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1. 发明申请

US20100236449A1 CALCIUM PHOSPHATE COMPOSITION AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：磷酸钙组合物及其生产方法
公开(公告)号：US20100236449A1
公开(公告)日：2010-09-23
申请号：US12160971
申请日：2007-01-15
申请人： Tadashi Hashimoto , Takahiro Sekiguchi , Koichi Okada
发明人： Tadashi Hashimoto , Takahiro Sekiguchi , Koichi Okada
IPC分类号： A61L24/02
CPC分类号： A61L27/425 , A61K6/0008 , A61K6/0067 , A61K6/0215 , A61K6/024 , A61K6/0245 , A61K6/025 , A61K6/0255 , A61K6/033 , A61K6/0643 , A61L24/0063 , C04B28/344 , C04B2111/00836 , C04B14/06 , C04B14/305 , C04B22/064 , A61K6/0038 , C08L1/286 , C08L1/284 , C08L1/28 , C08L71/02 , C08L89/00 , C08L29/04 , C08L33/08 , A61K6/097 , A61K6/087 , A61K6/083
摘要： A calcium phosphate composition comprising tetracalcium phosphate particles (A), calcium hydrogen phosphate particles (B) and at least one kind of inorganic particles (C) selected from silica particles or titania particles, wherein the mixing ratio (A/B) of (A) to (B) is from 45/55 to 55/45 in molar ratio, the inorganic particles (C) have an average particle diameter of from 0.002 to 0.5 μm, and the inorganic particles (C) are contained in an amount of 0.1 to 20 parts by weight based on 100 parts by weight of (A) and (B) in total. Thereby provided is a calcium phosphate composition such that when it is used as a material for bone repair, a formed bone has high mechanical strength and a high bone replacement rate is achieved.
摘要翻译：一种磷酸钙组合物，其包含磷酸二氢钙颗粒（A），磷酸氢钙颗粒（B）和至少一种选自二氧化硅颗粒或二氧化钛颗粒的无机颗粒（C），其中（A / B））至（B）的摩尔比为45/55〜55/45，无机粒子（C）的平均粒径为0.002〜0.5μm，无机粒子（C）的含量为0.1 相对于100重量份的（A）和（B）总计为20重量份。由此，提供了一种磷酸钙组合物，当其用作骨修复材料时，形成的骨骼具有高的机械强度，并且实现了高的骨置换率。

2. 发明授权

US08906151B2 Calcium phosphate composition and process for producing the same 有权
标题翻译：磷酸钙组合物及其制备方法
公开(公告)号：US08906151B2
公开(公告)日：2014-12-09
申请号：US12160971
申请日：2007-01-15
申请人： Tadashi Hashimoto , Takahiro Sekiguchi , Koichi Okada
发明人： Tadashi Hashimoto , Takahiro Sekiguchi , Koichi Okada
IPC分类号： A61L24/02 , A61L27/42 , A61K6/033 , A61L24/00 , C04B28/34 , A61K6/00 , A61K6/02 , A61K6/06 , C04B111/00
CPC分类号： A61L27/425 , A61K6/0008 , A61K6/0067 , A61K6/0215 , A61K6/024 , A61K6/0245 , A61K6/025 , A61K6/0255 , A61K6/033 , A61K6/0643 , A61L24/0063 , C04B28/344 , C04B2111/00836 , C04B14/06 , C04B14/305 , C04B22/064 , A61K6/0038 , C08L1/286 , C08L1/284 , C08L1/28 , C08L71/02 , C08L89/00 , C08L29/04 , C08L33/08 , A61K6/097 , A61K6/087 , A61K6/083
摘要： A calcium phosphate composition comprising tetracalcium phosphate particles (A), calcium hydrogen phosphate particles (B) and at least one kind of inorganic particles (C) selected from silica particles or titania particles, wherein the mixing ratio (A/B) of (A) to (B) is from 45/55 to 55/45 in molar ratio, the inorganic particles (C) have an average particle diameter of from 0.002 to 0.5 μm, and the inorganic particles (C) are contained in an amount of 0.1 to 20 parts by weight based on 100 parts by weight of (A) and (B) in total. Thereby provided is a calcium phosphate composition such that when it is used as a material for bone repair, a formed bone has high mechanical strength and a high bone replacement rate is achieved.
摘要翻译：一种磷酸钙组合物，其包含磷酸二氢钙颗粒（A），磷酸氢钙颗粒（B）和至少一种选自二氧化硅颗粒或二氧化钛颗粒的无机颗粒（C），其中（A / B））至（B）的摩尔比为45/55〜55/45，无机粒子（C）的平均粒径为0.002〜0.5μm，无机粒子（C）的含量为0.1 相对于100重量份的（A）和（B）总计为20重量份。由此，提供了一种磷酸钙组合物，当其用作骨修复材料时，形成的骨骼具有高的机械强度，并且实现了高的骨置换率。

