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1. 发明授权

US5512552A Bisphosphonic acid derivatives, and pharmaceutical use 失效
标题翻译：双膦酸衍生物和药物用途
公开(公告)号：US5512552A
公开(公告)日：1996-04-30
申请号：US303665
申请日：1994-09-09
申请人： Takashi Sohda , Iwao Yamazaki , Noriaki Kawamura , Shigehisa Taketomi
发明人： Takashi Sohda , Iwao Yamazaki , Noriaki Kawamura , Shigehisa Taketomi
IPC分类号： A61K31/66 , A61K31/663 , A61P19/08 , A61P19/10 , A61P29/00 , A61P43/00 , C07F9/38 , C07F9/40 , C07F9/58 , C07F9/6506 , C07F9/6512 , C07F9/6524 , C07F9/6539 , C07F9/6561
CPC分类号： C07F9/588 , C07F9/3873 , C07F9/405 , C07F9/65067 , C07F9/65127 , C07F9/6524 , C07F9/6539 , C07F9/6561
摘要： A bisphosphonic acid derivative of the general formula (I): ##STR1## wherein A is an optionally substituted cyclic group; R.sup.1 is hydrogen atom or a lower alkanoyl group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and are hydrogen atom or a lower alkyl group; m is 0, 1 or 2; and n is an integer from 2 to 10, or a salt thereof is disclosed. A process for its production and a bone resorption inhibitor containing the compound of the general formula (I) or a salt thereof are also disclosed.
摘要翻译：通式（I）的双膦酸衍生物：其中A是任选取代的环状基团; R1是氢原子或低级烷酰基; R2，R3，R4和R5相同或不同，为氢原子或低级烷基; m为0,1或2; n为2〜10的整数，或其盐。还公开了其生产方法和含有通式（I）化合物或其盐的骨吸收抑制剂。

2. 发明授权

US5376647A bisphosphonic acid derivatives, and useful as a bone resorption inhibitor 失效
标题翻译：双膦酸衍生物，可用作骨吸收抑制剂
公开(公告)号：US5376647A
公开(公告)日：1994-12-27
申请号：US3955
申请日：1993-01-19
申请人： Takashi Sohda , Iwao Yamazaki , Noriaki Kawamura , Shigehisa Taketomi
发明人： Takashi Sohda , Iwao Yamazaki , Noriaki Kawamura , Shigehisa Taketomi
IPC分类号： A61K31/66 , A61K31/663 , A61P19/08 , A61P19/10 , A61P29/00 , A61P43/00 , C07F9/38 , C07F9/40 , C07F9/58 , C07F9/6506 , C07F9/6512 , C07F9/6524 , C07F9/6539 , C07F9/6561 , A61K31/675
CPC分类号： C07F9/588 , C07F9/3873 , C07F9/405 , C07F9/65067 , C07F9/65127 , C07F9/6524 , C07F9/6539 , C07F9/6561
摘要： A bisphosphonic acid derivative of the general formula (I): ##STR1## wherein A is an optionally substituted cyclic group; R.sup.1 is hydrogen atom or a lower alkanoyl group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and are hydrogen atom or a lower alkyl group; m is 0, 1 or 2; and n is an integer from 2 to 10, or a salt thereof is disclosed. A process for its production and a bone resorption inhibitor containing the compound of the general formula (I) or a salt thereof are also disclosed.
摘要翻译：通式（I）的双膦酸衍生物：其中A是任选取代的环状基团; R1是氢原子或低级烷酰基; R2，R3，R4和R5相同或不同，为氢原子或低级烷基; m为0,1或2; n为2〜10的整数，或其盐。还公开了其生产方法和含有通式（I）化合物或其盐的骨吸收抑制剂。

