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1. 发明申请

WO1998011899A1 PLATELET FUNCTION POTENTIATOR AND METHOD OF CURING PLATELET DYSFUNCTION 审中-公开
标题翻译：电极功能电位器和固化电极功能的方法
公开(公告)号：WO1998011899A1
公开(公告)日：1998-03-26
申请号：PCT/JP1997003287
申请日：1997-09-17
申请人： TORAY INDUSTRIES, INC. , MIYAMOTO, Mitsuko , YAMADA, Naohiro , OHTAKE, Atsushi , WAKITA, Hisanori
发明人： TORAY INDUSTRIES, INC.
IPC分类号： A61K31/557
CPC分类号： A61K31/5585 , A61K31/34
摘要： A platelet function potentiator containing a prostaglandin I2 derivative as the active ingredient and a method of curing platelet dysfunction therewith. The potentiator is remarkably useful, because it has an excellent effect of activating platelets without causing the aggregation thereof.
摘要翻译：含有前列腺素I2衍生物作为活性成分的血小板功能增强剂和与其形成的血小板功能障碍的方法。增效剂是非常有用的，因为它具有极好的激活血小板而不引起聚集的效果。

2. 发明申请

WO1989003387A1 2,5,6,7-TETRANOR-4,8-INTER-m-PHENYLENE PGI2 DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND USE THEREOF 审中-公开
标题翻译： 2,5,6,7-四取代-4,8-间 - 间 - 苯基PGI 2衍生物，其制备方法及其用途
公开(公告)号：WO1989003387A1
公开(公告)日：1989-04-20
申请号：PCT/JP1988001048
申请日：1988-10-14
申请人： TORAY INDUSTRIES, INC. , OHNO, Kiyotaka , TAKAHASHI, Toshiya , OHTAKE, Atsushi , WAKITA, Hisanori , NISHIO, Shintaro
发明人： TORAY INDUSTRIES, INC.
IPC分类号： C07D307/93
CPC分类号： C07D407/14 , C07D307/93 , C07D493/04
摘要： 2,5,6,7-Tetranor-4,8-inter-m-phenylene PGI2 derivatives such as 16-methyl-2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 and its methyl ester, 17-methyl-2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 and its methyl ester, 15-phenyl-2,5,6,7,16,17,18,19,20-nonanor-4,8-inter-m-phenylene PGI2, 16-methyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI2, 16,16-dimethyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI2, 16-methyl-16-phenoxy-2,5,6,7,17,18,19,20-octanor-4,8-inter-m-phenylene PGI2, 16-methyl-16-phenoxy-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI2 and its methyl ester and 3-decarboxy-3-hydroxymethyl-16-methyl-16-phenoxy-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI2, useful as medicines, are disclosed. These derivatives are useful as, for example, antiulceric agents, hypotensives, and antithrombotic agents.

3. 发明申请

WO1996020925A1 BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME 审中-公开
标题翻译：苯并呋喃衍生的杂环衍生物及其用途
公开(公告)号：WO1996020925A1
公开(公告)日：1996-07-11
申请号：PCT/JP1996000011
申请日：1996-01-08
申请人： TORAY INDUSTRIES, INC. , OHNO, Makiko +hf , OHTAKE, Atsushi , HOSHI, Kazuhiro , TSUKAMOTO, Shunji , TAKEDA, Takahiro , YAMADA, Naohiro , MATSUMOTO, Kazuhisa , OHNO, Michihiro
发明人： TORAY INDUSTRIES, INC. , OHNO, Makiko +hf , OHNO, Kiyotaka +di
IPC分类号： C07D209/08
CPC分类号： C07D307/79 , C07D209/08 , C07D307/86 , C07D407/12 , C07D409/12 , C07D413/06
摘要： A novel compound represented by general formula (I), having a potent TXA2 receptor antagonism and a PGI2 receptor agonism, and being useful in the treatment and prevention of diseases in which TXA2 participates. In said formula, the meaning of each symbol is as defined in the specification.
摘要翻译：由通式（I）表示的具有强的TXA2受体拮抗作用和PGI2受体激动作用的新化合物，可用于治疗和预防TXA2参与的疾病。在所述公式中，每个符号的含义如说明书中所定义。

