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1. 发明授权

US5326702A Biological process for producing .alpha.-hydroxyamide or .alpha.-hydroxy acid 失效
标题翻译：生产α-羟基酰胺或α-羟基酸的生物工艺
公开(公告)号：US5326702A
公开(公告)日：1994-07-05
申请号：US791523
申请日：1991-11-14
申请人： Takakazu Endo , Tomohide Yamagami , Koji Tamura
发明人： Takakazu Endo , Tomohide Yamagami , Koji Tamura
IPC分类号： C12P7/42 , C12P13/02 , C12P41/00 , C12R1/01 , C12R1/05 , C12R1/06 , C12R1/125 , C12R1/13 , C12R1/20 , C12R1/365 , C12R1/38 , C12N1/12
CPC分类号： C12P13/02 , C12P41/006 , C12P7/42 , Y10S435/822 , Y10S435/823 , Y10S435/829 , Y10S435/83 , Y10S435/85 , Y10S435/874
摘要： A process for biologically producing an .alpha.-hydroxyamide or an .alpha.-hydroxy acid represented by formula (III) ##STR1## wherein R represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aryloxy group or a substituted or unsubstituted and saturated or unsaturated heterocyclic group; and X represents an amido group or a carboxyl group, comprising reacting an .alpha.-hydroxynitrile represented by formula (I): ##STR2## wherein R is as defined above, or a mixture of an aldehyde represented by formula (II):R--CHO (II)wherein R is as defined above, and hydrogen cyanide with a microorganism capable of producing such an amide or acid from the corresponding .alpha.-hydroxynitrile is disclosed, in which the reaction system contains a sulfite ion, a disulfite ion or a dithionite ion. The enzymatic activity of the microorganism lasts for an extended period of time.
摘要翻译：用于生物地生产由式（III）表示的α-羟基酰胺或α-羟基酸的方法（III）其中R表示取代或未取代的烷基，取代或未取代的烯基，取代或未取代的环烷基取代或未取代的烷氧基，取代或未取代的芳基，取代或未取代的芳氧基或取代或未取代的饱和或不饱和杂环基; X代表酰氨基或羧基，包括使由式（I）表示的α-羟基腈：其中R如上定义，或由式（II）表示的醛的混合物：公开了其中R如上所定义的R-CHO（II）和具有能够从相应的α-羟基腈产生这种酰胺或酸的微生物的氰化氢，其中反应体系含有亚硫酸根离子，二亚硫酸根离子或连二亚离子。微生物的酶活性持续较长时间。

2. 发明授权

US5705382A Method for preserving nitrile hydratase or nitrilase activity of microbial cells with inorganic salts 失效
标题翻译：用无机盐保存微生物细胞的腈水合酶或腈水解酶活性的方法
公开(公告)号：US5705382A
公开(公告)日：1998-01-06
申请号：US542291
申请日：1995-10-12
申请人： Takakazu Endo , Toshiaki Doi , Koji Tamura , Yuji Hirata , Kouzo Murao
发明人： Takakazu Endo , Toshiaki Doi , Koji Tamura , Yuji Hirata , Kouzo Murao
IPC分类号： C12N11/00 , C12N1/04 , C12N11/14 , C12R1/01 , C12N1/12 , C12N9/96 , C12N11/04
CPC分类号： C12N1/04 , C12N11/14
摘要： Cells having enzyme activity, and the enzyme activity thereof, are preserved for a prolonged period of time, as a suspension of microbial cells or as a suspension of immobilized cells in particles, in an aqueous medium that is a neutral or weakly basic aqueous solution of inorganic salts, having a molarity ranging from 100 mM to the saturation concentration of the inorganic salts. Preferably, the microbial cells are cells containing the enzyme, nitrile hydratase or nitrilase, such as Gordona terrae or Rhodococcus rhodochrous, and the inorganic salts are phosphates, borates, sulfates, sulfites or hydrochlorides. The present invention provides an industrially useful method for preserving a large quantity of cells or immobilized cells in particles having nitrile hydratase or nitrilase enzyme activity for a prolonged period of time (e.g., 300 days) without cell lysis or enzyme deterioration even at room temperature. The present invention also renders possible a sharp reduction in labor and cooling cost, which are necessary in the conventional preservation process.
摘要翻译：具有酶活性的细胞及其酶活性在水性培养基中作为微生物细胞的悬浮液或作为固定化细胞的悬浮液在水性培养基中保持较长时间，其为中性或弱碱性水溶液无机盐，其摩尔浓度范围为100mM至无机盐的饱和浓度。优选地，微生物细胞是含有酶，腈水合酶或腈水解酶的细胞，例如戈多纳土壤或玫瑰色红玫瑰色，无机盐是磷酸盐，硼酸盐，硫酸盐，亚硫酸盐或盐酸盐。本发明提供一种工业上有用的方法，即使在室温下，即使在室温下，也不会在细胞裂解或酶劣化的情况下长时间（例如，300天），在具有腈水合酶或腈水解酶活性的颗粒中保存大量细胞或固定化细胞。本发明还使得在常规保存过程中必需的劳动和冷却成本急剧下降。

