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1. 发明专利

IL289497D0 Heterodimeric antibodies that bind to cd38 and cd3 未知
公开(公告)号：IL289497D0
公开(公告)日：2022-02-01
申请号：IL28949721
申请日：2021-12-29
申请人： SORRENTO THERAPEUTICS INC , HE XIAO , ZHANG YANLIANG , LAI YUN WEI , KAUFMANN GUNNAR F , SWANSON BARBARA A , KERWIN LISA DIANE , RICHARDS SUSAN M
发明人： HE XIAO , ZHANG YANLIANG , LAI YUN WEI , KAUFMANN GUNNAR F , SWANSON BARBARA A , KERWIN LISA DIANE , RICHARDS SUSAN M
IPC分类号： A61P35/00 , A61K39/00 , A61P35/02 , C07K16/28
摘要： The present disclosure provides heterodimeric antibodies that bind to two different target antigens at the same time. In one embodiment, the heterodimeric antibodies are bispecific antibodies. In one embodiment, the heterodimeric antibodies comprise three polypeptides including: a first polypeptide comprising an scFv-Fc fusion polypeptide; a second polypeptide comprising an immunoglobulin heavy chain; and a third polypeptide comprising an immunoglobulin light chain. In one embodiment, the first polypeptide includes one or more point mutations that confer increased thermal-stability to the first polypeptide.

2. 发明专利

IL287158D0 Activatable multi-specific antigen binding protein complexes 未知
公开(公告)号：IL287158D0
公开(公告)日：2021-12-01
申请号：IL28715821
申请日：2021-10-11
申请人： SORRENTO THERAPEUTICS INC , ZHANG YANLIANG , KAUFMANN GUNNAR F , HE XIAO , LAI YUN WEI
发明人： ZHANG YANLIANG , KAUFMANN GUNNAR F , HE XIAO , LAI YUN WEI
IPC分类号： A61K39/00 , A61P35/00 , C07K16/28
摘要： The present disclosure provides several embodiments of multi-specific antigen binding protein complexes. In some embodiments, the multi-specific antigen binding protein complex is composed of either two or three polypeptide chains that assemble with each other to form heterodimeric complexes comprising two different Fab regions each capable of binding two different epitopes and comprising an Fc region which is capable of exhibiting Fc effector function, thus having a relatively simple structure compared to certain other multi-specific antibodies. In one embodiment, the multi-specific antigen binding protein complex is activatable as one of the polypeptide chains that compose the protein complex carries a cleavable linker.

3. 发明专利

AU2017101586A4 An innovative anti-tumor treatment derived from an methanolic isolate of Siberian ginseng (Eleutherococcus senticosus) 未知
公开(公告)号：AU2017101586A4
公开(公告)日：2017-12-14
申请号：AU2017101586
申请日：2017-11-09
申请人： CICHELLO SIMON , DOWELL ASHLEY MR , HE XIAO QIONG PROF , LEURY BRIAN PROF , WHOLESALE GROUP INT PTY LTD , YAO QIAN PROF
发明人： CICHELLO SIMON , YAO QIAN , DOWELL ASHLEY , LEURY BRIAN , HE XIAO-QIONG
IPC分类号： A61K36/258 , A61P35/00
摘要： Abstract An anti-tumor treatment derived from a methanolic isolate of Siberian ginseng (Eleutherococcus senticosus)

4. 发明申请

WO2010054112A2 PLASMA RESISTANT COATINGS FOR PLASMA CHAMBER COMPONENTS 审中-公开
标题翻译：用于等离子体室组分的抗菌涂料
公开(公告)号：WO2010054112A2
公开(公告)日：2010-05-14
申请号：PCT/US2009/063437
申请日：2009-11-05
申请人： APPLIED MATERIALS, INC. , SUN, Jennifer, Y. , HE, Xiao-Ming , THACH, Senh
发明人： SUN, Jennifer, Y. , HE, Xiao-Ming , THACH, Senh
IPC分类号： H05H1/34 , H01L21/3065
CPC分类号： H01J37/32477 , Y10T428/31678
摘要： Plasma resistant coating materials, plasma resistant coatings and methods of forming such coatings on hardware components. In one embodiment, hardware component is an electrostatic chuck (ESC) and the plasma resistant coating is formed on a surface of the ESC. The plasma resistant coatings are formed by methods other than thermal spraying to provide plasma resistant coatings having advantageous material properties.
摘要翻译：等离子体涂层材料，等离子体涂层以及在硬件部件上形成这种涂层的方法。在一个实施例中，硬件部件是静电卡盘（ESC），等离子体涂层形成在ESC的表面上。耐等离子涂层通过热喷涂以外的方法形成，以提供具有有利材料特性的等离子体涂层。