3. 发明授权

US5296499A Indole derivatives, their production and use 失效
标题翻译：吲哚衍生物，其生产和使用
公开(公告)号：US5296499A
公开(公告)日：1994-03-22
申请号：US963252
申请日：1992-10-19
申请人： Takashi Sohda , Iwao Yamazaki , Noriaki Kawamura
发明人： Takashi Sohda , Iwao Yamazaki , Noriaki Kawamura
IPC分类号： C07D209/42 , C07D209/60 , C07D209/70 , C07D405/04 , C07D491/04 , C07D491/056 , C07F9/572 , C07D209/18 , A61K31/405
CPC分类号： C07D405/04 , C07D209/42 , C07D209/60 , C07D209/70 , C07D491/04 , C07F9/5728
摘要： An agent for inhibiting bone resorption comprising an indole derivative of the formula (I): ##STR1## wherein each ring of A and B is optionally substituted, R is a hydrogen atom, a lower alkyl group or an acyl group, and A is a hydroxymethyl group or an esterified or amidated carboxyl group; or its pharmaceutically acceptable salt and a pharmaceutically acceptable carrier, diluent or excipient.
摘要翻译：用于抑制骨吸收的试剂，其包含式（I）的吲哚衍生物：其中A和B的每个环任选被取代，R是氢原子，低级烷基或酰基，以及 A是羟甲基或酯化或酰胺化的羧基; 或其药学上可接受的盐和药学上可接受的载体，稀释剂或赋形剂。

4. 发明授权

US4918171A Saikosaponin derivatives, their production and use 失效
标题翻译：西沙必利衍生物，其生产和使用
公开(公告)号：US4918171A
公开(公告)日：1990-04-17
申请号：US222549
申请日：1988-07-21
申请人： Haruji Oshio , Noriaki Kawamura , Taketoshi Saijo
发明人： Haruji Oshio , Noriaki Kawamura , Taketoshi Saijo
IPC分类号： C07H15/256 , C07H17/04 , C07J63/00 , C07J71/00
CPC分类号： C07H17/04 , C07H15/256 , C07J63/008 , C07J71/0005
摘要： A phosphate ester of saikosaponin a, b.sub.1, b.sub.2, c, d or h or saikogenin A, C or D, or a pharmaceutically acceptable salt thereof, which exhibits potent antiinflammatory activity against adjuvant arthritis and then can be used safely as a drug for the treatment and prevention of rheumatism, and a process for preparing the same characterized by phosphorylating the saikosaponin or saikogenin.

5. 发明授权

US4385832A Laser power transmitting optical fiber damage detecting device 失效
标题翻译：激光发射光纤损伤检测装置
公开(公告)号：US4385832A
公开(公告)日：1983-05-31
申请号：US182742
申请日：1980-08-29
申请人： Yuzuru Doi , Noriaki Kawamura
发明人： Yuzuru Doi , Noriaki Kawamura
IPC分类号： A61B18/20 , G01M11/00 , G02B6/00 , G01N21/88
CPC分类号： H04B10/07 , G01M11/31 , H04B10/071
摘要： A device for detecting damage in an optical fiber for transmitting high power laser beams. The optical fiber has an incident end face and an emergent end face with the emergent end face being coated with either a transmission increasing or a reflection increasing coating. A focusing optical system is provided between the laser light source and the incident end face of the optical fiber to focus the laser light reflected from the emergent end face back through the incident end face. A detector for detecting damage is disposed in path of the reflected laser light focused by the focusing optical system and outside the path of the laser light applied to the incident face.
摘要翻译：一种用于检测用于传输大功率激光束的光纤中的损坏的装置。光纤具有入射端面和出射端面，其出射端面被透射增加涂层或反射增加涂层涂覆。聚光光学系统设置在激光光源与光纤的入射端面之间，将从出射端面反射的激光反射回入射端面。用于检测损伤的检测器设置在由聚焦光学系统聚焦的反射激光的路径中并且在施加到入射面的激光的路径的外部。

