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1. 发明申请

WO2010006072A2 MTOR MODULATORS AND USES THEREOF 审中-公开
标题翻译： MTOR调制器及其用途
公开(公告)号：WO2010006072A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/049969
申请日：2009-07-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , INTELLIKINE, INC. , SHOKAT, Kevan, M. , FRUMAN, David , REN, Pingda , WILSON, Troy, Edward , LI, Liansheng , HSIEH, Andrew , FELDMAN, Morris , APSEL, Beth , LIU, Yi , ROMMEL, Christian , CHAN, Katrina , RUGGERO, Davide , PEARCE, David , JANES, Matthew
发明人： SHOKAT, Kevan, M. , FRUMAN, David , REN, Pingda , WILSON, Troy, Edward , LI, Liansheng , HSIEH, Andrew , FELDMAN, Morris , APSEL, Beth , LIU, Yi , ROMMEL, Christian , CHAN, Katrina , RUGGERO, Davide , PEARCE, David , JANES, Matthew
IPC分类号： C12Q1/48 , C12Q1/00 , G01N33/48 , C12N5/00 , G01N33/50
CPC分类号： A61K31/519 , C12Q1/485 , G01N2500/04 , G01N2510/00
摘要： The present invention provides methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes. The methods and compositions are particularly useful in inhibiting mTor selectively for therapeutic applications.
摘要翻译：本发明提供用于选择性调节某些蛋白激酶，特别是mTor复合物的方法和组合物。这些方法和组合物在抑制mTor选择性治疗应用中特别有用。

2. 发明申请

WO2012154695A2 TREATMENT OF POLYCYSTIC DISEASE 审中-公开
标题翻译：治疗多发性疾病
公开(公告)号：WO2012154695A2
公开(公告)日：2012-11-15
申请号：PCT/US2012/036841
申请日：2012-05-07
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , INTELLIKINE, INC. , PEARCE, David , LIU, Yi , MARTIN, Michael , ROMMEL, Christian , REN, Pingda , WILSON, Troy Edward
发明人： PEARCE, David , LIU, Yi , MARTIN, Michael , ROMMEL, Christian , REN, Pingda , WILSON, Troy Edward
IPC分类号： A61K31/519 , A61K31/505 , A61K31/423 , A61K31/421
CPC分类号： A61K31/52 , A61K31/366 , A61K31/437 , A61K31/4709 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/63 , G01N2800/347 , G01N2800/50 , G01N2800/52
摘要： The present invention provides methods of treating polycystic disorders. In particular, methods include the use of inhibitors targeting certain protein kinases, such as mTOR, to treat polycystic disease.
摘要翻译：本发明提供治疗多囊性疾病的方法。特别地，方法包括使用靶向某些蛋白激酶（例如mTOR）的抑制剂来治疗多囊性疾病。

3. 发明申请

WO2005024009A1 MODULATION OF HAIR GROWTH VIA SGK3 审中-公开
标题翻译：通过SGK3调制头发生长
公开(公告)号：WO2005024009A1
公开(公告)日：2005-03-17
申请号：PCT/EP2004/009907
申请日：2004-09-06
申请人： EBERHARD-KARLS-UNIVERSITÄT TÜBINGEN UNIVERSITÄTSKLINIKUM , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LANG, Florian , PEARCE, David , WANG, Jian , McCORMICK, James
发明人： LANG, Florian , PEARCE, David , WANG, Jian , McCORMICK, James
IPC分类号： C12N9/12
CPC分类号： C12N9/1205 , C12Y207/01037
摘要： The present invention relates to methods for identifying a hair growth modulating substance, to methods for preparing a pharmaceutical/cosmetic composition for treatment of hair growth disorders, to methods for treating a human being affected by a hair growth disorder, to hair growth modulating substances, to compositions comprising a substance which modulates the activity of SGK3 or causes a modulation of the activity of a SGK3-derived peptide in the above-mentioned "identifying"-methods, and to a transgenic non-human sgk3-1- animal for investigating hair growth disorders.
摘要翻译：本发明涉及用于鉴定毛发生长调节物质的方法，制备用于治疗毛发生长障碍的药物/化妆品组合物的方法，治疗受毛发生长障碍的人的治疗方法，毛发生长调节物质，涉及包含调节SGK3活性或在上述“鉴定”方法中调节SGK3衍生肽的活性的物质的组合物和用于调查头发的转基因非人sgk3-1-动物生长障碍。

