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1. 发明专利

DE69534263D1 未知
公开(公告)号：DE69534263D1
公开(公告)日：2005-07-14
申请号：DE69534263
申请日：1995-07-13
申请人： TRANSGENE SA , BIOMERIEUX SA
发明人： JACOBS ERIC , SILVESTRE NATHALIE , MOUGIN BRUNO , BISSARDON ODETTE , JOLIVET MICHEL
IPC分类号： A61K38/00 , A61K39/00 , C07K14/45 , C12N1/19 , C12N15/30 , C12N15/80 , C12N15/81 , C12N15/62 , C12N1/15 , C07K16/20 , G01N33/53 , G01N33/543 , A61K48/00 , A61K39/002
摘要： The present invention provides a reagent for the detection or monitoring of a Toxoplasma gondii infection, which includes as a reactive substance a truncated Toxoplasma gondii P30 protein in which all of the hydrophobic C-terminal region of the native protein starting with the amino acid positioned after the amino acid 299 (SEQ ID NO: 1) has been deleted and all of the region of the native protein having the sequence starting with amino acid 31 and ending with the amino acid 299 (SEQ ID NO: 1) is contained. The present invention further describes methods of screening for anti-Toxoplasma antibodies in a biological sample

2. 发明专利

ES2240975T3 CASETE DE EXPRESION DE UNA PROTEINA P30 DE TOXOPLASMA GONDII. 未知
公开(公告)号：ES2240975T3
公开(公告)日：2005-10-16
申请号：ES95925882
申请日：1995-07-13
申请人： TRANSGENE SA , BIOMERIEUX SA
发明人： JACOBS ERIC , SILVESTRE NATHALIE , MOUGIN BRUNO , BISSARDON ODETTE , JOLIVET MICHEL
IPC分类号： A61K38/00 , A61K39/00 , C07K14/45 , C12N1/19 , C12N15/30 , C12N15/80 , C12N15/81 , C12N15/62 , C12N1/15 , C07K16/20 , G01N33/53 , G01N33/543 , A61K48/00 , A61K39/002
摘要： LA PRESENTE INVENCION SE REFIERE A UNA CASILLA DE EXPRESION PARA LA PRODUCCION Y LA SECRECION DE UNA PROTEINA P30 DE TAXOPLASMA GONDII EN UNA CELULA NO MAMIFERA, UN VECTOR, UNA CELULA QUE LA COMPRENDE Y LOS ANTICUERPOS QUE PUEDEN SER GENERADOS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION DE LA PROTEINA P30, UN PROCEDIMIENTO DE DETECCION DE ANTICUERPOS ANTITOXOPLASMA O DE LA PROTEINA P30, LOS REACTIVOS CORRESPONDIENTES ASI COMO A UNA COMPOSICION FARMACEUTICAS PARA EL TRATAMIENTO O LA PREVENCION DE UNA INFECCION CON TOXOPLASMA GONDII.

3. 发明专利

CA2194873A1 CASSETTE D'EXPRESSION D'UNE PROTEINE P30 DE TOXOPLASMA GONDII 未知
公开(公告)号：CA2194873A1
公开(公告)日：1996-02-01
申请号：CA2194873
申请日：1995-07-13
申请人： TRANSGENE SA , BIOMERIEUX SA
发明人： JACOBS ERIC , SILVESTRE NATHALIE , MOUGIN BRUNO , BISSARDON ODETTE , JOLIVET MICHEL
IPC分类号： A61K38/00 , A61K39/00 , C07K14/45 , C12N1/19 , C12N15/30 , A61K48/00 , A61K39/012 , A61K38/16 , C07K16/20 , A61K35/56 , G01N33/569 , A61K35/66 , A61K31/70 , C12N15/79

4. 发明专利

DE69534263T2 未知
公开(公告)号：DE69534263T2
公开(公告)日：2006-05-04
申请号：DE69534263
申请日：1995-07-13
申请人： TRANSGENE SA , BIOMERIEUX SA
发明人： JACOBS ERIC , SILVESTRE NATHALIE , MOUGIN BRUNO , BISSARDON ODETTE , JOLIVET MICHEL
IPC分类号： C12N15/80 , A61K38/00 , A61K39/00 , A61K39/002 , A61K48/00 , C07K14/45 , C07K16/20 , C12N1/15 , C12N1/19 , C12N15/30 , C12N15/62 , C12N15/81 , G01N33/53 , G01N33/543
摘要： The present invention provides a reagent for the detection or monitoring of a Toxoplasma gondii infection, which includes as a reactive substance a truncated Toxoplasma gondii P30 protein in which all of the hydrophobic C-terminal region of the native protein starting with the amino acid positioned after the amino acid 299 (SEQ ID NO: 1) has been deleted and all of the region of the native protein having the sequence starting with amino acid 31 and ending with the amino acid 299 (SEQ ID NO: 1) is contained. The present invention further describes methods of screening for anti-Toxoplasma antibodies in a biological sample

