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1. 发明授权

US07329862B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07329862B2
公开(公告)日：2008-02-12
申请号：US11495534
申请日：2006-07-31
申请人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
发明人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
IPC分类号： H01J49/00
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/401
摘要： A mass spectrometer capable of analyzing a wide mass range with high sensitivity and high mass accuracy. A mass spectrometer has an ionization source generating ions; an ion transfer optics transferring the ions; a first linear trap accumulating the ions and ejecting the ions in the specific mass range; a second linear trap having an end electrode disposed at the exit end ejecting the ions to change a DC potential gradient relative to a DC potential of the end electrode and trapping the ions ejected from the first linear trap to repeatedly eject them in pulse form; a time-of-flight mass spectrometer accelerating the ions ejected from the second linear trap in the orthogonal direction to detect them; and a controller changing the time duration of the ions in which the ions are ejected from the second linear trap or delay time from the completion of ejection to application of an accelerating voltage of the time-of-flight mass spectrometer according to the mass range of the ions ejected from the first linear trap to the second linear trap.
摘要翻译：能够以高灵敏度和高质量精度分析宽质量范围的质谱仪。质谱仪具有产生离子的电离源; 离子转移光学器件转移离子; 积聚离子并在特定质量范围内喷射离子的第一线性阱; 第二线性阱，其具有设置在出射端处的终端电极，其排出离子，以相对于端电极的DC电位改变DC电位梯度，并且捕获从第一线性阱捕获的离子重复地以脉冲形式喷射; 飞行时间质谱仪在正交方向加速从第二线性阱捕获的离子以检测它们; 以及控制器，其将离子从第二线性阱捕获的离子或从完成喷射的延迟时间的持续时间改变为根据飞行时间质谱仪的加速电压的质量范围离子从第一线性捕集器喷射到第二线性阱。

2. 发明授权

US06967323B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06967323B2
公开(公告)日：2005-11-22
申请号：US10868933
申请日：2004-06-17
申请人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
发明人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
IPC分类号： G01N27/62 , G01N27/64 , H01J49/00 , H01J49/40 , H01J49/42
CPC分类号： H01J49/063 , H01J49/004 , H01J49/0481
摘要： An ion mass spectrometer comprising an ionization source for generating ions, a linear trap region for accumulation and dissociation of ions, and a time-of-flight mass spectrometer for mass spectroscopy of ions based on the flying time, and having a collision damping region introduced with a buffer gas for reducing the kinetic energy of ions ejected from the linear trap region and converting the ion packet into continuous beam and provided with plural electrodes for generating multipole electric fields in the inside between the linear trap region and the time-of-flight mass spectrometer, and having an ion transmission control mechanism for allowing or inhibiting incidence of ion from the linear trap region to the collision damping region between the linear trap region and the collision damping region.
摘要翻译：一种离子质谱仪，包括用于产生离子的电离源，用于离子的聚集和离解的线性捕获区域，以及用于基于飞行时间的离子质谱的飞行时间质谱仪，并且具有引入的碰撞阻尼区域使用缓冲气体，用于降低从线性捕获区域排出的离子的动能，并将离子包转换为连续光束，并设置有多个电极，用于在线性捕获区域和飞行时间之间的内部产生多极电场并且具有用于允许或抑制从线性捕获区域到线性捕获区域和碰撞阻尼区域之间的碰撞阻尼区域的入射的离子传输控制机构。

3. 发明授权

US07592589B2 Method of mass spectrometry and mass spectrometer 有权
标题翻译：质谱法和质谱仪
公开(公告)号：US07592589B2
公开(公告)日：2009-09-22
申请号：US11716615
申请日：2007-03-12
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
IPC分类号： H01J49/42
CPC分类号： H01J49/427 , H01J49/067 , H01J49/4225
摘要： A mass spectrometry device includes an ion source for ionizing a sample, an ion trap for trapping ions ionized by the ion source. A control unit for controlling voltages applied to lenses forming part of the ion trap, and a detection unit for detecting the ions trapped by said ion trap. The control unit causes a trap potential to be generated on a central axis of quadrupole rods forming part of the ion trap, causes part of the trapped ions to be oscillated in an intermediate direction between the quadrupole rods which are mutually adjacent to each other, and applies a voltage for ejecting the oscillated ions in a central-axis direction of the quadrupole rods by generating an extraction field.
摘要翻译：质谱装置包括用于离子化样品的离子源，用于捕获由离子源离子化的离子的离子阱。用于控制施加到形成所述离子阱的一部分的透镜的电压的控制单元，以及用于检测由所述离子阱捕获的离子的检测单元。控制单元在形成离子阱的一部分的四极杆的中心轴上产生捕获电位，使被捕获的离子的一部分在彼此相邻的四极棒之间的中间方向振荡，并且通过产生提取场来施加用于在四极棒的中心轴方向上弹出振荡的离子的电压。

