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1. 发明申请

WO2005069736A3 TRANSDERMAL DELIVERY SYSTEM FOR POLYNUCLEOTIDES 审中-公开
公开(公告)号：WO2005069736A3
公开(公告)日：2005-08-04
申请号：PCT/IL2005/000089
申请日：2005-01-25
申请人： TRANSPHARMA MEDICAL LTD. , BIRCHALL, James , LEVIN, Galit , GERSHONOWITZ, Amikam
发明人： BIRCHALL, James , LEVIN, Galit , GERSHONOWITZ, Amikam
IPC分类号： A61N1/30
摘要： The present invention relates to a system for intradermal or transdermal delivery of oligonucleotides or polynucleotides and to methods of use thereof. Particularly, the present invention relates to a system comprising an apparatus that generates micro-channels in the skin of a subject in conjunction with a pharmaceutical composition comprising an oligonucleotide or polynucleotide, wherein the oligonucleotide or polynucleotide can be delivered into the organism through the micro-channels. The system and methods of the present invention achieve expression of target proteins encoded by the polynucleotides, and hence are useful in immunization and gene therapy.

2. 发明申请

WO2006054299A2 COMBINED MICRO-CHANNEL GENERATION AND IONTOPHORESIS FOR TRANSDERMAL DELIVERY OF PHARMACEUTICAL AGENTS 审中-公开
标题翻译：用于药物代谢物转运的组合式微通道生成和异构体
公开(公告)号：WO2006054299A2
公开(公告)日：2006-05-26
申请号：PCT/IL2005/001219
申请日：2005-11-17
申请人： TRANSPHARMA MEDICAL LTD. , LEVIN, Galit , GERSHONOWITZ, Amikam , STERN, Meir , SHERMAN, Amir
发明人： LEVIN, Galit , GERSHONOWITZ, Amikam , STERN, Meir , SHERMAN, Amir
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： The present invention relates to methods of transdermal delivery of pharmaceutical agents. In particular, the present invention relates to a method for transdermal delivery comprising generating micro-channels on the skin of a subject and delivering iontophoretically a pharmaceutical agent through the micro-channels. The method provides synergistic transdermal delivery of pharmaceutical agents. .
摘要翻译：本发明涉及药剂的透皮递送方法。特别地，本发明涉及一种透皮递送方法，其包括在受试者的皮肤上产生微通道并通过微通道离子电渗地输送药剂。该方法提供药剂的协同透皮递送。。

3. 发明申请

WO2007077487A2 METHOD AND DEVICE FOR TRANSDERMAL IMMUNIZATION 审中-公开
标题翻译：用于转导性免疫的方法和装置
公开(公告)号：WO2007077487A2
公开(公告)日：2007-07-12
申请号：PCT/IB2006/003832
申请日：2006-12-22
申请人： TRANSPHARMA MEDICAL, LTD. , LEVIN, Galit , GERSHONOWITZ, Amikam , GADASI, Hana
发明人： LEVIN, Galit , GERSHONOWITZ, Amikam , GADASI, Hana
IPC分类号： A61N1/30 , A61K39/00
CPC分类号： A61N1/327 , A61K9/0021 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/54 , A61K2039/55544 , A61K2039/70 , A61N1/042 , C12N2760/16134 , C12N2760/16234
摘要： The present invention relates to methods and device for transdermal immunization. More particularly, the invention relates to a device for effective topical administration of antigens comprising an apparatus that generates micro-channels in the skin of a subject. The delivery system is useful for immunization against bacterial, viral, and fungal antigens and for treating tumors and allergies.
摘要翻译：本发明涉及经皮免疫的方法和装置。更具体地，本发明涉及用于有效局部施用抗原的装置，其包括在受试者的皮肤中产生微通道的装置。递送系统可用于免疫细菌，病毒和真菌抗原以及治疗肿瘤和过敏。

4. 发明申请

WO2006003659A2 DELIVERY SYSTEM FOR TRANSDERMAL IMMUNIZATION 审中-公开
标题翻译：用于经皮免疫的递送系统
公开(公告)号：WO2006003659A2
公开(公告)日：2006-01-12
申请号：PCT/IL2005/000710
申请日：2005-07-05
申请人： TRANSPHARMA MEDICAL LTD. , LEVIN, Galit , GERSHONOWITZ, Amikam , GADASI, Hana
发明人： LEVIN, Galit , GERSHONOWITZ, Amikam , GADASI, Hana
IPC分类号： A61K9/127
CPC分类号： A61N1/327 , A61K9/0009 , A61K9/0021 , A61N1/042 , A61N1/0436
摘要： The present invention relates to a delivery system for transdermal immunization. More particularly, the invention relates to a delivery system for effective topical administration of antigens comprising an apparatus that generates micro-channels in the skin of a subject. The delivery system is useful for immunization against bacterial, viral, and fungal antigens and for treating tumors and allergies.
摘要翻译：本发明涉及用于透皮免疫的递送系统。更具体地说，本发明涉及用于有效局部施用抗原的递送系统，其包括在受试者的皮肤中产生微通道的设备。该递送系统对于免疫抗细菌，病毒和真菌抗原以及用于治疗肿瘤和过敏是有用的。

