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1. 发明申请

WO2012061653A3 BIOFUEL AND CHEMICAL PRODUCTION BY RECOMBINANT MICROORGANISMS VIA FERMENTATION OF PROTEINACIOUS BIOMASS 审中-公开
公开(公告)号：WO2012061653A3
公开(公告)日：2012-05-10
申请号：PCT/US2011/059231
申请日：2011-11-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , CHO, Kwang, Myung , YAN, Yajun , HUO, Yixin
发明人： LIAO, James, C. , CHO, Kwang, Myung , YAN, Yajun , HUO, Yixin
IPC分类号： C12N1/21 , C12N1/19 , C12N1/15 , C12N15/63 , C12N15/52 , C12P7/00 , C12P13/00
摘要： Provided herein are metabolically modified microorganisms characterized by having an increased keto-acid flux when compared with the wild-type organism and comprising at least one polynucleotide encoding an enzyme that when expressed results in the production of a greater quantity of a chemical product when compared with the wild-type organism. The recombinant microorganisms are useful for producing a large number of chemical compositions from various nitrogen containing biomass compositions and other carbon sources. More specifically, provided herein are methods of producing alcohols, acetaldehyde, acetate, isobutyraldehyde, isobutyric acid, n- butyraldehyde, n-butyric acid, 2-methyl-l-butyraldehyde, 2-methyl-l -butyric acid, 3- methyl-l-butyraldehyde, 3 -methyl- 1 -butyric acid, ammonia, ammonium, amino acids, 2,3-butanediol, 1,4-butanediol, 2-methyl-l, 4-butanediol, 2-methyl- 1,4-butanediamine, isobutene, itaconate, acetoin, acetone, isobutene, 1,5-diaminopentane, L-lactic acid, D- lactic acid, shikimic acid, mevalonate, polyhydroxybutyrate (PHB), isoprenoids, fatty acids, homoalanine, 4-aminobutyric acid (GABA), succinic acid, malic acid, citric acid, adipic acid, p-hydroxy-cinnamic acid, tetrahydrofuran, 3-methyl-tetrahydrofuran, gamma-butyrolactone, pyrrolidinone, n-methylpyrrolidone, aspartic acid, lysine, cadeverine, 2-ketoadipic acid, and/or S-adenosyl-methionine (SAM) from a suitable nitrogen rich biomass.

2. 发明申请

WO2011137369A1 PRODUCTION OF GAMMA-AMINOBUTYRIC ACID BY RECOMBINANT MICROORGANISMS 审中-公开
标题翻译：通过重组微生物生产游离氨基酸
公开(公告)号：WO2011137369A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/034612
申请日：2011-04-29
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , CHO, Kwang, Myung
发明人： LIAO, James, C. , CHO, Kwang, Myung
IPC分类号： C12N1/21 , C12N9/88 , C12P13/00
CPC分类号： C12N9/88 , C12P13/005
摘要： Provided herein are metabolically-modified microorganisms useful for producing gamma-aminobutyric acid.
摘要翻译：本文提供了可用于产生γ-氨基丁酸的代谢修饰的微生物。

3. 发明申请

WO2011106696A3 COMPOSITIONS AND METHODS FOR THE PRODUCTION OF L-HOMOALANINE 审中-公开
标题翻译：用于生产L-高香赖氨酸的组合物和方法
公开(公告)号：WO2011106696A3
公开(公告)日：2011-09-01
申请号：PCT/US2011/026315
申请日：2011-02-25
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , ZHANG, Kechun , CHO, Kwang, Myung
发明人： LIAO, James, C. , ZHANG, Kechun , CHO, Kwang, Myung
IPC分类号： C12N9/04 , C07K14/00 , C07H21/00
摘要： Healthcare costs are a significant worldwide, with many patients being denied medications because of their high prices. One approach to addressing this problem involves the biosynthesis of chiral drug intermediates, an environmentally friendly solution that can be used to generate pharmaceuticals at much lower costs than conventional techniques. In this context, embodiments of the invention comprise methods and materials designed to allow microorganisms to biosynthesize the nonnatural amino acid L-homoalanine. As is known in the art, L-homoalanine is a chiral precursor of a variety of pharmaceutically valuable compounds including the anticonvulsant medications levetiracetam (sold under the trade name Keppra®) and brivaracetam, as well as ethambutol, a bacteriostatic antimycobacterial drug used to treat tuberculosis. Consequently, embodiments of the invention can be used in low cost, environmentally friendly processes to generate these and other valuable compounds.
摘要翻译：医疗保健费用在全球范围内非常重要，许多患者由于其高昂的价格而被拒绝服用药物。解决此问题的一种方法涉及手性药物中间体的生物合成，这是一种环保型溶液，可用于以比传统技术低得多的成本生成药物。在这种情况下，本发明的实施方案包括设计成允许微生物生物合成非天然氨基酸L-高丙氨酸的方法和材料。如本领域所知，L-高丙氨酸是多种药学上有价值的化合物的手性前体，包括抗惊厥药物左乙拉西坦（以商品名Keppra销售）和布立西坦，以及乙胺丁醇（一种抑菌抗分枝杆菌药物，用于治疗结核。因此，本发明的实施例可以用于低成本，环境友好的工艺中以产生这些和其他有价值的化合物。