3. 发明授权

US5223416A Process for producing R(-)-mandelic acid and derivatives thereof 失效
标题翻译：制备R（ - ） - 马来酸及其衍生物的方法
公开(公告)号：US5223416A
公开(公告)日：1993-06-29
申请号：US677175
申请日：1991-03-29
申请人： Takakazu Endo , Koji Tamura
发明人： Takakazu Endo , Koji Tamura
IPC分类号： C12P7/42 , C12P41/00
CPC分类号： C12P41/006 , C12P7/42 , Y10S435/822 , Y10S435/829 , Y10S435/839 , Y10S435/84 , Y10S435/872 , Y10S435/874
摘要： A process for the predominantly producing R(-)-mandelic acid or a derivative thereof which comprises subjecting (i) R,S-mandelonitrile or a derivative thereof, or (ii) a mixture of prussic acid and benzaldehyde or a derivative of benzaldehyde to the action of a microorganism selected from the group consisting of the genus Aureobacterium, Pseudomonas, Caseobacter, Alcaligenes, Acinetobacter, Brevibacterium, Nocardia, and Bacillus or treated cells thereof, which the microorganism is capable of stereospecifically hydrolyzing a nitrile group of the R,S-mandelonitrile or a derivative thereof, in a neutral or basic aqueous reaction system to produce the R(-)-mandelic acid.

4. 发明授权

US5714357A Process for producing optically active .alpha.-hydroxycarboxylic acid having phenyl group 失效
标题翻译：制备具有苯基的光学活性α-羟基羧酸的方法
公开(公告)号：US5714357A
公开(公告)日：1998-02-03
申请号：US764295
申请日：1996-12-12
申请人： Yoshihiro Hashimoto , Takakazu Endo , Koji Tamura , Yuji Hirata , Etsuko Kobayashi
发明人： Yoshihiro Hashimoto , Takakazu Endo , Koji Tamura , Yuji Hirata , Etsuko Kobayashi
IPC分类号： C12P7/42 , C12P41/00 , C12R1/01 , C12R1/05 , C12R1/13 , C12R1/38
CPC分类号： C12P7/42 , C12P41/006
摘要： A biological process for predominantly producing an optically active .alpha.-hydroxycarboxylic acid having a phenyl group directly from a racemic .alpha.-hydroxynitrile or a mixture of an aldehyde corresponding to the nitrile and prussic acid as a substrate is disclosed, comprising reacting a microorganism belonging to the genus Rhodococcus, Alcaligenes, Brevibacterium or Pseudomonas with the substrate in a neutral to basic aqueous medium. A desired optically active .alpha.-hydroxycarboxylic acid having a phenyl group can be obtained quantitatively at a high optical purity.
摘要翻译：公开了一种用于主要生产具有直接来自外消旋α-羟基腈的苯基的光学活性α-羟基羧酸或对应于腈和氢醌作为底物的醛的混合物的生物方法，其包括将属于属于红球菌属，产碱杆菌属，短杆菌属或假单胞菌属，在中性至碱性水性介质中具有底物。可以以高光学纯度定量获得具有苯基的所需光学活性α-羟基羧酸。

