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1. 发明申请

US20130317116A1 EXTERNAL SKIN PREPARATION 审中-公开
标题翻译：外用皮肤制剂
公开(公告)号：US20130317116A1
公开(公告)日：2013-11-28
申请号：US13982865
申请日：2012-02-02
申请人： Takashi Maoka , Takashi Ishibashi
发明人： Takashi Maoka , Takashi Ishibashi
IPC分类号： A61K8/35 , A61Q19/08
CPC分类号： A61K8/35 , A61K8/0216 , A61K8/23 , A61K8/97 , A61Q11/00 , A61Q19/00 , A61Q19/08
摘要： This invention provides an external skin preparation with high safety aimed at wrinkle improvement and wrinkle prevention. Specifically, the invention relates to an external skin preparation comprising, as an active ingredient, a carotenoid.
摘要翻译：本发明提供了一种具有高安全性的外用皮肤制剂，其目的在于改善皱纹和防止皱纹。具体地说，本发明涉及一种外用皮肤制剂，其包含作为活性成分的类胡萝卜素。

2. 发明授权

US06309666B1 Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract 失效
标题翻译：消毒道下部可释放的涂层胶囊形式的药物制剂
公开(公告)号：US06309666B1
公开(公告)日：2001-10-30
申请号：US08680753
申请日：1996-07-15
申请人： Harumi Hatano , Takahiro Ito , Takashi Ishibashi , Hiroyuki Yoshino , Masakazu Mizobe
发明人： Harumi Hatano , Takahiro Ito , Takashi Ishibashi , Hiroyuki Yoshino , Masakazu Mizobe
IPC分类号： A61K952
CPC分类号： A61K9/4891
摘要： A pharmaceutical preparation in the form of a coated capsule which can release contents of a capsule at a lower part of the digestive tract comprising (a) a hard capsule containing at least an acidic substance, (b) a polymer film soluble at low pH which is formed on a surface of said hard capsule, and (c) an enteric coating film which is formed on a surface of said polymer film soluble at low pH. According to the pharmaceutical preparation of the present invention, any kind of a medicament can be delivered to any desired site between the upper part of the small intestine and the lower part of the large intestine in the digestive tract by controlling the amount of polymer(s) used for the polymer film soluble at low pH and/or by selecting the kind of the polymer film soluble at low pH and/or the acidic substance without any complicated requirements for each medicament.
摘要翻译：一种涂层胶囊形式的药物制剂，其能够释放消化道下部的胶囊内含物，其包含（a）含有至少一种酸性物质的硬胶囊，（b）在低pH下可溶的聚合物膜，形成在所述硬胶囊的表面上，和（c）形成在所述聚合物膜的表面上的可溶于低pH的肠溶衣膜。根据本发明的药物制剂，通过控制聚合物的量（s），可以将任何种类的药物递送到消化道的小肠上部和大肠的下部之间的任意位置）和/或通过选择在低pH下可溶解的聚合物膜的种类和/或酸性物质，而对每种药物没有任何复杂的要求。

3. 发明授权

US5118443A Developer for pressure-sensitive recording sheets, aqueous dispersion of the developer and method for preparing the developer 失效
标题翻译：压敏记录片的开发者，开发者的水分散和准备开发者的方法
公开(公告)号：US5118443A
公开(公告)日：1992-06-02
申请号：US644678
申请日：1991-01-22
申请人： Toranosuke Saito , Takashi Ishibashi , Tomoharu Shiozaki , Tetsuo Shiraishi
发明人： Toranosuke Saito , Takashi Ishibashi , Tomoharu Shiozaki , Tetsuo Shiraishi
IPC分类号： B41M5/155
CPC分类号： B41M5/155
摘要： A developer comprising at least one polyvalent metal salt of a nuclear substituted salicylic acid of the following general formula is provided. ##STR1## In the formula, R.sub.1 represents an alkyl group having from 1 to 12 carbon atoms, R.sub.2 represents a hydrogen atom or an alkyl group having from 1 to 12 carbon atoms, R.sub.3 represents a hydrogen atom or a methyl group provided that at least one of R.sub.1 and R.sub.2 is a secondary butyl group, a secondary hexyl group, an isohexyl group, a secondary octyl group, an isononyl group, a secondary decyl group, a secondary dodecyl group or an isododecyl group and the total number of the carbon atoms in R.sub.1, R.sub.2 and R.sub.3 is from 9 to 18, M is a polyvalent metal atom, and m is a valence of M. An aqueous dispersion containing the developer and a method for preparing the developer are also described.

