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1. 发明申请

US20110230906A1 DEVICES, METHODS AND KITS FOR FORMING TRACTS IN TISSUE 审中-公开
标题翻译：用于形成组织中的牵引的装置，方法和工具
公开(公告)号：US20110230906A1
公开(公告)日：2011-09-22
申请号：US13004848
申请日：2011-01-11
申请人： D. Bruce Modesitt , George D. Hermann , Michael Drews , Joseph F. Paraschac , Brian Andrew Ellingwood , Dan J. Hammersmark
发明人： D. Bruce Modesitt , George D. Hermann , Michael Drews , Joseph F. Paraschac , Brian Andrew Ellingwood , Dan J. Hammersmark
IPC分类号： A61B17/34
CPC分类号： A61B17/3403 , A61B1/018 , A61B1/04 , A61B1/042 , A61B1/05 , A61B1/313 , A61B1/3132 , A61B1/3137 , A61B17/3421 , A61B17/3494 , A61B34/20 , A61B90/361 , A61B2017/00022 , A61B2017/00026 , A61B2017/00057 , A61B2017/00084 , A61B2017/00106 , A61B2017/00278 , A61B2017/00867 , A61B2017/3413 , A61B2017/3425 , A61B2017/3488 , A61B2018/00005 , A61B2034/2063 , A61B2090/064 , A61B2090/065 , A61B2090/378 , A61B2090/3786 , A61M5/427
摘要： Described here are methods, devices and kits for locating tissue and/or forming one or more tracts in tissue. In some variations, tissue may be located (e.g., using one or more optical sensors, ultrasound sensors, thermal sensors, or the like) and one or more tracts may be formed through the tissue after it has been located. In certain variations, the same device may be used both to locate tissue and to form one or more tracts in the tissue. In some variations, a tissue-piercing member for forming one or more tracts in tissue may comprise a first elongated portion and a second elongated portion, and an angle therebetween.
摘要翻译：这里描述了用于定位组织和/或在组织中形成一个或多个束的方法，装置和试剂盒。在一些变型中，可以定位组织（例如，使用一个或多个光学传感器，超声波传感器，热传感器等），并且可以在组织定位之后通过组织形成一个或多个束。在某些变型中，可以使用相同的装置来定位组织并在组织中形成一个或多个束。在一些变型中，用于在组织中形成一个或多个束的组织刺穿构件可以包括第一细长部分和第二细长部分以及它们之间的角度。

2. 发明申请

US20050177224A1 Vascular fixation device and method 审中-公开
标题翻译：血管固定装置及方法
公开(公告)号：US20050177224A1
公开(公告)日：2005-08-11
申请号：US10776570
申请日：2004-02-11
申请人： Thomas Fogarty , D. Modesitt , Neil Holmgren , Jamie van Hoften , Michael Drews
发明人： Thomas Fogarty , D. Modesitt , Neil Holmgren , Jamie van Hoften , Michael Drews
IPC分类号： A61F2/06 , A61F2/86
CPC分类号： A61F2/07 , A61F2/86 , A61F2/89 , A61F2002/061 , A61F2002/065 , A61F2002/075 , A61F2002/8486
摘要： An intravascular anchoring implant is disclosed. The present invention also relates to the attachment to the intravascular implant of second and possibly third implants, such as a graft attachment device and a vascular graft. Methods of using the implant within the vasculature of the body, particularly adjacent to vascular aneurysms, are also disclosed
摘要翻译：公开了一种血管内锚定植入物。本发明还涉及第二和可能的第三种植入物如血管移植物附着物，例如移植物附着装置和血管移植物。还公开了在体内脉管系统（特别是与血管动脉瘤相邻）内使用植入物的方法

