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1. 发明申请

WO2007077487A2 METHOD AND DEVICE FOR TRANSDERMAL IMMUNIZATION 审中-公开
标题翻译：用于转导性免疫的方法和装置
公开(公告)号：WO2007077487A2
公开(公告)日：2007-07-12
申请号：PCT/IB2006/003832
申请日：2006-12-22
申请人： TRANSPHARMA MEDICAL, LTD. , LEVIN, Galit , GERSHONOWITZ, Amikam , GADASI, Hana
发明人： LEVIN, Galit , GERSHONOWITZ, Amikam , GADASI, Hana
IPC分类号： A61N1/30 , A61K39/00
CPC分类号： A61N1/327 , A61K9/0021 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/54 , A61K2039/55544 , A61K2039/70 , A61N1/042 , C12N2760/16134 , C12N2760/16234
摘要： The present invention relates to methods and device for transdermal immunization. More particularly, the invention relates to a device for effective topical administration of antigens comprising an apparatus that generates micro-channels in the skin of a subject. The delivery system is useful for immunization against bacterial, viral, and fungal antigens and for treating tumors and allergies.
摘要翻译：本发明涉及经皮免疫的方法和装置。更具体地，本发明涉及用于有效局部施用抗原的装置，其包括在受试者的皮肤中产生微通道的装置。递送系统可用于免疫细菌，病毒和真菌抗原以及治疗肿瘤和过敏。

2. 发明申请

WO2006003659A2 DELIVERY SYSTEM FOR TRANSDERMAL IMMUNIZATION 审中-公开
标题翻译：用于经皮免疫的递送系统
公开(公告)号：WO2006003659A2
公开(公告)日：2006-01-12
申请号：PCT/IL2005/000710
申请日：2005-07-05
申请人： TRANSPHARMA MEDICAL LTD. , LEVIN, Galit , GERSHONOWITZ, Amikam , GADASI, Hana
发明人： LEVIN, Galit , GERSHONOWITZ, Amikam , GADASI, Hana
IPC分类号： A61K9/127
CPC分类号： A61N1/327 , A61K9/0009 , A61K9/0021 , A61N1/042 , A61N1/0436
摘要： The present invention relates to a delivery system for transdermal immunization. More particularly, the invention relates to a delivery system for effective topical administration of antigens comprising an apparatus that generates micro-channels in the skin of a subject. The delivery system is useful for immunization against bacterial, viral, and fungal antigens and for treating tumors and allergies.
摘要翻译：本发明涉及用于透皮免疫的递送系统。更具体地说，本发明涉及用于有效局部施用抗原的递送系统，其包括在受试者的皮肤中产生微通道的设备。该递送系统对于免疫抗细菌，病毒和真菌抗原以及用于治疗肿瘤和过敏是有用的。

3. 发明申请

WO2006054299A2 COMBINED MICRO-CHANNEL GENERATION AND IONTOPHORESIS FOR TRANSDERMAL DELIVERY OF PHARMACEUTICAL AGENTS 审中-公开
标题翻译：用于药物代谢物转运的组合式微通道生成和异构体
公开(公告)号：WO2006054299A2
公开(公告)日：2006-05-26
申请号：PCT/IL2005/001219
申请日：2005-11-17
申请人： TRANSPHARMA MEDICAL LTD. , LEVIN, Galit , GERSHONOWITZ, Amikam , STERN, Meir , SHERMAN, Amir
发明人： LEVIN, Galit , GERSHONOWITZ, Amikam , STERN, Meir , SHERMAN, Amir
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： The present invention relates to methods of transdermal delivery of pharmaceutical agents. In particular, the present invention relates to a method for transdermal delivery comprising generating micro-channels on the skin of a subject and delivering iontophoretically a pharmaceutical agent through the micro-channels. The method provides synergistic transdermal delivery of pharmaceutical agents. .
摘要翻译：本发明涉及药剂的透皮递送方法。特别地，本发明涉及一种透皮递送方法，其包括在受试者的皮肤上产生微通道并通过微通道离子电渗地输送药剂。该方法提供药剂的协同透皮递送。。

