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1. 发明授权

US06852972B2 Mass spectrometer 失效
标题翻译：质谱仪
公开(公告)号：US06852972B2
公开(公告)日：2005-02-08
申请号：US10446667
申请日：2003-05-29
申请人： Takashi Baba , Yuichiro Hashimoto , Kiyomi Yoshinari
发明人： Takashi Baba , Yuichiro Hashimoto , Kiyomi Yoshinari
IPC分类号： G01N27/62 , H01J49/40 , H01J49/42
CPC分类号： H01J49/424 , H01J49/004 , H01J49/401 , H01J49/427
摘要： Heavy ions are ejected earlier than light ions sequentially at almost zero energy and they are accelerated at a fixed voltage so as to be guided to a pusher of a TOF spectrometer. After ions are ejected in a procedure of giving an electric field gradient to an ion trap and linearly decreasing its RF voltage, a condition of spatially focusing ions having all mass numbers of a single point on the pusher is found. The focused ions are vertically accelerated using the pusher to perform the TOF mass spectrometry.
摘要翻译：重离子比轻离子顺序地以几乎零的能量排出，并且它们以固定电压被加速，以被引导到TOF光谱仪的推动器。在向离子阱提供电场梯度并线性地降低其RF电压的过程中排出离子之后，发现在推动器上具有单个质点数的空间聚焦的条件。使用推动器垂直加速聚焦的离子进行TOF质谱。

2. 发明授权

US07608819B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07608819B2
公开(公告)日：2009-10-27
申请号：US12078523
申请日：2008-04-01
申请人： Takashi Baba , Yuichiro Hashimoto
发明人： Takashi Baba , Yuichiro Hashimoto
IPC分类号： H01J49/00
CPC分类号： H01J49/4225 , H01J49/0054 , H01J49/422
摘要： The present invention provides a mass spectrometry capable of high-efficiency and high-throughput ECD. An electron source and a two-dimensional combined ion trap in which a magnetic field along and generally parallel to a central axis is applied are used, thereby to achieve the foregoing object. First, precursor ions are trapped. By adopting the two-dimensional combined ion trap, it is possible to obtain a high ion trapping efficiency upon being injected and trapping. Subsequently, electrons are made incident thereon in such a manner as to be wound along the central axis to which no radio frequency is applied by using a magnetic field. For this reason, it is possible to allow energy-controlled electrons to reach the precursor ions. It is possible to implement a mass spectrometer capable of avoiding heating due to a radio frequency electric field, and effecting high-throughput/high-efficiency ECD.
摘要翻译：本发明提供能够实现高效率和高通量ECD的质谱。使用其中施加沿着并且大致平行于中心轴的磁场的电子源和二维组合离子阱，从而实现上述目的。首先，前体离子被捕获。通过采用二维组合离子阱，可以在注入和捕获时获得高离子捕获效率。随后，使电子以这样的方式入射，即沿着不通过使用磁场施加射频的中心轴缠绕。因此，可以使能量控制的电子达到前体离子。可以实现能够避免由于射频电场引起的加热并且实现高通量/高效率ECD的质谱仪。

3. 发明授权

US07329862B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07329862B2
公开(公告)日：2008-02-12
申请号：US11495534
申请日：2006-07-31
申请人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
发明人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
IPC分类号： H01J49/00
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/401
摘要： A mass spectrometer capable of analyzing a wide mass range with high sensitivity and high mass accuracy. A mass spectrometer has an ionization source generating ions; an ion transfer optics transferring the ions; a first linear trap accumulating the ions and ejecting the ions in the specific mass range; a second linear trap having an end electrode disposed at the exit end ejecting the ions to change a DC potential gradient relative to a DC potential of the end electrode and trapping the ions ejected from the first linear trap to repeatedly eject them in pulse form; a time-of-flight mass spectrometer accelerating the ions ejected from the second linear trap in the orthogonal direction to detect them; and a controller changing the time duration of the ions in which the ions are ejected from the second linear trap or delay time from the completion of ejection to application of an accelerating voltage of the time-of-flight mass spectrometer according to the mass range of the ions ejected from the first linear trap to the second linear trap.
摘要翻译：能够以高灵敏度和高质量精度分析宽质量范围的质谱仪。质谱仪具有产生离子的电离源; 离子转移光学器件转移离子; 积聚离子并在特定质量范围内喷射离子的第一线性阱; 第二线性阱，其具有设置在出射端处的终端电极，其排出离子，以相对于端电极的DC电位改变DC电位梯度，并且捕获从第一线性阱捕获的离子重复地以脉冲形式喷射; 飞行时间质谱仪在正交方向加速从第二线性阱捕获的离子以检测它们; 以及控制器，其将离子从第二线性阱捕获的离子或从完成喷射的延迟时间的持续时间改变为根据飞行时间质谱仪的加速电压的质量范围离子从第一线性捕集器喷射到第二线性阱。

