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1. 发明申请

WO2014009438A2 MYCOBACTERIAL ANTIGEN VACCINE 审中-公开
公开(公告)号：WO2014009438A2
公开(公告)日：2014-01-16
申请号：PCT/EP2013/064624
申请日：2013-07-10
申请人： TRANSGENE SA
发明人： TUPIN, Emmanuel , MICOL, Romain , COUPET, Charles Antoine , INCHAUPSE, Geneviève , GOUANVIC, Marie , SILVESTRE, Nathalie , MARCHAND, Jean-Baptiste , BENY, Cécile
IPC分类号： A61K39/04
CPC分类号： A61K39/04 , A61K2039/51 , A61K2039/53 , C07K14/35 , C07K16/1289 , C07K2319/00 , C07K2319/40
摘要： The present invention relates generally to immunogenic combinations comprising at least five antigens of a Mycobacterium species as well as fusion thereof and nucleic acid molecules encoding such combined antigens and fusion. The present invention also relates to nucleic acid molecules, vectors, host cells and compositions comprising or encoding said combinations of mycobacterial antigens and fusion polypeptides as well as to methods for recombinantly producing them. The present invention also relates to methods of using said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions particularly for inducing or stimulating an immune response against a Mycobacterium infection or any disease caused by or associated with a Mycobacterium infection. The present invention also concerns antibodies directed to such mycobacterial antigens and fusion polypeptides that can be used in the diagnosis of a Mycobacterium infection and method of detection as well as kits of reagent comprising said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions or antibodies.
摘要翻译：本发明一般涉及包含至少五种分枝杆菌属物种的抗原及其融合物的免疫原性组合，以及编码这种组合抗原和融合物的核酸分子。本发明还涉及包含或编码所述分枝杆菌抗原和融合多肽组合的核酸分子，载体，宿主细胞和组合物，以及用于重组产生它们的方法。本发明还涉及使用所述分枝杆菌抗原，融合多肽，载体，宿主细胞，组合物特别用于诱导或刺激针对分枝杆菌感染或由分枝杆菌感染引起或与其相关的任何疾病的免疫应答的组合的方法。本发明还涉及可用于诊断分枝杆菌感染的此类分枝杆菌抗原和融合多肽的抗体和检测方法以及包含所述分枝杆菌抗原组合，融合多肽，载体，宿主细胞，组合物或抗体。

2. 发明申请

WO2014009433A1 MYCOBACTERIUM RESUSCITATION PROMOTING FACTOR FOR USE AS ADJUVANT 审中-公开
标题翻译： MYCOBACTERIUM RESUSCITATION促销因子作为ADJUVANT使用
公开(公告)号：WO2014009433A1
公开(公告)日：2014-01-16
申请号：PCT/EP2013/064617
申请日：2013-07-10
申请人： TRANSGENE SA
发明人： COUPET, Charles Antoine , INCHAUPSE, Geneviève , MARCHAND, Jean-Baptiste
IPC分类号： A61K38/16 , A61K39/04 , A61K39/39
CPC分类号： A61K38/164 , A61K39/04 , A61K39/385 , A61K39/39 , A61K2039/53 , A61K2039/70
摘要： The present invention relates to a product combination or acomposition comprising (a) one or more immunogen (s) and (b) a polypeptide comprising at least a Mycobacterium resuscitation promoting factor (Rpf) or a nucleic acid molecule encoding said polypeptide. The present invention also relates to such a polypeptide or its encoding nucleic acid molecule for use as an adjuvant in combination with one or more immunogen(s). The present invention also relates to a method for recombinant production of said polypeptide, product combination or composition as well as methods for therapeutic or prophylactic use using such elements.
摘要翻译：本发明涉及产品组合或分解，其包含（a）一种或多种免疫原和（b）至少包含分枝杆菌复苏促进因子（Rpf）或编码所述多肽的核酸分子的多肽。本发明还涉及用作与一种或多种免疫原组合的佐剂的这种多肽或其编码核酸分子。本发明还涉及用于重组生产所述多肽，产品组合或组合物的方法以及使用这些元件的治疗或预防用途的方法。

