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1. 发明授权

US5534510A 2-[1-(1,3-thiazolin-2-yl)azetidin-3-yl]thio-carbapenem derivatives 失效
标题翻译： 2- [1-（1,3-噻唑啉-2-基）氮杂环丁烷-3-基]硫代碳代青霉烯衍生物
公开(公告)号：US5534510A
公开(公告)日：1996-07-09
申请号：US267397
申请日：1994-06-29
申请人： Takao Abe , Takeshi Isoda , Chisato Sato , Ado Mihira , Satoshi Tamai , Toshio Kumagai
发明人： Takao Abe , Takeshi Isoda , Chisato Sato , Ado Mihira , Satoshi Tamai , Toshio Kumagai
IPC分类号： C07D477/00 , A61K31/397 , A61K31/425 , A61P31/04 , C07D417/04 , C07D477/20 , C07D487/04 , A61K31/40
CPC分类号： C07D477/20 , C07D417/04
摘要： Novel carbapenem compounds, (1R,5S,6S)-2-[1-(1,3-thiazolin-2-yl)azetidin-3-yl]thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapen-2-em-3 -carboxyic acid derivatives.These carbapenem compounds are represented by the following formula having a beta-coordinated methyl group introduced at the 1-position and a [1-(1,3-thiazolin-2-yl)azetidin-3-yl]thio group introduced at the 2-position. ##STR1## In the formula, R is hydrogen; lower alkyl group which is unsubstituted or substituted by hydroxy, lower alkoxy or lower alkoxy-lower alkoxy group; group --COOR.sup.1 (R.sup.1 is hydrogen or lower alkyl group); or group --CONR.sup.2 R.sup.3 (R.sup.2 and R.sup.3 are, independently each other, hydrogen or lower alkyl), andY is carboxy, --COO.sup..crclbar. or protected carboxy.These compounds are useful antibiotics for prevention and treatment of bacterial infections.
摘要翻译：新的碳青霉烯化合物（1R，5S，6S）-2- [1-（1,3-噻唑烷-2-基）氮杂环丁烷-3-基]硫基-6 - [（R）-1-羟乙基] -1- 甲基 - 碳代青霉-2-烯-3-羧酸衍生物。这些碳青霉烯化合物由在1位引入的β-配位甲基和在2位引入的[1-（1,3-噻唑啉-2-基）氮杂环丁烷-3-基]硫基的下式表示 -位置。在该式中，R是氢; 低级烷基，未取代或被羟基，低级烷氧基或低级烷氧基 - 低级烷氧基取代; 基团-COOR1（R1是氢或低级烷基）; 或基团-CONR 2 R 3（R 2和R 3彼此独立地为氢或低级烷基），Y为羧基，-COO（ - ）或被保护的羧基。这些化合物是预防和治疗细菌感染的有用的抗生素。

