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1. 发明授权

US5980866A Tissue adhesive suitable for spray application 失效
标题翻译：适用于喷涂应用的组织粘合剂
公开(公告)号：US5980866A
公开(公告)日：1999-11-09
申请号：US945882
申请日：1997-11-13
申请人： Takanori Uchida , Hiroshi Kaetsu , Nobuto Fukunaga , Noriko Shinya , Takahiro Sakamoto
发明人： Takanori Uchida , Hiroshi Kaetsu , Nobuto Fukunaga , Noriko Shinya , Takahiro Sakamoto
IPC分类号： A61B17/00 , A61L24/10 , A61L9/14 , A61L15/58 , A61L25/00
CPC分类号： A61L24/106 , A61B17/00491 , A61B2017/00495 , Y10S514/822
摘要： An adhesive for tissue capable of uniformly forming a high concentration of fibrin so as to provide a high closing effect is disclosed. The adhesive for tissue comprises a fibrinogen solution and a thrombin solution which solutions are separated from each other. The adhesive is to be mixed and spray coated together with a sterile gas and has a volume ratio of the fibrinogen solution to the thrombin solution of about 2:1 to 10:1. This adhesive is to be sprayed together with a sterile gas for the adhesion or closing of living tissue of a human being or animal.
摘要翻译： PCT No.PCT / JP97 / 00818 Sec。 371日期：1997年11月13日 102（e）1997年11月13日PCT PCT 1997年3月14日PCT公布。公开号WO97 / 33633 1997年9月18日公开了能够均匀地形成高浓度纤维蛋白以提供高闭合效果的组织的粘合剂。用于组织的粘合剂包括纤维蛋白原溶液和溶液彼此分离的凝血酶溶液。将粘合剂混合并用无菌气体喷涂，并且纤维蛋白原溶液与凝血酶溶液的体积比为约2:1至10:1。该粘合剂将与无菌气体一起喷洒以用于人或动物的活组织的粘附或闭合。

2. 发明授权

US06251370B1 Tissue adhesive suitable for spray application 失效
标题翻译：适用于喷涂应用的组织粘合剂
公开(公告)号：US06251370B1
公开(公告)日：2001-06-26
申请号：US09299916
申请日：1999-04-28
申请人： Takanori Uchida , Hiroshi Kaetsu , Nobuto Fukunaga , Noriko Shinya , Takahiro Sakamoto
发明人： Takanori Uchida , Hiroshi Kaetsu , Nobuto Fukunaga , Noriko Shinya , Takahiro Sakamoto
IPC分类号： A61L904
CPC分类号： A61L24/106 , A61B17/00491 , A61B2017/00495 , Y10S514/822
摘要： An adhesive for tissue capable of uniformly forming a high concentration of fibrin so as to provide a high closing effect is disclosed. The adhesive for tissue comprises a fibrinogen solution and a thrombin solution which solutions are separated from each other. The adhesive is to be mixed and spray coated together with a sterile gas and has a volume ratio of the fibrinogen solution to the thrombin solution of about 2:1 to 10:1. This adhesive is to be sprayed together with a sterile gas for the adhesion or closing of living tissue of a human being or animal.
摘要翻译：公开了能够均匀地形成高浓度纤维蛋白以提供高闭合效果的用于组织的粘合剂。用于组织的粘合剂包括纤维蛋白原溶液和溶液彼此分离的凝血酶溶液。将粘合剂混合并用无菌气体喷涂，并且纤维蛋白原溶液与凝血酶溶液的体积比为约2:1至10:1。该粘合剂将与无菌气体一起喷洒以用于人或动物的活组织的粘附或闭合。

3. 发明授权

US5582596A Applicator for applying a biocompatible adhesive 失效
标题翻译：施用生物相容性粘合剂的涂布器
公开(公告)号：US5582596A
公开(公告)日：1996-12-10
申请号：US244430
申请日：1994-05-26
申请人： Nobuto Fukunaga , Katsumi Kawakami , Takanori Uchida , Yoshimitsu Ishihara
发明人： Nobuto Fukunaga , Katsumi Kawakami , Takanori Uchida , Yoshimitsu Ishihara
IPC分类号： A61B17/00 , A61L26/00 , A61M5/00
CPC分类号： A61B17/00491 , A61L26/0061 , A61B2017/00495
摘要： An applicator for applying a biocompatible adhesive containing human or aal protein as a principal ingredient to a surgical site of living body includes a housing to which a sterile gas is supplied, a sterile-gas supply tube connected to the housing, two adjacent sterile-gas ejecting nozzles for ejecting the sterile gas in the same direction, two adapters to which respective nozzles of syringe barrels are connected, and a pair of solution tubes, each having one end connected to the adapter and the other end protruded outwardly from the sterile gas ejection nozzle through an interior of the housing. Respective solutions supplied from the syringes via the pair of barrel adapters are ejected from the outlets of the solution tubes. The sterile gas is ejected from two sterile-gas ejection nozzles in the same direction. Consequently, the solutions are sprayed and mixed by the sterile gas, and then applied to the surgical site.
摘要翻译： PCT No.PCT / JP93 / 01364 Sec。 371日期：1994年5月26日 102（e）日期1994年5月26日PCT提交1993年9月24日PCT公布。出版物WO94 / 07420 日本1994年4月14日将含有人或动物蛋白质的生物相容性粘合剂作为主要成分施用于生物体的手术部位的施加器包括：供给无菌气体的壳体，与壳体连接的无菌气体供给管，两个相邻的无菌气体喷嘴，用于沿相同方向喷射无菌气体，注射器筒的各个喷嘴连接到的两个适配器和一对溶液管，每个溶液管的一端连接到适配器，另一端向外突出从无菌气体喷射嘴通过壳体的内部。从注射器经由一对筒适配器提供的各种溶液从溶液管的出口喷出。无菌气体从两个无菌气体喷射嘴沿同一方向喷射。因此，将溶液喷雾并通过无菌气体混合，然后施加到手术部位。

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