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    • 4. 发明授权
    • 3-Aminoindazole derivatives
    • 3-氨基吲唑衍生物
    • US4474964A
    • 1984-10-02
    • US569524
    • 1984-01-09
    • Tadayuki IbukiTaisuke SugiharaHiromu KawakuboTakanori Sone
    • Tadayuki IbukiTaisuke SugiharaHiromu KawakuboTakanori Sone
    • C07D231/56C07D295/092C07D401/12C07D403/12
    • C07D231/56C07D295/088
    • A compound of the formula (I): ##STR1## wherein W.sub.1 is a hydrogen atom or a ##STR2## group wherein Y is a C.sub.1-6 alkylene group or a C.sub.1-6 alkylene group having a C.sub.1-6 alkyl group substituent; and R.sub.1 and R.sub.2 each independently is a hydrogen atom or a C.sub.1-6 alkyl group and R.sub.1 and R.sub.2 may form a C.sub.4-6 heterocyclic ring or a nitrogen-containing C.sub.4-6 heterocyclic ring together with the adjacent nitrogen atom and the C.sub.4-6 heterocyclic rings may have at least one C.sub.1-6 alkyl group, hydroxyl group or halogen atom;W.sub.2 is a hydrogen atom or a ##STR3## group wherein Z is a C.sub.1-6 alkylene group or a C.sub.1-6 alkylene group having a C.sub.1-6 alkyl group substituent; and R.sub.3 and R.sub.4 each independently is a hydrogen atom or a C.sub.1-6 alkyl group and R.sub.3 and R.sub.4 may form a C.sub.4-6 heterocyclic ring or a nitrogen-containing C.sub.4-6 heterocyclic ring together with the adjacent nitrogen atom and the C.sub.4-6 heterocyclic rings may have at least one C.sub.1-6 alkyl group, hydroxyl group or halogen atom;when W.sub.1 is a hydrogen atom, W.sub.2 is the ##STR4## group; and when W.sub.2 is a hydrogen atom, W.sub.1 is the ##STR5## group; and the pharmaceutically acceptable acid addition salt thereof having antiinflammatory, analgesic and digestive tract ulcer suppressing activity.
    • 式(I)的化合物:其中W1是氢原子或其中Y是C1-6亚烷基或具有C1-6烷基的C1-6亚烷基的基团 取代基; 并且R 1和R 2各自独立地为氢原子或C 1-6烷基,并且R 1和R 2可以与相邻的氮原子一起形成C 4-6杂环或含氮的C 4-6杂环,并且C 4-6 杂环可以具有至少一个C 1-6烷基,羟基或卤素原子; W2是氢原子或其中Z是C1-6亚烷基或具有C1-6烷基取代基的C1-6亚烷基的基团; 并且R 3和R 4各自独立地为氢原子或C 1-6烷基,并且R 3和R 4可以与相邻的氮原子一起形成C 4-6杂环或含氮的C 4-6杂环,且C 4-6 杂环可以具有至少一个C 1-6烷基,羟基或卤素原子; 当W1是氢原子时,W2是组; 当W2是氢原子时,W1是组; 和其药学上可接受的酸加成盐具有抗炎,止痛和消化道溃疡抑制活性。