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1. 发明申请

WO2003048152A2 INFLAMMATION MODULATORS 审中-公开
标题翻译：炎症调节剂
公开(公告)号：WO2003048152A2
公开(公告)日：2003-06-12
申请号：PCT/US2002/039134
申请日：2002-12-04
申请人： TULARIK INC. , F. HOFFMANN - LA ROCHE AG , CUSHING, Timothy, D. , HE, Xiao , SMITH, Marie-Louise , DeGRAFFENREID, Michael, R. , POWERS, Jay , TOMOOKA, Craig, S. , CLARK, David, L. , HAO, Xiaolin , JAEN, Juan, C. , LABELLE, Marc , WALKER, Nigel, P., C. , GILL, Adrian, L. , TALAMAS, Francisco, X. , LABADIE, Sharada, S.
发明人： CUSHING, Timothy, D. , HE, Xiao , SMITH, Marie-Louise , DeGRAFFENREID, Michael, R. , POWERS, Jay , TOMOOKA, Craig, S. , CLARK, David, L. , HAO, Xiaolin , JAEN, Juan, C. , LABELLE, Marc , WALKER, Nigel, P., C. , GILL, Adrian, L. , TALAMAS, Francisco, X. , LABADIE, Sharada, S.
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , A61K31/4709 , C07D401/14 , C07D405/14 , A61K2300/00
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain quinoline or quinazoline rings.
摘要翻译：本文提供了可用于治疗炎症，免疫调节，代谢和细胞增殖性病症或疾病的化合物，组合物和方法。特别地，本发明提供调节参与炎症，代谢和细胞增殖的蛋白质的表达和/或功能的化合物。主题化合物含有喹啉或喹唑啉环。

2. 发明申请

WO2004041285A1 ANTIINFLAMMATION AGENTS 审中-公开
标题翻译：抗炎药物
公开(公告)号：WO2004041285A1
公开(公告)日：2004-05-21
申请号：PCT/US2003/029143
申请日：2003-09-19
申请人： TULARIK INC. , BURKITT, Simon, A. , CARDOZO, Mario, G. , CUSHING, Timothy, D. , DeGRAFFENREID, Michael, R. , FARTHING, Christopher, N. , HAO, Xiaolin , JAEN, Juan, C. , JIAO, Xian, Yun , KOPECKY, David, J. , LABELLE, Marc , LIVELY, Sarah, E. , MCMINN, Dustin, L. , RASMUSSEN, Sven, P. , SHIN, Youngsook , SMITH, Andrew , SMITH, Marie-Louise
发明人： BURKITT, Simon, A. , CARDOZO, Mario, G. , CUSHING, Timothy, D. , DeGRAFFENREID, Michael, R. , FARTHING, Christopher, N. , HAO, Xiaolin , JAEN, Juan, C. , JIAO, Xian, Yun , KOPECKY, David, J. , LABELLE, Marc , LIVELY, Sarah, E. , MCMINN, Dustin, L. , RASMUSSEN, Sven, P. , SHIN, Youngsook , SMITH, Andrew , SMITH, Marie-Louise
IPC分类号： A61K31/54
CPC分类号： C07D231/56 , C07D239/74 , C07D471/04 , C07D491/04 , C07D495/04 , C07D495/14 , C07D513/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.
摘要翻译：本文提供了可用于治疗炎症，免疫调节，代谢，感染和细胞增殖性疾病或病症的化合物，组合物和方法。特别地，本发明提供调节参与炎症，代谢，感染和细胞增殖的蛋白质的表达和/或功能的化合物。主题化合物含有稠合的杂双环。