3. 发明申请

US20050165479A1 Heart valve assembly and methods for using them 有权
标题翻译：心脏瓣膜组件及其使用方法
公开(公告)号：US20050165479A1
公开(公告)日：2005-07-28
申请号：US10765725
申请日：2004-01-26
申请人： Michael Drews , Donnell Gurskis , Steven Bacich
发明人： Michael Drews , Donnell Gurskis , Steven Bacich
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2412 , A61F2250/006 , A61F2250/0097 , A61F2250/0098
摘要： A heart valve assembly includes a base including a multi-lobular annular shape within a plane, a valve member or other annular body including a multi-lobular shape complementary to the shape of the base, and cooperating connectors on the base and the annular body for connecting the annular body to the base. The base includes an anchoring ring, and a flexible cuff for attaching the base to a biological annulus. The base and the annular body include guides for aligning their multi-lobular shapes, e.g., visual, tactile, or other markers, or tethers that extend from the base that are slidable through the annular body. During use, the base is attached to a biological annulus, the annular body is directed adjacent the annulus, oriented such that the multi-lobular shape of the annular body valve member is aligned with the base, and the annular body is attached to the base.
摘要翻译：心脏瓣膜组件包括在平面内包括多小叶状环状的基部，阀构件或包括与基部的形状互补的多小叶形状的其它环形体，以及基部和环形体上的配合连接器，将环形体连接到基座。底座包括一个固定环，和一个用于将基座连接到生物环的柔性箍。基部和环形体包括用于对准其多小叶形状的引导件，例如从底部延伸的视觉，触觉或其它标记或系绳，其可滑动通过环形体。在使用过程中，基座附接到生物环形区域，环形体被定向成邻近环形区域，定向成使得环形体阀构件的多小叶形状与基部对准，并且环形体附接到基部。

4. 发明申请

US20110125178A1 DEVICES, METHODS AND KITS FOR FORMING TRACTS IN TISSUE 审中-公开
标题翻译：用于形成组织中的牵引的装置，方法和工具
公开(公告)号：US20110125178A1
公开(公告)日：2011-05-26
申请号：US12780768
申请日：2010-05-14
申请人： Michael Drews , D. Bruce Modesitt
发明人： Michael Drews , D. Bruce Modesitt
IPC分类号： A61B17/34 , A61B17/00
CPC分类号： A61B17/3478 , A61B2017/003
摘要： Described here are devices, methods, and kits for forming one or more tracts in tissue. The tracts may be formed in any suitable or desirable tissue, and may seal relatively quickly without the need for a supplemental closure device. In some variations, the methods may comprise advancing a tissue-piercing member along a predetermined path of a tract-forming device to form one or more tracts in tissue (e.g., a vessel wall). The tract or tracts may, for example, provide access for one or more tools.
摘要翻译：这里描述了用于在组织中形成一个或多个束的装置，方法和试剂盒。这些束可以形成在任何合适的或期望的组织中，并且可以相对快速地密封，而不需要补充关闭装置。在一些变型中，所述方法可以包括使组织刺穿构件沿道束形成装置的预定路径前进，以在组织（例如血管壁）中形成一个或多个束。道或束可以例如为一个或多个工具提供通路。

5. 发明申请

US20060195186A1 Connectors for two piece heart valves and methods for implanting such heart valves 审中-公开
标题翻译：用于两片心脏瓣膜的连接器和用于植入这种心脏瓣膜的方法
公开(公告)号：US20060195186A1
公开(公告)日：2006-08-31
申请号：US11069617
申请日：2005-02-28
申请人： Michael Drews , Donnell Gurskis , Ernest Lane , Dwight Knab
发明人： Michael Drews , Donnell Gurskis , Ernest Lane , Dwight Knab
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2210/009 , A61F2220/0016 , A61F2250/006 , A61F2250/0097
摘要： A heart valve assembly includes an annular prosthesis including an annular member and a sewing cuff extending radially from the annular member, and a valve member including a frame and a plurality of leaflets carried by struts. The annular prosthesis includes a plurality of pockets extending upwardly from the annular prosthesis for receiving a portion of the frame for securing the valve member to the annular prosthesis. Each pocket may include a flexible rim extending upwardly the sewing cuff and a cover at least partially defining a recess. The rim may be deflectable radially outwardly to accommodate a portion of the frame being received in the recess, and may be resiliently biased to return inwardly when released to cover the portion of the frame with the respective cover. The valve member may be further secured to the annular prosthesis by an interference fit between the rim and the frame.
摘要翻译：心脏瓣膜组件包括环形假体，其包括环形构件和从环形构件径向延伸的缝合箍，以及包括框架的阀构件和由支柱承载的多个传单。环形假体包括从环形假体向上延伸的多个口袋，用于接收框架的一部分，用于将阀构件固定到环形假体。每个口袋可以包括向上延伸到缝合箍的柔性边缘和至少部分地限定凹部的盖。边缘可以径向向外偏转以容纳框架的一部分被容纳在凹部中，并且当被释放以与相应的盖覆盖框架的该部分时，可以被弹性地偏置以向内返回。阀构件可以通过轮缘和框架之间的过盈配合进一步固定到环形假体上。