4. 发明授权

US5041604A Process for producing di(aryloxy)alkane 失效
标题翻译：制备二（芳氧基）烷烃的方法
公开(公告)号：US5041604A
公开(公告)日：1991-08-20
申请号：US540872
申请日：1990-06-20
申请人： Toranosuke Saito , Masakatu Kitani , Takashi Ishibashi
发明人： Toranosuke Saito , Masakatu Kitani , Takashi Ishibashi
IPC分类号： C07C65/21 , B01J23/02 , C07B31/00 , C07B41/04 , C07B61/00 , C07C41/00 , C07C41/01 , C07C41/16 , C07C43/20 , C07C45/00 , C07C49/84 , C07C51/00 , C07C67/00 , C07C201/00 , C07C201/12 , C07C205/38 , C07C253/00 , C07C253/30 , C07C255/37 , C07C255/54
CPC分类号： C07C41/16
摘要： A process for producing a high quality di(aryloxy)alkane with a high yield by the use of readily commercially available materials, without using any particular solvent or agent and by means of a simple operation and a general apparatus is provided, which process comprises subjecting a halogenated alkane of the formula (II)X--A--Y (II)wherein X and Y each represent a halogen atom and A represents a lower alkylene group, and a phenol of the formula (III) ##STR1## wherein R.sub.1 to R.sub.5 each are same or different, represent hydrogen, halogen, lower alkyl, lower alkoxy, carboxylic acid salt, acyl or nitro group, and may form a ring in conjunction of two adjacent groups,to condensation reaction in the presence of an alkali in an aqueous medium to form a di(aryloxy)alkane of the formula (I) ##STR2## and is characterized (i) by carrying out the condensation reaction in a molar ratio of the compound of the formula (II): the phenol of the formula (III): the alkali in terms of monovalent base of 1:1.5 to 3.0:1.5 to 3.0; or(ii) by carrying out the condensation reaction of the above (i) and adjusting the quantity of the aqueous medium phase after completion of the reaction can be 35% or less based on the oily phase; or(iii) by carrying out the condensation reaction of the above (i), feeding at least the alkali among the reaction components with progress of the reaction and adjusting the quantity of the aqueous medium phase as described in the above (ii).
摘要翻译：提供了一种通过使用容易商业化的材料生产高质量的二（芳氧基）烷烃的方法，而不使用任何特定的溶剂或试剂，并且通过简单的操作和一般的设备，该方法包括式（II）XAY（II）的卤化烷烃，其中X和Y各自表示卤素原子，A表示低级亚烷基，和式（III）的苯酚（III）其中R1至R5各自相同或不同，表示氢，卤素，低级烷基，低级烷氧基，羧酸盐，酰基或硝基，并且可以与两个相邻基团结合形成环，在碱的存在下在水性介质中进行缩合反应形成式（I）的二（芳氧基）烷烃（I），其特征在于（i）通过以式（II）的化合物与式（II）的苯酚的摩尔比进行缩合反应：式（III）：以碱为一价碱为1：1.5至3.0：1.5至3.0; 或者（ii）通过进行上述（i）的缩合反应，并且在反应完成后调整水介质相的量可以基于油相为35％以下。或者（iii）通过进行上述（i）的缩合反应，至少将反应成分中的碱与反应进行同时进行，并且如上述（ii）所述调节水相介质相的量。