3. 发明申请

WO2010054006A1 MODULATORS OF CXCR7 审中-公开
标题翻译： CXCR7的调节剂
公开(公告)号：WO2010054006A1
公开(公告)日：2010-05-14
申请号：PCT/US2009/063298
申请日：2009-11-04
申请人： CHEMOCENTRYX, INC. , CHEN, Xi , FAN, Pinchen , GLEASON, Mark, M. , JAEN, Juan, C. , LI, Lianfa , MCMAHON, Jeffrey, P. , POWERS, Jay , ZENG, Yibin , ZHANG, Penglie
发明人： CHEN, Xi , FAN, Pinchen , GLEASON, Mark, M. , JAEN, Juan, C. , LI, Lianfa , MCMAHON, Jeffrey, P. , POWERS, Jay , ZENG, Yibin , ZHANG, Penglie
IPC分类号： A61K31/497 , C07D403/00
CPC分类号： C07D417/14 , C07D401/14
摘要： Compounds having formula (I) or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.
摘要翻译：提供具有式（I）化合物或其药学上可接受的盐，水合物或N-氧化物，并且可用于与CXCR7的结合，以及治疗至少部分依赖于CXCR7活性的疾病。因此，本发明在另外的方面提供含有一种或多种上述化合物与药学上可接受的赋形剂混合的组合物。

4. 发明申请

WO2002064096A2 METHODS OF USING PYRIMIDINE-BASED ANTIVIRAL AGENTS 审中-公开
标题翻译：使用基于吡啶基的抗病毒剂的方法
公开(公告)号：WO2002064096A2
公开(公告)日：2002-08-22
申请号：PCT/US2002/004920
申请日：2002-02-14
申请人： TULARIK INC. , JAEN, Juan, C.
发明人： JAEN, Juan, C.
IPC分类号： A61K
CPC分类号： A61K45/06 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/55 , A61K2300/00
摘要： The invention provides novel methods of using substituted pyrimidine compounds and compositions for the treatment or prevention of diseases associated with CMV infection. In particular, the present invention provides methods for the treatment or prevention of cardiovascular diseases and organ transplant rejection.
摘要翻译：本发明提供了使用取代的嘧啶化合物和组合物治疗或预防与CMV感染有关的疾病的新方法。特别地，本发明提供了用于治疗或预防心血管疾病和器官移植排斥的方法。

5. 发明授权

EP1333834B1 ANTIINFLAMMATION AGENTS 有权
标题翻译：消炎药
公开(公告)号：EP1333834B1
公开(公告)日：2008-04-23
申请号：EP01987605.1
申请日：2001-10-23
申请人： Amgen Inc. , F. Hoffmann-la Roche AG
发明人： BROWNER, Michelle, F. , CLARK, David, L. , CUSHING, Timothy, D. , HAO, Xiaolin , HAWLEY, Ronald, C. , HE, Xiao , JAEN, Juan, C. , LABADIE, Sharada, S. , SMITH, Marie-Louise , TALAMAS, Francisco, X. , WALKER, Nigel, P., C. , LABELLE, Marc
IPC分类号： A61K31/535 , A61K31/44 , A61K31/47 , A61K31/415 , A61P19/02 , C07D221/00 , C07D233/00 , C07D413/00 , C07D471/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04 , C07D471/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.

6. 发明申请

WO2006020959A2 SUBSTITUTED BENZOFUSED HETEROCYCLES 审中-公开
标题翻译：取代的苯并呋喃酮
公开(公告)号：WO2006020959A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/028935
申请日：2005-08-12
申请人： AMGEN INC. , CHEN, Xi , CHEN, Xiaoqi , CONNORS, Richard, Victor , DAI, Kang , FU, Ying , JAEN, Juan, C. , KIM, Yong-Jae , LI, Leping , LIZARZABURU, Michael, E. , MIHALIC, Jeffrey, T. , SHUTTLEWORTH, Stephen, J.
发明人： CHEN, Xi , CHEN, Xiaoqi , CONNORS, Richard, Victor , DAI, Kang , FU, Ying , JAEN, Juan, C. , KIM, Yong-Jae , LI, Leping , LIZARZABURU, Michael, E. , MIHALIC, Jeffrey, T. , SHUTTLEWORTH, Stephen, J.
CPC分类号： C07D417/06 , C07D217/24 , C07D223/16 , C07D243/14 , C07D401/06 , C07D401/12 , C07D487/04 , C07D491/10
摘要： The present invention relates to the compounds of Formula (I), their preparation and pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions are useful, for example, for the treatment and prevention of obesity, obesity-related disorders and eating disorders.
摘要翻译：本发明涉及式（I）的化合物，其制备方法和包含它们的药物组合物。化合物和药物组合物可用于例如治疗和预防肥胖，肥胖相关疾病和进食障碍。

