专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011106696A3 COMPOSITIONS AND METHODS FOR THE PRODUCTION OF L-HOMOALANINE 审中-公开
标题翻译：用于生产L-高香赖氨酸的组合物和方法
公开(公告)号：WO2011106696A3
公开(公告)日：2011-09-01
申请号：PCT/US2011/026315
申请日：2011-02-25
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , ZHANG, Kechun , CHO, Kwang, Myung
发明人： LIAO, James, C. , ZHANG, Kechun , CHO, Kwang, Myung
IPC分类号： C12N9/04 , C07K14/00 , C07H21/00
摘要： Healthcare costs are a significant worldwide, with many patients being denied medications because of their high prices. One approach to addressing this problem involves the biosynthesis of chiral drug intermediates, an environmentally friendly solution that can be used to generate pharmaceuticals at much lower costs than conventional techniques. In this context, embodiments of the invention comprise methods and materials designed to allow microorganisms to biosynthesize the nonnatural amino acid L-homoalanine. As is known in the art, L-homoalanine is a chiral precursor of a variety of pharmaceutically valuable compounds including the anticonvulsant medications levetiracetam (sold under the trade name Keppra®) and brivaracetam, as well as ethambutol, a bacteriostatic antimycobacterial drug used to treat tuberculosis. Consequently, embodiments of the invention can be used in low cost, environmentally friendly processes to generate these and other valuable compounds.
摘要翻译：医疗保健费用在全球范围内非常重要，许多患者由于其高昂的价格而被拒绝服用药物。解决此问题的一种方法涉及手性药物中间体的生物合成，这是一种环保型溶液，可用于以比传统技术低得多的成本生成药物。在这种情况下，本发明的实施方案包括设计成允许微生物生物合成非天然氨基酸L-高丙氨酸的方法和材料。如本领域所知，L-高丙氨酸是多种药学上有价值的化合物的手性前体，包括抗惊厥药物左乙拉西坦（以商品名Keppra销售）和布立西坦，以及乙胺丁醇（一种抑菌抗分枝杆菌药物，用于治疗结核。因此，本发明的实施例可以用于低成本，环境友好的工艺中以产生这些和其他有价值的化合物。

2. 发明申请

WO2010045629A2 PRODUCTION OF C5-C8 ALCOHOLS USING EVOLVED ENZYMES AND METABOLICALLY ENGINEERED MICROORGANISMS 审中-公开
标题翻译：用改进的酶和代谢工程微生物生产C5-C8醇
公开(公告)号：WO2010045629A2
公开(公告)日：2010-04-22
申请号：PCT/US2009/061116
申请日：2009-10-18
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , ZHANG, Kechun
发明人： LIAO, James, C. , ZHANG, Kechun
IPC分类号： C12N9/00 , C12N1/21 , C12N15/52 , C12P7/04
CPC分类号： C12P7/04 , C12N9/1022 , C12N9/1025 , C12N9/88 , C12P7/16 , C12Y203/03013 , Y02E50/10
摘要： Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing higher alcohols including C5- C8 alcohol from a suitable substrate.
摘要翻译：本文提供了用于生产生物燃料的代谢修饰微生物。更具体地说，本文提供了从合适的底物生产包括C 5 -C 8醇的高级醇的方法。

3. 发明公开

EP2539444A2 COMPOSITIONS AND METHODS FOR THE PRODUCTION OF L-HOMOALANINE 审中-公开
标题翻译：组合物和方法L-高丙氨酸的制备
公开(公告)号：EP2539444A2
公开(公告)日：2013-01-02
申请号：EP11748179.6
申请日：2011-02-25
申请人： The Regents of the University of California
发明人： LIAO, James, C. , ZHANG, Kechun , CHO, Kwang, Myung
IPC分类号： C12N9/04 , C07K14/00 , C07H21/00
CPC分类号： C12N9/0016 , C12P13/04 , C12P13/06 , C12Y104/01002 , Y02P20/52
摘要： Healthcare costs are a significant worldwide, with many patients being denied medications because of their high prices. One approach to addressing this problem involves the biosynthesis of chiral drug intermediates, an environmentally friendly solution that can be used to generate pharmaceuticals at much lower costs than conventional techniques. In this context, embodiments of the invention comprise methods and materials designed to allow microorganisms to biosynthesize the nonnatural amino acid L-homoalanine. As is known in the art, L-homoalanine is a chiral precursor of a variety of pharmaceutically valuable compounds including the anticonvulsant medications levetiracetam (sold under the trade name Keppra®) and brivaracetam, as well as ethambutol, a bacteriostatic antimycobacterial drug used to treat tuberculosis. Consequently, embodiments of the invention can be used in low cost, environmentally friendly processes to generate these and other valuable compounds.