3. 发明申请

US20120027829A1 DENTIN MINERALIZING AGENT AND METHOD FOR PRODUCTION THEREOF 审中-公开
标题翻译： DENTIN矿化剂及其生产方法
公开(公告)号：US20120027829A1
公开(公告)日：2012-02-02
申请号：US13259681
申请日：2010-03-26
申请人： Tadashi Hashimoto , Mariko Sugiura , Shumei Ishihara , Mitsunobu Kawashima , Koichi Okada
发明人： Tadashi Hashimoto , Mariko Sugiura , Shumei Ishihara , Mitsunobu Kawashima , Koichi Okada
IPC分类号： A61K8/24 , A61Q11/00 , A61K8/02
CPC分类号： A61K33/42 , A61K6/0017 , A61K6/033 , A61K8/0241 , A61K8/24 , A61K33/16 , A61K45/06 , A61K2800/412 , A61Q11/00 , A61K2300/00
摘要： A dentin mineralizing agent comprising tetracalcium phosphate particles (A) and an alkali metal salt of phosphoric acid (B), wherein the dentin mineralizing agent contains the tetracalcium phosphate particles (A) in an amount of 1 to 80 parts by weight relative to 100 parts by weight of the whole amount of the dentin mineralizing agent, and the blended amount of the alkali metal salt of phosphoric acid (B) relative to 100 parts by weight of the tetracalcium phosphate particles (A) is 1 to 100 parts by weight. Thus is provided a dentin mineralizing agent by which a dense HAp is formed on a dentin surface and HAp is deposited to a deep portion of a dentinal tubule, so that it can close the dentinal tubule.
摘要翻译： 1.一种含有磷酸四钙粒子（A）和磷酸碱金属盐（B）的牙质矿化剂，其中所述牙质矿化剂相对于100份含有1〜80重量份的磷酸四钙粒子（A），相对于100重量份的磷酸四钙粒子（A），磷酸（B）的碱金属盐的配合量为1〜100重量份。因此，提供牙本质矿化剂，通过该牙本质矿化剂在牙本质表面上形成致密的HAp，并将HAp沉积到牙质小管的深部，使得其可以闭合牙质小管。

4. 发明申请

US20100323022A1 CALCIUM PHOSPHATE COMPOSITION AND PROCESS FOR PRODUCTION THEREOF 审中-公开
标题翻译：磷酸钙组合物及其生产方法
公开(公告)号：US20100323022A1
公开(公告)日：2010-12-23
申请号：US12866689
申请日：2009-02-05
申请人： Tadashi Hashimoto , Koichi Okada
发明人： Tadashi Hashimoto , Koichi Okada
IPC分类号： A61K9/14 , A61K33/42 , A61F2/28 , A61C5/00
CPC分类号： A61L24/02 , A61L27/12
摘要： A calcium phosphate composition comprising calcium phosphate particles (A) and a sulfonic acid salt (B), wherein the calcium phosphate composition contains 0.5 to 20 parts by weight of the sulfonic acid salt (B) based on 100 parts by weight of the calcium phosphate particles (A). This provides a calcium phosphate composition that has a time between the addition of a liquid agent to the calcium phosphate composition and the completion of setting in the use at a clinical site and the like, i.e., a setting time which is within an appropriate range and that is high in mechanical strength and good in marginal sealing ability.
摘要翻译：一种磷酸钙组合物，其包含磷酸钙颗粒（A）和磺酸盐（B），其中，基于100重量份的磷酸钙，磷酸钙组合物含有0.5至20重量份的磺酸盐（B）颗粒（A）。这提供了一种磷酸钙组合物，其在添加液体试剂到磷酸钙组合物之间的时间和在临床部位等的使用中的设定完成，即在适当范围内的凝固时间，以及机械强度高，边缘密封能力好。