2. 发明授权

US5783703A Sulfur-containing compounds method for their use and prodction 失效
标题翻译：含硫化合物的使用和生产方法
公开(公告)号：US5783703A
公开(公告)日：1998-07-21
申请号：US795428
申请日：1997-02-05
申请人： Kazuhiko Hayashi , Chisato Sato , Satoshi Tamai , Takao Abe , Takeshi Isoda , Ado Mihira , Toshio Kumagai
发明人： Kazuhiko Hayashi , Chisato Sato , Satoshi Tamai , Takao Abe , Takeshi Isoda , Ado Mihira , Toshio Kumagai
IPC分类号： C07D417/04
CPC分类号： C07D417/04
摘要： A first embodiment of the invention relates to novel carbapenem compounds, (1R, 5S, 6S)-2-�1-(1,3-thiazolin-2-yl)azetidin-3-yl!thio-6-�(R)-1-hydroxy-ethyl!-1-methylcarbapen-2-em-3-carboxyic acid derivatives. These carbapenem compounds are represented by the following formula having a beta-coordinated methyl group introduced at the 1-position and a �1-(1,3-thia-zolin-2-yl)azetidin-3-yl!thio group introduced at the 2-position. ##STR1## In the formula, R is hydrogen; lower alkyl group which is unsubstituted or substituted by hydroxy, lower alkoxy or lower alkoxy-lower alkoxy group; group --COOR.sup.1 (R.sup.1 is hydrogen or lower alkyl group); or group --CONR.sup.2 R.sup.3 (R.sup.2 and R.sup.3 are, independently each other, hydrogen or lower alkyl), and Y is carboxy, --COO.sup..crclbar. or protected carboxy. These compounds are useful antibiotics for prevention and treatment of bacterial infections. The second embodiment of the invention relates to 3-mercapto-1-(1,3-thiazolin-2-yl)azetidine represented by the following formula and its acid addition salts ##STR2## and to the production process therefor. The above compounds are useful as intermediates for preparing carbapenem compounds, which have strong antibacterial activity, with convenience and high yield.
摘要翻译：本发明的第一个实施方案涉及新的碳青霉烯化合物，（1R，5S，6S）-2- [1-（1,3-噻唑烷-2-基）氮杂环丁烷-3-基]硫基-6 - [（R） -1-羟基 - 乙基] -1-甲基碳代青霉-2-烯-3-羧酸衍生物。这些碳青霉烯类化合物由下式表示：在1-位引入的β-配位甲基和[1-（1,3-硫杂 - 唑啉-2-基）氮杂环丁烷-3-基]硫基引入到 2位。在该式中，R是氢; 低级烷基，未取代或被羟基，低级烷氧基或低级烷氧基 - 低级烷氧基取代; 基团-COOR1（R1是氢或低级烷基）; 或基团-CONR 2 R 3（R 2和R 3彼此独立地为氢或低级烷基），Y为羧基，-COO（ - ）或被保护的羧基。这些化合物是预防和治疗细菌感染的有用的抗生素。本发明的第二个实施方案涉及由下式表示的3-巯基-1-（1,3-噻唑啉-2-基）氮杂环丁烷及其酸加成盐及其制备方法。上述化合物可用作制备碳青霉烯类化合物的中间体，其具有强的抗菌活性，方便性和高产率。

3. 发明授权

US5679790A 2-�1-(1,3-thiazolin-2-yl)azetidin-3-yl!thio-carbapenem derivatives 失效
标题翻译： 2- [1-（1,3-噻唑啉-2-基）氮杂环丁烷-3-基]硫代碳代青霉烯衍生物
公开(公告)号：US5679790A
公开(公告)日：1997-10-21
申请号：US631224
申请日：1996-04-12
申请人： Takao Abe , Takeshi Isoda , Chisato Sato , Ado Mihira , Satoshi Tamai , Toshio Kumagai
发明人： Takao Abe , Takeshi Isoda , Chisato Sato , Ado Mihira , Satoshi Tamai , Toshio Kumagai
IPC分类号： C07D477/00 , A61K31/397 , A61K31/425 , A61P31/04 , C07D417/04 , C07D477/20 , C07D487/04
CPC分类号： C07D477/20 , C07D417/04
摘要： Novel carbapenem compounds, (1R,5S,6S)-2-�1-(1,3-thiazolin-2-yl)azetidin-3-yl!thio-6-�(R)-1-hydroxyethyl!-1-methyl-carbapen-2-em-3-carboxyic acid derivatives. These carbapenem compounds are represented by the following formula having a beta-coordinated methyl group introduced at the 1-position and a �1-(1,3-thiazolin-2-yl)azetidin-3-yl!thio group introduced at the 2-position. ##STR1## In the formula, R is hydrogen; lower alkyl group which is unsubstituted or substituted by hydroxy, lower alkoxy or lower alkoxy-lower alkoxy group; group --COOR.sup.1 (R.sup.1 is hydrogen or lower alkyl group); or group --CONR.sup.2 R.sup.3 (R.sup.2 and R.sup.3 are, independently each other, hydrogen or lower alkyl), and Y is carboxy, --COO.sup..crclbar. or protected carboxy. These compounds are useful antibiotics for prevention and treatment of bacterial infections.
摘要翻译：新型碳青霉烯化合物（1R，5S，6S）-2- [1-（1,3-噻唑烷-2-基）氮杂环丁烷-3-基]硫基-6 - [（R）-1-羟基乙基] -1 - 甲基 - 碳代青霉-2-烯-3-羧酸衍生物。这些碳青霉烯化合物由在1位引入的β-配位甲基和在2位引入的[1-（1,3-噻唑啉-2-基）氮杂环丁烷-3-基]硫基的下式表示 -位置。在该式中，R是氢; 低级烷基，未取代或被羟基，低级烷氧基或低级烷氧基 - 低级烷氧基取代; 基团-COOR1（R1是氢或低级烷基）; 或基团-CONR 2 R 3（R 2和R 3彼此独立地为氢或低级烷基），Y为羧基，-COO（ - ）或被保护的羧基。这些化合物是预防和治疗细菌感染的有用的抗生素。