4. 发明申请

WO1997017974A1 OCULAR DEPRESSOR 审中-公开
公开(公告)号：WO1997017974A1
公开(公告)日：1997-05-22
申请号：PCT/JP1996003351
申请日：1996-11-14
申请人： TORAY INDUSTRIES, INC. , KURUMATANI, Hajimu , KAWASHIMA, Ayako , ISOGAYA, Masafumi , WAKITA, Hisanori
发明人： TORAY INDUSTRIES, INC.
IPC分类号： A61K31/557
CPC分类号： A61K31/5585 , C07D307/93 , Y10S514/913
摘要： An ocular depressor containing as the active ingredient 4,8-inter-m-phenylene PGI2 derivatives typified by compounds represented by general formula (I), in particular, formula (II), or pharmacologically acceptable salts thereof. The drug is useful as a remedy for a number of states with high ocular tension such as glaucoma, ocular hypertension and postoperative high ocular tension.
摘要翻译：作为活性成分含有由通式（I）表示的化合物，特别是式（II）表示的化合物或其药理学上可接受的盐代表的活性成分4,8-间间苯撑PGI 2衍生物的眼压抑制剂。该药物可用作许多高眼压状态如青光眼，眼高压和术后高眼压的补救措施。

5. 发明申请

WO1997041864A1 OPHTHALMIC PREPARATIONS 审中-公开
标题翻译：眼科准备
公开(公告)号：WO1997041864A1
公开(公告)日：1997-11-13
申请号：PCT/JP1997001504
申请日：1997-05-01
申请人： KAKEN PHARMACEUTICAL CO., LTD. , TORAY INDUSTRIES, INC. , IKARI, Takashi , MATSUMURA, Yuzuru , NAKAMURA, Tsutomu , YAJIMA, Motoyuki , KURUMATANI, Hajimu , KAWASHIMA, Ayako , ISOGAYA, Masafumi , WAKITA, Hisanori
发明人： KAKEN PHARMACEUTICAL CO., LTD. , TORAY INDUSTRIES, INC.
IPC分类号： A61K31/557
CPC分类号： A61K31/5585 , C07D307/93 , Y10S514/913
摘要： Ophthalmic preparations exhibiting excellent pharmacological effects against various ophthalmic diseases, which comprise 4,8-inter-m-phenyleneprostaglandin I2 derivatives of general formula (I) or pharmacologically acceptable salts thereof as active ingredients.
摘要翻译：对各种眼科疾病具有优异的药理作用的眼科制剂，其包含通式（I）的4-8-间间苯二甲基前列腺素I2衍生物或其药理学上可接受的盐作为活性成分。

6. 发明申请

WO1990010003A1 PREPARATION OF 5,6,7-TRINOR-4,8-INTER-m-PHENYLENE PGI2 DERIVATIVES 审中-公开
标题翻译： 5,6,7-三硝基-4,8-间 - 间 - 苯基PGI 2衍生物的制备
公开(公告)号：WO1990010003A1
公开(公告)日：1990-09-07
申请号：PCT/JP1990000237
申请日：1990-02-27
申请人： TORAY INDUSTRIES, INC. , OHNO, Kiyotaka , NAGASE, Hiroshi , HOSONO, Yutaka , WAKITA, Hisanori , KAWAI, Koji , YOSHIWARA, Hideo
发明人： TORAY INDUSTRIES, INC.
IPC分类号： C07D307/93
CPC分类号： C07C43/247 , C07C2601/10 , C07D307/93
摘要： This invention provides a method of synthesizing 5,6,7-trinor-4,8-inter-m-phenylene PGI2 derivatives [VII] from 3a,8a-cis-dihydro-3H-5,7-dibromocyclopenta[b]benzofuran (1). The invention also provides two intermediates (8) and (11) used for preparing the compound (1).
摘要翻译：本发明提供了从3a，8a-顺 - 二氢-3H-5,7-二溴环戊二烯并[b]苯并呋喃（...）合成5,6,7-三硝基-4,8-间 - 间 - 亚苯基PGI 2衍生物[Ⅶ] 1）。本发明还提供用于制备化合物（1）的两种中间体（8）和（11）。

