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1. 发明申请

US20060194268A1 Method for measuring spinorphin 审中-公开
标题翻译：测定旋光子的方法
公开(公告)号：US20060194268A1
公开(公告)日：2006-08-31
申请号：US11209646
申请日：2005-08-24
申请人： Tadahiko Hazato , Yukio Yamamoto , Yoshiro Yamamura
发明人： Tadahiko Hazato , Yukio Yamamoto , Yoshiro Yamamura
IPC分类号： G01N33/537 , G01N33/543
CPC分类号： G01N33/564 , G01N2800/102
摘要： The present invention aims at providing a method for measuring spinorphin in a sample collected from a living body accurately with high sensitivity. The present invention provides a method for measuring spinorphin in a sample collected from a living body, comprising the steps of: (A) mixing a sample collected from a living body with trichloroacetic acid to give a solution phase and subjecting said solution phase and a solvent to a reverse phase column to elute spinorphin with said solvent; (B) contacting the spinorphin eluted in the step (A) with spinorphin immobilized on a carrier and a spinorphin antibody; (C) removing the spinorphin antibody that has not been bound to the spinorphin immobilized on the carrier; (D) contacting the spinorphin antibody bound to the spinorphin immobilized on the carrier obtained in the step (C) with a labeled secondary antibody that specifically binds to said spinorphin antibody so as to bind the spinorphin antibody bound to the spinorphin immobilized on the carrier and the labeled secondary antibody; and (E) measuring the amount of label in the labeled secondary antibody bound to the spinorphin antibody.
摘要翻译：本发明的目的在于提供一种以高灵敏度精确地从活体收集的样品中测定旋光子的方法。本发明提供了从活体收集的样品中测定旋光子的方法，包括以下步骤：（A）将从活体收集的样品与三氯乙酸混合，得到溶液相，并使所述溶液相和溶剂至反相柱，用所述溶剂洗脱旋毛虫; （B）使步骤（A）中洗脱的旋毛虫与固定在载体上的旋角蛋白和spinorphin抗体接触; （C）除去未结合到固定在载体上的旋风卟啉的旋风卟啉抗体; （D）使与固定在步骤（C）中获得的载体上的旋风卟啉结合的旋丝蛋白抗体与特异性结合所述spinorphin抗体的标记的二抗接触，以结合与固定在载体上的旋风卟啉结合的鸢尾碱抗体，和标记的二抗; 和（E）测量与spinorphin抗体结合的标记的二抗中的标记量。

2. 发明申请

US20060177886A1 Method for diagnosis of rheumatoid arthritis 审中-公开
标题翻译：类风湿关节炎的诊断方法
公开(公告)号：US20060177886A1
公开(公告)日：2006-08-10
申请号：US11209700
申请日：2005-08-24
申请人： Tadahiko Hazato , Yukio Yamamoto , Yoshiro Yamamura
发明人： Tadahiko Hazato , Yukio Yamamoto , Yoshiro Yamamura
IPC分类号： C12Q1/37
CPC分类号： G01N33/564 , G01N2333/948 , G01N2800/102
摘要： The present invention aims at providing a method for the diagnosis of RA. The present invention relates to a method for the diagnosis of rheumatoid arthritis, comprising measuring the dipeptidyl peptidase activity in a sample collected from a mammal.
摘要翻译：本发明旨在提供一种诊断RA的方法。本发明涉及一种用于诊断类风湿性关节炎的方法，包括测量从哺乳动物收集的样品中的二肽基肽酶活性。

3. 发明授权

US4613588A Benzaldehyde and 4,6-O-benzylidene-D-glucose for alleviating pain 失效
标题翻译：苯甲醛和4,6-O-亚苄基-D-葡萄糖以减轻疼痛
公开(公告)号：US4613588A
公开(公告)日：1986-09-23
申请号：US750327
申请日：1985-06-28
申请人： Takashi Katayama , Tadahiko Hazato
发明人： Takashi Katayama , Tadahiko Hazato
IPC分类号： C07C47/54 , A61K31/11 , A61K31/70 , A61K47/48 , A61P25/04 , A61P43/00 , C07C45/00 , C07C67/00 , C07H9/04 , C08B37/00 , C12N9/99
CPC分类号： A61K31/7004 , A61K31/11 , A61K47/48969 , B82Y5/00 , C07H9/04 , C08B37/0015
摘要： Benzaldehyde and 4,6-O-benzylidene-D-glucose have been found to have analgesic activity. It is believed that this analgesic activity results from the inhibition of enkephalinase. Therefore benzaldehyde and 4,6-O-benzylidene-D-glucose are also useful for inhibiting enkephalinase in humans.
摘要翻译：已经发现苯甲醛和4,6-O-亚苄基-D-葡萄糖具有止痛活性。据信这种止痛活性是由脑啡肽酶的抑制引起的。因此，苯甲醛和4,6-O-亚苄基-D-葡萄糖也可用于抑制人类脑啡肽酶。

4. 发明授权

US4748187A Opioid peptide-degrading enzyme inhibitor with a germanium compound 失效
标题翻译：阿片样肽降解酶抑制剂与锗化合物
公开(公告)号：US4748187A
公开(公告)日：1988-05-31
申请号：US930561
申请日：1986-11-14
申请人： Norihiro Kakimoto , Takashi Katayama , Tadahiko Hazato , Tsutomu Ohnishi
发明人： Norihiro Kakimoto , Takashi Katayama , Tadahiko Hazato , Tsutomu Ohnishi
IPC分类号： C07F7/30 , A61K31/28
CPC分类号： C07F7/30
摘要： The present invention provides (1) a new organogermanium compound of the following general formula: ##STR1## wherein A represents a hydrogen atom, a lower alkyl group such as a methyl or ethyl group or a phenyl group, B represents a hydrogen atom or a lower alkyl group as mentioned above and Z represents a hydroxyl or amino group and (2) an opioid peptide-degrading enzyme inhibitor containing the compound (1) as a principal ingredient.
摘要翻译：本发明提供（1）下述通式的新的有机锗化合物：其中A表示氢原子，低级烷基如甲基或乙基或苯基，B表示氢原子或低级烷基，Z表示羟基或氨基，（2）含有化合物（1）作为主要成分的阿片样肽降解酶抑制剂。

5. 发明授权

US4681960A Organogermanium compound 失效
标题翻译：有机锗化合物
公开(公告)号：US4681960A
公开(公告)日：1987-07-21
申请号：US626787
申请日：1984-07-02
申请人： Norihiro Kakimoto , Takashi Katayama , Tadahiko Hazato , Tsutomu Ohnishi
发明人： Norihiro Kakimoto , Takashi Katayama , Tadahiko Hazato , Tsutomu Ohnishi
IPC分类号： C07F7/30
CPC分类号： C07F7/30
摘要： The present invention provides (1) a new organogermanium compound of the following general formula: ##STR1## wherein A represents a hydrogen atom, a lower alkyl group such as a methyl or ethyl group or a phenyl group, B represents a hydrogen atom or a lower alkyl group as mentioned above and Z represents a hydroxyl or amino group and (2) an opioid peptide-degrading enzyme inhibitor containing the compound (1) as a principal ingredient.
摘要翻译：本发明提供（1）下述通式的新的有机锗化合物：其中A表示氢原子，低级烷基如甲基或乙基或苯基，B表示氢原子或低级烷基，Z表示羟基或氨基，（2）含有化合物（1）作为主要成分的阿片样肽降解酶抑制剂。

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