4. 发明申请

US20140161876A1 LIPOSOME-CONTAINING PREPARATION UTILIZING DISSOLUTION AID, AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译：利用溶解助剂制备脂质体的方法及其生产方法
公开(公告)号：US20140161876A1
公开(公告)日：2014-06-12
申请号：US14232743
申请日：2011-12-22
申请人： Takeshi Isoda
发明人： Takeshi Isoda
IPC分类号： A61K9/127 , C12N15/113 , A61K31/519 , A61K31/7068
CPC分类号： A61K9/127 , A61K9/1277 , A61K31/519 , A61K31/7068 , A61K47/44 , C12N15/113
摘要： The present invention may include a production process for a preparation containing univesicular liposomes that encapsulate a highly water-soluble drug (d) having a water solubility of higher than 10 mg/mL and have a volume-average particle diameter of 50 to 200 nm utilizing a two-step emulsification method, to enhance an encapsulation ratio of the highly water-soluble drug in the liposomes produced, as compared with the conventional one. In a primary emulsification step of the two-step emulsification method, a W1/O emulsion may be prepared by the use of an aqueous phase liquid (W1) in which the highly water-soluble drug (d) and a solubilizing aid (s) having log D of not more than −1 at pH 7.4 are dissolved in an aqueous solvent (w1).
摘要翻译：本发明可以包括含有非脂质体的制剂的制备方法，其包封水溶性高于10mg / mL的高度水溶性药物（d），并且使用体积平均粒径为50〜200nm的利用与常规的相比，提高了生产的脂质体中高度水溶性药物的包封率的两步乳化方法。在两步乳化法的初级乳化步骤中，W1 / O乳液可以通过使用其中高度水溶性药物（d）和增溶助剂（w）的水相液体（W1）在pH7.4下具有不大于-1的log D溶解在水性溶剂（w1）中。

5. 发明授权

US08052336B2 Optical module 失效
标题翻译：光模块
公开(公告)号：US08052336B2
公开(公告)日：2011-11-08
申请号：US12614370
申请日：2009-11-06
申请人： Hiroshi Nakagawa , Takeshi Isoda , Kosuke Sasada
发明人： Hiroshi Nakagawa , Takeshi Isoda , Kosuke Sasada
IPC分类号： G02B6/36
CPC分类号： G02B6/423 , G02B6/4277
摘要： In an optical module including a module main body 10, an optical device housed in the module main body 10, and an optical fiber 21 having an end placed in the module main body 10 and optically coupled to the optical device, the end of the optical fiber 21 is held between a semi-cylindrical part 31d of a shield cover 31 that covers the module main body 10 and a semi-cylindrical part 32c of a presser plate 32.
摘要翻译：在包括模块主体10，容纳在模块主体10中的光学装置和光纤21的光学模块中，具有端部放置在模块主体10中并光学耦合到光学装置的光纤21，光学器件的端部纤维21保持在覆盖模块主体10的屏蔽盖31的半圆柱形部分31d和压板32的半圆柱形部分32c之间。

6. 发明申请

US20110105203A1 Optical Communication Structure 审中-公开
标题翻译：光通信结构
公开(公告)号：US20110105203A1
公开(公告)日：2011-05-05
申请号：US12933928
申请日：2009-03-04
申请人： Hiroshi Nakagawa , Takeshi Isoda , Kosuke Sasada
发明人： Hiroshi Nakagawa , Takeshi Isoda , Kosuke Sasada
IPC分类号： H04M1/00
CPC分类号： H01L31/12 , G02B6/002 , G02B6/0048 , G02B6/3604 , G02B6/4298 , G02B6/43 , H04B10/1143 , H04M1/0235
摘要： An optical communication structure for performing optical communication using optical signals between a first housing (2) and a second housing (3) slidable to each other includes: a first optical communication element (12) which is provided in the first housing (2) and configured to transmit the optical signal; a second optical communication element (13) which is provided in the second housing (3) and configured to receive the optical signal transmitted from the first optical communication element (12); a sliding module configured to allow the sliding movement of the housings and stop the sliding movement at predetermined stop positions set in advance; and a light guide plate (4) which is provided in one of the first housing (2) and the second housing (3) and configured to reflect the optical signal, and has the same number of reflecting portions (5) as the number of the stop positions.
摘要翻译：一种用于在可相互滑动的第一壳体和第二壳体（3）之间使用光信号执行光通信的光通信结构包括：第一光通信元件（12），设置在第一壳体（2）和被配置为发送所述光信号; 第二光通信元件（13），设置在所述第二壳体（3）中并且被配置为接收从所述第一光通信元件（12）发送的光信号; 滑动模块，其构造成允许所述壳体的滑动运动并且在预先设定的预定停止位置处停止所述滑动运动; 以及导光板（4），其设置在所述第一壳体（2）和所述第二壳体（3）中的一个上并且被配置为反射所述光学信号，并且具有与所述光学信号的数量相同数量的反射部（5）停止位置。