5. 发明申请

WO2004050262A1 METHOD FOR LABELING FABRICS AND HEAT-TRANSFER LABEL WELL-SUITED FOR USE IN SAID METHOD CROSS-REFERENCE TO RELATED APPLICATIONS 审中-公开
标题翻译：用于标记织物和热转印标签的方法用于以适合方法使用的方法相关申请的交叉引用
公开(公告)号：WO2004050262A1
公开(公告)日：2004-06-17
申请号：PCT/US2003/038315
申请日：2003-12-02
申请人： AVERY DENNISON CORPORATION , TSAI, Kuolih , HSEIH, Dong-Tsai , SHU, Li , EDWARDS, David, N. , MORGENTHAU, Alan , CHIAO, Yi-Hung , HE, Xiao-Ming , SASAKI, Yukihiko , FERGUSON, Scott, Wayne
发明人： TSAI, Kuolih , HSEIH, Dong-Tsai , SHU, Li , EDWARDS, David, N. , MORGENTHAU, Alan , CHIAO, Yi-Hung , HE, Xiao-Ming , SASAKI, Yukihiko , FERGUSON, Scott, Wayne
IPC分类号： B05D5/10
CPC分类号： B32B27/08 , B32B7/06 , B32B7/12 , B32B27/00 , B32B27/32 , B32B27/36 , B32B27/40 , B32B2307/302 , B32B2317/12 , B32B2323/10 , B32B2367/00 , B32B2375/00 , B32B2519/02 , B41M3/14 , B41M5/506 , B41M5/508 , B41M5/5254 , B44C1/1712 , B65C5/04 , D06H1/02 , D06P1/004 , D06P5/003 , D06P5/007 , D06Q1/12 , G06K19/027 , G09F3/00 , G09F3/02 , G09F3/10 , Y10S428/913 , Y10S428/914 , Y10T428/24802 , Y10T428/2813 , Y10T428/2817 , Y10T428/2822 , Y10T428/2826 , Y10T428/2839 , Y10T428/2848
摘要： A method for labeling fabrics, such as fabric garments, and a heat-transfer label (311) well-suited for use in said method. In one embodiment, the heat-transfer label (311) comprises (i) a support portion (313), the support portion (313) comprising a carrier (315) and a release layer (317); (ii) a wax layer (319), the wax layer overcoating the release layer (317); and (iii) a transfer portion (321), the transfer portion (321) comprising an adhesive layer (323) printed directly onto the wax layer (319) and an ink design layer (325) printed directly onto the adhesive layer (323). Each of the adhesive layer (323) and the ink design layer includes a non-cross-linked PVC resin. The ink design layer may be screen printed onto the adhesive layer (323) or may be printed onto the adhesive layer (323) using thermal transfer printing, ink jet printing or laser printing.
摘要翻译：用于标记织物如织物衣服的方法和非常适合用于所述方法的热转印标签（311）。在一个实施例中，传热标签（311）包括（i）支撑部分（313），支撑部分（313）包括载体（315）和释放层（317）; （ii）蜡层（319），所述蜡层覆盖所述剥离层（317）; 和（iii）转印部分（321），所述转印部分（321）包括直接印刷到蜡层（319）上的粘合剂层（323）和直接印刷在粘合剂层（323）上的油墨设计层（325）。粘合剂层（323）和油墨设计层中的每一个包括非交联的PVC树脂。墨水设计层可以被丝网印刷到粘合剂层（323）上，或者可以使用热转印，喷墨打印或激光打印印刷到粘合剂层（323）上。