5. 发明授权

US07649728B2 Electricity removal apparatus 失效
标题翻译：除电装置
公开(公告)号：US07649728B2
公开(公告)日：2010-01-19
申请号：US11959556
申请日：2007-12-19
申请人： Tsukasa Fujita , Tadashi Hashimoto
发明人： Tsukasa Fujita , Tadashi Hashimoto
IPC分类号： H05F3/06
CPC分类号： H01T23/00
摘要： The present invention relates to suppressing wear and contamination of the electrode needle as well as effectively removing the electricity from a charged body. An electricity removal mode in which the electrode needle is applied with a high voltage to produce ions and a halt mode in which the electrode needle is halted are provided, that are alternatively selected based on a selection of a user. The halt mode includes a halt period during which the high voltage is not basically applied on the electrode needle. When a self discharge occurs by approach of a charged body in this halt period and an absolute value of current that flows through the resistance exceeds the first threshold value, the electricity removal operation is initiated in which the high voltage is applied on the electrode needle to produce ions. Subsequently, after a predetermined time period passes, for example, the electricity removal operation is terminated and the halt period is resumed.
摘要翻译：本发明涉及抑制电极针的磨损和污染以及有效地从带电体去除电力。提供其中电极针被施加高电压以产生离子的电去除模式，并且设置停止电极针的停止模式，其基于用户的选择而交替地选择。停止模式包括在电极针基本上不施加高电压的停止时间。当在该停止期间通过充电体的接近发生自放电，并且流过电阻的电流的绝对值超过第一阈值时，开始电除去操作，其中在电极针上施加高电压产生离子。随后，在经过预定时间段之后，例如，电力消除操作终止，并且恢复停止时段。

6. 发明申请

US20140194372A1 HEART FAILURE SUPPRESSING AGENT 有权
标题翻译：心脏衰竭抑制剂
公开(公告)号：US20140194372A1
公开(公告)日：2014-07-10
申请号：US14233581
申请日：2012-07-19
申请人： Hiroyuki Morita , Ryozo Nagai , Atsuko Nakayama , Tadashi Hashimoto
发明人： Hiroyuki Morita , Ryozo Nagai , Atsuko Nakayama , Tadashi Hashimoto
IPC分类号： A61K31/7048 , A61K31/353
CPC分类号： A61K31/7048 , A23L33/105 , A61K31/352 , A61K31/353 , C07D311/30 , C07H17/07
摘要： Provided are a medicine and a food product that suppress a heart disease such as cardiomegaly and heart failure. Specifically provided is an agent for suppressing a heart disease selected from heart failure, cardiac fibrosis, ventricular wall thickening and cardiomegaly, which comprises luteolin or a derivative thereof as an active ingredient.
摘要翻译：提供抑制心脏病，心脏衰竭和心力衰竭等心脏病的药物和食品。具体地提供了抑制选自心力衰竭，心脏纤维化，心室壁增厚和心脏扩大的心脏病的药剂，其包含木犀草素或其衍生物作为活性成分。

7. 发明申请

US20080151465A1 Electricity Removal Apparatus 失效
标题翻译：除电设备
公开(公告)号：US20080151465A1
公开(公告)日：2008-06-26
申请号：US11959556
申请日：2007-12-19
申请人： Tsukasa Fujita , Tadashi Hashimoto
发明人： Tsukasa Fujita , Tadashi Hashimoto
IPC分类号： H05F3/06
CPC分类号： H01T23/00
摘要： The present invention relates to suppressing wear and contamination of the electrode needle as well as effectively removing the electricity from a charged body. An electricity removal mode in which the electrode needle is applied with a high voltage to produce ions and a halt mode in which the electrode needle is halted are provided, that are alternatively selected based on a selection of a user. The halt mode includes a halt period during which the high voltage is not basically applied on the electrode needle. When a self discharge occurs by approach of a charged body in this halt period and an absolute value of current that flows through the resistance exceeds the first threshold value, the electricity removal operation is initiated in which the high voltage is applied on the electrode needle to produce ions. Subsequently, after a predetermined time period passes, for example, the electricity removal operation is terminated and the halt period is resumed.
摘要翻译：本发明涉及抑制电极针的磨损和污染以及有效地从带电体去除电力。提供其中电极针被施加高电压以产生离子的电去除模式，并且设置停止电极针的停止模式，其基于用户的选择而交替地选择。停止模式包括在电极针基本上不施加高电压的停止时间。当在该停止期间通过充电体的接近发生自放电，并且流过电阻的电流的绝对值超过第一阈值时，开始电除去操作，其中在电极针上施加高电压产生离子。随后，在经过预定时间段之后，例如，电力消除操作终止，并且恢复停止时段。

8. 发明授权

US4515269A Magazine for electronic devices 失效
标题翻译：电子设备杂志
公开(公告)号：US4515269A
公开(公告)日：1985-05-07
申请号：US452898
申请日：1982-12-27
申请人： Tadashi Hashimoto
发明人： Tadashi Hashimoto
IPC分类号： H01L23/60 , H05K13/00 , B65D85/30
CPC分类号： H05K13/0084 , H01L23/60 , H01L2924/0002
摘要： A magazine for electronic devices, prepared by folding a flat plastic sheet into a tubular structure comprises a bottom wall, two side walls and a top wall. At east one and at most three of said walls are partly or entirely formed by a double-sheet structure.
摘要翻译：通过将扁平塑料片折叠成管状结构而制备的用于电子设备的杂志包括底壁，两个侧壁和顶壁。在东部一个和最多三个所述壁部分地或完全由双层结构形成。