5. 发明授权

US07220430B2 Sustained-release preparation and process for producing the same 失效
标题翻译：缓释制剂及其制备方法
公开(公告)号：US07220430B2
公开(公告)日：2007-05-22
申请号：US10182239
申请日：2001-01-26
申请人： Takashi Ishibashi , Kengo Ikegami , Keigo Nagao , Hiroyuki Yoshino , Masakazu Mizobe
发明人： Takashi Ishibashi , Kengo Ikegami , Keigo Nagao , Hiroyuki Yoshino , Masakazu Mizobe
IPC分类号： A61K9/24 , A61K9/22 , A61K9/28 , A61K9/30 , A61K9/42
CPC分类号： A61K9/2886 , A61K9/282 , A61K9/2833 , A61K9/2866 , A61K9/5015 , A61K9/5031 , A61K9/5047 , A61K9/5073
摘要： The present invention is to provide a sustained release preparation comprising a drug-containing core substance and a multilayered coating layer covering the core substance, wherein all adjacent layers in the multilayered coating layer contain mutually different hydrophobic organic compound-water-soluble polymer mixtures; and, a method of producing a sustained release preparation, having a multilayered coating layer in which adjacent layers contain different hydrophobic organic compound-water-soluble polymer mixtures, which comprises spray-coating a solution containing a hydrophobic organic compound-water-soluble polymer mixture onto a drug-containing core substance, continuing to spray-coat a solution containing a different hydrophobic organic compound-water-soluble polymer mixture onto the resulting coating layer, and repeating this step.
摘要翻译：本发明提供一种包含药物核心物质和覆盖核心物质的多层涂层的缓释制剂，其中多层涂层中的所有相邻层含有相互不同的疏水性有机化合物 - 水溶性聚合物混合物; 以及制备缓释制剂的方法，其具有多层涂层，其中相邻层含有不同的疏水性有机化合物 - 水溶性聚合物混合物，其包括喷涂包含疏水性有机化合物 - 水溶性聚合物混合物的溶液向含药物的核心物质上继续将含有不同的疏水性有机化合物 - 水溶性聚合物混合物的溶液喷雾到所得涂层上，并重复该步骤。

6. 外观设计

USD490422S1 Handheld computer 失效
标题翻译：手提电脑
公开(公告)号：USD490422S1
公开(公告)日：2004-05-25
申请号：US29175266
申请日：2003-02-03
申请人： Yoshihiro Iwama , Yuichiro Kota , Minoru Ikeda , Takashi Ishibashi
设计人： Yoshihiro Iwama , Yuichiro Kota , Minoru Ikeda , Takashi Ishibashi

7. 发明授权

US5019548A Heat sensitive recording material 失效
公开(公告)号：US5019548A
公开(公告)日：1991-05-28
申请号：US397821
申请日：1989-08-24
申请人： Toshitake Suzuki , Fumio Seyama , Shuki Okauchi , Toranosuke Saito , Masakatu Kitani , Takashi Ishibashi
发明人： Toshitake Suzuki , Fumio Seyama , Shuki Okauchi , Toranosuke Saito , Masakatu Kitani , Takashi Ishibashi
IPC分类号： B41M5/30 , B41M5/333 , B41M5/337
CPC分类号： B41M5/3375 , B41M5/3335 , B41M5/3336
摘要： A heat sensitive recording material comprising a substrate and a recording layer thereon incorporating a colorless or light-colored basic dye and a color acceptor reactive with the dye to form a color when contacted therewith, the recording material being characterized in that, as the color acceptor is used at least one compound selected from the group consisting of 4-hydroxy-4'-isopropyloxydiphenylsulfone, 4,4'-(1,3-dimethylbutylidene) bisphenol, 4,4'-(1-phenylethylidene)bisphenol, 4,4'-(p-phenylenediisopropylidene)bisphenol and 4,4'-(m-phenylenediisopropylidene) bisphenol, and to the recording layer is added at least one of a heat-fusible substance represented by the formula [I] ##STR1## wherein X is hydrogen atom, halogen atom, C.sub.1.about.4 alkyl or C.sub.1.about.4 alkoxy.

8. 发明授权

US4542395A Heat-sensitive recording material 失效
标题翻译：热敏记录材料
公开(公告)号：US4542395A
公开(公告)日：1985-09-17
申请号：US668462
申请日：1984-11-05
申请人： Toranosuke Saito , Masakatu Kitani , Takashi Ishibashi , Naoto Arai , Takeshi Murakami , Toshitake Suzuki
发明人： Toranosuke Saito , Masakatu Kitani , Takashi Ishibashi , Naoto Arai , Takeshi Murakami , Toshitake Suzuki
IPC分类号： C09K9/02 , B41M5/333 , C07C27/00 , C07C37/14 , C07C39/17 , C07C67/00 , C09B11/02 , B41M5/18
CPC分类号： C07C37/14 , C07C39/17 , C07C2101/14
摘要： Novel phenolic compounds useful as a color developer suitable for satisfying the quality requirements of heat-sensitive recording materials are provided, which compounds are expressed by the general formula ##STR1## wherein R.sub.1 represents an alkyl group or a cycloalkyl group and R.sub.2 represents hydrogen atom or an alkyl group; and also heat-sensitive recording materials usable in a broad application field are provided, which recording materials are provided with a heat-sensitive recording layer composed mainly of a colorless basic dye and the above compounds as a color developer by which the dye forms colors, overlaid on a substrate.
摘要翻译：提供了可用作满足热敏记录材料的质量要求的显色剂的新型酚类化合物，该化合物由通式“IMAGE”表示，其中R1表示烷基或环烷基，R2表示氢原子或烷基; 并且还提供了可用于广泛应用领域的热敏记录材料，该记录材料设置有主要由无色碱性染料组成的热敏记录层和作为染料形成颜色的着色剂的上述化合物，覆盖在基板上。