4. 发明公开

EP2704723A2 TREATMENT OF POLYCYSTIC DISEASE 审中-公开
标题翻译：治疗多囊肾疾病
公开(公告)号：EP2704723A2
公开(公告)日：2014-03-12
申请号：EP12782025.6
申请日：2012-05-07
申请人： The Regents of the University of California , Intellikine, LLC
发明人： PEARCE, David , LIU, Yi , MARTIN, Michael , ROMMEL, Christian , REN, Pingda , WILSON, Troy Edward
IPC分类号： A61K31/519 , A61K31/505 , A61K31/423 , A61K31/421
CPC分类号： A61K31/52 , A61K31/366 , A61K31/437 , A61K31/4709 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/63 , G01N2800/347 , G01N2800/50 , G01N2800/52
摘要： The present invention provides methods of treating polycystic disorders. In particular, methods include the use of inhibitors targeting certain protein kinases, such as mTOR, to treat polycystic disease.

5. 发明申请

WO2012140391A1 RPT SIGNAL OFFSET LEARNING SYSTEM 审中-公开
标题翻译： RPT信号偏差学习系统
公开(公告)号：WO2012140391A1
公开(公告)日：2012-10-18
申请号：PCT/GB2011/050739
申请日：2011-04-13
申请人： CONTROLLED POWER TECHNOLOGIES LTD , TAO, Chang , HEGGIE, Richard , CRIDDLE, Mark , MADDISON, Wayne , PEARCE, David
发明人： TAO, Chang , HEGGIE, Richard , CRIDDLE, Mark , MADDISON, Wayne , PEARCE, David
IPC分类号： H02P6/16 , H02K29/06
CPC分类号： H02P6/16
摘要： A method for measuring a Rotor Position Transducer (RPT) signal offset with respect to reference points in the rotor-stator geometry in an electrical machine comprising pairs of adjacent phases; the method comprising the steps of applying a PWM controlled voltage of a predetermined maximum duty cycle value to a first phase, and simultaneously applying a PWM controlled voltage of a predetermined minimum value to a phase adjacent the first phase; subsequently applying a PWM walk-up step, and subsequently applying a walk-down step, and repeating the walk-up and walk-down for each pair of adjacent phases, and when RPT signal transition occurs, using encoder means, such as a software encoder, to determine the RPT signal offset for each rotor pole.
摘要翻译：一种用于测量相对于包括相邻相位的电机中的转子 - 定子几何中的参考点的转子位置传感器（RPT）信号偏移的方法; 该方法包括以下步骤：将预定的最大占空比值的PWM控制电压施加到第一相位，并且将与预定最小值的PWM控制电压同时施加到与第一相位相邻的相位; 随后应用PWM步进步骤，并且随后应用步进步骤，并且针对每对相邻相位重复步行和步行，并且当发生RPT信号转换时，使用诸如软件的编码器装置编码器，以确定每个转子极点的RPT信号偏移。