6. 发明申请

US20060122634A1 Apparatus and method for delivering fasteners during valve replacement 审中-公开
公开(公告)号：US20060122634A1
公开(公告)日：2006-06-08
申请号：US11004445
申请日：2004-12-03
申请人： Takashi Ino , Michael Drews , Donnell Gurskis
发明人： Takashi Ino , Michael Drews , Donnell Gurskis
IPC分类号： A61B17/10
CPC分类号： A61B17/0644 , A61B17/068 , A61B2017/00862
摘要： A fastener delivery tool includes a loading chamber for receiving a fastener having a pair of tines overlapping one another to define a loop in a parent or relaxed state. A retaining member retains the fastener in the loading chamber. The fastener delivery tool also includes a tongue, pusher member, and an ejection track communicating with the loading chamber. An actuator causes the tongue to move to engage the tines of the fastener to transform the fastener from the relaxed state to a constrained state defining a U-shape. The actuator also causes the pusher member to release the retaining member and advance the fastener down the ejection track in the constrained state. The tool also includes a trigger for ejecting the fastener completely from the ejection track. The fastener may be used to secure a prosthetic heart valve or components thereof into surrounding tissue, e.g., within a tissue annulus.

7. 发明申请

US20050240263A1 Biologically implantable prosthesis and methods of using the same 有权
标题翻译：生物可植入假体及其使用方法
公开(公告)号：US20050240263A1
公开(公告)日：2005-10-27
申请号：US11080009
申请日：2005-03-14
申请人： Thomas Fogarty , Michael Drews , Neil Holmgren , D. Modesitt
发明人： Thomas Fogarty , Michael Drews , Neil Holmgren , D. Modesitt
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61F2/02 , A61F2/24
CPC分类号： A61F2/2409 , A61B17/0401 , A61B2017/00243 , A61B2017/0406 , A61B2017/0417 , A61B2017/0496 , A61B2017/0608 , A61F2/2412 , A61F2/2415 , A61F2/2445 , A61F2002/30545 , A61F2220/0016 , A61F2220/0041 , A61F2220/0066 , A61F2220/0075 , A61F2250/001 , Y10S623/91
摘要： A heart valve assembly includes a first annular prosthesis for implantation within a tissue annulus, a second valve prosthesis, and a plurality of magnets on the first and second prostheses to secure the second prosthesis to the first prosthesis. In one embodiment, the magnets are arranged to allow the second prosthesis to be secured to the first prosthesis in a predetermined angular orientation. During use, the first annular prosthesis is implanted into the annulus, and the second valve prosthesis is inserted into the annulus. The magnets orient the second prosthesis relative to the first prosthesis to align the second prosthesis with the first prosthesis in a predetermined angular orientation; and secure the second prosthesis to the first prosthesis in the predetermined angular orientation.
摘要翻译：心脏瓣膜组件包括用于植入在组织环空中的第一环形假体，第二瓣膜假体以及在第一和第二假体上的多个磁体，以将第二假体固定到第一假体。在一个实施例中，磁体被布置成允许第二假体以预定的角度定向固定到第一假体。在使用期间，将第一环形假体植入到环形空间中，并且将第二瓣膜假体插入到环空中。所述磁体相对于所述第一假体定向所述第二假体以使所述第二假体与所述第一假体以预定的角度取向对准; 并且以预定的角度定向将第二假体固定到第一假体。

8. 发明申请

US20070016288A1 TWO-PIECE PERCUTANEOUS PROSTHETIC HEART VALVES AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：两种先天性心脏瓣膜及其制造和使用方法
公开(公告)号：US20070016288A1
公开(公告)日：2007-01-18
申请号：US11457437
申请日：2006-07-13
申请人： Donnell Gurskis , Michael Drews
发明人： Donnell Gurskis , Michael Drews
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/0075 , A61F2250/006
摘要： A percutaneous heart valve assembly includes a gasket member or other first prosthesis and a valve member or other second prosthesis. The first and second prostheses are contractible from an enlarged or relaxed condition into a contracted or delivery condition. The prostheses may be loaded into the same or separate catheters or other delivery devices for delivery through a patient's vasculature to an implantation site, e.g., a biological annulus within a heart. The first prosthesis may be deployed adjacent or within the biological annulus and secured at least partially into the biological annulus. The second prosthesis may then be deployed adjacent the biological annulus, expanded, and docked to the first prosthesis. In one embodiment, the first and/or second prostheses may be advanced over one or more sutures or other filaments secured to tissue surrounding or adjacent the biological annulus.
摘要翻译：经皮心脏瓣膜组件包括垫圈构件或其它第一假体以及阀构件或其它第二假体。第一和第二假体从扩大或放松的状态收缩成合同或交付条件。假体可以装载到相同或分开的导管或其它递送装置中，以通过患者的脉管系统递送到植入部位，例如心脏内的生物环带。第一假体可以部署在生物环圈附近或内部，并至少部分地固定在生物环空中。然后可以将第二假体部署在生物环带附近，扩展并对接到第一假体。在一个实施例中，第一和/或第二假体可以在固定到围绕或邻近生物环的组织的一个或多个缝线或其它细丝上前进。