4. 发明申请

WO2005069736A3 TRANSDERMAL DELIVERY SYSTEM FOR POLYNUCLEOTIDES 审中-公开
公开(公告)号：WO2005069736A3
公开(公告)日：2005-08-04
申请号：PCT/IL2005/000089
申请日：2005-01-25
申请人： TRANSPHARMA MEDICAL LTD. , BIRCHALL, James , LEVIN, Galit , GERSHONOWITZ, Amikam
发明人： BIRCHALL, James , LEVIN, Galit , GERSHONOWITZ, Amikam
IPC分类号： A61N1/30
摘要： The present invention relates to a system for intradermal or transdermal delivery of oligonucleotides or polynucleotides and to methods of use thereof. Particularly, the present invention relates to a system comprising an apparatus that generates micro-channels in the skin of a subject in conjunction with a pharmaceutical composition comprising an oligonucleotide or polynucleotide, wherein the oligonucleotide or polynucleotide can be delivered into the organism through the micro-channels. The system and methods of the present invention achieve expression of target proteins encoded by the polynucleotides, and hence are useful in immunization and gene therapy.

5. 发明申请

WO2012049678A2 METHOD AND SYSTEM FOR CARE AND SAFETY OF A LIVING CREATURE IN A CLOSED SPACE 审中-公开
标题翻译：封闭空间中生活用品的护理和安全的方法和系统
公开(公告)号：WO2012049678A2
公开(公告)日：2012-04-19
申请号：PCT/IL2011/000798
申请日：2011-10-10
申请人： GERSHONOWITZ, Amikam
发明人： GERSHONOWITZ, Amikam
IPC分类号： G06T7/20
CPC分类号： B60R21/01538 , B60R2021/01252
摘要： I It is provided a living creature module for preventing continued inappropriate confinement of a living creature to a closed space, and a method for operating the module. The module includes a processor configured for receiving indications of the closed space, receiving indications for presence of a living creature, analyzing the indications and initiating emergency operations for preventing continued confinement. The indications for presence of a living creature may be issued by a volume sensor, an image sensor, a microphone, a sensor of carbon dioxide level, or a sensor of oxygen level, for example. The module is linked to a temperature sensor sensing the interior of the closed space, and includes a communication interface for conveying data items to recipients". The data items are an identification of the inappropriate confinement status, indications of the closed space, indications of the presence of the living creature, and location of the closed space. Possible recipients are a police station, a control center and the owner of the closed space. The closed space may be the interior of a vehicle, while the living creature may be a baby or a small child. The processor is linked to a global positioning system(GPS) device or to a cellular communication device.
摘要翻译： I提供了一种生物模块，用于防止活体继续不适当地封闭到封闭空间，以及一种操作模块的方法。该模块包括处理器，其被配置为接收封闭空间的指示，接收生物的存在的指示，分析指示并启动紧急操作以防止继续限制。存在生物的指示可以由例如体积传感器，图像传感器，麦克风，二氧化碳浓度传感器或氧气传感器来发出。该模块连接到感测封闭空间内部的温度传感器，并且包括用于将数据项传送给接收者的通信接口“，数据项是不适当的限制状态的标识，封闭空间的指示，生物的存在和封闭空间的位置，可能的收件人是派出所，控制中心和封闭空间的拥有者，封闭的空间可能是车内，而生物可能是一个婴儿或一个小孩子，处理器链接到全球定位系统（GPS）设备或蜂窝通信设备。

6. 发明申请

WO2008001377A3 NEEDLELESS INJECTIONS FOR ADMINISTERING COMPOSITIONS TO THE SKIN 审中-公开
公开(公告)号：WO2008001377A3
公开(公告)日：2008-01-03
申请号：PCT/IL2007/000795
申请日：2007-06-28
申请人： PERF-ACTION TECHNOLOGIES LTD. , BAROR, Eyal , SHALEV, Pinchas , GERSHONOWITZ, Amikam , AZAR, Zion
发明人： BAROR, Eyal , SHALEV, Pinchas , GERSHONOWITZ, Amikam , AZAR, Zion
IPC分类号： A61M5/30 , A61M5/48
摘要： The present invention relates to intradermal and subcutaneous needleless jet injections of compositions and methods and apparatus for delivering desired substances to targeted layers of the skin, while avoiding needle injuries to the treated subject. In particular, the present invention relates to methods of repairing cosmetic defects such as skin contour irregularities.