5. 发明专利

AT297470T 未知
公开(公告)号：AT297470T
公开(公告)日：2005-06-15
申请号：AT95925882
申请日：1995-07-13
申请人： TRANSGENE SA , BIOMERIEUX SA
发明人： JACOBS ERIC , SILVESTRE NATHALIE , MOUGIN BRUNO , BISSARDON ODETTE , JOLIVET MICHEL
IPC分类号： A61K38/00 , A61K39/00 , C07K14/45 , C12N1/19 , C12N15/30 , C12N15/80 , C12N15/81 , C12N15/62 , C12N1/15 , C07K16/20 , G01N33/53
摘要： The present invention provides a reagent for the detection or monitoring of a Toxoplasma gondii infection, which includes as a reactive substance a truncated Toxoplasma gondii P30 protein in which all of the hydrophobic C-terminal region of the native protein starting with the amino acid positioned after the amino acid 299 (SEQ ID NO: 1) has been deleted and all of the region of the native protein having the sequence starting with amino acid 31 and ending with the amino acid 299 (SEQ ID NO: 1) is contained. The present invention further describes methods of screening for anti-Toxoplasma antibodies in a biological sample

6. 发明专利

JP2013027397A Avian telomerase reverse transcriptase 审中-公开
标题翻译： AVIAN TELOMERASE逆向转录
公开(公告)号：JP2013027397A
公开(公告)日：2013-02-07
申请号：JP2012198723
申请日：2012-09-10
申请人： Transgene Sa , トランジェーヌ、ソシエテ、アノニムTransgene S.A.
发明人： HERVE PHILIPPE , BALLOUL JEAN-MARC , KAPFER MARINA , SILVESTRE NATHALIE
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N9/10
CPC分类号： C12N9/1276
摘要： PROBLEM TO BE SOLVED: To provide a novel recombinant telomerase reverse transcriptases, nucleic acid molecules coding them, cells comprising the nucleic acid molecule and use of these cells for the production of substance of interest.SOLUTION: A polypeptide having a specific amino acid sequence and having a TERT activity, and the nucleic acid encoding the polypeptide are disclosed. A method that makes a cell that belongs to Anatidae immortal by the expression of the polypeptide is disclosed. A production method of the substance of interest by using the cell is disclosed. In addition, the use of the cell for the replication of a virus that includes a complementation cassette that enables the proliferation of the defective virus is disclosed.
摘要翻译：要解决的问题：为了提供新的重组端粒酶逆转录酶，编码它们的核酸分子，包含核酸分子的细胞和这些细胞用于产生感兴趣的物质的用途。解决方案：公开了具有特定氨基酸序列并具有TERT活性的多肽和编码该多肽的核酸。公开了通过多肽的表达使得属于不朽的id科的细胞的方法。公开了通过使用电池的感兴趣物质的制备方法。另外，公开了细胞用于复制病毒的应用，该病毒包括能够增加缺陷病毒的互补盒。版权所有（C）2013，JPO＆INPIT

7. 发明申请

WO2008138649A2 SIGNALING PEPTIDES 审中-公开
标题翻译：信号肽
公开(公告)号：WO2008138649A2
公开(公告)日：2008-11-20
申请号：PCT/EP2008051035
申请日：2008-01-29
申请人： TRANSGENE SA , SILVESTRE NATHALIE , JACOBS ERIC
发明人： SILVESTRE NATHALIE , JACOBS ERIC
IPC分类号： C07K14/145 , C12N15/85
CPC分类号： C12N15/85 , C07K14/005 , C07K2319/02 , C07K2319/03 , C12N2760/20122 , C12N2840/20
摘要： The present invention provides novel peptides of specified sequence and their use as a signal peptide or a membrane-anchoring peptide. It also relates to chimeric polypeptide comprising one or more such peptides and a polypeptide of interest as well as nucleic acid molecule, vectors, infectious viral particles and host cells encoding such peptides and chimeric polypeptides. The present invention also relates to a pharmaceutical composition comprising such elements and a pharmaceutically acceptable vehicle. The present invention also provides a method for recombinantly producing a polypeptide using such peptides, especially for directing expression of a polypeptide of interest extracellularly or anchored at the surface of the plasma membrane.
摘要翻译：本发明提供具有特定序列的新型肽及其作为信号肽或膜 - 锚定肽的用途。它还涉及包含一种或多种这样的肽和目的多肽以及编码这些肽和嵌合多肽的核酸分子，载体，感染性病毒颗粒和宿主细胞的嵌合多肽。本发明还涉及包含这些元件和药学上可接受的载体的药物组合物。本发明还提供了一种使用这些肽重组产生多肽的方法，特别是用于引导细胞外或锚定在质膜表面的感兴趣多肽的表达。