4. 发明申请

US20070069124A1 Mass spectrometer 有权
公开(公告)号：US20070069124A1
公开(公告)日：2007-03-29
申请号：US11605437
申请日：2006-11-29
申请人： Takashi Baba , Yuichiro Hashimoto
发明人： Takashi Baba , Yuichiro Hashimoto
IPC分类号： H01J49/00
CPC分类号： H01J49/4225 , H01J49/0054 , H01J49/422
摘要： The present invention provides a mass spectrometry capable of high-efficiency and high-throughput ECD. An electron source and a two-dimensional combined ion trap in which a magnetic field along and generally parallel to a central axis is applied are used, thereby to achieve the foregoing object. First, precursor ions are trapped. By adopting the two-dimensional combined ion trap, it is possible to obtain a high ion trapping efficiency upon being injected and trapping. Subsequently, electrons are made incident thereon in such a manner as to be wound along the central axis to which no radio frequency is applied by using a magnetic field. For this reason, it is possible to allow energy-controlled electrons to reach the precursor ions. It is possible to implement a mass spectrometer capable of avoiding heating due to a radio frequency electric field, and effecting high-throughput/high-efficiency ECD.

5. 发明授权

US06967323B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06967323B2
公开(公告)日：2005-11-22
申请号：US10868933
申请日：2004-06-17
申请人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
发明人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
IPC分类号： G01N27/62 , G01N27/64 , H01J49/00 , H01J49/40 , H01J49/42
CPC分类号： H01J49/063 , H01J49/004 , H01J49/0481
摘要： An ion mass spectrometer comprising an ionization source for generating ions, a linear trap region for accumulation and dissociation of ions, and a time-of-flight mass spectrometer for mass spectroscopy of ions based on the flying time, and having a collision damping region introduced with a buffer gas for reducing the kinetic energy of ions ejected from the linear trap region and converting the ion packet into continuous beam and provided with plural electrodes for generating multipole electric fields in the inside between the linear trap region and the time-of-flight mass spectrometer, and having an ion transmission control mechanism for allowing or inhibiting incidence of ion from the linear trap region to the collision damping region between the linear trap region and the collision damping region.
摘要翻译：一种离子质谱仪，包括用于产生离子的电离源，用于离子的聚集和离解的线性捕获区域，以及用于基于飞行时间的离子质谱的飞行时间质谱仪，并且具有引入的碰撞阻尼区域使用缓冲气体，用于降低从线性捕获区域排出的离子的动能，并将离子包转换为连续光束，并设置有多个电极，用于在线性捕获区域和飞行时间之间的内部产生多极电场并且具有用于允许或抑制从线性捕获区域到线性捕获区域和碰撞阻尼区域之间的碰撞阻尼区域的入射的离子传输控制机构。

6. 发明授权

US07675033B2 Method of mass spectrometry and mass spectrometer 有权
标题翻译：质谱法和质谱仪
公开(公告)号：US07675033B2
公开(公告)日：2010-03-09
申请号：US11631033
申请日：2006-03-08
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
IPC分类号： H01J49/42
CPC分类号： H01J49/427 , H01J49/067 , H01J49/4225
摘要： In a mass spectrometer introducing ions produced at an ion source, and including quadrupole rods which have an inlet and an outlet and to which a radio-frequency voltage is applied, the mass spectrometer, i.e., a mass spectrometry device implemented by a linear trap which exhibits high ejection efficiency, high mass resolution, and low ejection energy, executes the following steps: Trapping at least part of the ions by a trap potential generated on the central axis of a quadrupole field, oscillating part of the trapped ions in an intermediate direction between the mutually-adjacent quadrupole rods, ejecting the oscillated ions by an extraction field, and detecting the ejected ions or introducing the ejected ions into another detection process.
摘要翻译：在质谱仪中引入在离子源处产生的离子，并且包括具有入口和出口的四极棒，并且施加射频电压，质谱仪即通过线性捕获器实现的质谱装置表现出高喷射效率，高质量分辨率和低喷射能量，执行以下步骤：通过在四极场的中心轴上产生的捕获电位捕获至少一部分离子，在中间方向上振荡部分捕获的离子在相邻的四极棒之间，通过提取场喷射振荡的离子，并检测喷出的离子或将喷出的离子引入另一检测过程。

7. 发明授权

US07381946B2 Mass spectrometer 有权
公开(公告)号：US07381946B2
公开(公告)日：2008-06-03
申请号：US11605437
申请日：2006-11-29
申请人： Takashi Baba , Yuichiro Hashimoto
发明人： Takashi Baba , Yuichiro Hashimoto
IPC分类号： H01J49/26
CPC分类号： H01J49/4225 , H01J49/0054 , H01J49/422
摘要： The present invention provides a mass spectrometry capable of high-efficiency and high-throughput ECD. An electron source and a two-dimensional combined ion trap in which a magnetic field along and generally parallel to a central axis is applied are used, thereby to achieve the foregoing object. First, precursor ions are trapped. By adopting the two-dimensional combined ion trap, it is possible to obtain a high ion trapping efficiency upon being injected and trapping. Subsequently, electrons are made incident thereon in such a manner as to be wound along the central axis to which no radio frequency is applied by using a magnetic field. For this reason, it is possible to allow energy-controlled electrons to reach the precursor ions. It is possible to implement a mass spectrometer capable of avoiding heating due to a radio frequency electric field, and effecting high-throughput/high-efficiency ECD.

