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1. 发明申请

WO1997037178A1 HIGH VOLUME HYPERPOLARIZER FOR SPIN-POLARIZED NOBLE GAS 审中-公开
标题翻译：用于旋转极化气体的高容量超高分子
公开(公告)号：WO1997037178A1
公开(公告)日：1997-10-09
申请号：PCT/US1997005084
申请日：1997-03-27
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： THE TRUSTEES OF PRINCETON UNIVERSITY , CATES, Gordon, D., Jr. , DRIEHUYS, Bastian , HAPPER, William , MIRON, Eli , SAAM, Brian , WALTER, Daniel , MIDDLETON, Hunter
IPC分类号： F25J01/00
CPC分类号： G01R33/282 , A61K49/1815 , Y10S62/919 , Y10S62/925
摘要： A method and apparatus for accumulation of hyperpolarized 129Xe is disclosed. The method and apparatus of the invention enable the continuous or episodic accumulation of flowing hyperpolarized 129Xe in frozen form. The method also permits the accumulation of hyperpolarized 129Xe to the substantial exclusion of other gases, thereby enabling the purification of hyperpolarized 129Xe. The invention further includes 129Xe accumulation means (17) which is integrated with 129Xe hyperpolarization means in a continuous or pulsed flow arrangement. The method and apparatus enable large scale production, storage, and usage of hyperpolarized 129Xe for numerous purposes, including imaging of human and animal subject through magnetic resonance imaging (MRI) techniques.
摘要翻译：公开了一种用于积聚超极化的129Xe的方法和装置。本发明的方法和装置能够使流动的超极化的129Xe以冷冻形式连续或偶然地积累。该方法还允许超极化129Xe的积累以实质排除其它气体，从而使得能够纯化超极化的129Xe。本发明还包括与连续或脉冲流动布置的129Xe超极化装置集成的129Xe积累装置（17）。该方法和装置能够用于许多目的的超极化129Xe的大规模生产，储存和使用，包括通过磁共振成像（MRI）技术对人和动物受试者的成像。

2. 发明申请

WO1996039912A1 COATINGS FOR PRODUCTION OF HYPERPOLARIZED NOBLE GASES 审中-公开
标题翻译：用于生产超高性能气体的涂料
公开(公告)号：WO1996039912A1
公开(公告)日：1996-12-19
申请号：PCT/US1996009402
申请日：1996-06-07
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： THE TRUSTEES OF PRINCETON UNIVERSITY , DRIEHUYS, Bastiaan , HAPPER, William , CATES, Gordon, D., Jr.
IPC分类号： A47G19/22
CPC分类号： G01R33/282 , A61K49/1815 , B65D25/14 , C01B23/00 , F17C1/16 , F17C2203/0607 , F17C2221/07 , F17C2270/0536 , Y10T428/1321 , Y10T428/31612
摘要： The invention provides a method of inhibiting surface-induced nuclear spin relaxation and surface trapping of a hyperpolarized noble gas, most preferably Xe, by polymercoated surfaces. The method includes inhibiting the amount of interaction of the noble gas with a polymeric coating on the surface of apparatus which contacts the noble gas. Preferably, the method includes inhibiting noble gas nuclear spin relaxation by replacing at least some of the protons in the polymer with substituents which have non-zero nuclear spin and/or reduced polymer permeability. A preferred substituent having non-zero spin is deuterium. A preferred modification which reduces permeability includes introducing into the polymer a substituent such as a halogen, more preferably fluorine. The method also provides containers having surfaces which have been coated with a polymer which inhibits noble gas trapping and nuclear spin relaxation. Furthermore, the invention provides methods for enhancing the production and storage of a hyperpolarized noble gas by decreasing the relaxation of nuclear spin and limiting the trapping of the noble gas in a polymeric coating of apparatus containing the noble gas.
摘要翻译：本发明提供一种通过聚合物涂层表面抑制表面诱导的核自旋松弛和超极化惰性气体，最优选<129> Xe的表面捕获的方法。该方法包括抑制惰性气体与接触惰性气体的设备表面上的聚合物涂层的相互作用量。优选地，该方法包括通过用具有非零核自旋和/或降低的聚合物渗透性的取代基代替聚合物中的至少一些质子来抑制惰性气体核自旋弛豫。具有非零自旋的优选取代基是氘。降低渗透性的优选改进方案包括向聚合物中引入取代基如卤素，更优选氟。该方法还提供具有已经涂覆有抑制惰性气体捕获和核自旋弛豫的聚合物的表面的容器。此外，本发明提供了通过减少核旋转的松弛并限制在含有惰性气体的装置的聚合物涂层中捕集惰性气体来增强超极化惰性气体的生产和储存的方法。