4. 发明授权

EP2346991B1 PRODUCTION OF C5-C8 ALCOHOLS USING EVOLVED ENZYMES AND METABOLICALLY ENGINEERED MICROORGANISMS 有权
标题翻译： C5-C8醇的基础上发展起来的一系列酶的生产和代谢工程微生物
公开(公告)号：EP2346991B1
公开(公告)日：2016-12-28
申请号：EP09821377.0
申请日：2009-10-18
申请人： The Regents of the University of California
发明人： LIAO, James, C. , ZHANG, Kechun
IPC分类号： C12N9/10 , C12N9/88 , C12N1/21 , C12P7/04 , C12P7/16
CPC分类号： C12P7/04 , C12N9/1022 , C12N9/1025 , C12N9/88 , C12P7/16 , C12Y203/03013 , Y02E50/10

5. 发明公开

EP2346991A2 PRODUCTION OF C5-C8 ALCOHOLS USING EVOLVED ENZYMES AND METABOLICALLY ENGINEERED MICROORGANISMS 有权
标题翻译： C5-C8醇的基础上发展起来的一系列酶的生产和代谢工程微生物
公开(公告)号：EP2346991A2
公开(公告)日：2011-07-27
申请号：EP09821377.0
申请日：2009-10-18
申请人： The Regents Of The University Of California
发明人： LIAO, James, C. , ZHANG, Kechun
IPC分类号： C12N9/00 , C12N1/21 , C12N15/52 , C12P7/04
CPC分类号： C12P7/04 , C12N9/1022 , C12N9/1025 , C12N9/88 , C12P7/16 , C12Y203/03013 , Y02E50/10
摘要： Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing higher alcohols including C5- C8 alcohol from a suitable substrate.

6. 发明申请

WO2015161169A1 POLY(BETA-METHYL-DELTA-VALEROLACTONE) BLOCK POLYMERS 审中-公开
标题翻译：聚（β-甲基 - 三偏磷酸酯）嵌段聚合物
公开(公告)号：WO2015161169A1
公开(公告)日：2015-10-22
申请号：PCT/US2015/026325
申请日：2015-04-17
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , HILLMYER, Marc, A. , SCHNEIDERMAN, Deborah, Kay , BATES, Frank, Steven , ZHANG, Kechun
发明人： HILLMYER, Marc, A. , SCHNEIDERMAN, Deborah, Kay , BATES, Frank, Steven , ZHANG, Kechun
IPC分类号： C08G63/00 , C08G81/02 , C08G63/08 , C08G18/42
CPC分类号： C08G81/00 , C08G18/10 , C08G18/4266 , C08G18/4275 , C08G18/428 , C08G18/7671 , C08G63/00 , C08G63/08 , C08G18/3206
摘要： Block copolymers include a poly β-methyl-δ-valerolactone (PMVL) block. The PMVL blocks can be formed from biosynthesized β-methyl-δ-valero lactone (MVL). The block copolymers can include hard blocks. The block copolymers can be thermoplastic elastomers.
摘要翻译：嵌段共聚物包括聚β-甲基-δ-戊内酯（PMVL）嵌段。 PMVL嵌段可以由生物合成的β-甲基-δ-戊内酯（MVL）形成。嵌段共聚物可以包括硬嵌段。该嵌段共聚物可以是热塑性弹性体。

7. 发明申请

WO2012109534A2 CELLS AND METHODS FOR PRODUCING ISOBUTYRIC ACID 审中-公开
标题翻译：用于生产异丁酸的细胞和方法
公开(公告)号：WO2012109534A2
公开(公告)日：2012-08-16
申请号：PCT/US2012/024640
申请日：2012-02-10
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , ZHANG, Kechun , XIONG, Mingyong , WOODRUFF, Adam P.
发明人： ZHANG, Kechun , XIONG, Mingyong , WOODRUFF, Adam P.
IPC分类号： C12N1/20 , C12N9/00 , C12N9/16 , C12P7/52
CPC分类号： C12N15/70 , C12N1/20 , C12N9/0008 , C12N9/16 , C12P7/52
摘要： Disclosed herein are cells and methods for renewably producing isobutyrate. In some cases, the cells can include a heterologous DNA that encodes at least one enzyme that catalyzes the conversion of isobutyraldehyde to isobutyrate. In other cases, the cells can include a genetically modified enzyme that catalyzes the conversion of isobutyraldehyde to isobutyrate to a degree greater than the wild-type version of the enzyme. In other cases, the cells can include one or more enzyme that catalyze the conversion of 2-ketovaline to isobutyrate. Generally, methods include growing the cells in a medium that includes a carbon source that the cells are able to convert to isobutyrate.
摘要翻译：本文公开了用于可再生产异丁酸酯的电池和方法。在一些情况下，细胞可以包括编码至少一种催化异丁醛向异丁酸转化的酶的异源DNA。在其他情况下，细胞可以包括催化异丁醛向异丁酸转化到大于野生型版本的酶的遗传修饰的酶。在其他情况下，细胞可以包括一种或多种催化2-酮戊酸向异丁酸转化的酶。通常，方法包括在包含细胞能够转化为异丁酸酯的碳源的培养基中培养细胞。