8. 发明授权

US07208728B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07208728B2
公开(公告)日：2007-04-24
申请号：US10997896
申请日：2004-11-29
申请人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
发明人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
IPC分类号： H01J49/00
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/401
摘要： A mass spectrometer capable of analyzing a wide mass range with high sensitivity and high mass accuracy. A mass spectrometer has an ionization source generating ions; an ion transfer optics transferring the ions; a first linear trap accumulating the ions and ejecting the ions in the specific mass range; a second linear trap having an end electrode disposed at the exit end ejecting the ions to change a DC potential gradient relative to a DC potential of the end electrode and trapping the ions ejected from the first linear trap to repeatedly eject them in pulse form; a time-of-flight mass spectrometer accelerating the ions ejected from the second linear trap in the orthogonal direction to detect them; and a controller changing the time duration of the ions in which the ions are ejected from the second linear trap or delay time from the completion of ejection to application of an accelerating voltage of the time-of-flight mass spectrometer according to the mass range of the ions ejected from the first linear trap to the second linear trap.
摘要翻译：能够以高灵敏度和高质量精度分析宽质量范围的质谱仪。质谱仪具有产生离子的电离源; 离子转移光学器件转移离子; 积聚离子并在特定质量范围内喷射离子的第一线性阱; 第二线性阱，其具有设置在出射端处的终端电极，其排出离子，以相对于端电极的DC电位改变DC电位梯度，并且捕获从第一线性阱捕获的离子重复地以脉冲形式喷射; 飞行时间质谱仪在正交方向加速从第二线性阱捕获的离子以检测它们; 以及控制器，其将离子从第二线性阱捕获的离子或从完成喷射的延迟时间的持续时间改变为根据飞行时间质谱仪的加速电压的质量范围离子从第一线性捕集器喷射到第二线性阱。

9. 发明申请

US20050023452A1 Mass spectrometer 有权
公开(公告)号：US20050023452A1
公开(公告)日：2005-02-03
申请号：US10868933
申请日：2004-06-17
申请人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
发明人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
IPC分类号： G01N27/62 , G01N27/64 , H01J49/00 , H01J49/40 , H01J49/42
CPC分类号： H01J49/063 , H01J49/004 , H01J49/0481
摘要： An ion mass spectrometer comprising an ionization source for generating ions, a linear trap region for accumulation and dissociation of ions, and a time-of-flight mass spectrometer for mass spectroscopy of ions based on the flying time, and having a collision damping region introduced with a buffer gas for reducing the kinetic energy of ions ejected from the linear trap region and converting the ion packet into continuous beam and provided with plural electrodes for generating multipole electric fields in the inside between the linear trap region and the time-of-flight mass spectrometer, and having an ion transmission control mechanism for allowing or inhibiting incidence of ion from the linear trap region to the collision damping region between the linear trap region and the collision damping region.

10. 发明授权

US07592589B2 Method of mass spectrometry and mass spectrometer 有权
标题翻译：质谱法和质谱仪
公开(公告)号：US07592589B2
公开(公告)日：2009-09-22
申请号：US11716615
申请日：2007-03-12
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
IPC分类号： H01J49/42
CPC分类号： H01J49/427 , H01J49/067 , H01J49/4225
摘要： A mass spectrometry device includes an ion source for ionizing a sample, an ion trap for trapping ions ionized by the ion source. A control unit for controlling voltages applied to lenses forming part of the ion trap, and a detection unit for detecting the ions trapped by said ion trap. The control unit causes a trap potential to be generated on a central axis of quadrupole rods forming part of the ion trap, causes part of the trapped ions to be oscillated in an intermediate direction between the quadrupole rods which are mutually adjacent to each other, and applies a voltage for ejecting the oscillated ions in a central-axis direction of the quadrupole rods by generating an extraction field.
摘要翻译：质谱装置包括用于离子化样品的离子源，用于捕获由离子源离子化的离子的离子阱。用于控制施加到形成所述离子阱的一部分的透镜的电压的控制单元，以及用于检测由所述离子阱捕获的离子的检测单元。控制单元在形成离子阱的一部分的四极杆的中心轴上产生捕获电位，使被捕获的离子的一部分在彼此相邻的四极棒之间的中间方向振荡，并且通过产生提取场来施加用于在四极棒的中心轴方向上弹出振荡的离子的电压。

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