3. 发明申请

WO1997037177A1 CRYOGENIC ACCUMULATOR FOR SPIN-POLARIZED XENON-129 审中-公开
标题翻译：用于旋转极化XENON-129的低温累加器
公开(公告)号：WO1997037177A1
公开(公告)日：1997-10-09
申请号：PCT/US1997005004
申请日：1997-03-27
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： THE TRUSTEES OF PRINCETON UNIVERSITY , CATES, Gordon, D., Jr. , DRIEHUYS, Bastiaan , HAPPER, William , MIRON, Eli , SAAM, Brian , WALTER, Daniel
IPC分类号： F25J01/00
CPC分类号： G01R33/282 , A61K49/1815 , C01B23/0036 , C01B2210/0037 , F25J3/0685 , F25J2205/20 , F25J2210/42 , F25J2215/36 , F25J2270/60 , F25J2270/904 , F25J2290/62 , H05H3/02 , Y10S62/919 , Y10S62/925
摘要： A method and apparatus for accumulation of hyperpolarized X e is disclosed. The method and apparatus of the invention enable the continuous or episodic accumulation of flowing hyperpolarized Xe in frozen form. The method also permits the accumulation of hyperpolarized Xe. The invention further includes Xe accumulation means (17) which is integrated with Xe hyperpolarization means in a continuous or pulsed flow arrangement. The method and apparatus enable large scale production, storage, and usage of hyperpolarized Xe for numerous purposes, including imaging of human and animal subjects through magnetic resonance imaging (MRI) techniques.
摘要翻译：公开了一种用于积极超极化X e的方法和装置。本发明的方法和装置能够使冷冻形式的流动超极化的Xe连续或偶然地积累。该方法还允许超极化the积累。本发明还包括与连续或脉冲流动布置的129氙超极化装置集成的Xe积累装置（17）。该方法和装置能够通过磁共振成像（MRI）技术在许多目的上大规模地生产，储存和使用超极化的Xe，包括人类和动物受试者的成像。

4. 发明申请

WO1995027438A1 MAGNETIC RESONANCE IMAGING USING HYPERPOLARIZED NOBLE GASES 审中-公开
标题翻译：使用超高压NOBLE气体的磁共振成像
公开(公告)号：WO1995027438A1
公开(公告)日：1995-10-19
申请号：PCT/US1995004175
申请日：1995-04-04
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , THE TRUSTEES OF PRINCETON UNIVERSITY OFFICE OF RESEARCH AND PROJECT ADMINISTRATION
发明人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , THE TRUSTEES OF PRINCETON UNIVERSITY OFFICE OF RESEARCH AND PROJECT ADMINISTRATION , BALAMORE, Dilip , CATES, Gordon, D., Jr. , DRIEHUYS, Bastiaan , HAPPER, William , SAAM, Brian , WISHNIA, Arnold , ALBERT, Mitchell, S.
IPC分类号： A61B05/055
CPC分类号： G01R33/5601 , A61K49/1806 , A61K49/1815 , G01R33/282 , Y10T436/24
摘要： A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of the noble gas. The noble gas is selected from noble gas isotopes having nuclear spin, preferably Xenon-129 and/or Helium-3. The noble gas is at least thermally or equilibrium polarized and is preferably hyperpolarized, most preferably hyperpolarized by optical (laser) pumping in the presence of an alkali metal or by metastability exchange. The generation of the representation of the noble gas spatial distribution includes at least one dimension, preferably 2 or 3 dimensions of the spatial distribution. The noble gas may be imaged according to the invention in chemical or biological systems, preferably in a human or animal subject or organ system or tissue thereof. Also, apparatus for nuclear magnetic resonance imaging of the spatial distribution of at least one noble gas includes means for imaging a noble gas by NMR spectrometry and means for providing and/or storing imageable quantities of a noble gas, preferably hyperpolarized Xenon-129 and/or Helium-3. Also, a medical composition includes a medically acceptable bifunctional gas effective for in vivo anesthesiological and NMR imaging functions, including at least one noble gas, preferably hyperpolarized Xenon-129 and/or Helium-3.
摘要翻译：通过核磁共振光谱法对惰性气体的空间分布进行成像的方法包括通过NMR光谱法检测至少一种惰性气体的空间分布，并产生稀有气体的所述空间分布的表示。稀有气体选自具有核自旋的惰性气体同位素，优选氙129和/或氦-3。惰性气体至少是热或平衡极化的，并且优选是超极化的，最优选通过在碱金属存在下的光学（激光）泵送或通过亚稳定性交换进行超极化。惰性气体空间分布的表示的产生包括空间分布的至少一个维度，优选2或3维度。惰性气体可以根据本发明在化学或生物系统中成像，优选在人或动物受试者或器官系统或组织中成像。此外，用于核磁共振成像至少一种稀有气体的空间分布的装置包括用于通过NMR光谱法成像惰性气体的装置，以及用于提供和/或存储可成像量的惰性气体，优选超极化氙129和/ 或氦-3。此外，医疗组合物包括有效体内麻醉和NMR成像功能的医学上可接受的双功能气体，包括至少一种惰性气体，优选超极化氙129和/或氦-3。

