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1. 发明申请

WO2014009438A3 MYCOBACTERIAL ANTIGEN VACCINE 审中-公开
标题翻译： MYCOBACTERIAL抗原疫苗
公开(公告)号：WO2014009438A3
公开(公告)日：2014-04-10
申请号：PCT/EP2013064624
申请日：2013-07-10
申请人： TRANSGENE SA
发明人： TUPIN EMMANUEL , MICOL ROMAIN , COUPET CHARLES ANTOINE , INCHAUPSE GENEVIÈVE , GOUANVIC MARIE , SILVESTRE NATHALIE , MARCHAND JEAN-BAPTISTE , BENY CÉCILE
IPC分类号： A61K39/04
CPC分类号： A61K39/04 , A61K2039/51 , A61K2039/53 , C07K14/35 , C07K16/1289 , C07K2319/00 , C07K2319/40
摘要： The present invention relates generally to immunogenic combinations comprising at least five antigens of a Mycobacterium species as well as fusion thereof and nucleic acid molecules encoding such combined antigens and fusion. The present invention also relates to nucleic acid molecules, vectors, host cells and compositions comprising or encoding said combinations of mycobacterial antigens and fusion polypeptides as well as to methods for recombinantly producing them. The present invention also relates to methods of using said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions particularly for inducing or stimulating an immune response against a Mycobacterium infection or any disease caused by or associated with a Mycobacterium infection. The present invention also concerns antibodies directed to such mycobacterial antigens and fusion polypeptides that can be used in the diagnosis of a Mycobacterium infection and method of detection as well as kits of reagent comprising said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions or antibodies.
摘要翻译：本发明一般涉及包含分枝杆菌属物种的至少五种抗原及其融合物和编码这种组合抗原和融合物的核酸分子的免疫原性组合。本发明还涉及包含或编码分枝杆菌抗原和融合多肽的所述组合的核酸分子，载体，宿主细胞和组合物以及重组产生它们的方法。本发明还涉及使用分枝杆菌抗原，融合多肽，载体，宿主细胞，特别用于诱导或刺激针对分枝杆菌感染的免疫应答或由分枝杆菌感染引起或与分枝杆菌感染相关的任何疾病的组合的组合的方法。本发明还涉及可用于诊断分枝杆菌感染的这种分枝杆菌抗原和融合多肽的抗体以及检测方法以及包含分枝杆菌抗原，融合多肽，载体，宿主细胞的所述组合的试剂盒，组合物或抗体。

2. 发明专利

CA2878800A1 MYCOBACTERIAL ANTIGEN VACCINE 未知
公开(公告)号：CA2878800A1
公开(公告)日：2014-01-16
申请号：CA2878800
申请日：2013-07-10
申请人： TRANSGENE SA
发明人： TUPIN EMMANUEL , MICOL ROMAIN , COUPET CHARLES ANTOINE , INCHAUPSE GENEVIEVE , GOUANVIC MARIE , SILVESTRE NATHALIE , MARCHAND JEAN-BAPTISTE , BENY CECILE
IPC分类号： A61K39/04
摘要： The present invention relates generally to immunogenic combinations comprising at least five antigens of a Mycobacterium species as well as fusion thereof and nucleic acid molecules encoding such combined antigens and fusion. The present invention also relates to nucleic acid molecules, vectors, host cells and compositions comprising or encoding said combinations of mycobacterial antigens and fusion polypeptides as well as to methods for recombinantly producing them. The present invention also relates to methods of using said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions particularly for inducing or stimulating an immune response against a Mycobacterium infection or any disease caused by or associated with a Mycobacterium infection. The present invention also concerns antibodies directed to such mycobacterial antigens and fusion polypeptides that can be used in the diagnosis of a Mycobacterium infection and method of detection as well as kits of reagent comprising said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions or antibodies.