4. 发明申请

WO2011057288A2 ISOBUTANOL PRODUCTION WITH CORYNEBACTERIUM GLUTAMICUM 审中-公开
标题翻译： ISOBUTANOL生产与CORYNEBACTERIUM GLUTAMICUM
公开(公告)号：WO2011057288A2
公开(公告)日：2011-05-12
申请号：PCT/US2010/056068
申请日：2010-11-09
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , SMITH, Kevin, M. , CHO, Kwang-Myung
发明人： LIAO, James, C. , SMITH, Kevin, M. , CHO, Kwang-Myung
IPC分类号： C12N1/21 , C12N15/52 , C12P7/16 , C12R1/15
CPC分类号： C12P7/16 , C12N9/88 , C12P7/04 , C12P7/22 , Y02E50/10
摘要： Provided herein are metabolically-modif ied microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1- butanol, 1-propanol, 2-methyl-l-butanol, 3-methyl-l-butanol and 2- phenylethanol from a suitable substrate.
摘要翻译：本文提供了可用于生产生物燃料的代谢修饰的微生物。更具体地，本文提供了从合适的底物生产高级醇，包括异丁醇，1-丁醇，1-丙醇，2-甲基-1-丁醇，3-甲基-1-丁醇和2-苯基乙醇的方法。

5. 发明申请

WO2011088425A2 ELECTRO-AUTOTROPHIC SYNTHESIS OF HIGHER ALCOHOLS 审中-公开
标题翻译：电子自动合成高级酒精
公开(公告)号：WO2011088425A2
公开(公告)日：2011-07-21
申请号：PCT/US2011/021436
申请日：2011-01-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , CHO, Kwang-Myung
发明人： LIAO, James, C. , CHO, Kwang-Myung
CPC分类号： C12P7/22 , C12N9/0006 , C12N9/88 , C12P7/04 , C12P7/16 , C12Y101/01001 , C12Y401/01072 , Y02E50/10 , Y02P20/134 , Y02P20/52 , Y02P20/59
摘要： The disclosure provides a process that converts CO 2 to higher alcohols (e.g. isobutanol) using electricity as the energy source. This process stores electricity (e.g. from solar energy, nuclear energy, and the like) in liquid fuels that can be used as high octane number gasoline substitutes. Instead of deriving reducing power from photosynthesis, this process derives reducing power from electrically generated mediators, either H 2 or formate. H 2 can be derived from electrolysis of water. Formate can be generated by electrochemical reduction of CO 2 . After delivering the reducing power in the cell, formate becomes CO 2 and recycles back. Therefore, the biological CO 2 fixation process can occur in the dark.
摘要翻译：本公开提供了使用电作为能量源将CO 2转化为高级醇（例如异丁醇）的方法。该方法在可用作高辛烷值汽油替代物的液体燃料中储存电力（例如来自太阳能，核能等）。不是从光合作用中获得降低功率，而是从电生成的介质H2或甲酸中减少功率。 H2可以从电解水中得到。甲酸可以通过电化学还原二氧化碳产生。在细胞中提供还原能力后，甲酸成为二氧化碳并循环回收。因此，生物二氧化碳固定过程可能发生在黑暗中。

6. 发明申请

WO2011137192A1 PRODUCTION OF 1,4-BUTANEDIOL BY RECOMBINANT MICROORGANISMS 审中-公开
标题翻译：通过重组微生物生产1,4-丁二醇
公开(公告)号：WO2011137192A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/034198
申请日：2011-04-27
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , YAN, Yajun
发明人： LIAO, James, C. , YAN, Yajun
IPC分类号： C12P7/16 , C12P7/18
CPC分类号： C12N15/70 , C12N15/52 , C12P7/16 , C12P7/18 , Y02E50/10
摘要： Provided herein are metabolically-modified microorganisms useful for producing 1,4-butanediol.
摘要翻译：本文提供了可用于生产1,4-丁二醇的代谢改性微生物。