5. 发明公开

EP0896655A1 HIGH VOLUME HYPERPOLARIZER FOR SPIN-POLARIZED NOBLE GAS 失效
标题翻译： DEVICE FOR自旋极化惰性气体的高容量HYPER极化
公开(公告)号：EP0896655A1
公开(公告)日：1999-02-17
申请号：EP97917681.0
申请日：1997-03-27
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： CATES, Gordon, D., Jr. , DRIEHUYS, Bastian , HAPPER, William , MIRON, Eli , SAAM, Brian , WALTER, Daniel , MIDDLETON, Hunter
IPC分类号： F25J1 , A61B5 , A61K49 , G01R33
CPC分类号： G01R33/282 , A61K49/1815 , Y10S62/919 , Y10S62/925
摘要： A method and apparatus for hyperpolarization of flowing noble gases is disclosed. The apparatus is capable of hyperpolarizing noble gases in a continuous flow arrangement. Noble gases such as xenon-129 and helium-3 can be hyperpolarized using the disclosed method and apparatus. Preferably, the noble gas is hyperpolarized via spin exchange between atoms of the noble gas and an alkali metal such as rubidium. Also, a method and apparatus for accumulation (17) and/or storage of hyperpolarized noble gases in a continuous flow arrangement is provided. The method and apparatus enable large scale production, storage, and usage of hyperpolarized noble gases for numerous purposes, including imaging of human and animal subjects through magnetic resonance imaging (MRI) techniques.

6. 发明授权

EP1015086B1 SPIN POLARIZATION OF A NOBLE GAS VIA SPIN-EXCHANGE WITH OPTICALLY POLARIZED ALKALI METALS 有权
标题翻译：具有光学SPIN交易所的惰性气体的自旋极化泵送碱金属
公开(公告)号：EP1015086B1
公开(公告)日：2007-07-04
申请号：EP98940943.8
申请日：1998-08-17
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： ROMALIS, Mikhail, V. , ERICKSON, Christopher, J. , CATES, Gordon, D., Jr. , HAPPER, William
IPC分类号： B01D1/00 , G01R33/28
CPC分类号： G01R33/282
摘要： The present invention relates to a method and apparatus for hyperpolarizing a noble gas by spin-exchange optical pumping which includes a polarization cell containing the noble gas, a primary alkali metal and an auxiliary alkali metal. The polarization cell is illuminated with radiation to optically polarize the primary alkali metal. This enables spin-exchange interaction between the primary alkali metal, the auxiliary alkali metal and the noble gas resulting in a hyperpolarized noble gas.

7. 发明公开

EP1015086A2 ALKALI METAL HYBRID SPIN-EXCHANGE OPTICAL PUMPING 有权
标题翻译：具有光学SPIN交易所的惰性气体的自旋极化泵送碱金属
公开(公告)号：EP1015086A2
公开(公告)日：2000-07-05
申请号：EP98940943.8
申请日：1998-08-17
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： ROMALIS, Mikhail, V. , ERICKSON, Christopher, J. , CATES, Gordon, D., Jr. , HAPPER, William
IPC分类号： B01D1/00
CPC分类号： G01R33/282
摘要： The present invention relates to a method and apparatus for hyperpolarizing a noble gas by spin-exchange optical pumping which includes a polarization cell containing the noble gas, a primary alkali metal and an auxiliary alkali metal. The polarization cell is illuminated with radiation to optically polarize the primary alkali metal. This enables spin-exchange interaction between the primary alkali metal, the auxiliary alkali metal and the noble gas resulting in a hyperpolarized noble gas.