3. 发明专利

ZA201500784B MYCOBACTERIAL ANTIGEN VACCINE 未知
公开(公告)号：ZA201500784B
公开(公告)日：2020-07-29
申请号：ZA201500784
申请日：2015-02-03
申请人： TRANSGENE SA
发明人： TUPIN EMMANUEL , MICOL ROMAIN , COUPET CHARLES ANTOINE , INCHAUPSE GENEVIÈVE , GOUANVIC MARIE , SILVESTRE NATHALIE , MARCHAND JEAN-BAPTISTE , BENY CÉCILE
摘要： The present invention relates generally to immunogenic combinations comprising at least five antigens of a Mycobacterium species as well as fusion thereof and nucleic acid molecules encoding such combined antigens and fusion. The present invention also relates to nucleic acid molecules, vectors, host cells and compositions comprising or encoding said combinations of mycobacterial antigens and fusion polypeptides as well as to methods for recombinantly producing them. The present invention also relates to methods of using said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions particularly for inducing or stimulating an immune response against a Mycobacterium infection or any disease caused by or associated with a Mycobacterium infection. The present invention also concerns antibodies directed to such mycobacterial antigens and fusion polypeptides that can be used in the diagnosis of a Mycobacterium infection and method of detection as well as kits of reagent comprising said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions or antibodies.

4. 发明专利

MY173004A MYCOBACTERIAL ANTIGEN VACCINE 未知
公开(公告)号：MY173004A
公开(公告)日：2019-12-18
申请号：MYPI2015000055
申请日：2013-07-10
申请人： TRANSGENE SA
发明人： SILVESTRE NATHALIE , TUPIN EMMANUEL , MICOL ROMAIN , COUPET CHARLES ANTOINE , INCHAUPSE GENEVIEVE , GOUANVIC MARIE , MARCHAND JEAN-BAPTISTE , BENY CECILE
IPC分类号： C12P21/02 , A61K39/04 , C12N1/21 , C12N7/01 , C12N15/09
摘要： The present invention relates generally to immunogenic combinations comprising at least five antigens of a Mycobacterium species as well as fusion thereof and nucleic acid molecules encoding such combined antigens and fusion. The present invention also relates to nucleic acid molecules, vectors, host cells and compositions comprising or encoding said combinations of mycobacterial antigens and fusion polypeptides as well as to methods for recombinantly producing them. The present invention also relates to methods of using said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions particularly for inducing or stimulating an immune response against a Mycobacterium infection or any disease caused by or associated with a Mycobacterium infection. The present invention also concerns antibodies directed to such mycobacterial antigens and fusion polypeptides that can be used in the diagnosis of a Mycobacterium infection and method of detection as well as kits of reagent comprising said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions or antibodies.

5. 发明专利

SG11201500171YA MYCOBACTERIAL ANTIGEN VACCINE 未知
公开(公告)号：SG11201500171YA
公开(公告)日：2015-02-27
申请号：SG11201500171Y
申请日：2013-07-10
申请人： TRANSGENE SA
发明人： TUPIN EMMANUEL , MICOL ROMAIN , COUPET CHARLES ANTOINE , INCHAUPSE GENEVIÈVE , GOUANVIC MARIE , SILVESTRE NATHALIE , MARCHAND JEAN-BAPTISTE , BENY CÉCILE
IPC分类号： A61K39/04
摘要： The present invention relates generally to immunogenic combinations comprising at least five antigens of a Mycobacterium species as well as fusion thereof and nucleic acid molecules encoding such combined antigens and fusion. The present invention also relates to nucleic acid molecules, vectors, host cells and compositions comprising or encoding said combinations of mycobacterial antigens and fusion polypeptides as well as to methods for recombinantly producing them. The present invention also relates to methods of using said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions particularly for inducing or stimulating an immune response against a Mycobacterium infection or any disease caused by or associated with a Mycobacterium infection. The present invention also concerns antibodies directed to such mycobacterial antigens and fusion polypeptides that can be used in the diagnosis of a Mycobacterium infection and method of detection as well as kits of reagent comprising said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions or antibodies.