7. 发明申请

US20100215582A1 LIPOSOME AND METHOD FOR PRODUCING LIPOSOME 审中-公开
标题翻译：用于生产脂质体的脂质体和方法
公开(公告)号：US20100215582A1
公开(公告)日：2010-08-26
申请号：US12599159
申请日：2008-05-13
申请人： Takeshi Isoda
发明人： Takeshi Isoda
IPC分类号： A61K9/127 , A61K31/7088 , A61P35/00 , A61K49/00
CPC分类号： A61K9/1277 , A23P10/30 , A61K8/14 , A61K8/416 , A61K8/4986 , A61K8/63 , A61K8/68 , A61K9/1271 , A61K9/1272 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K47/62 , A61K47/6911 , A61K49/0002 , A61K49/0466 , A61Q11/00 , A61Q19/00 , B01J13/02 , C12N15/88 , C12N2810/85
摘要： It is intended to provide a liposome preparation which is a liposome, has a lipid bilayer membrane composed of an inner membrane constituted by a lipid including one or more types of functional lipids (a lipid capable of chemically interacting with another compound such as a charged lipid, a polarizable lipid, a lipid-soluble lipid or a water-soluble lipid) and an outer membrane constituted by a lipid with or without including one or more types of functional lipids, and is characterized in that at least a condition that the amount of any one type of functional lipid contained in the inner membrane is larger than in the outer membrane is satisfied. The liposome preparation is suitable as a liposome for encapsulating a contrast agent (a neutral substance having a hydroxy group), siRNA (an anionic substance) having an anticancer activity or the like. Its encapsulation ratio of drug agents, dispersion stability, control release and the like have been improved.
摘要翻译：本发明提供一种脂质体制剂，其是具有由包含一种或多种类型的功能性脂质的脂质构成的内膜构成的脂质双层膜（能够与另一种化合物如带电脂质化学相互作用的脂质，可极化脂质，脂溶性脂质或水溶性脂质）和由具有或不包含一种或多种类型的功能性脂质的脂质构成的外膜，其特征在于，至少一种条件是，内膜中含有的任何一种功能性脂质都比外膜要大。脂质体制剂适合用作包封具有抗癌活性的对比剂（具有羟基的中性物质），siRNA（阴离子物质）的脂质体。其药剂的包封率，分散稳定性，控制释放等已得到改善。

8. 发明申请

US20090245734A1 Optical Connector 失效
标题翻译：光连接器
公开(公告)号：US20090245734A1
公开(公告)日：2009-10-01
申请号：US12408548
申请日：2009-03-20
申请人： Hiroshi Nakagawa , Takeshi Isoda
发明人： Hiroshi Nakagawa , Takeshi Isoda
IPC分类号： G02B6/36
CPC分类号： G02B6/3887 , G02B6/3869 , G02B6/3879 , G02B6/4292
摘要： An optical connector includes a receptacle body 40 having an engage hole 46 formed in a peripheral wall 45 of a chamber 44, a pigtail body 50 having a base body 51 contained in the chamber 44 and a locking protrusion 56 engaged in the engage hole 46 to attach the pigtail body 50, and a ferrule assembly 60 being inserted in a container 53 in the base body 51 so that the ferrule 62 is positioned in a receptacle cylinder 52, and a spring 70 inserted through an opening 54 in the base body 51 and pressing the ferrule 62 forward, wherein a stopper 73 is formed in the spring 70 as an integral part of the spring 70. A locking part 73b included in the stopper 73 is positioned in a recess 63 in the ferrule 62.
摘要翻译：光连接器包括：容纳体40，其具有形成在室44的周壁45中的接合孔46;辫尾体50，其具有容纳在室44中的基体51;以及锁定突起56，其接合在接合孔46中将辫子主体50连接在一起，将套圈组件60插入到基体51中的容器53中，使得套圈62位于容纳筒52中，弹簧70插入基体51中的开口54和向前按压套圈62，其中止动件73形成在弹簧70中作为弹簧70的一体部分。包括在止动件73中的锁定部分73b位于套圈62中的凹部63中。