4. 发明授权

US07348554B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07348554B2
公开(公告)日：2008-03-25
申请号：US11146157
申请日：2005-06-07
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Hiroyuki Satake , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Hiroyuki Satake , Izumi Waki
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/4265
摘要： A mass spectrometer includes: an ion source for ionizing a specimen to generate ions, an ion transport portion for transporting the ions, a linear ion trap portion for accumulating the transported ions by a potential formed axially, and a control portion of ejecting the ions within a second m/z range different from a first m/z range, from the linear ion trap portion, and substantially at the same timing as the timing of accumulating the ions within the first m/z range from the transport portion into the linear ion trap portion. The ion transportation portion having a mass selection means for selecting the ions in the first m/z range.
摘要翻译：质谱仪包括：离子源，用于离子化样品以产生离子;离子传输部分，用于输送离子;线性离子捕获部分，用于通过轴向形成的电位积聚所运送的离子;以及控制部分，与线性离子阱部分不同于第一m / z范围的第二m / z范围，并且基本上与从运输部分到线性离子的离子在第一m / z范围内的积累时间基本相同的时刻陷阱部分。该离子传送部分具有用于选择第一m / z范围内的离子的质量选择装置。

5. 发明申请

US20070181804A1 Method of mass spectrometry and mass spectrometer 有权
标题翻译：质谱法和质谱仪
公开(公告)号：US20070181804A1
公开(公告)日：2007-08-09
申请号：US11716615
申请日：2007-03-12
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
IPC分类号： B01D59/44
CPC分类号： H01J49/427 , H01J49/067 , H01J49/4225
摘要： A mass spectrometry device includes an ion source for ionizing a sample, an ion trap for trapping ions ionized by the ion source. A control unit for controlling voltages applied to lenses forming part of the ion trap, and a detection unit for detecting the ions trapped by said ion trap. The control unit causes a trap potential to be generated on a central axis of quadrupole rods forming part of the ion trap, causes part of the trapped ions to be oscillated in an intermediate direction between the quadrupole rods which are mutually adjacent to each other, and applies a voltage for ejecting the oscillated ions in a central-axis direction of the quadrupole rods by generating an extraction field.
摘要翻译：质谱装置包括用于离子化样品的离子源，用于捕获由离子源离子化的离子的离子阱。用于控制施加到形成所述离子阱的一部分的透镜的电压的控制单元，以及用于检测由所述离子阱捕获的离子的检测单元。控制单元在形成离子阱的一部分的四极杆的中心轴上产生捕获电位，使被捕获的离子的一部分在彼此相邻的四极棒之间的中间方向振荡，并且通过产生提取场来施加用于在四极棒的中心轴方向上弹出振荡的离子的电压。

6. 发明申请

US20050269504A1 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20050269504A1
公开(公告)日：2005-12-08
申请号：US11146157
申请日：2005-06-07
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Hiroyuki Satake , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Hiroyuki Satake , Izumi Waki
IPC分类号： G01N27/62 , H01J49/06 , H01J49/16 , H01J49/40 , H01J49/42
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/4265
摘要： A mass spectrometer using a linear ion trap capable of efficiently suppressing the space charge and enabling scanning for a wide m/z range at a high Duty Cycle is provided. The mass spectrometer comprises: an ion source for ionizing a specimen to generate ions, an ion transport portion for transporting the ions, a linear ion trap portion for accumulating the transported ions by a potential formed axially, and a control portion of ejecting the ions within a second m/z range different from a first m/z range from the linear ion trap portion substantially at the same timing as the timing of accumulating the ions within the first m/z range to the linear ion trap portion, in which the control portion conducts control of ejecting the ions mass selectively from the linear ion trap portion by any of voltage application of (1) applying a supplemental AC voltage between at least a pair of linear ion trap rods constituting the linear ion trap portion, (2) applying a supplemental AC voltage to an end lens constituting the linear ion trap portion, and (3) applying a supplemental AC voltage between inserted lenses, the inserted lenses constituting the linear ion trap portion. The ion transportation portion having a mass selection means for selecting the ions in the first m/z range.
摘要翻译：提供了使用能够有效地抑制空间电荷且能够在高占空比下扫描宽m / z范围的线性离子阱的质谱仪。该质谱仪包括：用于离子化离子的离子源，用于输送离子的离子传输部分，用于通过轴向形成的电势积聚运送的离子的线性离子捕获部分，以及将离子排出的控制部分基本上与在线性离子阱部分内将离子累积到第一m / z范围内的时刻相同的定时，与线性离子阱部分的第一m / z范围不同的第二m / z范围，其中控制通过施加（1）在构成线性离子阱部分的至少一对线性离子阱捕获棒之间施加补充AC电压的任何电压施加（2）施加的线性离子阱部分，构成线性离子阱部分的端部透镜的补充AC电压，以及（3）在插入的透镜之间施加补充AC电压，构成线性离子阱po的插入透镜 rtion。该离子传送部分具有用于选择第一m / z范围内的离子的质量选择装置。