5. 发明申请

WO2010029552A9 TRANSDERMAL DELIVERY OF OLIGOSACCHARIDES 审中-公开
公开(公告)号：WO2010029552A9
公开(公告)日：2010-03-18
申请号：PCT/IL2009/000889
申请日：2009-09-10
申请人： TRANSPHARMA MEDICAL LTD. , LEVIN, Galit , SACKS, Hagit , STERN, Meir , MAZOOZ, Galit
发明人： LEVIN, Galit , SACKS, Hagit , STERN, Meir , MAZOOZ, Galit
IPC分类号： A61F13/70
摘要： The present invention relates to a system for facilitating transdermal delivery of oligosaccharides comprising an apparatus that generates micro-channels in the skin of a subject and a skin patch comprising a pharmaceutical composition comprising as an active agent an oligosaccharide. Particularly, the composition comprises an oligosaccharide of 5-20 monosaccharide units, such as a pentasaccharide, which exerts anticoagulant activity. The system is capable of delivering the oligosaccharides into the blood circulation for treating thromboembolic diseases.

6. 发明申请

WO2004039428A2 TRANSDERMAL DELIVERY SYSTEM FOR DRIED PARTICULATE OR LYOPHILIZED MEDICATIONS 审中-公开
标题翻译：用于干燥颗粒或冻干药物的透皮递送系统
公开(公告)号：WO2004039428A2
公开(公告)日：2004-05-13
申请号：PCT/IL2003/000903
申请日：2003-10-30
申请人： TRANSPHARMA MEDICAL LTD. , STERN, Meir , LEVIN, Galit
发明人： STERN, Meir , LEVIN, Galit
IPC分类号： A61M
CPC分类号： A61L15/44 , A61K9/0021 , A61K9/703 , A61L2300/252 , A61L2300/414 , A61L2300/43 , A61L2300/602 , A61M37/00 , A61N1/0416 , A61N1/0476 , A61N1/327
摘要： The present invention provides a system for transdermal delivery of dried or lyophilized pharmaceutical compositions and methods using thereof. The system comprises an apparatus for facilitating transdermal delivery of an agent that generates hydrophilic micro-channels, and a patch comprising a therapeutically active agent. The present invention is useful for transdermal delivery of hydrophilic agents, particularly of high molecular weight proteins.
摘要翻译：本发明提供用于透皮递送干燥或冻干的药物组合物的系统和使用它的方法。该系统包括用于促进产生亲水性微通道的试剂的透皮递送的装置和包含治疗活性剂的贴剂。本发明可用于亲水剂，特别是高分子量蛋白质的透皮递送。

7. 发明申请

WO2010097790A1 ELECTRICAL SKIN REJUVENATION 审中-公开
标题翻译：电动皮肤护理
公开(公告)号：WO2010097790A1
公开(公告)日：2010-09-02
申请号：PCT/IL2010/000149
申请日：2010-02-22
申请人： TRANSPHARMA MEDICAL LTD. , LEVIN, Galit , SOHN, Zev
发明人： LEVIN, Galit , SOHN, Zev
IPC分类号： A61N1/00
CPC分类号： A61N1/40 , A61B18/14 , A61B2018/00452 , A61B2018/0047 , A61B2018/143 , A61N1/328
摘要： A method is provided for reducing a wrinkle on a skin surface (42). The method includes identifying a person having a skin surface (42) with a wrinkle and in response to identifying the person, positioning at respective sites on the skin surface (42) an array (44) of electrodes (60) coupled to an energy source (46). While the electrodes (60) are at the respective sites: during a first time period, applying energy from the energy source (46) to drive the electrodes (60) to apply radio frequency (RF) current at a first voltage, capable of ablating an epidermal layer of the skin; and during a second time period, applying energy from the energy source (46) to drive the electrodes (60) to apply current at a second voltage, lower than the first voltage. Other embodiments are also described.
摘要翻译：提供了一种用于减少皮肤表面（42）上的皱纹的方法。该方法包括识别具有皱纹的皮肤表面（42）的人，并且响应于识别人，在皮肤表面（42）上的相应位置处定位耦合到能量源的电极阵列（44）（46）。当电极（60）处于相应位置时：在第一时间段期间，从能量源（46）施加能量以驱动电极（60）以施加能够消融的第一电压的射频（RF）电流表皮层皮肤; 并且在第二时间段期间，从能量源（46）施加能量以驱动电极（60）以比第一电压低的第二电压施加电流。还描述了其它实施例。