5. 发明授权

US5296373A Process for producing R(-)-mandelic acid or a derivative thereof from a mandelonitrile using rhodococcus 失效
标题翻译：使用罗红球菌从扁桃腈生产R（ - ） - 扁桃酸或其衍生物的方法
公开(公告)号：US5296373A
公开(公告)日：1994-03-22
申请号：US904335
申请日：1992-06-25
申请人： Takakazu Endo , Koji Tamura
发明人： Takakazu Endo , Koji Tamura
IPC分类号： C12P7/42 , C12P41/00 , C12R1/01
CPC分类号： C12P7/42 , C12P41/006 , Y10S435/822
摘要： A process for treating R,S-mandelonitrile or a derivative thereof or a mixture of benzaldehyde or a derivative thereof, and; hydrogen cyanide, with a microorganism belonging to the genus Rhodococcus sp. HT29-7 (FERM BP-3857) in an almost neutral or basic aqueous medium to thereby directly produce a predominant amount of R(-)-mandelic acid or a derivative thereof, whereby the racemic R,S-mandelonitrile or a derivative thereof or benzaldehyde or a derivative thereof and hydrogen cyanide can be directly converted into R(-)-mandelic acid or a derivative thereof at a ratio of about 80 to 100% and at an optical purity of almost 100%.sub.ee without performing any optical resolution.
摘要翻译：一种处理R，S-扁桃腈或其衍生物或苯甲醛或其衍生物的混合物的方法，氰化氢，属于红球菌属的微生物。 HT29-7（FERM BP-3857）在几乎中性或碱性水性介质中，从而直接产生主要量的R（ - ） - 扁桃酸或其衍生物，由此外消旋R，S-扁桃腈或其衍生物或苯甲醛或其衍生物，氰化氢可以以约80-100％的比例直接转化为R（ - ） - 扁桃酸或其衍生物，光学纯度几乎为100％ee，而不进行任何光学拆分。

6. 发明授权

US5580765A Process for producing optically active a-hydroxycarboxylic acid having phenyl group using gordona terrae 失效
标题翻译：使用戈多纳土生产具有苯基的光学活性α-羟基羧酸的方法
公开(公告)号：US5580765A
公开(公告)日：1996-12-03
申请号：US191164
申请日：1994-02-03
申请人： Yoshihiro Hashimoto , Takakazu Endo , Koji Tamura , Yuji Hirata
发明人： Yoshihiro Hashimoto , Takakazu Endo , Koji Tamura , Yuji Hirata
IPC分类号： C12P7/42 , C12P41/00 , C12R1/01
CPC分类号： C12P41/006 , C12P7/42 , Y10S435/822
摘要： A biological process for predominantly producing an optically active .alpha.-hydroxycarboxylic acid having a phenyl group directly from a racemic .alpha.-hydroxynitrile or a mixture of an aldehyde corresponding to the nitrile and prussic acid as a substrate is disclosed, comprising reacting a microorganism belonging to the genus Gordona with the substrate in a neutral to basic aqueous medium. A desired optically active .alpha.-hydroxycarboxylic acid having a phenyl group can be obtained quantitatively at a high optical purity.
摘要翻译：公开了一种用于主要生产具有直接来自外消旋α-羟基腈的苯基的光学活性α-羟基羧酸或对应于腈和氢醌作为底物的醛的混合物的生物方法，其包括将属于 Gordona属与中性至碱性水性介质中的底物。可以以高光学纯度定量获得具有苯基的所需光学活性α-羟基羧酸。

7. 发明授权

US08049049B2 Method of upgrading biomass, upgraded biomass, biomass water slurry and method of producing same, upgraded biomass gas, and method of gasifying biomass 有权
标题翻译：升级生物质，升级生物质，生物质水泥浆及其生产方法，升级生物质气体和气化生物质的方法
公开(公告)号：US08049049B2
公开(公告)日：2011-11-01
申请号：US12264169
申请日：2008-11-03
申请人： Chiaki Suyama , Shinichi Tokuda , Masao Tsurui , Yoshinori Suto , Koji Tamura , Tsutomu Katagiri , Teruo Nagai , Jin Ogawa , Takeshi Yamaguchi
发明人： Chiaki Suyama , Shinichi Tokuda , Masao Tsurui , Yoshinori Suto , Koji Tamura , Tsutomu Katagiri , Teruo Nagai , Jin Ogawa , Takeshi Yamaguchi
IPC分类号： C07C1/00 , C10L5/00 , C10B53/08
CPC分类号： C10L1/326 , C10G31/08 , C10J3/00 , C10J2300/0916 , C10J2300/092 , C10J2300/0973 , C10J2300/1846 , C10L5/44 , C10L9/086 , C10L2250/06 , C10L2290/04 , C10L2290/24 , C10L2290/28 , Y02E50/10 , Y02E50/30
摘要： This method of upgrading a biomass comprises: an upgrading step for performing upgrading treatment of a cellulose based biomass with an oxygen/carbon atomic ratio of at least 0.5, in presence of water and under a pressure of at least saturated water vapor pressure, and reducing said oxygen/carbon atomic ratio of said biomass to no more than 0.38, and a separation step for separating an upgraded reactant obtained from said upgrading step into a solid component and a liquid component.
摘要翻译：这种升级生物质的方法包括：在水和至少饱和水蒸汽压的压力下，在氧/碳原子比为至少0.5的纤维素基生物质的基础上进行升级处理的升级步骤，并且还原所述生物质的氧/碳原子比不大于0.38，以及将从所述升级步骤获得的升级反应物分离成固体组分和液体组分的分离步骤。