7. 发明授权

US06797949B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06797949B2
公开(公告)日：2004-09-28
申请号：US10288450
申请日：2002-11-06
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Akihiko Okumura , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Akihiko Okumura , Izumi Waki
IPC分类号： B01D5944
CPC分类号： H01J49/424 , H01J49/0059
摘要： There is provided a tandem mass spectrometry that, in a quadrupole ion trap, allows small mass-number product ions to be detected without lowering the sensitivity and the resolution. In the quadrupole ion trap, ions are produced by an ion source. Next, the ions are accumulated within a 3-dimensional quadrupole electric field formed by a pair of endcap electrodes and a ring electrode. Finally, the accumulated ions are isolated and dissociated, then being detected. In this quadrupole ion trap, there are provided a mechanism for introducing a laser light, and a mechanism for generating a supplemental alternating-current electric field at the time of the ion dissociation. Moreover, the direction of the supplemental alternating-current electric field and the introduction direction of the laser light are made identical to each other.
摘要翻译：提供串联质谱法，其在四极离子阱中允许检测小质量数产物离子而不降低灵敏度和分辨率。在四极离子阱中，离子由离子源产生。接下来，离子积聚在由一对端盖电极和环状电极形成的3维四极电场中。最后，积聚的离子被分离并解离，然后被检测。在该四极离子阱中，提供了用于引入激光的机构，以及用于在离子离解时产生补充的交流电场的机构。此外，补充交流电场的方向和激光的引入方向彼此相同。

8. 发明申请

US20090189065A1 Method of mass spectrometry and mass spectrometer 有权
标题翻译：质谱法和质谱仪
公开(公告)号：US20090189065A1
公开(公告)日：2009-07-30
申请号：US11631033
申请日：2006-03-08
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
IPC分类号： B01D59/44
CPC分类号： H01J49/427 , H01J49/067 , H01J49/4225
摘要： In a mass spectrometer introducing ions produced at an ion source, and including quadrupole rods which have an inlet and an outlet and to which a radio-frequency voltage is applied, the mass spectrometer, i.e., a mass spectrometry device implemented by a linear trap which exhibits high ejection efficiency, high mass resolution, and low ejection energy, executes the following steps: Trapping at least part of the ions by a trap potential generated on the central axis of a quadrupole field, oscillating part of the trapped ions in an intermediate direction between the mutually-adjacent quadrupole rods, ejecting the oscillated ions by an extraction field, and detecting the ejected ions or introducing the ejected ions into another detection process.
摘要翻译：在质谱仪中引入在离子源处产生的离子，并且包括具有入口和出口的四极棒，并且施加射频电压，质谱仪即通过线性捕获器实现的质谱装置表现出高喷射效率，高质量分辨率和低喷射能量，执行以下步骤：通过在四极场的中心轴上产生的捕获电位捕获至少一部分离子，在中间方向上振荡部分捕获的离子在相邻的四极棒之间，通过提取场喷射振荡的离子，并检测喷出的离子或将喷出的离子引入另一检测过程。

9. 发明申请

US20080156979A1 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20080156979A1
公开(公告)日：2008-07-03
申请号：US12010977
申请日：2008-01-31
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Hiroyuki Satake , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Hiroyuki Satake , Izumi Waki
IPC分类号： B01D59/44
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/4265
摘要： Amass spectrometer includes: an ion source for ionizing a specimen to generate ions, an ion transport portion for transporting the ions, a linear ion trap portion for accumulating the transported ions by a potential formed axially, and a control portion of ejecting the ions within a second m/z range different from a first m/z range, from the linear ion trap portion, and substantially at the same timing as the timing of accumulating the ions within the first m/z range from the transport portion into the linear ion trap portion. The ion transportation portion having a mass selection means for selecting the ions in the first m/z range.
摘要翻译：阿马斯光谱仪包括：用于电离样品以产生离子的离子源，用于输送离子的离子传输部分，用于通过轴向形成的电势积聚所运送的离子的线性离子捕获部分，以及将离子喷射到第二m / z范围与第一m / z范围不同于线性离子阱部分，并且基本上与从运输部分到线性离子阱的第一m / z范围内积聚离子的定时基本相同一部分。该离子传送部分具有用于选择第一m / z范围内的离子的质量选择装置。

10. 发明申请

US20080073508A1 REACTION CELL AND MASS SPECTROMETER 有权
标题翻译：反应池和质谱仪
公开(公告)号：US20080073508A1
公开(公告)日：2008-03-27
申请号：US11671562
申请日：2007-02-06
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
IPC分类号： H01J49/00
CPC分类号： H01J49/4295 , H01J49/005 , H01J49/0054
摘要： An ion trap in which highly accurate isolation, ECD, and CID can be efficiently performed. A reaction cell and a mass spectrometer of the present invention include an ion-trap which has a plurality of rod electrodes and creates a multipole field, a means for generating a magnetic field in the axial direction of the ion-trap, a means for creating a DC harmonic potential in the axial direction of the ion-trap, and an electron source for introducing electrons into the central axis of the ion-trap. The identification ability is greatly improved compared with the prior art.
摘要翻译：可以有效地执行高精度隔离，ECD和CID的离子阱。本发明的反应池和质谱仪包括具有多个棒电极并产生多极场的离子阱，用于在离子阱的轴向产生磁场的装置，用于产生在离子阱的轴向上的DC谐波电位和用于将电子引入离子阱的中心轴的电子源。与现有技术相比，识别能力大大提高。

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