6. 发明申请

WO2003086009A1 SWITCHED-GEOMETRY MICROPHONE ARRAY ARRANGEMENT AND METHOD FOR PROCESSING OUTPUTS FROM A PLURALITY OF MICROPHONES 审中-公开
标题翻译：开关几何麦克风阵列布置和从多个麦克风处理输出的方法
公开(公告)号：WO2003086009A1
公开(公告)日：2003-10-16
申请号：PCT/EP2003/000789
申请日：2003-01-27
申请人： MOTOROLA INC , PEARCE, David , REX, James
发明人： PEARCE, David , REX, James
IPC分类号： H04R3/00
CPC分类号： H04R1/406 , H04R3/005 , H04R2201/401 , H04R2201/403
摘要： A switched-geometry arrangement and method for processing outputs from microphones (40.1-40.M) by: receiving signals from the microphones at respective inputs; switching (41.1-41.M) the signals received at the inputs between outputs; summing (42.2.1-42.M.N) desired ones of the outputs and performing array processing (43) to produce a switched-geometry output signal. Operating the switches alters the configuration of microphones connected to the array processor (43), and the switching and subsequent processing may be adaptively operated in dependence on the output signal. Performing the switching in analogue circuitry and subsequent processing digitally allows lower cost, size and power consumption than fully digital processing. Most advantage is expected when a large number of microphones (say 50 or more) is connected to a much smaller number of array signal processor inputs, and especially when the analogue switches and adders are integrated into a silicon chip along with a microphone (e.g. MEMS device) array.
摘要翻译：一种用于通过以下步骤处理来自麦克风（40.1-40.M）的输出的开关几何结构和方法：在相应的输入处从麦克风接收信号; 切换（41.1-41.M）在输出端之间输入的信号; 求和（42.2.1-42.M.N）期望的输出和执行阵列处理（43）以产生切换几何输出信号。操作开关改变连接到阵列处理器（43）的麦克风的配置，并且切换和后续处理可以根据输出信号自适应地操作。在数字处理中进行模拟电路和后续处理的切换允许比完全数字处理更低的成本，尺寸和功耗。当大量麦克风（例如50个或更多）连接到更少数量的阵列信号处理器输入端时，尤其是当模拟开关和加法器与麦克风一起集成到硅芯片中（例如MEMS 设备）数组。

7. 发明申请

WO2002103451A1 CAMERA LENS POSITIONING USING AN ELECTRO-ACTIVE DEVICE 审中-公开
标题翻译：使用电动活动装置的相机镜头定位
公开(公告)号：WO2002103451A1
公开(公告)日：2002-12-27
申请号：PCT/GB2002/002821
申请日：2002-06-19
申请人： 1... LIMITED , MCKEVITT, Gareth , HOOLEY, Anthony , ALLAN, James , PEARCE, David , LENEL, Ursula, Ruth
发明人： MCKEVITT, Gareth , HOOLEY, Anthony , ALLAN, James , PEARCE, David , LENEL, Ursula, Ruth
IPC分类号： G03B17/00
CPC分类号： G02B7/023 , G03B17/00 , H04N5/2254
摘要： A camera (30) uses an electro-active device (11) to position a movable lens. The electro-active device (11) comprises an electro-active structure in the form of a continuous electro-active member (12) curving in a helix around a minor axis (13) which is in itself curved for example in a helix around a major axis (14). The continuous member (12) has a bender construction of a plurality of layers (21 and 22) including at least one layer of electro-active material so that it bends, on activation, around the minor axis (13). Concomitantly with the bending, the electro-active structure twists around the minor axis. Concomitantly with that twisting, relative displacement of the ends (16) of the device (11) occurs due to the combination of the twisting around the minor axis (13) and the fact that the minor axis (13) is curved. This structure of the electro-active device (11) is compact and provides for linear displacement, thereby making it suitable for positioning the lens of the camera (30).
摘要翻译：相机（30）使用电动装置（11）来定位可移动透镜。电活性器件（11）包括呈短轴弯曲的连续电活性部件（12）形式的电活性结构，短轴（13）本身例如以螺旋形弯曲长轴（14）。连续构件（12）具有包括至少一层电活性材料层的多个层（21和22）的弯曲结构，使得其在启动时绕短轴（13）弯曲。伴随着弯曲，电活动结构围绕短轴扭转。伴随着扭转，由于围绕短轴（13）的扭转和短轴（13）弯曲的事实的组合，发生装置（11）的端部（16）的相对位移。电动装置（11）的这种结构是紧凑的并且提供线性位移，从而使其适合于定位相机（30）的透镜。