8. 发明授权

EP0837641B1 CONTAINER FOR HYPERPOLARIZED NOBLE GASES HAVING A SURFACE COATED WITH A MODIFIED POLYMER 失效
标题翻译：容器超极化稀有气体与改性聚合物涂在表面
公开(公告)号：EP0837641B1
公开(公告)日：2007-11-14
申请号：EP96918293.0
申请日：1996-06-07
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： DRIEHUYS, Bastiaan , HAPPER, William , CATES, Gordon, D., Jr.
IPC分类号： C08G77/12 , C08L83/04 , C09D183/04 , A47G19/22 , B32B1/08 , B32B9/00 , B32B17/06 , B05D3/00
CPC分类号： G01R33/282 , A61K49/1815 , B65D25/14 , C01B23/00 , F17C1/16 , F17C2203/0607 , F17C2221/07 , F17C2270/0536 , Y10T428/1321 , Y10T428/31612
摘要： The invention provides a method of inhibiting surface-induced nuclear spin relaxation and surface trapping of a hyperpolarized noble gas, most preferably Xe, by polymercoated surfaces. The method includes inhibiting the amount of interaction of the noble gas with a polymeric coating on the surface of apparatus which contacts the noble gas. Preferably, the method includes inhibiting noble gas nuclear spin relaxation by replacing at least some of the protons in the polymer with substituents which have non-zero nuclear spin and/or reduced polymer permeability. A preferred substituent having non-zero spin is deuterium. A preferred modification which reduces permeability includes introducing into the polymer a substituent such as a halogen, more preferably fluorine. The method also provides containers having surfaces which have been coated with a polymer which inhibits noble gas trapping and nuclear spin relaxation. Furthermore, the invention provides methods for enhancing the production and storage of a hyperpolarized noble gas by decreasing the relaxation of nuclear spin and limiting the trapping of the noble gas in a polymeric coating of apparatus containing the noble gas.

9. 发明授权

EP0890066B1 CRYOGENIC ACCUMULATOR FOR SPIN-POLARIZED XENON-129 失效
标题翻译：低温贮藏FOR自旋极化氙129
公开(公告)号：EP0890066B1
公开(公告)日：2003-03-19
申请号：EP97917656.7
申请日：1997-03-27
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： CATES, Gordon, D., Jr. , DRIEHUYS, Bastiaan , HAPPER, William , MIRON, Eli, Dr. , SAAM, Brian, Washington University at St. Louis , WALTER, Daniel
IPC分类号： F25J1/00 , A61K49/00 , G01R33/28
CPC分类号： G01R33/282 , A61K49/1815 , C01B23/0036 , C01B2210/0037 , F25J3/0685 , F25J2205/20 , F25J2210/42 , F25J2215/36 , F25J2270/60 , F25J2270/904 , F25J2290/62 , H05H3/02 , Y10S62/919 , Y10S62/925
摘要： A method and apparatus for accumulation of hyperpolarized 129X e is disclosed. The method and apparatus of the invention enable the continuous or episodic accumulation of flowing hyperpolarized 129Xe in frozen form. The method also permits the accumulation of hyperpolarized 129Xe. The invention further includes 129Xe accumulation means (17) which is integrated with 129Xe hyperpolarization means in a continuous or pulsed flow arrangement. The method and apparatus enable large scale production, storage, and usage of hyperpolarized 129Xe for numerous purposes, including imaging of human and animal subjects through magnetic resonance imaging (MRI) techniques.

10. 发明公开

EP0890066A1 CRYOGENIC ACCUMULATOR FOR SPIN-POLARIZED XENON-129 失效
标题翻译：低温内存自旋极化氙129
公开(公告)号：EP0890066A1
公开(公告)日：1999-01-13
申请号：EP97917656.0
申请日：1997-03-27
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： CATES, Gordon, D., Jr. , DRIEHUYS, Bastiaan , HAPPER, William , MIRON, Eli , SAAM, Brian , WALTER, Daniel
IPC分类号： A61B5 , A61K49 , C01B23 , F25J1 , F25J3 , G01R33 , H05H3
CPC分类号： G01R33/282 , A61K49/1815 , C01B23/0036 , C01B2210/0037 , F25J3/0685 , F25J2205/20 , F25J2210/42 , F25J2215/36 , F25J2270/60 , F25J2270/904 , F25J2290/62 , H05H3/02 , Y10S62/919 , Y10S62/925
摘要： A method and apparatus for accumulation of hyperpolarized 129X e is disclosed. The method and apparatus of the invention enable the continuous or episodic accumulation of flowing hyperpolarized 129Xe in frozen form. The method also permits the accumulation of hyperpolarized 129Xe. The invention further includes 129Xe accumulation means (17) which is integrated with 129Xe hyperpolarization means in a continuous or pulsed flow arrangement. The method and apparatus enable large scale production, storage, and usage of hyperpolarized 129Xe for numerous purposes, including imaging of human and animal subjects through magnetic resonance imaging (MRI) techniques.

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