9. 发明授权

US07242869B2 Optical component and optical transmitter-receiver for use in two-way optical communication 有权
标题翻译：用于双向光通信的光学元件和光发射机
公开(公告)号：US07242869B2
公开(公告)日：2007-07-10
申请号：US10436968
申请日：2003-05-12
申请人： Keiji Mine , Hiroshi Nakagawa , Takeshi Isoda
发明人： Keiji Mine , Hiroshi Nakagawa , Takeshi Isoda
IPC分类号： H04B10/00 , G02B6/26
CPC分类号： H04B10/40 , G02B6/4201 , G02B6/4206 , G02B6/4214 , G02B6/4246 , G02B6/4292 , H01S5/4012
摘要： A prism 11 is formed which has a first face 11a opposing an end face of an optical fiber 21 and receiving a light-to-be-received from the optical fiber, second and third faces 11b and 11c adjoining opposite ends of the first face 11a at right angles and opposing each other, a fourth face 11d for reflecting the light-to-be-received from the face 11a toward the face 11b, and a fifth face 11e reflecting a light-to-be-transmitted as projected from a light source through the face 11c toward the face 11a. First and second light-to-be-received converging lenses 12 and 13 are disposed on the faces 11a and 11b of the prism 11 and first and second light-to-be-transmitted converging lenses 14 and 15 are disposed on the faces 11a and 11c. The tilt angles β1 and β2 of the faces 11d and 11e with respect to the optical fiber axis 21a are less than 45°. With this configuration, if the light-to-be-received enters the light-receiving element 22 and the light-emitting element 23 and is reflected by these elements, such reflected light is prevented from returning back into the optical fiber whereby occurrence of far-end crosstalk can be suppressed.
摘要翻译：形成棱镜11，其具有与光纤21的端面相对的第一面11a，并且从光纤接收待接收的光，与第二面相邻的第二和第三面11b和11c 第一面11a形成为直角并且彼此相对的第二面11d，用于将面11a上的光从面11a反射的第四面11d以及反射光 - 从光源通过面11c投射到面11a。第一和第二光接收会聚透镜12和13设置在棱镜11的面11a和11b上，第一和第二光透过会聚透镜14和15设置在面 11 a和11 c。面11d和11e相对于光纤轴21a的倾斜角度β1和β2小于45°。利用这种结构，如果受光元件进入光接收元件22和发光元件23并被这些元件反射，则防止这种反射光返回到光纤中，从而发生远 - 可以抑制串扰。

10. 发明授权

US5905130A Process for the production of polysilazane 失效
标题翻译：聚硅氮烷生产工艺
公开(公告)号：US5905130A
公开(公告)日：1999-05-18
申请号：US894663
申请日：1997-08-25
申请人： Hirohiko Nakahara , Osamu Funayama , Takeshi Isoda
发明人： Hirohiko Nakahara , Osamu Funayama , Takeshi Isoda
IPC分类号： C08G77/62 , C08G77/08
CPC分类号： C08G77/62
摘要： Disclosed is a process for the production of a polysilazane containing Si--N linkages in the main chain thereof. According to the present invention, the polysilazane is produced by reacting a polyaminosilane compound with a polyhydrogenated nitrogen-containing compound in the presence of a basic catalyst or by reacting a polyhydrogenated silicon compound with a polyhydrogenated nitrogen-containing compound in the presence of a basic solid oxide catalyst.
摘要翻译： PCT No.PCT / JP97 / 00005 Sec。 371日期1997年8月25日第 102（e）日期1997年8月25日PCT 1997年1月6日PCT PCT。出版物WO97 / 24391 日期1997年7月10日公开是在其主链中生产含有Si-N键的聚硅氮烷的方法。根据本发明，聚硅氮烷是在碱性催化剂的存在下使聚氨基硅烷化合物与多氢化含氮化合物反应制备的，或者是通过使多氢化硅化合物与多氢化含氮化合物在碱性固体氧化物催化剂。

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