernatant is extracted in the same way by salting out with ammonium sulfate (ca. 65-85%). The antigen fraction from both cell wall and culture supernatant is obtained in such an operation. The antigen can be used as a preparation antigen to Staphylococcus antigen. Namely, the antibody obtained from mammal and avian immunized by this antigen can be used to treat the above-described infections. The composition containing the antibody provides a preventive effect.
摘要翻译：抗原组成来源于细胞壁表面提取的蛋白质和葡萄球菌的培养上清液提取物。该菌株在血琼脂平板上具有高毒性和β溶血性。它们通过离子交换和凝胶过滤柱色谱法混合和纯化。这种制备方法可用于所有革兰阳性杆菌。具有约10,000-70,000分子量的抗原是某些种类的包含蛋白质（约10-20％）和碳水化合物（约75-90％）的糖蛋白。在低于抗原蛋白变性点的温度下，使用pH 6.5-8.5的高渗缓冲溶液从细胞中提取它们，并用硫酸铵（约65-85％）盐析。通过用硫酸铵盐析（约65-85％），以相同的方式提取培养物上清液。在这种操作中获得来自细胞壁和培养上清液的抗原级分。抗原可用作葡萄球菌抗原的制备抗原。也就是说，从哺乳动物获得的抗体和由该抗原免疫的鸟类可以用于治疗上述感染。含有抗体的组合物提供预防效果。

2. 发明授权

US5721488A Method and apparatus for testing integrated magnetic head assembly 失效
标题翻译：集成磁头组件的测试方法和装置
公开(公告)号：US5721488A
公开(公告)日：1998-02-24
申请号：US656846
申请日：1996-05-30
申请人： Masanori Sakai , Katsuhiko Tomita , Yuzuru Iwai
发明人： Masanori Sakai , Katsuhiko Tomita , Yuzuru Iwai
IPC分类号： G11B5/39 , G11B5/455 , G01R33/12
CPC分类号： G11B5/455 , G11B5/3967 , Y10T29/49004
摘要： A method and apparatus for testing an integrated magnetic head assembly for normal operation. The head assembly includes an inductive write element and a MR read element. The method includes a step of applying an external alternating magnetic field to a plurality of magnetic head assemblies which are aligned on a head block and are not yet individually separated from the head block, in a direction perpendicular to an ABS of the head block, and also applying high frequency current to the inductive write element so that alternating leakage magnetic field from the inductive write element is applied to the MR read element, and a step of measuring varying resistance characteristics of the MR read element with respect to the variation of the external alternating magnetic field and to the variation of the alternating leakage magnetic field.
摘要翻译：一种用于测试用于正常操作的集成磁头组件的方法和装置。磁头组件包括电感写入元件和MR读取元件。该方法包括将外部交变磁场施加到多个磁头组件的步骤，所述多个磁头组件沿着与头部块的ABS垂直的方向在头部块上排列并且还没有从头部块单独地分离;以及还向感性写入元件施加高频电流，使得来自感应写入元件的交变泄漏磁场被施加到MR读取元件，以及测量MR读取元件相对于外部变化的变化的电阻特性的步骤交变磁场和交变磁场的变化。

3. 发明授权

US4666715A Antibiotic AM-5344-A.sub.2 substance and process for the production thereof 失效
标题翻译：抗生素AM-5344-A2物质及其生产方法
公开(公告)号：US4666715A
公开(公告)日：1987-05-19
申请号：US507385
申请日：1983-06-24
申请人： Satoshi Omura , Yuzuru Iwai , Kiyoizumi Hinotozawa , Atsushi Hirano
发明人： Satoshi Omura , Yuzuru Iwai , Kiyoizumi Hinotozawa , Atsushi Hirano
IPC分类号： C07G11/00 , A61K35/74 , A61P31/04 , C12P1/06 , C12R1/465
CPC分类号： C12R1/465 , C12P1/06
摘要： An antibiotic AM-5344-A.sub.2 substance, and a process for the preparation of the antibiotic AM-5344-A.sub.2 substance are described. The antibiotic AM-5344-A.sub.2 substance is prepared by cultivating an AM-5344-A.sub.2 substance-producing strain belonging to the genus Streptomyces, for example, Streptomyces sp. Am-5344 in a nutrient medium, and recovering the Am-5344-A.sub.2 substance from the culture.
摘要翻译：描述了一种抗生素AM-5344-A2物质，以及制备抗生素AM-5344-A2物质的方法。抗生素AM-5344-A2物质是通过培养属于链霉菌属的AM-5344-A2物质生产菌株，例如链霉菌属（Streptomyces sp。）， Am-5344在营养培养基中，并从培养物中回收Am-5344-A2物质。

