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1. 发明申请

US20070260305A1 GUIDE SHIELDS FOR MULTIPLE COMPONENT PROSTHETIC HEART VALVE ASSEMBLIES AND APPARATUS AND METHODS FOR USING THEM 有权
标题翻译：多组分前置心脏瓣膜组件的指导手册及其使用方法
公开(公告)号：US20070260305A1
公开(公告)日：2007-11-08
申请号：US11742390
申请日：2007-04-30
申请人： Michael Drews , Donnell Gurskis , Mimi Fitterer , Takashi Ino , James Hong
发明人： Michael Drews , Donnell Gurskis , Mimi Fitterer , Takashi Ino , James Hong
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61B17/0469 , A61B2017/00243 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2436 , A61F2/2439 , A61F2220/0008 , A61F2220/0033 , A61F2220/0075 , A61F2220/0083 , A61F2230/0006 , A61F2250/0063 , A61F2250/0069 , A61F2250/0091
摘要： A heart valve assembly includes an annular prosthesis and a plurality of guide shields removably attached around a circumference of the annular prosthesis. A plurality of elongate guide rails extend from the annular prosthesis, which are releasably retained by the guide shields. During use, the annular prosthesis is directed into a biological annulus, e.g., with the guide rails retained by the guide shields, and secured to tissue surrounding the biological annulus using fasteners. The guide rails are released from the guide shields, and a valve prosthesis is advanced over the leaders and through a passage defined by the guide shields towards the annular prosthesis. The guide rails may include retentions elements that secure the valve prosthesis to the annular prosthesis. The guide shields are removed from the annular prosthesis, the guide rails are separated from the annular prosthesis, and are removed from the biological annulus.
摘要翻译：心脏瓣膜组件包括环形假体和可移除地附接在环形假体圆周周围的多个导向屏蔽件。多个细长的导轨从环形假体延伸，环形假体由导向屏蔽件可释放地保持。在使用期间，环形假体被引导到生物环带中，例如，导轨由导向屏蔽件保持，并且使用紧固件固定到生物环带周围的组织。导轨从导向罩释放，并且阀门假肢前进到领导者上并通过由导向罩限定的通道朝向环形假体。导轨可以包括将瓣膜假体固定到环形假体的保持元件。引导罩从环形假体中移出，导轨与环形假体分离，并从生物环空中移除。

2. 发明申请

US20060122634A1 Apparatus and method for delivering fasteners during valve replacement 审中-公开
公开(公告)号：US20060122634A1
公开(公告)日：2006-06-08
申请号：US11004445
申请日：2004-12-03
申请人： Takashi Ino , Michael Drews , Donnell Gurskis
发明人： Takashi Ino , Michael Drews , Donnell Gurskis
IPC分类号： A61B17/10
CPC分类号： A61B17/0644 , A61B17/068 , A61B2017/00862
摘要： A fastener delivery tool includes a loading chamber for receiving a fastener having a pair of tines overlapping one another to define a loop in a parent or relaxed state. A retaining member retains the fastener in the loading chamber. The fastener delivery tool also includes a tongue, pusher member, and an ejection track communicating with the loading chamber. An actuator causes the tongue to move to engage the tines of the fastener to transform the fastener from the relaxed state to a constrained state defining a U-shape. The actuator also causes the pusher member to release the retaining member and advance the fastener down the ejection track in the constrained state. The tool also includes a trigger for ejecting the fastener completely from the ejection track. The fastener may be used to secure a prosthetic heart valve or components thereof into surrounding tissue, e.g., within a tissue annulus.

3. 发明申请

US20080119875A1 APPARATUS AND METHOD FOR DELIVERING FASTENERS DURING VALVE REPLACEMENT 有权
标题翻译：阀门更换期间输送紧固件的装置和方法
公开(公告)号：US20080119875A1
公开(公告)日：2008-05-22
申请号：US12022898
申请日：2008-01-30
申请人： Takashi Ino , Michael Drews , Donnell Gurskis
发明人： Takashi Ino , Michael Drews , Donnell Gurskis
IPC分类号： A61B17/10 , B25C5/00 , A61B17/064
CPC分类号： A61B17/0644 , A61B17/068 , A61B2017/00862
摘要： A fastener delivery tool includes a loading chamber for receiving a fastener having a pair of tines overlapping one another to define a loop in a parent or relaxed state. A retaining member retains the fastener in the loading chamber. The fastener delivery tool also includes a tongue, pusher member, and an ejection track communicating with the loading chamber. An actuator causes the tongue to move to engage the tines of the fastener to transform the fastener from the relaxed state to a constrained state defining a U-shape. The actuator also causes the pusher member to release the retaining member and advance the fastener down the ejection track in the constrained state. The tool also includes a trigger for ejecting the fastener completely from the ejection track. The fastener may be used to secure a prosthetic heart valve or components thereof into surrounding tissue, e.g., within a tissue annulus.
摘要翻译：紧固件输送工具包括用于接纳紧固件的装载室，所述紧固件具有一对彼此重叠的齿，以限定处于母体或松弛状态的环。保持构件将紧固件保持在装载室中。紧固件输送工具还包括舌头，推动器构件和与装载室连通的排出轨道。致动器使舌头移动以接合紧固件的尖齿，以将紧固件从松弛状态转变为限定U形的约束状态。致动器还使得推动器构件释放保持构件并且在紧固状态下将紧固件向下推出排出轨道。该工具还包括用于从弹出轨道完全弹出紧固件的触发器。紧固件可以用于将假体心脏瓣膜或其部件固定到周围组织中，例如在组织环空中。