8. 发明申请

WO2004112689A3 TRANSDERMAL DELIVERY SYSTEM FOR COSMETIC AGENTS 审中-公开
公开(公告)号：WO2004112689A3
公开(公告)日：2004-12-29
申请号：PCT/IL2004/000561
申请日：2004-06-23
申请人： TRANSPHARMA MEDICAL LTD. , LEVIN, Galit , SACKS, Hagit , RUDAEV, Sergey
发明人： LEVIN, Galit , SACKS, Hagit , RUDAEV, Sergey
IPC分类号： A61N1/30
摘要： The present invention relates to an intradermal or transdermal delivery system for cosmetic agents. In particular, the invention relates to an intradermal or transdermal delivery system for topical administration of cosmetic agents, particularly water-soluble, poorly water-soluble, or water-insoluble cosmetic agents, in conjunction with an apparatus that generates micro-channels in the skin of a subject. The intradermal or transdermal delivery system is useful in treating skin conditions such as cellulite, hyperpigmentation, skin aging, and acne.

9. 发明申请

WO2010010555A2 TRANSDERMAL SYSTEM FOR EXTENDED DELIVERY OF INCRETINS AND INCRETIN MIMETIC PEPTIDES 审中-公开
标题翻译：用于延长递送和增加纤维蛋白质的变态系统
公开(公告)号：WO2010010555A2
公开(公告)日：2010-01-28
申请号：PCT/IL2009/000713
申请日：2009-07-21
申请人： TRANSPHARMA MEDICAL LTD. , MEVORAT-KAPLAN, Keren , LEVIN, Galit , SACKS, Hagit , STERN, Meir
发明人： MEVORAT-KAPLAN, Keren , LEVIN, Galit , SACKS, Hagit , STERN, Meir
IPC分类号： A61K38/22
CPC分类号： A61K9/7084 , A61K38/2278
摘要： The present invention relates to a transdermal system for extended delivery of incretins and incretin mimetic peptides, and to methods of use thereof. Particularly, the present invention relates to a transdermal system comprising an apparatus that generates micro-channels in the skin of a subject in conjunction with a transdermal patch that comprises a drug reservoir layer comprising a formulation which comprises an incretin or incretin mimetic peptide. The system is useful for extended delivery of incretins and incretin mimetic peptides, particularly of exendin-4, for treating diabetes mellitus and obesity.
摘要翻译：本发明涉及用于延长递送肠降血糖素和肠降胆固醇模拟肽的透皮系统及其使用方法。特别地，本发明涉及一种透皮系统，其包括与包括含有肠降血糖素或模拟肽的肠胃素的制剂的药物储存层结合的透皮贴剂一起在受试者的皮肤中产生微通道的装置。该系统对于延长递送肠溶素和肠易激肽模拟肽（特别是毒蜥外泌肽-4）用于治疗糖尿病和肥胖症是有用的。

10. 发明申请

WO2004112689A2 TRANSDERMAL DELIVERY SYSTEM FOR COSMETIC AGENTS 审中-公开
标题翻译：化妆品代理转运系统
公开(公告)号：WO2004112689A2
公开(公告)日：2004-12-29
申请号：PCT/IL2004/000561
申请日：2004-06-23
申请人： TRANSPHARMA MEDICAL LTD. , LEVIN, Galit , SACKS, Hagit , RUDAEV, Sergey
发明人： LEVIN, Galit , SACKS, Hagit , RUDAEV, Sergey
IPC分类号： A61K
CPC分类号： A61N1/327 , A61B18/14 , A61B2017/00765 , A61K8/347 , A61K8/368 , A61K8/4953 , A61N1/0424 , A61Q19/02 , A61Q19/06 , A61Q19/08
摘要： The present invention relates to an intradermal or transdermal delivery system for cosmetic agents. In particular, the invention relates to an intradermal or transdermal delivery system for topical administration of cosmetic agents, particularly water-soluble, poorly water-soluble, or water-insoluble cosmetic agents, in conjunction with an apparatus that generates micro-channels in the skin of a subject. The intradermal or transdermal delivery system is useful in treating skin conditions such as cellulite, hyperpigmentation, skin aging, and acne.
摘要翻译：本发明涉及用于化妆品的皮内或透皮递送系统。特别地，本发明涉及用于局部施用化妆品，特别是水溶性，难溶于水或水不溶性的化妆品的皮肤内或透皮递送系统，与在皮肤中产生微通道的装置相结合的主题。皮内或透皮递送系统可用于治疗皮肤病症如脂肪团，色素沉着过度，皮肤老化和痤疮。

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