7. 发明公开

EP1768742A2 DELIVERY SYSTEM FOR TRANSDERMAL IMMUNIZATION 审中-公开
标题翻译：用于经皮免疫的递送系统
公开(公告)号：EP1768742A2
公开(公告)日：2007-04-04
申请号：EP05758964.0
申请日：2005-07-05
申请人： Transpharma Medical Ltd.
发明人： LEVIN, Galit , GERSHONOWITZ, Amikam , GADASI, Hana
IPC分类号： A61N1/30
CPC分类号： A61N1/327 , A61K9/0009 , A61K9/0021 , A61N1/042 , A61N1/0436
摘要： The present invention relates to a delivery system for transdermal immunization. More particularly, the invention relates to a delivery system for effective topical administration of antigens comprising an apparatus that generates micro-channels in the skin of a subject. The delivery system is useful for immunization against bacterial, viral, and fungal antigens and for treating tumors and allergies.
摘要翻译：本发明涉及用于透皮免疫的递送系统。更具体地说，本发明涉及用于有效局部施用抗原的递送系统，其包括在受试者的皮肤中产生微通道的设备。该递送系统对于免疫针对细菌，病毒和真菌抗原以及用于治疗肿瘤和变态反应是有用的。

8. 发明公开

EP1971393A2 METHOD AND DEVICE FOR TRANSDERMAL IMMUNIZATION 审中-公开
标题翻译：方法和装置用于透皮免疫
公开(公告)号：EP1971393A2
公开(公告)日：2008-09-24
申请号：EP06842316.9
申请日：2006-12-22
申请人： Transpharma Medical Ltd.
发明人： LEVIN, Galit , GERSHONOWITZ, Amikam , GADASI, Hana
IPC分类号： A61N1/30 , A61K39/00
CPC分类号： A61N1/327 , A61K9/0021 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/54 , A61K2039/55544 , A61K2039/70 , A61N1/042 , C12N2760/16134 , C12N2760/16234
摘要： The present invention relates to methods and device for transdermal immunization. More particularly, the invention relates to a device for effective topical administration of antigens comprising an apparatus that generates micro-channels in the skin of a subject. The delivery system is useful for immunization against bacterial, viral, and fungal antigens and for treating tumors and allergies.

9. 发明公开

EP1718362A2 TRANSDERMAL DELIVERY SYSTEM FOR POLYNUCLEOTIDES 审中-公开
标题翻译：系统多核苷酸透皮给药
公开(公告)号：EP1718362A2
公开(公告)日：2006-11-08
申请号：EP05703132.0
申请日：2005-01-25
申请人： Transpharma Medical Ltd.
发明人： BIRCHALL, James , LEVIN, Galit , GERSHONOWITZ, Amikam
IPC分类号： A61N1/30
CPC分类号： A61N1/327
摘要： The present invention relates to a system for intradermal or transdermal delivery of oligonucleotides or polynucleotides and to methods of use thereof. Particularly, the present invention relates to a system comprising an apparatus that generates micro-channels in the skin of a subject in conjunction with a pharmaceutical composition comprising an oligonucleotide or polynucleotide, wherein the oligonucleotide or polynucleotide can be delivered into the organism through the micro-channels. The system and methods of the present invention achieve expression of target proteins encoded by the polynucleotides, and hence are useful in immunization and gene therapy.

10. 发明公开

EP1848498A2 COMBINED MICRO-CHANNEL GENERATION AND IONTOPHORESIS FOR TRANSDERMAL DELIVERY OF PHARMACEUTICAL AGENTS 审中-公开
标题翻译：联合微通道生产和透皮电离子透入摄食制药
公开(公告)号：EP1848498A2
公开(公告)日：2007-10-31
申请号：EP05808273.6
申请日：2005-11-17
申请人： Transpharma Medical Ltd.
发明人： LEVIN, Galit , GERSHONOWITZ, Amikam , STERN, Meir , SHERMAN, Amir
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： The present invention relates to methods of transdermal delivery of pharmaceutical agents. In particular, the present invention relates to a method for transdermal delivery comprising generating micro-channels on the skin of a subject and delivering iontophoretically a pharmaceutical agent through the micro-channels. The method provides synergistic transdermal delivery of pharmaceutical agents.

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