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1. 发明申请

US20100043010A1 DATA PROCESSING METHOD, CLUSTER SYSTEM, AND DATA PROCESSING PROGRAM 失效
标题翻译：数据处理方法，集群系统和数据处理程序
公开(公告)号：US20100043010A1
公开(公告)日：2010-02-18
申请号：US12366731
申请日：2009-02-06
申请人： Takahiro Yokoyama , Tsunehiko Baba , Masanori Kawashima , Kazuho Tanaka
发明人： Takahiro Yokoyama , Tsunehiko Baba , Masanori Kawashima , Kazuho Tanaka
IPC分类号： G06F9/46
CPC分类号： G06F13/4022 , G06F11/2038 , G06F11/2041 , G06F11/2048 , G06F11/2097
摘要： Provided is a data processing system which includes: a first computer for receiving a processing request for a task processing, executing the processing, and holding data used therein; and a second computer for holding a duplicate of the data held in the first computer, halting the first computer if the first computer is determined to be halted, and receiving and processing the processing request. The first computer receives at least an update request as the processing request including request identification information to which unique numbers assigned to the individual processing requests in an ascending order are allocated, updates the held data, and transmits the update request including the request identification information to the second computer. The second computer stores a transmitted reference request and the update request as the processing requests, and processes the processing requests in an ascending order of the unique numbers included in the individual processing requests.
摘要翻译：提供一种数据处理系统，其包括：第一计算机，用于接收任务处理的处理请求，执行处理并保存其中使用的数据; 以及第二计算机，用于保存保存在第一计算机中的数据的副本，如果确定第一计算机被停止，则停止第一计算机，并且接收和处理处理请求。第一计算机至少接收到作为处理请求的更新请求，包括分配给按照升序分配给各个处理请求的唯一编号的请求标识信息，更新所保持的数据，并将包括请求标识信息的更新请求发送到第二台电脑。第二计算机将发送的参考请求和更新请求存储为处理请求，并且以包括在各个处理请求中的唯一编号的升序来处理处理请求。

2. 发明授权

US08359601B2 Data processing method, cluster system, and data processing program 失效
标题翻译：数据处理方法，集群系统和数据处理程序
公开(公告)号：US08359601B2
公开(公告)日：2013-01-22
申请号：US12366731
申请日：2009-02-06
申请人： Takahiro Yokoyama , Tsunehiko Baba , Masanori Kawashima , Kazuho Tanaka
发明人： Takahiro Yokoyama , Tsunehiko Baba , Masanori Kawashima , Kazuho Tanaka
IPC分类号： G06F17/30
CPC分类号： G06F13/4022 , G06F11/2038 , G06F11/2041 , G06F11/2048 , G06F11/2097
摘要： Provided is a data processing system which includes: a first computer for receiving a processing request for a task processing, executing the processing, and holding data used therein; and a second computer for holding a duplicate of the data held in the first computer, halting the first computer if the first computer is determined to be halted, and receiving and processing the processing request. The first computer receives at least an update request as the processing request including request identification information to which unique numbers assigned to the individual processing requests in an ascending order are allocated, updates the held data, and transmits the update request including the request identification information to the second computer. The second computer stores a transmitted reference request and the update request as the processing requests, and processes the processing requests in an ascending order of the unique numbers included in the individual processing requests.
摘要翻译：提供一种数据处理系统，其包括：第一计算机，用于接收任务处理的处理请求，执行处理并保存其中使用的数据; 以及第二计算机，用于保存保存在第一计算机中的数据的副本，如果确定第一计算机被停止，则停止第一计算机，并且接收和处理处理请求。第一计算机至少接收到作为处理请求的更新请求，包括分配给按照升序分配给各个处理请求的唯一编号的请求标识信息，更新所保持的数据，并将包含请求标识信息的更新请求发送到第二台电脑。第二计算机将发送的参考请求和更新请求存储为处理请求，并且以包括在各个处理请求中的唯一编号的升序来处理处理请求。

