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1. 发明申请

WO1995014081A1 METHOD FOR DETECTION OF INFLAMMATORY AGENTS 审中-公开
标题翻译：检测炎症因子的方法
公开(公告)号：WO1995014081A1
公开(公告)日：1995-05-26
申请号：PCT/US1994013236
申请日：1994-11-18
申请人： THE SCRIPPS RESEARCH INSTITUTE
发明人： THE SCRIPPS RESEARCH INSTITUTE , PUGIN, Jerome , ULEVITCH, Richard , TOBIAS, Peter, S.
IPC分类号： C12N05/08
CPC分类号： G01N33/56972 , G01N33/5005 , G01N33/6863 , G01N2333/525 , G01N2333/54 , G01N2333/70596 , G01N2400/50
摘要： An improved method for detection of agents in an analyte sample from a mammal, which agents will stimulate mononuclear cells to release factors for endothelial cell activation. The method is based on the discovery that an indirect pathway for endothelial cell activation mediated by mononuclear blood cells is substantially more efficient in stimulating the production of cytokines and cell adhesion molecules by endothelial cells than a direct, serum-dependent pathway. The method of the invention therefore utilizes the indirect pathway to activate cultured endothelial cells by exposing them to an amplification mixture comprising the analyte sample and mononuclear blood cells. Activation, if any, of the cultured endothelial cells is then determined by described detection means. Using this improved method, mononuclear cell stimulatory agents (such as inflammatory agents) can be detected in an analyte sample at picomolar or greater concentrations.
摘要翻译：用于检测来自哺乳动物的分析物样品中的试剂的改进方法，所述试剂将刺激单核细胞释放内皮细胞活化因子。该方法基于以下发现：由单核血细胞介导的内皮细胞活化的间接途径在内皮细胞刺激细胞因子和细胞粘附分子的产生方面比直接的血清依赖性途径更有效。因此，本发明的方法利用间接途径将培养的内皮细胞暴露于包含分析物样品和单核血细胞的扩增混合物中。然后通过描述的检测手段确定培养的内皮细胞的活化（如果有的话）。使用这种改进的方法，可以在皮摩尔浓度或更高浓度的分析物样品中检测单核细胞刺激剂（如炎症剂）。

2. 发明申请

WO1995014039A1 MONOCLONAL ANTIBODIES IMMUNOREACTIVE WITH LIPOPOLYSACCHARIDE BINDING PROTEIN (LBP) AND METHODS OF THEIR USE 审中-公开
标题翻译：单克隆抗体与脂多糖结合蛋白（LBP）的免疫反应及其使用方法
公开(公告)号：WO1995014039A1
公开(公告)日：1995-05-26
申请号：PCT/US1994013199
申请日：1994-11-15
申请人： THE SCRIPPS RESEARCH INSTITUTE
发明人： THE SCRIPPS RESEARCH INSTITUTE , KIRKLAND, Theo , TOBIAS, Peter , ULEVITCH, Richard , MORIARTY, Ann , LETURCQ, Didier
IPC分类号： C07K16/18
CPC分类号： A61K49/0058 , A61K38/00 , A61K49/0043 , A61K51/1018 , C07K16/18 , Y10S436/804
摘要： The present invention concerns a method of treating LBP-mediated LPS-induced myeloid cell activation comprising administering a therapeutically effective amount of an anti-LBP monoclonal antibody molecule. A therapeutic composition comprising anti-LBP antibody molecules in a pharmaceutically acceptable excipient is also contemplated.
摘要翻译：本发明涉及治疗LBP介导的LPS诱导的骨髓细胞活化的方法，包括给予治疗有效量的抗LBP单克隆抗体分子。还考虑了在药学上可接受的赋形剂中包含抗LBP抗体分子的治疗组合物。

3. 发明授权

EP0485430B1 METHODS AND COMPOSITIONS FOR AMELIORATING THE SYMPTOMS OF SEPSIS 有权转让
标题翻译：方法和组合物用于改善败血症的症状
公开(公告)号：EP0485430B1
公开(公告)日：1998-09-16
申请号：EP90911485.2
申请日：1990-07-30
申请人： THE SCRIPPS RESEARCH INSTITUTE , ROCKEFELLER UNIVERSITY
发明人： ULEVITCH, Richard , TOBIAS, Peter , WRIGHT, Samuel, D. , MATHISON, John, D.
IPC分类号： A01N37/18 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2896 , A61K38/00 , A61K39/395 , A61K2039/505 , A61K2039/545 , A61K2300/00

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