9. 发明授权

US09326990B2 Heart failure suppressing agent 有权
标题翻译：心力衰竭抑制剂
公开(公告)号：US09326990B2
公开(公告)日：2016-05-03
申请号：US14233581
申请日：2012-07-19
申请人： Hiroyuki Morita , Ryozo Nagai , Atsuko Nakayama , Tadashi Hashimoto
发明人： Hiroyuki Morita , Ryozo Nagai , Atsuko Nakayama , Tadashi Hashimoto
IPC分类号： A61K31/7048 , A61K31/352 , A61K31/353 , C07D311/30 , A23L1/30 , C07H17/07
CPC分类号： A61K31/7048 , A23L33/105 , A61K31/352 , A61K31/353 , C07D311/30 , C07H17/07
摘要： Provided are a medicine and a food product that suppress a heart disease such as cardiomegaly and heart failure. Specifically provided is an agent for suppressing a heart disease selected from heart failure, cardiac fibrosis, ventricular wall thickening and cardiomegaly, which comprises luteolin or a derivative thereof as an active ingredient.
摘要翻译：提供抑制心脏病，心脏衰竭和心力衰竭等心脏病的药物和食品。具体地提供了抑制选自心力衰竭，心脏纤维化，心室壁增厚和心脏扩大的心脏病的药剂，其包含木犀草素或其衍生物作为活性成分。

10. 发明申请

US20130189337A1 DENTINAL TUBULE SEALANT AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：耳塞式密封剂及其制造方法
公开(公告)号：US20130189337A1
公开(公告)日：2013-07-25
申请号：US13878083
申请日：2011-09-30
申请人： Tadashi Hashimoto , Mizuko Oshita , Shumei Ishihara
发明人： Tadashi Hashimoto , Mizuko Oshita , Shumei Ishihara
IPC分类号： A61K8/24 , A61Q11/00 , A61K8/19
CPC分类号： A61K8/24 , A61K6/0017 , A61K6/033 , A61K6/0643 , A61K8/19 , A61K2800/59 , A61Q11/00
摘要： A dentinal tubule sealant comprises poorly-soluble calcium phosphate particles (A), a phosphorus-free calcium compound (B), and water (C), wherein the particles (A) are at least one member selected from the group consisting of dicalcium phosphate anhydrous [CaHPO4] particles, α-tricalcium phosphate [α-Ca3(PO4)2] particles, β-tricalcium phosphate [β-Ca3(PO4)2] particles, amorphous calcium phosphate [Ca3(PO4)2.nH2O] particles, calcium pyrophosphate [Ca2P2O7] particles, calcium pyrophosphate dihydrate [Ca2P2O7.2H2O] particles, octacalcium phosphate pentahydrate [Ca8H2(PO4)6.5H2O] particles, and dicalcium phosphate dihydrate [CaHPO4.2H2O] particles, and the dentinal tubule sealant contains 30 to 76% by weight of the particles (A), 0.001 to 4% by weight of the compound (B), and 23 to 69% by weight of the water (C). Thus, there is provided a dentinal tubule sealant capable of sealing dentinal tubules of an exposed dentin and also remineralizing the surrounding dentin after the sealing.
摘要翻译：牙质小管密封剂包含难溶的磷酸钙颗粒（A），无磷钙化合物（B）和水（C），其中颗粒（A）是选自磷酸二钙无水[CaHPO 4]颗粒，α-磷酸三钙[α-Ca 3（PO 4）2]颗粒，β-磷酸三钙[β-Ca 3（PO 4）2]颗粒，无定形磷酸钙[Ca 3（PO 4）2·nH 2 O]颗粒，焦磷酸钙[Ca2P2O7]颗粒，焦磷酸钙二水合物[Ca2P2O7.2H2O]颗粒，五水合磷酸五钙[Ca8H2（PO4）6.5H2O]颗粒和磷酸二钙二水合物[CaHPO4.2H2O]颗粒，而牙质小管密封剂含有30至76 （A）的重量％，化合物（B）0.001〜4重量％，水（C）23〜69重量％。因此，提供了能够密封暴露的牙本质的牙质小管的牙质小管密封剂，并且在密封之后还使周围的牙本质再矿化。

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