6. 发明专利

MX366206B VACUNA DE ANTÍGENO MICOBACTERIANO. 未知
公开(公告)号：MX366206B
公开(公告)日：2019-07-02
申请号：MX2015000449
申请日：2013-07-10
申请人： TRANSGENE SA
发明人： SILVESTRE NATHALIE , MARCHAND JEAN-BAPTISTE , TUPIN EMMANUEL , MICOL ROMAIN , COUPET CHARLES ANTOINE , INCHAUPSE GENEVIÈVE , GOUANVIC MARIE , BENY CÉCILE
IPC分类号： A61K39/04 , A61P31/06 , C07K14/35
摘要： La presente invención se refiere a combinaciones inmunogénicas que comprenden al menos cinco antígenos de una especie de Micobacteria así como también una fusión de los mismos y moléculas de ácido nucleico que codifican para tales antígenos combinados y fusión; la presente invención también se relaciona a moléculas de ácido nucleico, vectores, células hospederas y composiciones que comprende o codifican dichas combinaciones de antígenos micobacterianos y polipéptidos de fusión así como también métodos para producirlos recombinantemente; la presente invención también se relaciona a métodos para usar dichas combinaciones de antígenos micobacterianos, polipéptidos de fusión, vectores, células hospederas, composiciones particularmente para inducir o estimular una respuesta inmune contra una infección de Micobacteria o cualquier enfermedad causada por o asociada con una infección por Micobacteria; la presente invención también se relaciona a anticuerpos dirigidos a dichos antígenos micobacterianos y polipéptidos de fusión que pueden ser utiles en el diagnóstico de una infección por Micobacteria y un método de detección así como también equipos de reactivos que comprenden dichas combinaciones de antígenos micobacterianos, polipéptidos de fusión, vectores, células hospederas, composiciones o anticuerpos.

7. 发明专利

UA119228C2 ВАКЦИНА НА ОСНОВІ МІКОБАКТЕРІАЛЬНИХ АНТИГЕНІВ 未知
公开(公告)号：UA119228C2
公开(公告)日：2019-05-27
申请号：UA201501068
申请日：2013-07-10
申请人： TRANSGENE SA
发明人： TUPIN EMMANUEL , MICOL ROMAIN , COUPET CHARLES ANTOINE , INCHAUPSE GENEVIEVE , GOUANVIC MARIE , SILVESTRE NATHALIE , MARCHAND JEAN-BAPTISTE , BENY CECILE
IPC分类号： A61K39/04 , C12N15/31 , A61P31/06 , C12N15/62 , C12N15/863
摘要： Винахідстосуєтьсявекторанаосновівірусувіспиабокомбінаціїдвохабобільшевекторівнаосновівірусувіспи, якийміститьоднуабобільшеніжоднумолекулунуклеїновоїкислоти, щокодуютьщонайменше 5 мікобактеріальнихантигенів, якінезалежноотриманіз видівродумікобактерій, демолекула(и) нуклеїновоїкислотикодуєщонайменше ESAT-6 (Rv3875), Ag85B (Rv1886) та TB10.4 (Rv0288) активноїфази; кодуєщонайменшеодинантигенз фазилатентноїінфекції, вибранийз групи, щоскладаєтьсяз Rv0111, Rv0569, Rv1733c, Rv1807, Rv1813, Rv2029c, Rv2626 і Rv3407; такодуєщонайменше RpfB і RpfD зфазипожвавленняінфекції. Винахідтакожстосуєтьсякомпозиції, щоміститьвекторнаосновівірусувіспи, длязастосуваннядляпопередженняаболікуванняінфекціїмікобактерією, особливо M. tuberculosis, абобудь-якогозахворюванняі патологічногостану, викликаногоабоасоційованогоз такоюінфекцієюмікобактерією.