4. 发明申请

US20070225801A1 VALVE INTRODUCERS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：阀门介绍及其使用方法
公开(公告)号：US20070225801A1
公开(公告)日：2007-09-27
申请号：US11685192
申请日：2007-03-12
申请人： Michael Drews , Donnell Gurskis , Takashi Ino , Oleg Svanidze
发明人： Michael Drews , Donnell Gurskis , Takashi Ino , Oleg Svanidze
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2250/0059
摘要： A valve introducer is provided for delivering a valve prosthesis into a biological annulus. During use, a gasket member is introduced into the biological annulus, and secured relative to the biological annulus. A distal end of a valve introducer is introduced into a passage communicating with the biological annulus, and disposed adjacent the gasket member. A valve prosthesis is advanced through the valve introducer towards the gasket member, and secured to the gasket member. In one embodiment, the valve introducer and valve prosthesis have corresponding shapes, requiring the valve prosthesis to be oriented to properly align the valve prosthesis before advancing the valve prosthesis into the valve introducer. Optionally, the valve introducer is compressed or otherwise manipulated to reduce a profile of the distal end before introduction into the passage, which may facilitate introducing the valve introducer through the passage, e.g., past the sino-tubular junction.
摘要翻译：提供了一种阀导管器，用于将瓣膜假体递送到生物环空中。在使用期间，垫圈构件被引入到生物环空中，并相对于生物环固定。阀导入器的远端被引入到与生物环带连通的通道中，并且邻近垫圈构件设置。阀门假体通过阀导入器前进到垫圈构件，并固定到垫圈构件。在一个实施例中，阀导入器和瓣膜假体具有相应的形状，需要在将瓣膜假体推入瓣膜引导器之前将瓣膜假体定向成适当对准瓣膜假体。可选地，阀导入器被压缩或以其他方式操纵以在引入通道之前减小远端的轮廓，这可以有助于引导阀导入器穿过通道，例如通过中肠管结。

5. 发明申请

US20050165479A1 Heart valve assembly and methods for using them 有权
标题翻译：心脏瓣膜组件及其使用方法
公开(公告)号：US20050165479A1
公开(公告)日：2005-07-28
申请号：US10765725
申请日：2004-01-26
申请人： Michael Drews , Donnell Gurskis , Steven Bacich
发明人： Michael Drews , Donnell Gurskis , Steven Bacich
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2412 , A61F2250/006 , A61F2250/0097 , A61F2250/0098
摘要： A heart valve assembly includes a base including a multi-lobular annular shape within a plane, a valve member or other annular body including a multi-lobular shape complementary to the shape of the base, and cooperating connectors on the base and the annular body for connecting the annular body to the base. The base includes an anchoring ring, and a flexible cuff for attaching the base to a biological annulus. The base and the annular body include guides for aligning their multi-lobular shapes, e.g., visual, tactile, or other markers, or tethers that extend from the base that are slidable through the annular body. During use, the base is attached to a biological annulus, the annular body is directed adjacent the annulus, oriented such that the multi-lobular shape of the annular body valve member is aligned with the base, and the annular body is attached to the base.
摘要翻译：心脏瓣膜组件包括在平面内包括多小叶状环状的基部，阀构件或包括与基部的形状互补的多小叶形状的其它环形体，以及基部和环形体上的配合连接器，将环形体连接到基座。底座包括一个固定环，和一个用于将基座连接到生物环的柔性箍。基部和环形体包括用于对准其多小叶形状的引导件，例如从底部延伸的视觉，触觉或其它标记或系绳，其可滑动通过环形体。在使用过程中，基座附接到生物环形区域，环形体被定向成邻近环形区域，定向成使得环形体阀构件的多小叶形状与基部对准，并且环形体附接到基部。