7. 发明申请

WO2010045629A2 PRODUCTION OF C5-C8 ALCOHOLS USING EVOLVED ENZYMES AND METABOLICALLY ENGINEERED MICROORGANISMS 审中-公开
标题翻译：用改进的酶和代谢工程微生物生产C5-C8醇
公开(公告)号：WO2010045629A2
公开(公告)日：2010-04-22
申请号：PCT/US2009/061116
申请日：2009-10-18
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , ZHANG, Kechun
发明人： LIAO, James, C. , ZHANG, Kechun
IPC分类号： C12N9/00 , C12N1/21 , C12N15/52 , C12P7/04
CPC分类号： C12P7/04 , C12N9/1022 , C12N9/1025 , C12N9/88 , C12P7/16 , C12Y203/03013 , Y02E50/10
摘要： Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing higher alcohols including C5- C8 alcohol from a suitable substrate.
摘要翻译：本文提供了用于生产生物燃料的代谢修饰微生物。更具体地说，本文提供了从合适的底物生产包括C 5 -C 8醇的高级醇的方法。

8. 发明申请

WO2009049274A2 MICROORGANISM ENGINEERED TO PRODUCE ISOPROPANOL 审中-公开
标题翻译：微生物工程生产异丙酚
公开(公告)号：WO2009049274A2
公开(公告)日：2009-04-16
申请号：PCT/US2008/079667
申请日：2008-10-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , ATSUMI, Shota , HANAI, Taizo
发明人： LIAO, James, C. , ATSUMI, Shota , HANAI, Taizo
IPC分类号： C12P21/06 , C12P7/04
CPC分类号： C12P7/04
摘要： Provided herein are metabolically-modified microorganisms useful for producing biofuels.
摘要翻译：本文提供了可用于生产生物燃料的经代谢修饰的微生物。

9. 发明申请

WO2011037598A1 CONVERSION OF CO2 TO HIGHER ALCOHOLS USING RECOMBINANT PHOTOSYNTHETIC MICROORGANISMS 审中-公开
标题翻译：使用重组光化学微生物将二氧化碳转化成高级酒精
公开(公告)号：WO2011037598A1
公开(公告)日：2011-03-31
申请号：PCT/US2009/068868
申请日：2009-12-18
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , ATSUMI, Shota
发明人： LIAO, James, C. , ATSUMI, Shota
IPC分类号： C12N15/03
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/1022 , C12N9/88 , C12P7/04 , C12P7/22 , C12Y101/01002 , C12Y202/01006 , C12Y401/01039 , C12Y402/01009 , Y02E50/10
摘要： Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1- butanol, 1-propanol, 2-methyl-1-butanol, 3-methyl-1-butanol and 2- phenylethanol from a suitable substrate.
摘要翻译：本文提供了可用于生产生物燃料的经代谢修饰的微生物。更具体地，本文提供了从合适的底物生产高级醇的方法，其包括异丁醇，1-丁醇，1-丙醇，2-甲基-1-丁醇，3-甲基-1-丁醇和2-苯基乙醇。

10. 发明申请

WO2008098227A2 BIOFUEL PRODUCTION BY RECOMBINANT MICROORGANISMS 审中-公开
标题翻译：重组微生物生物燃料生产
公开(公告)号：WO2008098227A2
公开(公告)日：2008-08-14
申请号：PCT/US2008/053514
申请日：2008-02-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , ATSUMI, Shota , SMITH, Kevin, M. , SHEN, Roa Pu, Claire , CANN, Anthony, F. , CONNOR, Michael, R.
发明人： LIAO, James, C. , ATSUMI, Shota , SMITH, Kevin, M. , SHEN, Roa Pu, Claire , CANN, Anthony, F. , CONNOR, Michael, R.
IPC分类号： C12N1/21
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/1022 , C12N9/1025 , C12N9/1029 , C12N9/88 , C12N15/52 , C12P7/04 , C12P7/22 , C12Y101/01001 , C12Y101/01085 , C12Y101/01086 , C12Y202/01006 , C12Y203/01182 , C12Y203/03013 , C12Y401/01 , C12Y402/01009 , C12Y402/01019 , C12Y402/01033 , Y02E50/10 , Y02E50/17
摘要： Provided herein are metabolically-modif ied microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1-butanol, 1-propanol, 2-methyl-l-butanol, 3- methyl-1-butanol and 2-phenylethanol from a suitable substrate.
摘要翻译：本文提供了用于生产生物燃料的代谢改性的微生物。更具体而言，本文提供了由合适的底物生产高级醇的方法，所述高级醇包括异丁醇，1-丁醇，1-丙醇，2-甲基-1-丁醇，3-甲基-1-丁醇和2-苯基乙醇。

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