4. 发明申请

US20090279213A1 Stabilized shields for magnetic recording heads 有权
标题翻译：磁记录头稳定屏蔽
公开(公告)号：US20090279213A1
公开(公告)日：2009-11-12
申请号：US12151921
申请日：2008-05-09
申请人： Yan Wu , Glen Garfunkel , Min Li , Yuzuru Iwai , Moris Dovek
发明人： Yan Wu , Glen Garfunkel , Min Li , Yuzuru Iwai , Moris Dovek
IPC分类号： G11B5/33
CPC分类号： G11B5/3163 , G11B5/3912 , G11B5/398
摘要： A basic design is disclosed for bottom shield (S1) and top shield (S2) of the reader shields in a magnetic read-write head. The critical part of new design includes an antiferromagnetic film which pins an antiferromagnetically coupled trilayer (AFCT). The simplest embodiment for top shield, for example, would be a film sequence of FM/Ru/FM/AFM. This replaces the normal top shield design which typically comprises a ferromagnetic seed layer and a thicker plated ferromagnetic film. Processes for manufacturing these shields are also described.
摘要翻译：公开了一种读写器的屏蔽罩（S1）和屏蔽罩（S2）在磁读写头中屏蔽的基本设计。新设计的关键部分包括引导反铁磁耦合三层（AFCT）的反铁磁膜。例如，用于顶部屏蔽的最简单的实施例将是FM / Ru / FM / AFM的胶片序列。这代替通常的顶层屏蔽设计，其通常包括铁磁种子层和较厚的镀层铁磁膜。还描述了用于制造这些屏蔽的工艺。

5. 发明授权

US4886884A Derivatives from cervinomycin based antibiotics 失效
标题翻译：衍生物来自基于西门子霉素的抗生素
公开(公告)号：US4886884A
公开(公告)日：1989-12-12
申请号：US124786
申请日：1987-10-19
申请人： Satoshi Omura , Akira Nakagawa , Yuzuru Iwai
发明人： Satoshi Omura , Akira Nakagawa , Yuzuru Iwai
IPC分类号： C07D498/04 , A61K31/435 , A61P31/04 , C07D498/14
CPC分类号： C07D498/14
摘要： The present invention is to provide a novel cervinomycin derivative represented by formula ##STR1## wherein ring B represents ##STR2## at least one of R.sub.1, R.sub.2 and R.sub.3 represents an acyl group or an alkyl group and the others represent a hydrogen atom; and R.sub.4 is a hydrogen atom or an alkyl group, and a process for producing said derivatives. The present derivative is free from the problems of the conventional cervinomycin, i.e., the low solubility in various solvents, high toxicity, and low activity against Gram-positive bacteria.