3. 发明申请

US20100138540A1 Method of managing organization of a computer system, computer system, and program for managing organization 审中-公开
标题翻译：计算机系统的组织管理，计算机系统和组织管理方法
公开(公告)号：US20100138540A1
公开(公告)日：2010-06-03
申请号：US12457578
申请日：2009-06-16
申请人： Kazuho Tanaka , Tsunehiko Baba , Takahiro Yokoyama , Hiroyuki Osaki
发明人： Kazuho Tanaka , Tsunehiko Baba , Takahiro Yokoyama , Hiroyuki Osaki
IPC分类号： G06F15/173
CPC分类号： G06F9/505
摘要： There is provided a method of managing an organization of a computer system including a plurality of servers each capable of executing requested services, the services belonging to a service group defined based on data necessary for executing the services. Service groups are assigned to the plurality of servers. The method including: selecting, when a load imposed on a server exceeds a predetermined upper limit, a server of transfer destination for executing some of the services to be executed on the server having the load exceeding the upper limit; selecting at least one service group out of service groups assigned to the server having the load exceeding the upper limit; assigning the selected service group to the server of transfer destination; and transferring data necessary for executing services belonging to the selected service group from the server having the load exceeding the upper limit to the server of transfer destination.
摘要翻译：提供了一种管理计算机系统的组织的方法，所述计算机系统的组织包括多个能够执行所请求的服务的服务器，所述服务属于基于执行服务所必需的数据而定义的服务组。服务组被分配给多个服务器。该方法包括：当服务器上施加的负载超过预定上限时，选择用于执行负载超过上限的服务器上要执行的一些服务的传送目的地服务器; 从分配给负载超过上限的服务器的服务组中选择至少一个服务组; 将所选择的服务组分配给转移目的地的服务器; 以及从负载超过上限的服务器向传送目的地的服务器传送属于所选服务组的服务所需的数据。

4. 发明授权

US08527531B2 Stream data generating method, stream data generating device and a recording medium storing stream data generating program 有权
标题翻译：流数据生成方法，流数据生成装置和存储流数据生成程序的记录介质
公开(公告)号：US08527531B2
公开(公告)日：2013-09-03
申请号：US12626041
申请日：2009-11-25
申请人： Kazuho Tanaka , Takahiro Yokoyama , Tomohiro Hanai , Satoru Watanabe , Atsuro Handa
发明人： Kazuho Tanaka , Takahiro Yokoyama , Tomohiro Hanai , Satoru Watanabe , Atsuro Handa
IPC分类号： G06F17/00
CPC分类号： G06F17/30017
摘要： A stream data generating method for a computer system for generating stream data having time information applied thereto in a time series order and processing the generated stream data on the basis of a registered query. The computer system includes a storage for storing therein query information indicative of a plurality of sorts of constituent elements forming stream data corresponding to the query on the basis of the query and a stream definition indicative of the plurality of constituent elements, a data generator for generating and transmitting stream data; and a stream data processor for processing the stream data transmitted from the data generator. The data generator a less quantity of stream data to be transmitted to the stream data processor on the basis of the query information.
摘要翻译：一种计算机系统的流数据生成方法，用于产生具有时间序列顺序应用于其中的时间信息的流数据，并且基于注册查询处理所生成的流数据。计算机系统包括用于在其中存储指示基于查询形成与查询相对应的流数据的多种组成元素的查询信息和指示多个组成元素的流定义的存储器，用于生成并发送流数据; 以及用于处理从数据发生器发送的流数据的流数据处理器。基于查询信息，数据生成器将要传送到流数据处理器的数据量较少。

5. 发明授权

US07812160B2 Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 有权
标题翻译：可用于治疗由CRTH2介导的疾病的嘧啶衍生物
公开(公告)号：US07812160B2
公开(公告)日：2010-10-12
申请号：US10554668
申请日：2004-04-14
申请人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
发明人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
IPC分类号： C07D239/42 , C07D239/34 , C07D239/48 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12 , A61K31/505 , A61K31/506 , A61P11/06
CPC分类号： C07D239/42 , C07D239/30 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12
摘要： The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
摘要翻译：本发明涉及式（I）的嘧啶衍生物及其盐，其可用作药物制剂的活性成分。本发明的嘧啶衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病，特别是用于治疗过敏性疾病，如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

