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1. 发明授权

US07217352B2 Capillary electrophoresis device 有权
标题翻译：毛细管电泳装置
公开(公告)号：US07217352B2
公开(公告)日：2007-05-15
申请号：US10446107
申请日：2003-05-28
申请人： Taisaku Seino , Tomoyuki Sakai , Miho Ozawa , Masaya Kojima , Eric S. Nordman
发明人： Taisaku Seino , Tomoyuki Sakai , Miho Ozawa , Masaya Kojima , Eric S. Nordman
IPC分类号： G01N27/26
CPC分类号： G01N27/44704 , G01N27/44782
摘要： An electrophoresis device is disclosed that is capable of reducing waves occurring in a fluid in which the capillary tips of a capillary assay are immersed. A plurality of partition plate members can be provided in a container containing the fluid to divide the surface of the fluid into several sections. The container can be transported at a high speed, and the capillary tips can be immersed in the fluid quickly, thereby preventing resolution degradation caused by a long period of exposure of the capillary tips to air. Throughput of sample analysis can also be improved because it is not necessary to wait until waves disappear before conducting an analysis.
摘要翻译：公开了一种电泳装置，其能够减少毛细管测定的毛细管尖端浸入其中的流体中发生的波。可以在容纳流体的容器中设置多个隔板构件，以将流体的表面分成若干部分。容器可以高速运输，并且毛细管尖端可以快速地浸入流体中，从而防止毛细管尖端长时间暴露于空气引起的分解降解。也可以提高样本分析的吞吐量，因为在进行分析之前不必等到波浪消失。

2. 发明授权

US07459068B2 Multi-capillary electrophoresis apparatus 有权
标题翻译：多毛细管电泳仪
公开(公告)号：US07459068B2
公开(公告)日：2008-12-02
申请号：US10309729
申请日：2002-12-04
申请人： Eric S. Nordman , Miho Ozawa , Masaya Kojima , Ryoji Inaba , Yoshitaka Kodama , Motohiro Yamazaki
发明人： Eric S. Nordman , Miho Ozawa , Masaya Kojima , Ryoji Inaba , Yoshitaka Kodama , Motohiro Yamazaki
IPC分类号： G01N27/26 , G01N27/447
CPC分类号： G01N27/44704 , G01N27/44708 , G01N27/44782
摘要： A multi-capillary electrophoresis apparatus is provided for reducing errors during analysis caused by fluctuations in electrophoresis time among plural capillaries of the apparatus. The multi-capillary electrophoresis apparatus can contain a multi-capillary array that has a separation medium filled therein for isolating a sample. A detector component can be provided at a position remote from a sample injecting end of the array for acquiring information from the sample. A buffer container can be provided for holding a buffer solution into which the sample injecting end can be immersed. One or more temperature controlling component devices can be arranged for controlling a temperature of the buffer solution, of the detector component, or of both the buffer solution and the detector component.
摘要翻译：提供了一种多毛细管电泳装置，用于减少由于装置的多个毛细管之间的电泳时间波动引起的分析过程中的误差。多毛细管电泳装置可以包含多个毛细管阵列，其具有填充在其中的分离介质，用于分离样品。可以在远离阵列的样品注入端的位置处提供检测器部件，以从样品获取信息。可以提供缓冲容器用于保持可以浸入样品注入端的缓冲溶液。可以布置一个或多个温度控制部件装置，用于控制缓冲溶液，检测器部件或缓冲溶液和检测器部件两者的温度。

3. 发明授权

US07316770B2 Method of electrophoresis, electrophoresis apparatus and capillary array 有权
标题翻译：电泳方法，电泳装置和毛细管阵列
公开(公告)号：US07316770B2
公开(公告)日：2008-01-08
申请号：US09814860
申请日：2001-03-23
申请人： Ryoji Inaba , Tomoyuki Sakai , Satoshi Takahashi , Muneo Maeshima , Miho Ozawa , Masaya Kojima , Daizo Tokinaga
发明人： Ryoji Inaba , Tomoyuki Sakai , Satoshi Takahashi , Muneo Maeshima , Miho Ozawa , Masaya Kojima , Daizo Tokinaga
IPC分类号： G01N27/26
CPC分类号： G01N27/44708 , G01N27/44782
摘要： A method of electrophoresis, an electrophoresis apparatus and a capillary array in which a fluorescently labelled sample is supplied into capillaries in a capillary array constituted by a plurality of capillaries and including a sample supply portion, an electrophoresis medium supply portion and a detection portion while controlling the temperature of the capillary array through gas circulation, the sample is caused to migrate and separated in the capillaries through electrophoresis, and at the region where the capillaries are contacted or come close each other a plurality of capillaries are contacted to a solid body so as to dissipate heat generated from the capillaries to the solid body.
摘要翻译：一种电泳方法，电泳装置和毛细管阵列，其中荧光标记的样品被供应到由多个毛细管构成的毛细管阵列的毛细管中，并且包括样品供应部分，电泳介质供应部分和检测部分，同时控制通过气体循环的毛细管阵列的温度，通过电泳使样品在毛细管中迁移和分离，并且在毛细管接触或彼此靠近的区域，多个毛细管与固体接触，以便以将从毛细管产生的热量散发到固体。