8. 发明申请

WO2013044220A2 MODULAR GARDEN AND DISPLAY SYSTEMS 审中-公开
标题翻译：模块化花园和显示系统
公开(公告)号：WO2013044220A2
公开(公告)日：2013-03-28
申请号：PCT/US2012/056892
申请日：2012-09-24
申请人： THE KITCHEN COMMUNITY , LEWIN, Jen , PEARCE, David , ROBINSON, Travis
发明人： LEWIN, Jen , PEARCE, David , ROBINSON, Travis
IPC分类号： A01G9/02 , A01G27/02 , A01G31/06
CPC分类号： A01G9/027 , A01G9/28
摘要： A modular raised bed garden system includes a number of raised-bed modules that may be assembled according to one or numerous different configurations. The raised bed modules include a first arcuate-shaped bed module having a first radius of curvature and a second arcuate-shaped bed module having a second radius of curvature that is smaller than the first radius of curvature. The first bed module may be coupled to the second bed module, forming a raised bed garden system. The modules may be connected end-to-end through a connection module, such as one or more bolts secured through end-plates of each module. A third arcuate-shaped bed module having a smaller third radius of curvature may be coupled to the system and arranged to produce a spiral or S shaped system. Display and trellis modules may be coupled with the raised beds to provide shading and aesthetic features.
摘要翻译：模块化升高床花园系统包括可以根据一种或多种不同配置组装的多个升高床模块。凸起床模块包括具有第一曲率半径的第一弧形床模块和具有小于第一曲率半径的第二曲率半径的第二弧形床模块。第一床模块可以联接到第二床模块，形成升高的床花园系统。模块可以通过连接模块端对端地连接，例如通过每个模块的端板固定的一个或多个螺栓。具有较小的第三曲率半径的第三弧形床模块可以联接到系统并被布置成产生螺旋形或S形系统。显示器和网格模块可以与升高的床结合以提供阴影和美观特征。

9. 发明申请

WO2002082857A3 ACTUATOR ASSEMBLY 审中-公开
公开(公告)号：WO2002082857A3
公开(公告)日：2002-10-17
申请号：PCT/GB2002/001537
申请日：2002-04-03
申请人： THE UNIVERSTIY OF BIRMINGHAM , PEARCE, David
发明人： PEARCE, David
IPC分类号： H04R17/00
摘要： An actuator assembly comprises a first member (6a,6b), a second member (4a,4b) and at least one connecting arm (10a,10b) of fixed length connecting the first and second members (6a,6b;4a,4b). The assembly also comprises an actuator (12,14) which is operably engaged with the first member (6a,6b) so as to be capable of applying a rotating force to the first member (6a,6b). In use, rotational movement of the first member (6a,6b) causes relative linear movement of the first and second members (6a,6b;4a,4b) along an axis. The invention also relates to a loudspeaker driver unit and a sensor incorporating the actuator assembly. In the sensor embodiments, the actuator is an electrical transducer.

10. 发明申请

WO2012025571A2 CABLE FITTING COMPRISING A FIELD-CONTROL ELEMENT AND METHOD OF PRODUCING A CABLE FITTING 审中-公开
标题翻译：包含现场控制元件的电缆连接件和制造电缆连接件的方法
公开(公告)号：WO2012025571A2
公开(公告)日：2012-03-01
申请号：PCT/EP2011/064576
申请日：2011-08-24
申请人： TYCO ELECTRONICS RAYCHEM GMBH , TYCO ELECTRONICS UK LTD , GRAF, Richard , PEARCE, David
发明人： GRAF, Richard , PEARCE, David
IPC分类号： H02G15/103
CPC分类号： H02G15/064 , H02G15/103 , H02G15/184
摘要： The present invention relates to a cable fitting (100, 101, 02, 200, 300, 301, 400, 401, 402) for mounting to a cable (140), comprising a field-control element (110, 210, 310, 410) of an electrically conductive material. The field-control element is a partly everted tubular component (110, 210, 310, 410) comprising a curved section (111, 211, 311, 411, 412) being formed by the everting. The invention further relates to a method for producing such a cable fitting as well as to a field-control element for a cable fitting.
摘要翻译：本发明涉及一种用于安装到电缆（140）的电缆配件（100,101,02,200,300,301,400,401,402），其包括磁场控制元件（110,210,310,410））导电材料。外壳控制元件是部分弯曲的管状部件（110,210,310,410），其包括通过弯曲形成的弯曲部分（111,211,311,411,412）。本发明还涉及一种用于制造这种电缆配件的方法以及用于电缆配件的现场控制元件。

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