6. 发明申请

US20070129355A1 Pyrimidine derivatives useful for the treatment of diseases mediated by crth2 有权
标题翻译：可用于治疗由crth2介导的疾病的嘧啶衍生物
公开(公告)号：US20070129355A1
公开(公告)日：2007-06-07
申请号：US10554668
申请日：2004-04-14
申请人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
发明人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/506 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D239/42 , C07D239/30 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12
摘要： The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
摘要翻译：本发明涉及式（I）的嘧啶衍生物及其盐，其可用作药物制剂的活性成分。本发明的嘧啶衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病，特别是用于治疗过敏性疾病，如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

7. 发明授权

US07173150B2 Process for recovering terephthalic acid from pulverized product of spent polyethylene terephthalate and system for use in such process 失效
标题翻译：从废聚对苯二甲酸乙二醇酯的粉碎产物中回收对苯二甲酸的方法和用于该方法的体系
公开(公告)号：US07173150B2
公开(公告)日：2007-02-06
申请号：US10424042
申请日：2003-04-24
申请人： Jinichi Yazaki , Kozaburo Sakano , Nobuyuki Funakoshi , Kazuho Tanaka
发明人： Jinichi Yazaki , Kozaburo Sakano , Nobuyuki Funakoshi , Kazuho Tanaka
IPC分类号： C07C51/09
CPC分类号： C07C51/43 , C07C51/09 , C07C51/412 , C07C51/47 , C08J11/24 , C08J2367/02 , Y02W30/706 , C07C63/28 , C07C63/26
摘要： This invention provides a process a process for recovering terephthalic acid from pulverized products of spent polyethylene terephthalate. This process comprises (1) a decomposition reaction step where the pulverized products of spent polyethylene terephthalate are continuously subjected to decomposition reaction in ethylene glycol in the presence of alkali, which is equimolar or excessmolar relative to the polyethylene terephthalate, so that salt of terephthalic acid and ethylene glycol can be continuously obtained; (2) a solid-liquid separation, dissolution, impurities-removing step where the ethylene glycol is separated from decomposition reaction slurry of salt of terephthalic acid and ethylene glycol, and the solid salt of terephthalic acid is dissolved into water, while insoluble impurities are removed; (3) a neutralization, crystallization step, where solution of said salt of terephthalic acid is neutralized with acid so that terephthalic acid can be crystallized; (4) a solid-liquid separation, washing stop where slurry of terephthalic acid crystals is subjected to solid-liquid separation so that the terephthalic acid crystals can be obtained and washed; and (5) a drying, pulverization step where the washed terephthalic acid crystals are dried and pulverized.
摘要翻译：本发明提供一种从废聚对苯二甲酸乙二醇酯的粉碎产物中回收对苯二甲酸的方法。该方法包括：（1）分解反应步骤，其中废聚对苯二甲酸乙二醇酯的粉碎产物在相对于聚对苯二甲酸乙二醇酯等摩尔或过量的碱的存在下在乙二醇中连续进行分解反应，使得对苯二甲酸的盐可连续获得乙二醇; （2）从对苯二甲酸和乙二醇盐的分解反应浆液中分离出乙二醇和对苯二甲酸的固体盐的固液分离，溶解，杂质去除步骤溶解在水中，不溶性杂质为删除（3）中和，结晶步骤，其中所述对苯二甲酸盐的溶液用酸中和，使对苯二甲酸可以结晶; （4）固液分离，其中对苯二甲酸晶体的浆液进行固液分离以使得可以获得和洗涤对苯二甲酸晶体的洗涤停止; 和（5）干燥，粉碎步骤，其中将洗涤的对苯二甲酸晶体干燥并粉碎。

8. 发明授权

US07960393B2 Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 有权
标题翻译：可用于治疗由CRTH2介导的疾病的嘧啶衍生物
公开(公告)号：US07960393B2
公开(公告)日：2011-06-14
申请号：US12868663
申请日：2010-08-25
申请人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
发明人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
IPC分类号： A61K31/505 , A61K31/506 , A61P11/06 , C07D239/34 , C07D239/42 , C07D239/48 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12
CPC分类号： C07D239/42 , C07D239/30 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12
摘要： The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
摘要翻译：本发明涉及式（I）的嘧啶衍生物及其盐，其可用作药物制剂的活性成分。本发明的嘧啶衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病，特别是用于治疗过敏性疾病，如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