8. 发明申请

US20060112638A1 Method of modifying biomass, modified biomass aqueous biomass sluryy and method of producing the same, modified biomass gas and method of gasifying biomass 失效
标题翻译：改良生物质，改性生物质含水生物质泥沙的方法及其生产方法，改良生物质气体和气化生物质的方法
公开(公告)号：US20060112638A1
公开(公告)日：2006-06-01
申请号：US10523749
申请日：2003-04-25
申请人： Chiaki Suyama , Shinichi Tokuda , Masao Tsurui , Yoshimori Suto , Koji Tamura , Tsutomu Katagiri , Teruo Nagai , Jin Ogawa , Takeshi Yamaguchi
发明人： Chiaki Suyama , Shinichi Tokuda , Masao Tsurui , Yoshimori Suto , Koji Tamura , Tsutomu Katagiri , Teruo Nagai , Jin Ogawa , Takeshi Yamaguchi
IPC分类号： C10J3/46
CPC分类号： C10L1/326 , C10G31/08 , C10J3/00 , C10J2300/0916 , C10J2300/092 , C10J2300/0973 , C10J2300/1846 , C10L5/44 , C10L9/086 , C10L2250/06 , C10L2290/04 , C10L2290/24 , C10L2290/28 , Y02E50/10 , Y02E50/30
摘要： This method of upgrading a biomass comprises: an upgrading step for performing upgrading treatment of a cellulose based biomass with an oxygen/carbon atomic ratio of at least 0.5, in presence of water and under a pressure of at least saturated water vapor pressure, and reducing said oxygen/carbon atomic ratio of said biomass to no more than 0.38, and a separation step for separating an upgraded reactant obtained from said upgrading step into a solid component and a liquid component.
摘要翻译：这种升级生物质的方法包括：在水和至少饱和水蒸汽压的压力下，在氧/碳原子比为至少0.5的纤维素基生物质的基础上进行升级处理的升级步骤，并且还原所述生物质的氧/碳原子比不大于0.38，以及将从所述升级步骤获得的升级反应物分离成固体组分和液体组分的分离步骤。

9. 发明授权

US5216679A Solid-state tunable laser resonator 失效
标题翻译：固态可调激光谐振器
公开(公告)号：US5216679A
公开(公告)日：1993-06-01
申请号：US688262
申请日：1991-04-22
申请人： Koji Tamura , Takashi Arisawa , Toku Shimizu
发明人： Koji Tamura , Takashi Arisawa , Toku Shimizu
IPC分类号： B01D59/34 , G01N3/00 , G02F1/35 , G02F1/37 , H01S3/094 , H01S3/1055 , H01S3/109 , H01S3/16
CPC分类号： H01S3/1055 , G02F1/3534 , G02F1/37 , H01S3/094 , H01S3/1625 , H01S3/1636
摘要： A solid state tunable laser resonator having a laser element, an excitation light source for outputting a pumping light, and elements for selecting a wavelength of the pumping light and directing the wavelength of the pumping light onto the laser element at a first point thereof on a first axis substantially parallel to an axis of oscillation light emitted by the laser element. The laser resonator may also include elements for directing the pumping light onto the laser element at a second additional point thereof. The laser resonator can be used as a laser light source having a wide tunable range with a narrow line width.
摘要翻译：一种具有激光元件的固体可调激光谐振器，用于输出泵浦光的激发光源，以及用于选择泵浦光的波长并将泵浦光的波长在其第一点上引导到激光元件上的元件，第一轴基本上平行于由激光元件发射的振荡光轴。激光谐振器还可以包括用于在其第二附加点处将泵浦光引导到激光元件上的元件。激光谐振器可以用作具有窄线宽宽的可调范围的激光光源。

10. 发明授权

US5035823A Refrigerant compositions of 1,11-trifluoroethane 失效
标题翻译： 1,11-三氟乙烷的制冷剂组合物
公开(公告)号：US5035823A
公开(公告)日：1991-07-30
申请号：US362385
申请日：1989-05-19
申请人： Koji Tamura , Hiroshi Kashiwagi , Masahiro Noguchi
发明人： Koji Tamura , Hiroshi Kashiwagi , Masahiro Noguchi
IPC分类号： F25B1/00 , C07K5/00 , C09K5/04
CPC分类号： C09K5/045 , C09K2205/122 , C09K2205/22
摘要： The present invention provides a refrigerant comprising 1,1,1-trifluoroethane and either chlorotetrafluoroethane or tetrafluoroethane.

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