6. 发明申请

WO2003107079A2 METHOD FOR ROLL-TO-ROLL DEPOSITION OF OPTICALLY TRANSPARENT AND HIGH CONDUCTIVITY METALLIC THIN FILMS 审中-公开
标题翻译：光学透明和高电导率金属薄膜的滚动沉积方法
公开(公告)号：WO2003107079A2
公开(公告)日：2003-12-24
申请号：PCT/US2003/018755
申请日：2003-06-12
申请人： AVERY DENNISON CORPORATION , HE, Xiao-Ming , HEYDARPOUR, Ramin
发明人： HE, Xiao-Ming , HEYDARPOUR, Ramin
IPC分类号： G02F
CPC分类号： C23C14/562 , B29D11/0073 , C23C14/022 , C23C14/08 , C23C14/205 , G02F1/133305 , G02F1/13439 , H01B1/02 , H01B1/08 , H05K1/0393 , H05K3/381 , H05K2201/0338 , H05K2203/095 , H05K2203/1545 , Y10T428/31504
摘要： Methods for roll-to-roll deposition of optically transparent and high conductivity metallic thin films are disclosed. In general, a method according to the present invention comprises: (1) providing a flexible plastic substrate; (2) depositing a multi-layered conductive metallic film on the flexible plastic substrate by a thin-film deposition technique to form a composite film; and (3) collecting the composite film in continuous rolls. Typically, the thin conductive metallic film is an InCeO-Ag-InCeO film. Typically, the thin-film deposition technique is DC magnetron sputtering. Another aspect of the invention is a composite film produced by a method according to the present invention. Still another aspect of the invention is a composite film comprising InCeO-Ag-InCeO film formed on a flexible plastic substrate, wherein the composite fillm has a combination of properties including: transmittance of at least 90% throughout the visible region; an electrical resistance of no greater than about 10 Ω/square; a root-mean-square roughness of no greater than about 2.5 nm; and an interlayer adhesion between the InCeO/Ag/InCeO metallic film and the remainder of the composite film that is sufficiently great to survive a 180° peel adhesion test.
摘要翻译：公开了光学透明和高导电性金属薄膜的卷对卷沉积的方法。通常，根据本发明的方法包括：（1）提供柔性塑料基板; （2）通过薄膜沉积技术在柔性塑料基板上沉积多层导电金属膜以形成复合膜; 和（3）将复合膜收集在连续辊中。通常，薄导电金属膜是InCeO-Ag-InCeO膜。通常，薄膜沉积技术是直流磁控溅射。本发明的另一方面是通过根据本发明的方法制造的复合膜。本发明的另一方面是一种复合膜，其包括在柔性塑料基材上形成的InCeO-Ag-InCeO膜，其中复合填料具有以下特性的组合，包括：透过整个可见区域至少90％的透射率; 电阻不大于约10欧姆/平方; 均方根粗糙度不大于约2.5nm; 以及InCeO / Ag / InCeO金属膜与复合膜的剩余部分之间的层间粘合，其足够大以承受180°剥离粘合试验。

7. 发明申请

WO9923092A3 3-AMINOALKYLAMINO-2H-1,4-BENZOXA(THIA-)ZINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译： 3-氨基亚氨基-2H-1,4-苯并噻唑（THIA-）锌和含有它们的药物组合物
公开(公告)号：WO9923092A3
公开(公告)日：1999-08-05
申请号：PCT/US9822936
申请日：1998-10-28
申请人： NEUROGEN CORP , HE XIAO SHU
发明人： HE XIAO-SHU
IPC分类号： C07D279/16 , A61K31/538 , A61K31/5415 , A61P21/02 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , C07D265/36 , C07D413/12 , C07D417/12 , A61K31/54
CPC分类号： C07D413/12 , C07D265/36 , C07D417/12
摘要： Disclosed are compounds of formula (I) or the pharmaceutically acceptable acid addition salts thereof, wherein: Ar represents aryl or heteroaryl; R1 and R2 are the same or different and represent organic or inorganic substituents; R5 is hydrogen or C1-C6 alkyl; W represents CH or nitrogen; X is oxygen or sulfur; and A represents an alkylene group, which compounds bind selectively with high affinity to the dopamine D4 receptor subtype and are therefore of use in treatment of various neuropsychological disorders.
摘要翻译：公开了式（I）化合物或其药学上可接受的酸加成盐，其中：Ar表示芳基或杂芳基; R1和R2相同或不同，代表有机或无机取代基; R5是氢或C1-C6烷基; W表示CH或氮; X是氧或硫; 并且A表示亚烷基，该化合物以高亲和力选择性结合多巴胺D4受体亚型，因此可用于治疗各种神经心理障碍。