8. 发明申请

WO2013180810A1 BIOSYNTHETIC PATHWAYS, RECOMBINANT CELLS, AND METHODS 审中-公开
标题翻译：生物路径，重组细胞和方法
公开(公告)号：WO2013180810A1
公开(公告)日：2013-12-05
申请号：PCT/US2013/031470
申请日：2013-03-14
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , ZHANG, Kechun , XIONG, Mingyong , TAI, Yi-shu
发明人： ZHANG, Kechun , XIONG, Mingyong , TAI, Yi-shu
IPC分类号： C12P7/62
CPC分类号： C12P7/62 , C12N9/1029
摘要： This disclosure describes engineered biosynthetic pathways, recombinant cells, and methods relating to biosynthesis of esters. The recombinant cells may be modified to exhibit increased biosynthesis of an ester compared to a wild-type control. The recombinant cell may be incubated in medium that includes a carbon source under conditions effective for the recombinant cell to produce an ester. This disclosure also describes a method that generally includes introducing into a host cell a heterologous polynucleotide encoding at least one polypeptide that catalyzes a step in converting a carbon source to an ester, wherein the at least one polynucleotide is operably linked to a promoter so that the modified host cell catalyzes conversion of the carbon source to an ester.
摘要翻译：本公开描述了工程化生物合成途径，重组细胞和与酯的生物合成相关的方法。与野生型对照相比，重组细胞可以被修饰以显示酯的增加的生物合成。可以在对重组细胞有效产生酯的条件下，将包含碳源的培养基中培养重组细胞。本公开还描述了一种方法，其通常包括向宿主细胞中引入编码至少一种多肽的异源多核苷酸，所述多核苷酸催化将碳源转化成酯的步骤，其中所述至少一种多核苷酸可操作地连接至启动子，使得改性宿主细胞催化碳源向酯的转化。

9. 发明申请

WO2013169350A1 BIOSYNTHETIC PATHWAYS, RECOMBINANT CELLS, AND METHODS 审中-公开
标题翻译：生物路径，重组细胞和方法
公开(公告)号：WO2013169350A1
公开(公告)日：2013-11-14
申请号：PCT/US2013/030719
申请日：2013-03-13
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , ZHANG, Kechun , DHANDE, Yogesh, K.
发明人： ZHANG, Kechun , DHANDE, Yogesh, K.
IPC分类号： C12N9/02 , C12N9/88 , C12N15/52
CPC分类号： C12P7/40 , C12N9/0004 , C12N9/0008 , C12N9/88 , C12Y102/01003 , C12Y401/01
摘要： This disclosure describes, generally, recombinant cells modified to exhibit increased biosynthesis of pentanoic acid, methods of making such recombinant cells, and methods of inducing the cells to produce pentanoic acid. This disclosure also describes, generally, recombinant cells modified to exhibit increased biosynthesis of 2-methylbutyric acid, methods of making such recombinant cells, and methods of inducing the cells to produce 2-methylbutyric acid.
摘要翻译：本公开通常描述了修饰以显示戊酸生物合成增加的重组细胞，制备这种重组细胞的方法，以及诱导细胞产生戊酸的方法。本公开通常还描述了修饰以显示2-甲基丁酸的增加的生物合成的重组细胞，制备这种重组细胞的方法，以及诱导细胞产生2-甲基丁酸的方法。

10. 发明申请

WO2014172596A2 BIOSYNTHETIC PATHWAYS AND PRODUCTS 审中-公开
标题翻译：生物合成途径和产品
公开(公告)号：WO2014172596A2
公开(公告)日：2014-10-23
申请号：PCT/US2014/034588
申请日：2014-04-18
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , ZHANG, Kechun , XIONG, Mingyong
发明人： ZHANG, Kechun , XIONG, Mingyong
IPC分类号： C12P17/18
CPC分类号： C12P17/06 , C07D309/30 , C07D309/32 , C07D309/38 , C12N9/1025 , C12N9/1029 , C12P7/42
摘要： This disclosure describes biosynthesized compounds including anhydromevalonolactone and β-methyl-δ-valerolactone. This disclosure further describes biosynthetic methods for making these compounds. In some embodiments, the biosynthetic methods can include a combination of biosynthesis and chemical steps to produce β-methyl-δ-valerolactone. Finally, this disclosure described recombinant cells useful for the biosynthesis of these compounds.
摘要翻译：本公开内容描述了生物合成的化合物，包括脱水瓦伦内酯和β-甲基-δ-戊内酯。本公开进一步描述了用于制备这些化合物的生物合成方法。在一些实施方案中，生物合成方法可以包括生物合成和化学步骤的组合以产生β-甲基-δ-戊内酯。最后，本公开描述了用于生物合成这些化合物的重组细胞。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式