6. 发明申请

US20120164468A1 METAL SUBSTRATE/METAL IMPREGNATED CARBON COMPOSITE MATERIAL STRUCTURE AND METHOD FOR MANUFACTURING SAID STRUCTURE 有权
标题翻译：金属基板/金属印制碳复合材料结构及制造结构的方法
公开(公告)号：US20120164468A1
公开(公告)日：2012-06-28
申请号：US11909349
申请日：2005-03-23
申请人： Noriaki Kawamura
发明人： Noriaki Kawamura
IPC分类号： B32B15/04 , B32B15/20 , B23K31/02
CPC分类号： H01L23/3736 , B32B15/14 , H01L23/15 , H01L23/373 , H01L23/3732 , H01L23/3735 , H01L2924/0002 , Y10T428/12007 , Y10T428/12083 , H01L2924/00
摘要： Provided are a heat releasing material for an electronic device being manufactured by the junction of a metal impregnated carbon composite material on a copper or aluminum substrate with reduced warpage; and a method for manufacturing the heat releasing material. A metal substrate/metal impregnated carbon composite material structure, characterized in that it comprises a metal substrate comprising a metal sheet, plate or block and, being joined on the metal substrate via a brazing material, a metal impregnated carbon composite material having a thickness of 0.1 mm to 2 mm; and a method for manufacturing the metal substrate/metal impregnated carbon composite material structure, characterized in that it comprises a step wherein a brazing material is caused to be present between the metal substrate and the metal impregnated carbon composite material, and they are kept at a temperature of 500° C. or higher and under a pressure of 0.2 MPa or more and then cooled.
摘要翻译：提供一种用于电子器件的散热材料，其通过金属浸渍的碳复合材料在铜或铝衬底上的接合处制造，具有减小的翘曲; 以及制造散热材料的方法。金属基板/金属浸渍碳复合材料结构，其特征在于，它包括金属基板，包括金属板，板或块，并通过钎焊材料接合在金属基板上，金属浸渍碳复合材料的厚度为 0.1毫米至2毫米; 以及金属基材/金属浸渍碳复合材料结构体的制造方法，其特征在于，包括使所述金属基材和所述浸渍了金属的碳复合材料之间存在钎焊材料的工序，将其保持在温度为500℃以上，压力为0.2MPa以上，然后冷却。

7. 发明授权

US06649265B1 Carbon-based metal composite material, method for preparation thereof and use thereof 有权
标题翻译：碳基金属复合材料，其制备方法和用途
公开(公告)号：US06649265B1
公开(公告)日：2003-11-18
申请号：US09600032
申请日：2000-07-11
申请人： Noriaki Kawamura , Eiki Tsushima , Nobuyuki Suzuki
发明人： Noriaki Kawamura , Eiki Tsushima , Nobuyuki Suzuki
IPC分类号： B32B500
CPC分类号： C04B41/009 , C04B41/51 , C04B41/5127 , C04B41/5144 , C04B41/5155 , C04B41/88 , C04B2111/00844 , C22C1/1036 , C22C29/00 , C22C32/0084 , H01L23/142 , H01L23/3733 , H01L2224/48091 , H01L2224/48227 , H05K1/05 , Y10T428/249953 , Y10T428/249955 , Y10T428/249967 , Y10T428/2918 , Y10T428/2958 , Y10T428/30 , C04B41/4521 , C04B41/4523 , C04B35/522 , C04B35/52 , C04B35/83 , H01L2924/00014
摘要： According to the present invention, there is provided a carbon-based metal composite material comprising a carbonaceous matrix and a metal component dispersed in said carbonaceous matrix, wherein at least 90 volume percent of the pores of the carbonaceous matrix is substituted with said metal component, and the content of said metal component is 35% or less based on the total volume of said carbon-based metal composite material; a method of producing a carbon-based metal composite material wherein impregnation of the carbon formed body with molten metal under pressure is carried out by pre-heating said carbon formed body and then impregnating the open pores of the carbon formed body with molten metal under a pressure of at least 200 kg/cm2 of the cross-sectional area of the plunger; and a substrate-shaped formed body for an electronic component comprising a carbon-based metal composite material.
摘要翻译：根据本发明，提供一种碳基金属复合材料，其包含分散在所述碳质基质中的碳质基质和金属成分，其中所述碳质基质的至少90体积％的孔被所述金属成分取代，并且所述金属成分的含量相对于所述碳系金属复合材料的总体积为35％以下。一种碳 - 金属复合材料的制造方法，其中，在压力下用熔融金属浸渍碳成形体，通过预先加热所述碳成形体，然后在熔融金属的下方浸渍碳成形体的开孔至少200kg / cm 2的柱塞横截面积的压力; 以及包含碳基金属复合材料的电子部件用基板状成形体。