8. 发明申请

WO1996039403A1 1-(N'-(ARYLALKYLAMINOALKYL)) AMINOISOINDOLES AS DOPAMINE RECEPTOR LIGANDS 审中-公开
标题翻译： 1-（N' - （ARYLALKYLAMINOALKYL））氨基磺酸盐作为多巴胺受体配体
公开(公告)号：WO1996039403A1
公开(公告)日：1996-12-12
申请号：PCT/US1996008836
申请日：1996-06-04
申请人： NEUROGEN CORPORATION , HE, Xiao-shu , deCOSTA, Brian , WASLEY, Jan, W., F.
发明人： NEUROGEN CORPORATION
IPC分类号： C07D403/12
CPC分类号： C07D401/12 , C07D209/44 , C07D403/12
摘要： Disclosed are compounds of formula (1) or the pharmaceutically acceptable salts thereof, wherein the 6-membered A ring may be optionally substituted with up to four groups independently selected from halogen, hydroxy, lower alkyl, or lower alkoxy; Ar represents optionally substituted aryl or heteroaryl, Z represents carbon or nitrogen provided that where Z is carbon, R11 represents hydrogen, halogen, hydroxy, lower alkyl, or lower alkoxy, or phenyl optionally substituted with one or two groups selected from hydrogen, halogen, hydroxy, lower alkyl, or lower alkoxy; and where Z is nitrogen, R11 represents an electron pair; R5 is hydrogen or lower alkyl; L and m represent integers; n is 0, or an integer; R12 and R13 independently represent lower alkyl; or together may together form an optionally substituted 5-11 membered ring with the nitrogen atoms to which they are bonded; CR'R" represents a methylene group optionally substituted with lower alkyl; and k is an integer of from 1 to 3, which compounds are useful in treating various neuropsychological disorders including, for example, schizophrenia, dementia, depression, anxiety, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.
摘要翻译：公开了式（1）的化合物或其药学上可接受的盐，其中6元环可以任选被至多四个独立地选自卤素，羟基，低级烷基或低级烷氧基的基团取代; Ar表示任选取代的芳基或杂芳基，Z表示碳或氮，条件是其中Z为碳，R11表示氢，卤素，羟基，低级烷基或低级烷氧基，或任选被一个或两个选自氢，卤素，羟基，低级烷基或低级烷氧基; 并且其中Z是氮，R11表示电子对; R5是氢或低级烷基; L和m表示整数; n为0，或整数; R 12和R 13独立地表示低级烷基; 或者一起可以与它们所键合的氮原子一起形成任选取代的5-11元环; CR'R“表示任选被低级烷基取代的亚甲基; k为1〜3的整数，该化合物可用于治疗各种神经心理障碍，包括例如精神分裂症，痴呆，抑郁，焦虑，帕金森样运动障碍和与使用神经安定药相关的运动障碍。

9. 发明申请

WO2013023345A1 METHOD AND APPARATUS FOR CODING AND TRANSMITTING 3D VIDEO SEQUENCES IN A WIRELESS COMMUNICATION SYSTEM 审中-公开
标题翻译：用于在无线通信系统中编码和发送3D视频序列的方法和装置
公开(公告)号：WO2013023345A1
公开(公告)日：2013-02-21
申请号：PCT/CN2011/078359
申请日：2011-08-12
申请人： MOTOROLA MOBILITY, INC. , CHEN, Jin-Yue , HE, Xiao-Mei
发明人： CHEN, Jin-Yue , HE, Xiao-Mei
IPC分类号： H04N13/00
CPC分类号： H04N13/161 , H04N13/106 , H04N13/194
摘要： A communication system is provided that includes a source multimedia communication device that supports three dimension (3D) video streaming to a destination multimedia communication device. The source multimedia communication device receives multiview video data from multiple multiview video data sources, generates spatial disparity information based on the multiview video data, determine a 3D video content quality level capability of the destination multimedia communication device or user selected service category (low 3D scene or high 3D scene), select a 3D video content quality level for the video data based on the determined 3D video content quality level capability or user selected service category, and encodes the multiview video data based on the selected 3D video content quality level or user selected service category to produce encoded video data for conveyance to the destination multimedia communication device.
摘要翻译：提供了一种通信系统，其包括支持到目的地多媒体通信设备的三维（3D）视频流的源多媒体通信设备。源多媒体通信设备从多个多视点视频数据源接收多视点视频数据，基于多视点视频数据生成空间视差信息，确定目标多媒体通信设备或用户选择的服务类别（低3D场景）的3D视频内容质量等级能力或高3D场景），基于所确定的3D视频内容质量等级能力或用户选择的服务类别为视频数据选择3D视频内容质量等级，并且基于所选择的3D视频内容质量等级或用户对多视点视频数据进行编码选择的服务类别以产生用于传送到目的地多媒体通信设备的编码视频数据。

10. 发明申请

WO2011123751A2 HETEROCYCLIC COMPOUNDS AND THEIR USES 审中-公开
公开(公告)号：WO2011123751A2
公开(公告)日：2011-10-06
申请号：PCT/US2011/030888
申请日：2011-04-01
申请人： AMGEN INC. , CUSHING, Timothy, D. , DUQUETTE, Jason, A. , HE, Xiao , LOHMAN, Julia, Winslow , SHIN, Youngsook
发明人： CUSHING, Timothy, D. , DUQUETTE, Jason, A. , HE, Xiao , LOHMAN, Julia, Winslow , SHIN, Youngsook
IPC分类号： C07D401/14 , C07D403/12 , C07D471/04 , C07D409/12 , C07D473/34 , C07D487/04 , A61K31/506 , A61P29/00
CPC分类号： C07D403/12 , C07D401/14 , C07D409/12 , C07D471/04 , C07D473/34 , C07D487/04
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

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