4. 发明授权

US08246806B2 Multi-capillary array electrophoresis device 有权
标题翻译：多毛细管阵列电泳装置
公开(公告)号：US08246806B2
公开(公告)日：2012-08-21
申请号：US11714222
申请日：2007-03-06
申请人： Ryoji Inaba , Tomohiro Shoji , Shozo Kasai , Masaya Kojima , Yasushi Shimizu , Seiichi Ugai , Eric S. Nordman
发明人： Ryoji Inaba , Tomohiro Shoji , Shozo Kasai , Masaya Kojima , Yasushi Shimizu , Seiichi Ugai , Eric S. Nordman
IPC分类号： G01N27/453
CPC分类号： G01N27/44782 , G01N27/44721
摘要： An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.
摘要翻译：电泳装置包括具有设置在阵列的毛细管之间的液体或固体的多毛细管阵列。液体或固体的折射率高于空气的折射率，小于水的折射率，并减少了由毛细管散射的激光束的数量。还提供了调节通过多毛细管阵列的毛细管的折射和反射的激发光束的方法，以减少激光束的强度损失并增加设置在毛细管中的各个样品的照射。

5. 发明授权

US07054004B2 Capillary array and capillary array photodetector 有权
公开(公告)号：US07054004B2
公开(公告)日：2006-05-30
申请号：US10704827
申请日：2003-11-12
申请人： Ryoji Inaba , Toshiaki Kita , Miho Ozawa , Tomonari Morioka , Akihiro Suzuki , Yasushi Shimizu , Masaya Kojima
发明人： Ryoji Inaba , Toshiaki Kita , Miho Ozawa , Tomonari Morioka , Akihiro Suzuki , Yasushi Shimizu , Masaya Kojima
IPC分类号： G01N21/00 , C02F1/40
CPC分类号： G01N27/44721 , G01N27/44782
摘要： A multi-focus capillary array that can reduce crosstalk and a capillary array photodetector are provided. On a substrate 20 on which a plurality of capillaries are aligned, a perforation 72 is formed in at least a part of an area in the rear of the capillaries when the capillary array is viewed from the photodetector.

6. 发明申请

US20050067285A1 Electrophoresis device 审中-公开
标题翻译：电泳装置
公开(公告)号：US20050067285A1
公开(公告)日：2005-03-31
申请号：US10913517
申请日：2004-08-09
申请人： Ryoji Inaba , Miho Ozawa , Akihiro Suzuki , Daizo Tokinaga , Tomohiro Shoji , Yoshitaka Kodama , Isao Haraura , Masaya Kojima
发明人： Ryoji Inaba , Miho Ozawa , Akihiro Suzuki , Daizo Tokinaga , Tomohiro Shoji , Yoshitaka Kodama , Isao Haraura , Masaya Kojima
IPC分类号： G01N21/64 , G01N27/447 , G01N27/453
CPC分类号： G01N27/44782 , G01N27/44721
摘要： The present invention is related to the decrease of crosstalk, in which part of light emission from a specific capillary is overlayed on the light emission position of its adjoining capillaries and is detected as signal from adjacent capillaries. Study conducted by the inventor has found that the crosstalk contains at least the following components. The signal light from a capillary may propagate through an adjoining capillary or a plurality of capillaries, the reflection at the inner surface of the outer diameter of quartz capillary makes plural signal paths to the photodetector. The crosstalk component may be focused at a point at a predetermined distance from the center axis of the capillary. The present invention is aimed at the control of the range of image to be detected as the capillary signal among the images focused on the photodetector from the capillaries. The present invention may decrease the crosstalk by controlling the detection of the light emission from the adjacent capillaries.
摘要翻译：本发明涉及串扰的减少，其中来自特定毛细管的光发射的一部分覆盖在其相邻的毛细管的发光位置上，并被检测为来自相邻毛细管的信号。发明人进行的研究发现串扰至少包含以下组件。来自毛细管的信号光可以通过邻接的毛细管或多个毛细管传播，石英毛细管的外径的内表面的反射使得到达光电检测器的多个信号路径。串扰分量可以聚焦在距离毛细管的中心轴预定距离的点处。本发明的目的在于控制从毛细管聚焦在光电检测器上的图像中的毛细管信号的被检测图像的范围。本发明可以通过控制来自相邻毛细管的光发射的检测来减小串扰。