6. 发明申请

US20060195185A1 Two piece heart valves including multiple lobe valves and methods for implanting them 有权
标题翻译：两片心脏瓣膜包括多瓣瓣和植入它们的方法
公开(公告)号：US20060195185A1
公开(公告)日：2006-08-31
申请号：US11069457
申请日：2005-02-28
申请人： Ernest Lane , Michael Drews , Donnell Gurskis , Oleg Svanidze
发明人： Ernest Lane , Michael Drews , Donnell Gurskis , Oleg Svanidze
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2409 , A61F2/2418 , A61F2/2427 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2250/006 , A61F2250/0097
摘要： A heart valve assembly including an annular prosthesis implantable within a biological annulus, a prosthetic valve including a multiple lobular shape for implantation above the biological annulus, and one or more connectors for securing the prosthetic valve to the annular prosthesis. A flexible sewing cuff extends radially from the annular prosthesis that is resiliently flexible for conforming to the multiple lobular shape of the prosthetic valve to enhance a seal between the prosthetic valve and the annular prosthesis. The sewing cuff may include a core resiliently conformable with anatomy surrounding the biological annulus and fabric covering at least a portion of the core.
摘要翻译：一种心脏瓣膜组件，包括可植入生物环境内的环形假体，包括用于植入生物环空以上的多个小叶形状的假体瓣和用于将假体瓣固定到环形假体的一个或多个连接器。弹性缝合针从弹性柔性的环形假体径向延伸，以符合人工瓣膜的多个小叶形状，以增强人造瓣膜和环形假体之间的密封。缝合箍可以包括弹性地与包围生物环的解剖结构的芯和覆盖芯的至少一部分的织物。

7. 发明申请

US20070016288A1 TWO-PIECE PERCUTANEOUS PROSTHETIC HEART VALVES AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：两种先天性心脏瓣膜及其制造和使用方法
公开(公告)号：US20070016288A1
公开(公告)日：2007-01-18
申请号：US11457437
申请日：2006-07-13
申请人： Donnell Gurskis , Michael Drews
发明人： Donnell Gurskis , Michael Drews
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/0075 , A61F2250/006
摘要： A percutaneous heart valve assembly includes a gasket member or other first prosthesis and a valve member or other second prosthesis. The first and second prostheses are contractible from an enlarged or relaxed condition into a contracted or delivery condition. The prostheses may be loaded into the same or separate catheters or other delivery devices for delivery through a patient's vasculature to an implantation site, e.g., a biological annulus within a heart. The first prosthesis may be deployed adjacent or within the biological annulus and secured at least partially into the biological annulus. The second prosthesis may then be deployed adjacent the biological annulus, expanded, and docked to the first prosthesis. In one embodiment, the first and/or second prostheses may be advanced over one or more sutures or other filaments secured to tissue surrounding or adjacent the biological annulus.
摘要翻译：经皮心脏瓣膜组件包括垫圈构件或其它第一假体以及阀构件或其它第二假体。第一和第二假体从扩大或放松的状态收缩成合同或交付条件。假体可以装载到相同或分开的导管或其它递送装置中，以通过患者的脉管系统递送到植入部位，例如心脏内的生物环带。第一假体可以部署在生物环圈附近或内部，并至少部分地固定在生物环空中。然后可以将第二假体部署在生物环带附近，扩展并对接到第一假体。在一个实施例中，第一和/或第二假体可以在固定到围绕或邻近生物环的组织的一个或多个缝线或其它细丝上前进。

8. 发明申请

US20070016285A1 Gasket with Collar for Prosthetic Heart Valves and Methods for Using Them 有权
标题翻译：用于心脏心脏瓣膜的垫圈及其使用方法
公开(公告)号：US20070016285A1
公开(公告)日：2007-01-18
申请号：US11420720
申请日：2006-05-26
申请人： Ernest Lane , Michael Drews , Donnell Gurskis
发明人： Ernest Lane , Michael Drews , Donnell Gurskis
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2412
摘要： A heart valve assembly includes a prosthesis for receiving a prosthetic valve to replace a preexisting natural or prosthetic heart valve within a biological annulus adjacent a sinus cavity. The prosthesis includes an annular member implantable within the biological annulus for contacting tissue surrounding the biological annulus to provide an opening through the biological annulus, a collar extending upwardly from the annular member, and a sewing cuff extending radially outwardly from the annular member and/or collar. Optionally, the annular member and/or collar may be resiliently compressible, expandable, and/or otherwise biased. A valve member, e.g., a mechanical or bioprosthetic valve may be coupled to the collar, e.g., using a drawstring, sutures, or other connectors, to secure the valve member to the gasket member.
摘要翻译：心脏瓣膜组件包括用于接收假体瓣膜的假体，以替代邻近窦腔的生物环空中的预先存在的天然或假体心脏瓣膜。假体包括可植入生物环境内的环形构件，用于接触围绕生物环的组织以提供通过生物环空的开口，从环形构件向上延伸的环和从环形构件径向向外延伸的缝合口和/或领。可选地，环形构件和/或套环可以是可弹性压缩的，可膨胀的和/或以其它方式偏置的。阀构件，例如机械或生物假肢阀可以例如使用束带，缝合线或其它连接器联接到套环，以将阀构件固定到垫圈构件。