7. 发明申请

WO1994006785A1 NOVEL SULFONIC ACIDE DERIVATIVE AND MEDICINAL USE THEREOF 审中-公开
标题翻译：新型磺胺类药物衍生物和药物使用
公开(公告)号：WO1994006785A1
公开(公告)日：1994-03-31
申请号：PCT/JP1993001339
申请日：1993-09-17
申请人： TORAY INDUSTRIES, INC. , OHNO, Kiyotaka , OHTAKE, Atsushi , NISHIO, Shintaro , HOSHI, Kazuhiro , TSUKAMOTO, Shunji
发明人： TORAY INDUSTRIES, INC.
IPC分类号： C07D307/77
CPC分类号： C07D307/93
摘要： A sulfonamide derivative represented by general formula (I) and a thromboxane A2 receptor antagonist containing the same as the active ingredient, wherein R1 represents (i) -COOR2 wherein R2 represents (1) hydrogen, (2) a pharmacologically acceptable cation, or (3) a C1-C14 alkyl, or (ii) -C(=O)-R3 wherein R3 represents a C1-C4 alkyl; A represents (i) -(CH2)n- wherein n represents an integer of 0 to 3, (ii) -CH=CH-, or (iii) -O-C(R4)(R5)- wherein R4 and R5 may be the same or different from each other and each represents (1) hydrogen or (2) a C1-C4 alkyl, and W represents -NH- or -O-. This compound has an excellent thromboxane A2 receptor antagonism and hence can be used as a highly active and persistent thromboxane A2 receptor antagonist.
摘要翻译：由通式（I）表示的磺酰胺衍生物和含有与活性成分相同的凝血恶烷A2受体拮抗剂，其中R1表示（i）-COOR2，其中R2表示（1）氢，（2）药理学可接受的阳离子或（ 3）C 1 -C 14烷基，或（ii）-C（= O）-R 3，其中R 3表示C 1 -C 4烷基; A表示（i） - （CH 2）n - 其中n表示0至3的整数，（ii）-CH = CH-或（iii）-OC（R4）（R5） - 其中R4和R5可以是相同或不同，并且各自表示（1）氢或（2）C 1 -C 4烷基，W表示-NH-或-O-。该化合物具有优异的血栓素A2受体拮抗作用，因此可用作高活性和持续性血栓素A2受体拮抗剂。

8. 发明申请

WO1998023290A1 ANTIPRURITIC AGENT 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO1998023290A1
公开(公告)日：1998-06-04
申请号：PCT/JP1997004267
申请日：1997-11-21
申请人： TORAY INDUSTRIES, INC. , NAGASE, Hiroshi , UTSUMI, Jun , ENDOH, Takashi , TANAKA, Toshiaki , KAMEI, Junzo , KAWAMURA, Kuniaki
发明人： TORAY INDUSTRIES, INC.
IPC分类号： A61K45/00
CPC分类号： A61K31/541 , A61K31/40 , A61K31/4025 , A61K31/435 , A61K31/485 , A61K31/5377 , C07D489/00 , C07D489/08
摘要： An antipruritic agent comprising as the active ingredient an opioid kappa receptor agonist useful for the treatment of pruritus in various diseases accompanied by pruritus, and novel morphinane quaternary ammonium salt derivatives and morphinane N-oxide derivatives.
摘要翻译：包含作为活性成分的止痒剂，其可用于治疗伴有瘙痒症的各种疾病中的瘙痒症，以及新的吗啡烷季铵盐衍生物和吗啡烷N-氧化物衍生物。