9. 发明授权

US4535190A Phenolic compounds and a heat-sensitive recording material containing the same 失效
标题翻译：酚类化合物和含有它们的热敏记录材料
公开(公告)号：US4535190A
公开(公告)日：1985-08-13
申请号：US592598
申请日：1984-03-23
申请人： Naoto Arai , Takeshi Murakami , Toshitake Suzuki , Toranosuke Saito , Masakatu Kitani , Takashi Ishibashi
发明人： Naoto Arai , Takeshi Murakami , Toshitake Suzuki , Toranosuke Saito , Masakatu Kitani , Takashi Ishibashi
IPC分类号： C09K9/02 , B41M5/333 , C07C27/00 , C07C37/14 , C07C39/17 , C07C67/00 , C09B11/02 , C07C39/12
CPC分类号： C07C37/14 , C07C39/17 , C07C2101/14
摘要： Novel phenolic compounds useful as a color developer suitable for satisfying the quality requirements of heat-sensitive recording materials are provided, which compounds are expressed by the general formula ##STR1## wherein R.sub.1 represents an alkyl group or a cycloalkyl group and R.sub.2 represents hydrogen atom or an alkyl group; and also heat-sensitive recording materials usable in a broad application field are provided, which recording materials are provided with a heat-sensitive recording layer composed mainly of a colorless basic dye and the above compounds as a color developer by which the dye forms colors, overlaid on a substrate.
摘要翻译：提供了可用作满足热敏记录材料的质量要求的显色剂的新型酚类化合物，该化合物由通式“IMAGE”表示，其中R1表示烷基或环烷基，R2表示氢原子或烷基; 并且还提供了可用于广泛应用领域的热敏记录材料，该记录材料设置有主要由无色碱性染料组成的热敏记录层和作为染料形成颜色的着色剂的上述化合物，覆盖在基板上。

10. 发明授权

US08659192B2 Rotary electrical apparatus 有权
标题翻译：旋转电器
公开(公告)号：US08659192B2
公开(公告)日：2014-02-25
申请号：US13232116
申请日：2011-09-14
申请人： Shigetaka Isogai , Keiichiro Kawashima , Takashi Ishibashi , Masahiro Omura
发明人： Shigetaka Isogai , Keiichiro Kawashima , Takashi Ishibashi , Masahiro Omura
IPC分类号： H02K9/19
CPC分类号： H02K7/006 , H02K9/193
摘要： A rotary electrical apparatus includes a housing, a stator including a center axis inclined by a predetermined angle relative to a horizontal direction in a case where the housing is fixed to a mounting member, a rotor, and an oil stored at a lower side within the housing relative to the center axis and functioning as at least one of a cooling oil, a lubricating oil, and an operating oil. The housing includes an oil inlet port and an oil discharge port allowing the oil to be discharged once a predetermined amount of the oil is stored within the housing, the oil discharge port being displaced from a first oil passage on which the oil supplied from the oil inlet port moves downward along an inner peripheral wall surface of the housing in a state where the housing is held so that the center axis is arranged to be horizontal.
摘要翻译：旋转电气设备包括壳体，定子，其包括在壳体固定到安装构件的情况下相对于水平方向倾斜预定角度的中心轴线，转子和存储在所述壳体内的下侧的油壳体相对于中心轴线并且用作冷却油，润滑油和工作油中的至少一种。壳体包括进油口和排油口，一旦预定量的油被储存在壳体内，允许油排放一次，排油口从第一油通道排出，油从其上供油入口端口在壳体被保持使得中心轴线被布置为水平的状态下沿着壳体的内周壁表面向下移动。

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