8. 发明申请

WO2007077256B1 AVIAN TELOMERASE REVERSE TRANSCRIPTASE 审中-公开
标题翻译： AVIAN TELOMERASE逆向转录
公开(公告)号：WO2007077256B1
公开(公告)日：2007-10-25
申请号：PCT/EP2007050120
申请日：2007-01-05
申请人： TRANSGENE SA , ERBS PHILIPPE , BALLOUL JEAN-MARC , KAPFER MARINA , SILVESTRE NATHALIE
发明人： ERBS PHILIPPE , BALLOUL JEAN-MARC , KAPFER MARINA , SILVESTRE NATHALIE
IPC分类号： C12N9/12
CPC分类号： C12N9/1276
摘要： The present invention notably relates to novel recombinant telomerase reverse transcriptases, nucleic acid molecules coding them, cells comprising said nucleic acid molecule and use of these cells for the production of substance of interest.
摘要翻译：本发明特别涉及新型重组端粒酶逆转录酶，编码它们的核酸分子，包含所述核酸分子的细胞以及这些细胞用于生产感兴趣的物质的用途。

9. 发明申请

WO2011015656A3 COMPOSITION FOR TREATING HBV INFECTION 审中-公开
标题翻译：治疗HBV感染的组合物
公开(公告)号：WO2011015656A3
公开(公告)日：2011-03-31
申请号：PCT/EP2010061492
申请日：2010-08-06
申请人： TRANSGENE SA , MARTIN PERRINE , INCHAUSPE GENEVIEVE , SILVESTRE NATHALIE , SCHMITT DORIS
发明人： MARTIN PERRINE , INCHAUSPE GENEVIEVE , SILVESTRE NATHALIE , SCHMITT DORIS
IPC分类号： A61K39/29 , A61P31/12
CPC分类号： A61K39/29 , A61K39/12 , A61K39/292 , A61K2039/53 , A61K2039/545 , A61K2039/57 , C12N7/00 , C12N9/1252 , C12N15/86 , C12N2710/10043 , C12N2710/24143 , C12N2730/10134 , C12Y207/07007
摘要： The present invention provides a composition comprising hepatitis B virus (HBV) component(s), and which may be either nucleic acid- or polypeptide-based as well as nucleic acid molecules and vectors encoding such HBV component(s). It also relates to infectious viral particles and host cells comprising such nucleic acid molecules or vectors. It also provides composition and kits of parts comprising such nucleic acid molecules, vectors, infectious viral particles or host cells and the therapeutic use thereof for preventing or treating HBV infections.
摘要翻译：本发明提供了一种包含乙型肝炎病毒（HBV）组分的组合物，其可以是基于核酸或多肽的以及编码这种或这些HBV组分的核酸分子和载体。它还涉及包含这种核酸分子或载体的感染性病毒颗粒和宿主细胞。它还提供了包含此类核酸分子，载体，感染性病毒颗粒或宿主细胞的组分和试剂盒以及其用于预防或治疗HBV感染的治疗用途。

10. 发明申请

WO2014009438A3 MYCOBACTERIAL ANTIGEN VACCINE 审中-公开
标题翻译： MYCOBACTERIAL抗原疫苗
公开(公告)号：WO2014009438A3
公开(公告)日：2014-04-10
申请号：PCT/EP2013064624
申请日：2013-07-10
申请人： TRANSGENE SA
发明人： TUPIN EMMANUEL , MICOL ROMAIN , COUPET CHARLES ANTOINE , INCHAUPSE GENEVIÈVE , GOUANVIC MARIE , SILVESTRE NATHALIE , MARCHAND JEAN-BAPTISTE , BENY CÉCILE
IPC分类号： A61K39/04
CPC分类号： A61K39/04 , A61K2039/51 , A61K2039/53 , C07K14/35 , C07K16/1289 , C07K2319/00 , C07K2319/40
摘要： The present invention relates generally to immunogenic combinations comprising at least five antigens of a Mycobacterium species as well as fusion thereof and nucleic acid molecules encoding such combined antigens and fusion. The present invention also relates to nucleic acid molecules, vectors, host cells and compositions comprising or encoding said combinations of mycobacterial antigens and fusion polypeptides as well as to methods for recombinantly producing them. The present invention also relates to methods of using said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions particularly for inducing or stimulating an immune response against a Mycobacterium infection or any disease caused by or associated with a Mycobacterium infection. The present invention also concerns antibodies directed to such mycobacterial antigens and fusion polypeptides that can be used in the diagnosis of a Mycobacterium infection and method of detection as well as kits of reagent comprising said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions or antibodies.
摘要翻译：本发明一般涉及包含分枝杆菌属物种的至少五种抗原及其融合物和编码这种组合抗原和融合物的核酸分子的免疫原性组合。本发明还涉及包含或编码分枝杆菌抗原和融合多肽的所述组合的核酸分子，载体，宿主细胞和组合物以及重组产生它们的方法。本发明还涉及使用分枝杆菌抗原，融合多肽，载体，宿主细胞，特别用于诱导或刺激针对分枝杆菌感染的免疫应答或由分枝杆菌感染引起或与分枝杆菌感染相关的任何疾病的组合的组合的方法。本发明还涉及可用于诊断分枝杆菌感染的这种分枝杆菌抗原和融合多肽的抗体以及检测方法以及包含分枝杆菌抗原，融合多肽，载体，宿主细胞的所述组合的试剂盒，组合物或抗体。

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