9. 发明申请

WO1998021030A1 MULTI-LAYER MOLDINGS AND POLYPHENYLENE SULFIDE RESIN COMPOSITION 审中-公开
标题翻译：多层模塑和聚苯乙烯树脂组合物
公开(公告)号：WO1998021030A1
公开(公告)日：1998-05-22
申请号：PCT/JP1997004048
申请日：1997-11-06
申请人： TORAY INDUSTRIES, INC.
发明人： TORAY INDUSTRIES, INC. , TATEYAMA, Masaru , MATSUI, Kazufumi , SHIMIZU, Sachio , OHNO, Katsuya , SHIMASAKI, Norio , ISHIO, Atsushi , KOBAYASHI, Kazuhiko
IPC分类号： B32B27/00
CPC分类号： C08L81/02 , B32B1/08 , B32B27/08 , B32B27/286 , B32B27/32 , B32B27/34 , B32B27/36 , B32B2367/00 , B32B2377/00 , B32B2597/00 , C08L2666/02 , C08L2666/14
摘要： Multi-layer moldings comprising (A) a layer made of a polyphenylene sulfide resin (hereinafter abbreviated to "PPS resin") composition and (B) a layer made of thermoplastic resin other than the PPS resin which are laminated with each other, characterized in that the PPS resin composition forming the layer (A) is one comprising (A1) 100 parts by weight of a PPS resin, (A2) 1 to 80 parts by weight of a thermoplastic resin having at least one functional group selected among epoxy, acid anhydrides, carboxyl and salts thereof and carboxylate esters and (A3) 5 to 80 parts by weight of the same thermpolastic resin as that forming the layer (B). The moldings are excellent in resistance to hot water, antifreeze, chemicals, heat, wear and permeation of gases, and in tight adhesion between the layers.
摘要翻译：包括（A）由聚苯硫醚树脂（以下简称为“PPS树脂”）组合物制成的层和（B）彼此层压的除PPS树脂之外的由热塑性树脂制成的层的多层模制品，其特征在于，形成层（A）的PPS树脂组合物是包含（A1）100重量份的PPS树脂，（A2）1〜80重量份的具有至少一个官能团的热塑性树脂的环氧树脂，酸酸酐，羧基和其盐和羧酸酯，和（A3）5-80重量份与形成层（B）的相同的热塑性树脂。模制品在耐热水，防冻剂，化学品，热，磨损和气体渗透性以及层间密合性方面均优异。

10. 发明申请

WO1998003460A1 PROCESS FOR THE PREPARATION OF ALKYL CARBOXYLATES 审中-公开
标题翻译：制备羧酸烷基酯的方法
公开(公告)号：WO1998003460A1
公开(公告)日：1998-01-29
申请号：PCT/JP1997002488
申请日：1997-07-17
申请人： TORAY INDUSTRIES, INC. , SODA AROMATIC CO., LTD. , NIWA, Atsushi , IMAMURA, Shinzo , HASEBE, Akio , ITO, Nobuhiko
发明人： TORAY INDUSTRIES, INC. , SODA AROMATIC CO., LTD.
IPC分类号： C07C67/08
CPC分类号： C07C67/08 , C07C69/34
摘要： A process for preparing high-purity alkyl carboxylates efficiently by esterifying a carboxylic acid with an alcohol in the presence of an acid catalyst, characterized in that a solid acid catalyst is used as the catalyst and that the esterification is completed by conducting dehydration in the course of the esterification to remove the formed water from the reaction system and thereafter resuming the esterification. The dialkyl esters of alkanedioic acids prepared by the process can suitably be used as intermediates for the preparation of drugs, agricultural chemicals, perfumes, dyes, liquid-crystal materials, polymers and so on.
摘要翻译：一种通过在酸催化剂存在下用醇酯化羧酸而有效制备高纯度烷基羧酸盐的方法，其特征在于使用固体酸催化剂作为催化剂，通过在该过程中进行脱水来完成酯化反应的酯化反应以从反应体系中除去形成的水，然后恢复酯化。通过该方法制备的链烷二酸的二烷基酯可以适当地用作制备药物，农药，香料，染料，液晶材料，聚合物等的中间体。

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