8. 发明专利

EA029492B1 ВАКЦИНА НА ОСНОВЕ МИКОБАКТЕРИАЛЬНЫХ АНТИГЕНОВ 未知
公开(公告)号：EA029492B1
公开(公告)日：2018-04-30
申请号：EA201590184
申请日：2013-07-10
申请人： TRANSGENE SA
发明人： TUPIN EMMANUEL , MICOL ROMAIN , COUPET CHARLES ANTOINE , INCHAUPSE GENEVIEVE , GOUANVIC MARIE , SILVESTRE NATHALIE , MARCHAND JEAN-BAPTISTE , BENY CECILE
IPC分类号： A61K39/04
摘要： Изобретение, вобщем, относитсяк иммуногеннымкомбинациям, содержащимпоменьшеймерепятьантигеновизвидовродамикобактерий, атакжек ихгибридами молекуламнуклеиновойкислоты, кодирующимтакиеобъединенныеантигеныи гибриды. Настоящееизобретениетакжеотноситсяк молекуламнуклеиновойкислоты, векторам, клеткам-хозяевами композициям, содержащимиликодирующимуказанныекомбинациимикобактериальныхантигенови слитыеполипептиды, атакжек способамихрекомбинантнойпродукции. Настоящееизобретениетакжеотноситсяк способампримененияуказанныхкомбинациймикобактериальныхантигенов, слитыхполипептидов, векторов, клеток-хозяев, композиций, вчастностидляиндуцированияилистимулированияиммунногоответапротивинфекциимикобактериейилилюбогозаболевания, вызванногоилиассоциированногос инфекциеймикобактерией. Настоящееизобретениетакжекасаетсяантител, направленныхнатакиемикобактериальныеантигеныи слитыеполипептиды, которыеможноиспользоватьв диагностикеинфекциимикобактерией, испособадетекции, атакженаборовреактивов, содержащихуказанныекомбинациимикобактериальныхантигенов, слитыеполипептиды, векторы, клетки-хозяева, композицииилиантитела.

9. 发明专利

HK1207962A1 MYCOBACTERIAL ANTIGEN VACCINE 未知
公开(公告)号：HK1207962A1
公开(公告)日：2016-02-19
申请号：HK15108554
申请日：2015-09-01
申请人： TRANSGENE SA
发明人： TUPIN EMMANUEL , MICOL ROMAIN , COUPET CHARLES ANTOINE , INCHAUPSE GENEVIVE , GOUANVIC MARIE , SILVESTRE NATHALIE , MARCHAND JEAN-BAPTISTE , BENY CCILE
IPC分类号： A61K20060101
摘要： The present invention relates generally to immunogenic combinations comprising at least five antigens of a Mycobacterium species as well as fusion thereof and nucleic acid molecules encoding such combined antigens and fusion. The present invention also relates to nucleic acid molecules, vectors, host cells and compositions comprising or encoding said combinations of mycobacterial antigens and fusion polypeptides as well as to methods for recombinantly producing them. The present invention also relates to methods of using said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions particularly for inducing or stimulating an immune response against a Mycobacterium infection or any disease caused by or associated with a Mycobacterium infection. The present invention also concerns antibodies directed to such mycobacterial antigens and fusion polypeptides that can be used in the diagnosis of a Mycobacterium infection and method of detection as well as kits of reagent comprising said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions or antibodies.

10. 发明专利

MX2015000449A VACUNA DE ANTIGENO MICOBACTERIANO. 未知
公开(公告)号：MX2015000449A
公开(公告)日：2015-07-14
申请号：MX2015000449
申请日：2013-07-10
申请人： TRANSGENE SA
发明人： SILVESTRE NATHALIE , MARCHAND JEAN-BAPTISTE , TUPIN EMMANUEL , MICOL ROMAIN , COUPET CHARLES ANTOINE , INCHAUPSE GENEVIÈVE , GOUANVIC MARIE , BENY CÉCILE
IPC分类号： A61K39/04
摘要： La presente invención está dirigida generalmente a combinaciones inmunogénicas que comprenden al menos cinco antígenos de una especie de Micobacteria así como también una fusión de los mismos y moléculas de ácido nucleico que codifican para tales antígenos combinados y fusión; la presente invención también se relaciona a moléculas de ácido nucleico, vectores, células hospederas y composiciones que comprende o codifican dichas combinaciones de antígenos micobacterianos y polipéptidos de fusión así como también métodos para producirlos recombinantemente; la presente invención también se relaciona a métodos para usar dichas combinaciones de antígenos micobacterianos, polipéptidos de fusión, vectores, células hospederas, composiciones particularmente para inducir o estimular una respuesta inmune contra una infección de Micobacteria o cualquier enfermedad causada por o asociada con una infección por Micobacteria; la presente invención también se relaciona a anticuerpos dirigidos a dichos antígenos micobacterianos y polipéptidos de fusión que pueden ser utiles en el diagnóstico de una infección por Micobacteria y un método de detección así como también equipos de reactivos que comprenden dichas combinaciones de antígenos micobacterianos, polipéptidos de fusión, vectores, células hospederas, composiciones o anticuerpos.

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