9. 发明申请

US20070016285A1 Gasket with Collar for Prosthetic Heart Valves and Methods for Using Them 有权
标题翻译：用于心脏心脏瓣膜的垫圈及其使用方法
公开(公告)号：US20070016285A1
公开(公告)日：2007-01-18
申请号：US11420720
申请日：2006-05-26
申请人： Ernest Lane , Michael Drews , Donnell Gurskis
发明人： Ernest Lane , Michael Drews , Donnell Gurskis
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2412
摘要： A heart valve assembly includes a prosthesis for receiving a prosthetic valve to replace a preexisting natural or prosthetic heart valve within a biological annulus adjacent a sinus cavity. The prosthesis includes an annular member implantable within the biological annulus for contacting tissue surrounding the biological annulus to provide an opening through the biological annulus, a collar extending upwardly from the annular member, and a sewing cuff extending radially outwardly from the annular member and/or collar. Optionally, the annular member and/or collar may be resiliently compressible, expandable, and/or otherwise biased. A valve member, e.g., a mechanical or bioprosthetic valve may be coupled to the collar, e.g., using a drawstring, sutures, or other connectors, to secure the valve member to the gasket member.
摘要翻译：心脏瓣膜组件包括用于接收假体瓣膜的假体，以替代邻近窦腔的生物环空中的预先存在的天然或假体心脏瓣膜。假体包括可植入生物环境内的环形构件，用于接触围绕生物环的组织以提供通过生物环空的开口，从环形构件向上延伸的环和从环形构件径向向外延伸的缝合口和/或领。可选地，环形构件和/或套环可以是可弹性压缩的，可膨胀的和/或以其它方式偏置的。阀构件，例如机械或生物假肢阀可以例如使用束带，缝合线或其它连接器联接到套环，以将阀构件固定到垫圈构件。

10. 发明申请

US20060195184A1 Conformable prosthesis for implanting two-piece heart valves and methods for using them 有权
标题翻译：用于植入两件式心脏瓣膜的适形假体及其使用方法
公开(公告)号：US20060195184A1
公开(公告)日：2006-08-31
申请号：US11069081
申请日：2005-02-28
申请人： Ernest Lane , Michael Drews , Donnell Gurskis
发明人： Ernest Lane , Michael Drews , Donnell Gurskis
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2210/009 , A61F2220/0016 , A61F2250/006 , A61F2250/0097
摘要： A heart valve assembly includes an annular prosthesis and a valve prosthesis. The annular prosthesis includes an annular ring for dilating tissue within a biological annulus and a conformable sewing cuff extending radially from the annular member. The valve prosthesis includes a frame and a valve component. The annular ring is introduced into the biological annulus to dilate tissue surrounding the biological annulus and the sewing cuff conforms to tissue above the biological annulus. Fasteners are directed through the sewing cuff to secure the annular prosthesis to the biological annulus. The annular prosthesis may include a baleen element for biasing fabric on the annular ring outwardly to enhance sealing against the biological annulus. A valve prosthesis is then advanced into the sinus cavity, and secured relative to the annular prosthesis. The sewing cuff may enhance a seal between the valve prosthesis and annular prosthesis.
摘要翻译：心脏瓣膜组件包括环形假体和瓣膜假体。环形假体包括用于扩张生物环境内的组织的环形环和从环形构件径向延伸的适形的缝合箍。瓣膜假体包括框架和阀部件。将环形环引入生物环中以扩张生物环带周围的组织，缝合箍符合生物环带上方的组织。紧固件被引导通过缝合箍，以将环形假体固定到生物环。环形假体可以包括用于在环形环上向外偏压织物以增强针对生物环空的密封的打孔元件。然后，瓣膜假体前进到窦腔中，并相对于环形假体固定。缝合袖口可以增强瓣膜假体和环形假体之间的密封。

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