3. 发明公开

EP2872172A2 MYCOBACTERIAL ANTIGEN VACCINE 审中-公开
标题翻译： IMPFSTOFF MIT EINEM MYKOBAKTERIELLEN ANTIGEN
公开(公告)号：EP2872172A2
公开(公告)日：2015-05-20
申请号：EP13735275.3
申请日：2013-07-10
申请人： Transgene SA
发明人： TUPIN, Emmanuel , MICOL, Romain , COUPET, Charles Antoine , INCHAUPSE, Geneviève , GOUANVIC, Marie , SILVESTRE, Nathalie , MARCHAND, Jean-Baptiste , BENY, Cécile
IPC分类号： A61K39/04
CPC分类号： A61K39/04 , A61K2039/51 , A61K2039/53 , C07K14/35 , C07K16/1289 , C07K2319/00 , C07K2319/40
摘要： The present invention relates generally to immunogenic combinations comprising at least five antigens of a Mycobacterium species as well as fusion thereof and nucleic acid molecules encoding such combined antigens and fusion. The present invention also relates to nucleic acid molecules, vectors, host cells and compositions comprising or encoding said combinations of mycobacterial antigens and fusion polypeptides as well as to methods for recombinantly producing them. The present invention also relates to methods of using said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions particularly for inducing or stimulating an immune response against a Mycobacterium infection or any disease caused by or associated with a Mycobacterium infection. The present invention also concerns antibodies directed to such mycobacterial antigens and fusion polypeptides that can be used in the diagnosis of a Mycobacterium infection and method of detection as well as kits of reagent comprising said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions or antibodies.
摘要翻译：本发明一般涉及包含分枝杆菌属物种的至少五种抗原及其融合物和编码这种组合抗原和融合物的核酸分子的免疫原性组合。本发明还涉及包含或编码分枝杆菌抗原和融合多肽的所述组合的核酸分子，载体，宿主细胞和组合物，以及重组产生它们的方法。本发明还涉及使用分枝杆菌抗原，融合多肽，载体，宿主细胞，特别是用于诱导或刺激针对分枝杆菌感染的免疫应答或由分枝杆菌感染引起或与分枝杆菌感染相关的任何疾病的组合的组合的方法。本发明还涉及针对可用于诊断分枝杆菌感染的这种分枝杆菌抗原和融合多肽的抗体以及检测方法以及包含分枝杆菌抗原，融合多肽，载体，宿主细胞的所述组合的试剂盒，组合物或抗体。

4. 发明授权

EP2872172B1 MYCOBACTERIAL ANTIGEN VACCINE 有权
公开(公告)号：EP2872172B1
公开(公告)日：2018-11-14
申请号：EP13735275.3
申请日：2013-07-10
申请人： Transgene SA
发明人： TUPIN, Emmanuel , MICOL, Romain , COUPET, Charles Antoine , INCHAUPSE, Geneviève , GOUANVIC, Marie , SILVESTRE, Nathalie , MARCHAND, Jean-Baptiste , BENY, Cécile
IPC分类号： A61K39/04
CPC分类号： A61K39/04 , A61K2039/51 , A61K2039/53 , C07K14/35 , C07K16/1289 , C07K2319/00 , C07K2319/40
摘要： The present invention relates generally to immunogenic combinations comprising at least five antigens of a Mycobacterium species as well as fusion thereof and nucleic acid molecules encoding such combined antigens and fusion. The present invention also relates to nucleic acid molecules, vectors, host cells and compositions comprising or encoding said combinations of mycobacterial antigens and fusion polypeptides as well as to methods for recombinantly producing them. The present invention also relates to methods of using said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions particularly for inducing or stimulating an immune response against a Mycobacterium infection or any disease caused by or associated with a Mycobacterium infection. The present invention also concerns antibodies directed to such mycobacterial antigens and fusion polypeptides that can be used in the diagnosis of a Mycobacterium infection and method of detection as well as kits of reagent comprising said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions or antibodies.

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