6. 发明授权

US4533547A Antiviral antibiotic substance AM-2722 and process for production thereof 失效
标题翻译：抗病毒抗生素AM-2722及其生产方法
公开(公告)号：US4533547A
公开(公告)日：1985-08-06
申请号：US262242
申请日：1981-05-11
申请人： Satoshi Omura , Akira Nakagawa , Hiroshi Hashimoto , Yasuhiko Kojima , Yuzuru Iwai , Ruiko Oiwa , Atsushi Hirano
发明人： Satoshi Omura , Akira Nakagawa , Hiroshi Hashimoto , Yasuhiko Kojima , Yuzuru Iwai , Ruiko Oiwa , Atsushi Hirano
IPC分类号： C07G11/00 , A61K35/74 , A61P31/12 , C12P1/06 , C12R1/465
CPC分类号： C12R1/465 , C12P1/06
摘要： A novel antiviral antibiotic AM-2722 is described represented by the molecular formula C.sub.19 H.sub.26 NO.sub.3 Cl, and having the following physicochemical properties:(1) specific rotary power: [.alpha.].sub.D.sup.20 -0.5 (C-1, chloroform);(2) the UV spectrum shown in FIG. 1; and(3) the IR spectrum shown in FIG. 2.Also described is a process for producing the antiviral antibiotic AM-2722, wherein a microorganism of Streptomyces which has the ability to produce the antibiotic AM-2722 is cultured aerobically in a nutrient medium and the antibiotic AM-2722 accumulated in the medium and the microorganism cells is recovered.
摘要翻译：描述了由分子式C 19 H 26 NO 3 Cl表示的新型抗病毒抗生素AM-2722，并且具有以下物理化学性质：（1）比旋光度：αD20-0.5（C-1，氯仿）; （2）图1所示的紫外光谱。 1; 和（3）图1所示的IR光谱。还描述了生产抗病毒抗生素AM-2722的方法，其中具有生产抗生素AM-2722能力的链霉菌微生物在营养培养基中有氧培养，抗生素AM-2722积累在培养基中，回收微生物细胞。

7. 发明授权

US07027271B2 Magnetoresistive device in a thin-film magnetic head and method of manufacturing same having particular electrode overlay configuration 失效
标题翻译：薄膜磁头中的磁阻器件及其具有特定电极覆盖结构的制造方法
公开(公告)号：US07027271B2
公开(公告)日：2006-04-11
申请号：US09911408
申请日：2001-07-25
申请人： Kenji Inage , Yoshihiro Kudo , Ken-ichi Takano , Koichi Terunuma , Yuzuru Iwai
发明人： Kenji Inage , Yoshihiro Kudo , Ken-ichi Takano , Koichi Terunuma , Yuzuru Iwai
IPC分类号： G11B5/39 , G11B5/127
CPC分类号： B82Y25/00 , B82Y10/00 , G01R33/093 , G11B5/3903 , G11B5/3909 , G11B2005/3996 , H01L43/08
摘要： A magnetoresisive device comprises an MR element, bias field applying layers located adjacent to the side portions of the MR element, and two electrode layers that feed a sense current to the MR element. The electrode layers overlap one of the surfaces of the MR element. The total overlap amount of the two electrode layers is smaller than 0.3 μm. The MR element is a spin-valve GMR element. The MR element incorporates a base layer, a free layer, a spacer layer, a pinned layer, an antiferromagnetic layer, and a cap layer that are stacked in this order. The pinned layer includes a nonmagnetic spacer layer, and two ferromagnetic layers that sandwich this spacer layer.
摘要翻译：磁感应装置包括MR元件，邻近MR元件的侧部定位的偏置场施加层和向MR元件馈送感测电流的两个电极层。电极层与MR元件的一个表面重叠。两个电极层的总重叠量小于0.3μm。 MR元件是自旋阀GMR元件。 MR元件包括依次层叠的基底层，自由层，间隔层，钉扎层，反铁磁层和盖层。被钉扎层包括非磁性间隔层和夹住该间隔层的两个铁磁层。

8. 发明授权

US06317291B1 Thin-film magnetic head having improved data writing characteristics and a method of making the same 有权
标题翻译：具有改进的数据写入特性的薄膜磁头及其制造方法
公开(公告)号：US06317291B1
公开(公告)日：2001-11-13
申请号：US09389753
申请日：1999-09-07
申请人： Yuzuru Iwai , Noboru Yamanaka , Yoshihiro Kudo
发明人： Yuzuru Iwai , Noboru Yamanaka , Yoshihiro Kudo
IPC分类号： G11B531
CPC分类号： B82Y25/00 , B82Y10/00 , G11B5/09 , G11B5/3109 , G11B5/313 , G11B2005/3996
摘要： It is an object of the invention to improve characteristics of a thin-film magnetic head in the case where the frequency of data to write is high, in particular. In a thin-film magnetic head of the invention an induction-type magnetic transducer includes two magnetic pole layers and a thin-film coil placed between the pole layers and insulated from the pole layers. The distance between the outermost end of the coil and a medium facing surface is greater than a throat height and measures 10 &mgr;m or less.
摘要翻译：特别是在要写入数据的频率高的情况下，本发明的目的是改进薄膜磁头的特性。在本发明的薄膜磁头中，感应型磁换能器包括两个磁极层和设置在极层之间并与极层绝缘的薄膜线圈。线圈的最外端和面向介质的表面之间的距离大于喉部高度，并且测量10um或更小。