9. 发明申请

US20060195184A1 Conformable prosthesis for implanting two-piece heart valves and methods for using them 有权
标题翻译：用于植入两件式心脏瓣膜的适形假体及其使用方法
公开(公告)号：US20060195184A1
公开(公告)日：2006-08-31
申请号：US11069081
申请日：2005-02-28
申请人： Ernest Lane , Michael Drews , Donnell Gurskis
发明人： Ernest Lane , Michael Drews , Donnell Gurskis
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2210/009 , A61F2220/0016 , A61F2250/006 , A61F2250/0097
摘要： A heart valve assembly includes an annular prosthesis and a valve prosthesis. The annular prosthesis includes an annular ring for dilating tissue within a biological annulus and a conformable sewing cuff extending radially from the annular member. The valve prosthesis includes a frame and a valve component. The annular ring is introduced into the biological annulus to dilate tissue surrounding the biological annulus and the sewing cuff conforms to tissue above the biological annulus. Fasteners are directed through the sewing cuff to secure the annular prosthesis to the biological annulus. The annular prosthesis may include a baleen element for biasing fabric on the annular ring outwardly to enhance sealing against the biological annulus. A valve prosthesis is then advanced into the sinus cavity, and secured relative to the annular prosthesis. The sewing cuff may enhance a seal between the valve prosthesis and annular prosthesis.
摘要翻译：心脏瓣膜组件包括环形假体和瓣膜假体。环形假体包括用于扩张生物环境内的组织的环形环和从环形构件径向延伸的适形的缝合箍。瓣膜假体包括框架和阀部件。将环形环引入生物环中以扩张生物环带周围的组织，缝合箍符合生物环带上方的组织。紧固件被引导通过缝合箍，以将环形假体固定到生物环。环形假体可以包括用于在环形环上向外偏压织物以增强针对生物环空的密封的打孔元件。然后，瓣膜假体前进到窦腔中，并相对于环形假体固定。缝合袖口可以增强瓣膜假体和环形假体之间的密封。

10. 发明申请

US20050080454A1 Attachment device and methods of using the same 有权
标题翻译：附件装置及其使用方法
公开(公告)号：US20050080454A1
公开(公告)日：2005-04-14
申请号：US10681700
申请日：2003-10-08
申请人： Michael Drews , Donnell Gurskis , Steven Bacich
发明人： Michael Drews , Donnell Gurskis , Steven Bacich
IPC分类号： A61B17/064 , A61B17/068 , A61B17/08 , A61B17/122
CPC分类号： A61B17/064 , A61B17/0682 , A61B17/083 , A61B17/1227 , A61B2017/0641 , A61F2/2427 , Y10S623/904
摘要： Devices for attaching a first mass and a second mass and methods of making and using the same are disclosed. The devices can be made from an resilient, elastic or deformable materials. The devices can be used to attach a heart valve ring to a biological annulus. The devices can also be used for wound closure or a variety of other procedures such as anchoring a prosthesis to surrounding tissue or another prosthesis, tissue repair, such as in the closure of congenital defects such as septal heart defects, tissue or vessel anastomosis, fixation of tissue with or without a reinforcing mesh for hernia repair, orthopedic anchoring such as in bone fusing or tendon or muscle repair, ophthalmic indications, laparoscopic or endoscopic tissue repair or placement of prostheses, or use by robotic devices for procedures such as those above performed remotely.
摘要翻译：公开了用于附接第一质量块和第二质量块的装置及其制造和使用方法。设备可以由弹性，弹性或可变形材料制成。该装置可用于将心脏瓣膜环附接到生物环。该装置还可以用于伤口闭合或各种其他程序，例如将假体锚定到周围组织或另一假体，组织修复，例如闭合先天性缺陷，例如中隔心脏缺陷，组织或血管吻合，固定具有或不具有用于疝修补的加强网的组织，矫形锚固例如骨融合或肌腱或肌肉修复，眼科适应症，腹腔镜或内窥镜组织修复或假体放置，或由机器人装置用于上述方法远程

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