8. 发明授权

US09390999B2 Metal substrate/metal impregnated carbon composite material structure and method for manufacturing said structure 有权
标题翻译：金属基材/金属浸渍碳复合材料结构及其制造方法
公开(公告)号：US09390999B2
公开(公告)日：2016-07-12
申请号：US11909349
申请日：2005-03-21
申请人： Noriaki Kawamura
发明人： Noriaki Kawamura
IPC分类号： B32B9/00 , H01L23/373 , B32B15/14 , H01L23/15
CPC分类号： H01L23/3736 , B32B15/14 , H01L23/15 , H01L23/373 , H01L23/3732 , H01L23/3735 , H01L2924/0002 , Y10T428/12007 , Y10T428/12083 , H01L2924/00
摘要： Provided are a heat releasing material for an electronic device being manufactured by the junction of a metal impregnated carbon composite material on a copper or aluminum substrate with reduced warpage; and a method for manufacturing the heat releasing material. A metal substrate/metal impregnated carbon composite material structure, characterized in that it comprises a metal substrate comprising a metal sheet, plate or block and, being joined on the metal substrate via a brazing material, a metal impregnated carbon composite material having a thickness of 0.1 mm to 2 mm; and a method for manufacturing the metal substrate/metal impregnated carbon composite material structure, characterized in that it comprises a step wherein a brazing material is caused to be present between the metal substrate and the metal impregnated carbon composite material, and they are kept at a temperature of 500° C. or higher and under a pressure of 0.2 MPa or more and then cooled.
摘要翻译：提供一种用于电子器件的散热材料，其通过金属浸渍的碳复合材料在铜或铝衬底上的接合处制造，具有减小的翘曲; 以及制造散热材料的方法。金属基板/金属浸渍碳复合材料结构，其特征在于，它包括金属基板，包括金属板，板或块，并通过钎焊材料接合在金属基板上，金属浸渍碳复合材料的厚度为 0.1毫米至2毫米; 以及金属基材/金属浸渍碳复合材料结构体的制造方法，其特征在于，包括使所述金属基材和所述浸渍了金属的碳复合材料之间存在钎焊材料的工序，将其保持在温度为500℃以上，压力为0.2MPa以上，然后冷却。

9. 发明授权

US4421382A Fiber retaining device for power laser 失效
标题翻译：功率激光光纤保持装置
公开(公告)号：US4421382A
公开(公告)日：1983-12-20
申请号：US241440
申请日：1981-03-06
申请人： Yuzuru Doi , Teruyuki Kakeda , Noriaki Kawamura
发明人： Yuzuru Doi , Teruyuki Kakeda , Noriaki Kawamura
IPC分类号： A61B18/20 , A61B18/22 , G02B6/32 , G02B6/36 , G02B6/42 , G02B7/26
CPC分类号： G02B6/4296 , A61B18/22 , G02B6/32 , G02B6/3624 , G02B6/3644 , G02B6/40
摘要： A retaining device having a cylindrical centering portion and a conical chucking portion for holding a bundle of optical fibers for use with a medical laser scalpel.
摘要翻译：一种保持装置，具有圆柱形定心部分和用于保持用于医疗激光手术刀的光纤束的圆锥形夹持部分。

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