9. 发明授权

US5236735A Method of producing a thin film magnetic head 失效
标题翻译：薄膜磁头的制造方法
公开(公告)号：US5236735A
公开(公告)日：1993-08-17
申请号：US715012
申请日：1991-06-13
申请人： Makoto Yoshida , Yuzuru Iwai , Noboru Yamanaka , Jun Shouzi , Tsutomu Koyanagi , Mikio Matsuzaki , Nobuya Ohyama , Yoshiaki Tanaka
发明人： Makoto Yoshida , Yuzuru Iwai , Noboru Yamanaka , Jun Shouzi , Tsutomu Koyanagi , Mikio Matsuzaki , Nobuya Ohyama , Yoshiaki Tanaka
IPC分类号： G11B5/31
CPC分类号： G11B5/3106 , G11B5/3113 , G11B5/3163
摘要： A method of producing a thin film magnetic head comprises forming a thin film magnetic circuit including a magnetic film and a conductive coil film on a substrate, and heating the thin film magnetic circuit at a temperature in a range of from 270.degree. C. to 400.degree. C. before forming a protective layer covering the thin film magnetic circuit.
摘要翻译：一种制造薄膜磁头的方法包括在基板上形成包括磁性膜和导电线圈膜的薄膜磁路，并在270℃至400℃的温度范围内加热薄膜磁路在形成覆盖薄膜磁路的保护层之前。

10. 发明授权

US4493845A Antibiotic AM-3603 失效
标题翻译：抗生素AM-3603
公开(公告)号：US4493845A
公开(公告)日：1985-01-15
申请号：US434818
申请日：1982-10-18
申请人： Satoshi Omura , Yoshitake Tanaka , Yuzuru Iwai , Yoko Takahashi , Akira Nakagawa
发明人： Satoshi Omura , Yoshitake Tanaka , Yuzuru Iwai , Yoko Takahashi , Akira Nakagawa
IPC分类号： C07H17/08 , A61K31/325 , A61K31/35 , A61K35/74 , A61P31/04 , C07G11/00 , C12P1/06 , C12P17/18 , C07D491/08
CPC分类号： C12R1/465 , C12P1/06
摘要： Antibiotic AM-3603 which is also designated as irumamycin is represented by the following formula: ##STR1## This substance is active upon certain Gram-positive bacteria, phytopathogenic fungi and dermatophytes, and is of interest in treating various diseases of humans and animals caused by infectious bacteria and fungi and also useful for agricultural purposes. Antibiotic AM-3603 may be prepared by fermentation, in which a microorganism capable of producing AM-3603 is cultured in a medium to accumulate AM-3603 in the cultured broths, from which AM-3603 is recovered. A preferred strain is Streptomyces sp. AM-3603 (FERM-P 5619; NRRL 12518).
摘要翻译：也被称为伊马利霉素的抗生素AM-3603由下式表示：该物质对某些革兰氏阳性菌，植物病原真菌和皮肤癣菌有活性，并且对于治疗人类和动物引起的各种疾病感兴趣感染性细菌和真菌，也可用于农业目的。抗生素AM-3603可以通过发酵制备，其中能够产生AM-3603的微生物在培养基中培养以在收集AM-3603的培养肉汤中积累AM-3603。优选的菌株是链霉菌属（Streptomyces sp。）。 AM-3603（FERM-P 5619; NRRL 12518）。

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