9. 发明申请

US20080119478A1 2,3-Dihydro-6-Nitroimidazo (2,1-b) Oxazole Compounds for the Treatment of Tuberculosis 有权
标题翻译： 2,3-二氢-6-硝基咪唑（2,1-b）恶唑化合物治疗结核病
公开(公告)号：US20080119478A1
公开(公告)日：2008-05-22
申请号：US10574597
申请日：2004-10-29
申请人： Hidetsugu Tsubouchi , Hirofumi Sasaki , Motohiro Itotani , Yoshikazu Haraguchi , Shin Miyamura , Makoto Matsumoto , Hiroyuki Hashizume , Tatsuo Tomishige , Masanori Kawasaki , Kinue Ohguro , Takumi Sumida , Takeshi Hasegawa , Kazuho Tanaka , Isao Takemura
发明人： Hidetsugu Tsubouchi , Hirofumi Sasaki , Motohiro Itotani , Yoshikazu Haraguchi , Shin Miyamura , Makoto Matsumoto , Hiroyuki Hashizume , Tatsuo Tomishige , Masanori Kawasaki , Kinue Ohguro , Takumi Sumida , Takeshi Hasegawa , Kazuho Tanaka , Isao Takemura
IPC分类号： A61K31/497 , A61K31/41 , A61K31/445 , C07D211/68 , C07D413/00 , C07D498/02 , C07D215/00 , A61P31/00 , A61K31/47
CPC分类号： C07D498/04
摘要： The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1) in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and —(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30) and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.
摘要翻译：本发明提供由上述通式（1）中的通式（1）表示的2,3-二氢-6-硝基咪唑并[2,1-b]恶唑化合物，R1表示氢原子或C1-C6 烷基，n表示0〜6的整数，R 1和 - （CH 2）n R 2可以与下述式（30）表示的螺环连同相邻的碳原子（在式中，RRR表示哌啶环上可具有取代基的哌啶基），（30），R 2表示苯并噻唑氧基，喹啉氧基，吡啶氧基等。本发明化合物对结核分枝杆菌，多药耐药结核分枝杆菌和非典型酸性抗菌细菌具有优异的杀菌作用。

10. 发明授权

US08163753B2 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis 有权
标题翻译： 2,3-二氢-6-硝基咪唑并（2,1-b）恶唑化合物，用于治疗结核病
公开(公告)号：US08163753B2
公开(公告)日：2012-04-24
申请号：US10574597
申请日：2004-10-29
申请人： Hidetsugu Tsubouchi , Hirofumi Sasaki , Motohiro Itotani , Yoshikazu Haraguchi , Shin Miyamura , Makoto Matsumoto , Hiroyuki Hashizume , Tatsuo Tomishige , Masanori Kawasaki , Kinue Ohguro , Takumi Sumida , Takeshi Hasegawa , Kazuho Tanaka , Isao Takemura
发明人： Hidetsugu Tsubouchi , Hirofumi Sasaki , Motohiro Itotani , Yoshikazu Haraguchi , Shin Miyamura , Makoto Matsumoto , Hiroyuki Hashizume , Tatsuo Tomishige , Masanori Kawasaki , Kinue Ohguro , Takumi Sumida , Takeshi Hasegawa , Kazuho Tanaka , Isao Takemura
IPC分类号： A61K31/497 , A61K31/47 , A61K31/445 , A61K31/42 , C07D419/06 , C07D215/04 , C07D213/72 , C07D498/04
CPC分类号： C07D498/04
摘要： The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1) in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and —(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30) and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.
摘要翻译：本发明提供由上述通式（1）中的通式（1）表示的2,3-二氢-6-硝基咪唑并[2,1-b]恶唑化合物，R1表示氢原子或C1-C6 烷基，n表示0〜6的整数，R1和 - （CH2）nR2可以与相邻的碳原子一起形成由下式（30）表示的螺环（在下式中，RRR表示哌啶基其可以在哌啶环上具有取代基），（30），R 2表示苯并噻唑氧基，喹啉氧基，吡啶氧基等。本发明化合物对结核分枝杆菌，多药耐药结核分枝杆菌和非典型酸性抗菌细菌具有优异的杀菌作用。

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