7. 发明申请

US20120076101A1 RADIO COMMUNICATION TERMINAL, BASE STATION, RADIO COMMUNICATION METHOD AND RADIO COMMUNICATION SYSTEM 有权
标题翻译：无线电通信终端，基站，无线电通信方法和无线电通信系统
公开(公告)号：US20120076101A1
公开(公告)日：2012-03-29
申请号：US13321917
申请日：2010-05-26
申请人： Masaya Kojima
发明人： Masaya Kojima
IPC分类号： H04W72/04 , H04W92/00
CPC分类号： H04L5/0048 , H04W72/0453
摘要： A radio communication terminal (100) includes a correction unit (154) configured to correct data signals by using reference signals included in a received frame from a base station (200), a determination unit (140) for determining whether it is possible to have good radio communication with the base station (200) based on a condition of radio communication with the base station (200), a transmission frame generation unit (110), upon determination that it is possible to perform good radio communication, for generating a transmission frame with a reduced number of reference signals as a notification signal, and a transmission unit (120) for transmitting the notification signal to the base station (200). The correction unit (154) corrects the data signal by using the reference signals included in the received frame in which at least one reference signal is replaced with the data signal, from the base station (200) corresponding to the notification signal.
摘要翻译：无线电通信终端（100）包括校正单元（154），其被配置为通过使用包括在来自基站（200）的接收帧中的参考信号来校正数据信号，确定单元（140），用于确定是否可以具有基于与基站（200）的无线电通信的条件与基站（200）进行良好的无线电通信，传输帧生成单元（110）在确定可以执行良好的无线电通信以用于生成传输帧，具有减少数量的参考信号作为通知信号;以及发送单元（120），用于将通知信号发送到基站（200）。校正单元（154）从与通知信号相对应的基站（200）通过使用包含在其中至少一个参考信号被数据信号替代的接收帧中的参考信号来校正数据信号。

8. 发明授权

US07540949B2 Capillary array electrophoresis apparatus and method of separating and analyzing specimen 有权
公开(公告)号：US07540949B2
公开(公告)日：2009-06-02
申请号：US11188644
申请日：2005-07-26
申请人： Masaya Kojima , Muneo Maeshima , Yoshiyuki Okishima , Tomohiro Shoji , Wataru Matsuo
发明人： Masaya Kojima , Muneo Maeshima , Yoshiyuki Okishima , Tomohiro Shoji , Wataru Matsuo
IPC分类号： G01N27/453
CPC分类号： G01N27/44782 , G01N27/44704
摘要： At a wall constituting a space for a thermostatic oven in an electrophoresis apparatus, a capillary array attachment portion is formed which permits attachment of a plurality of capillary arrays having different length. Thereby, a selected capillary array constituted by collecting a plurality of capillaries can be easily attached to the electrophoresis apparatus depending on measurement purpose.

9. 发明申请

US20070175761A1 Multi-capillary array electrophoresis device 有权
公开(公告)号：US20070175761A1
公开(公告)日：2007-08-02
申请号：US11714221
申请日：2007-03-06
申请人： Ryoji Inaba , Tomohiro Shoji , Shozo Kasai , Masaya Kojima , Yasushi Shimizu , Selichi Ugai , Eric Nordman
发明人： Ryoji Inaba , Tomohiro Shoji , Shozo Kasai , Masaya Kojima , Yasushi Shimizu , Selichi Ugai , Eric Nordman
IPC分类号： G01N27/00
CPC分类号： G01N27/44782 , G01N27/44721
摘要： An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.

10. 发明授权

US07081191B2 Capillary electrophoresis device 有权
标题翻译：毛细管电泳装置
公开(公告)号：US07081191B2
公开(公告)日：2006-07-25
申请号：US10239308
申请日：2002-01-18
申请人： Tomihiro Shoji , Masaya Kojima , Yoshiyuki Okishima , Ryoji Inaba
发明人： Tomihiro Shoji , Masaya Kojima , Yoshiyuki Okishima , Ryoji Inaba
IPC分类号： G01N27/447 , G01N27/953
CPC分类号： G01N27/44769 , G01N27/447
摘要： The capillary electrophoresis device using one pressure-resistant syringe (125) is capable of automatically suctioning in polymer solution and injecting polymer solution into a capillary array (100). An electric hook (131) is installed for pulling up the syringe plunger on a push-in action type syringe (125). A check valve (124) is inserted between a polymer bottle (123) and syringe to prevent solution from flowing back into the polymer bottle. As a result, one syringe portion of polymer solution can be suctioned and injected, a large volume of polymer solution can be continuously used and device processing capability is improved.
摘要翻译：使用一个耐压注射器（125）的毛细管电泳装置能够在聚合物溶液中自动抽吸并将聚合物溶液注入毛细管阵列（100）中。安装电钩（131）以将注射器柱塞提升在推入式注射器（125）上。将止回阀（124）插入聚合物瓶（123）和注射器之间以防止溶液流回到聚合物瓶中。结果，可以吸引和注入聚合物溶液的一个注射器部分，可以连续使用大量的聚合物溶液，并且提高装置处理能力。

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