7. 发明公开

EP1053227A1 PPAR-GAMMA MODULATORS 有权
标题翻译： PPAR-γ调节剂
公开(公告)号：EP1053227A1
公开(公告)日：2000-11-22
申请号：EP99901492.1
申请日：1999-01-20
申请人： TULARIK, INC.
发明人： DE LA BROUSE-ELWOOD, Fabienne , JAEN, Juan, C. , MCGEE, Lawrence, R. , MIAO, Shi-Chang , RUBENSTEIN, Steven, Marc , CHEN, Jin-Long , CUSHING, Timothy, D. , FLYGARE, John, A. , HOUZE, Jonathan, B. , KEARNEY, Patrick, C.
IPC分类号： C07D213/65 , A61K31/435 , C07D239/34 , C07D213/643 , C07D233/70 , C07D413/12
CPC分类号： C07D213/70 , C07C311/21 , C07D213/65 , C07D215/20 , C07D217/04 , C07D405/12
摘要： Modulators of PPARη activity are provided having formula (I): in which the symbol Ar represents an aryl group; the letter X represents a divalent linkage selected from the group consisting of =C1-C6alkylene, -(C1-C6)alkylenoxy, -O-, -C(O)-, -N(R11)-, -N(R11)C(O)-, -S(O)¿k?- and a single bond, in which R?11¿ is a member selected from the group consisting of hydrogen, alkyl, heteroalkyl, and arylalkyl and the subscript k is an integer of from 0 to 2. The letter Y, in formula (I) represents a divalent linkage selected from the group consisting of alkylene, -O-, -C(O)-, -N(R12)-S(O)¿m?-, -N(R?13¿)-S(O)¿m-N(R?13)-, -N(R12)C(O)-, -S(O)¿n?-, a single bond, and combinations thereof in which R?12 and R13¿ are members independently selected from the group consisting of hydrogen, alkyl, heteroalkyl and arylalkyl; and the subscripts m and n independently integers of from 0 to 2. The symbol R1 represents a member selected from the group consisting of hydrogen, alkyl, heteroalkyl, aryl, arylalkyl, -CO¿2R?14, -CO(R)14, -C(O)NR15R16, -S(O)¿p-R?14, -S(O)¿q?-NR?15R16¿, -O-C(O)-OR17, -O-C(O)-R17, -O-C(O)-NR?15R16, -N(R14¿)-C(O)-NR?15R16, -N(R14¿)-C(O)-R17 and -N(R14)-C(O)-OR17, in which R14 is a member selected from the group consisting of hydrogen, alkyl, heteroalkyl, aryl and arylalkyl, and R?15 and R16¿ are members independently selected from the group consisting of hydrogen, alkyl, heteroalkyl, aryl and arylalkyl, or taken together with the nitrogen to which each is attached from a 5-, 6- or 7-membered ring. The symbol R17 represents a member selected from the group consisting of alkyl, heteroalkyl, aryl and arylalkyl. Additionally, for the R1 groups described above, the subscript p is an integer of from 0 to 3, and the subscript q is an integer of from 1 to 2. The symbol R2 represents a member selected from the group consisting of alkyl, heteroalkyl, aryl and arylalkyl. In another aspect, the present invention provides compounds of formula (I), as well as pharmaceutical compositions containing the compounds described above for the treatment of conditions such as type II diabetes and obesity.

8. 发明公开

EP1333834A2 ANTIINFLAMMATION AGENTS 有权
标题翻译：消炎药
公开(公告)号：EP1333834A2
公开(公告)日：2003-08-13
申请号：EP01987605.1
申请日：2001-10-23
申请人： Tularik Inc. , F. Hoffman-la Roche AG
发明人： BROWNER, Michelle, F. , CLARK, David, L. , CUSHING, Timothy, D. , HAO, Xiaolin , HAWLEY, Ronald, C. , HE, Xiao , JAEN, Juan, C. , LABADIE, Sharada, S. , SMITH, Marie-Louise , TALAMAS, Francisco, X. , WALKER, Nigel, P., C.
IPC分类号： A61K31/535 , A61K31/44 , A61K31/47 , A61K31/415 , A61P19/02 , C07D221/00 , C07D233/00 , C07D413/00 , C07D471/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04 , C07D471/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.

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