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1. 发明申请

WO2021108601A1 FORMULATIONS OF TERAMEPROCOL AND TEMOZOLOMIDE AND THEIR USE IN STIMULATION OF HUMORAL IMMUNITY IN TUMORS 审中-公开
公开(公告)号：WO2021108601A1
公开(公告)日：2021-06-03
申请号：PCT/US2020/062288
申请日：2020-11-25
申请人： THE JOHNS HOPKINS UNIVERSITY , ACADEMIA SINICA , NATIONAL CHIAO TUNG UNIVERSITY
发明人： HUANG, Ru Chih C. , CHUN, Jong Ho , LIN, Yu-Ling , LIANG, Yu-Chuan , LIAO, Kunag-Wen , JACKSON, Tiffany , MOLD, David
IPC分类号： A61K31/4188 , A61K31/495 , A61K47/02
摘要： The present invention provides novel pharmaceutical formulations comprising derivatives of NDGA, including M4N (tetra-0-methyl nordihydroguaiaretic acid) and temozolomide and their use in the inhibition and treatment of neoplastic diseases, including glioblastoma multiforme, lung and other cancers.

3. 发明申请

WO2013116821A9 COMPOSITIONS COMPRISING NDGA DERIVATIVES AND SORAFENIB AND THEIR USE IN TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2013116821A9
公开(公告)日：2013-08-08
申请号：PCT/US2013/024595
申请日：2013-02-04
申请人： THE JOHNS HOPKINS UNIVERSITY , HUANG, Ru Chih , MOLD, David , RULAND, Christopher , LIANG, Yu-Chuan , CHUN, Jong Ho
发明人： HUANG, Ru Chih , RULAND, Christopher , LIANG, Yu-Chuan , CHUN, Jong Ho
IPC分类号： A61K31/045 , A61K31/03 , A61K31/12 , A61P35/00
摘要： The present invention provides pharmaceutical compositions comprising derivatives of NDGA, including M4N (tetra-O-methyl nordihydroguaiaretic acid) and sorafenib and their use in the inhibition and treatment of neoplastic diseases, such as liver cancer, colon cancer, breast cancer, brain cancers and ovarian cancers, for example, in a subject. Compositions comprising derivatives of NDGA, including M4N, sorafenib and additional therapeutic agents are also provided.

4. 发明授权

EP2809308B1 COMPOSITIONS COMPRISING NDGA DERIVATIVES AND SORAFENIB AND THEIR USE IN TREATMENT OF CANCER 有权
公开(公告)号：EP2809308B1
公开(公告)日：2018-06-27
申请号：EP13744007.9
申请日：2013-02-04
申请人： The Johns Hopkins University
发明人： HUANG, Ru Chih , RULAND, Christopher , LIANG, Yu-Chuan , CHUN, Jong Ho , MOLD, David
IPC分类号： A61K31/045 , A61K31/03 , A61K31/12 , A61P35/00
CPC分类号： A61K31/7016 , A61K31/05 , A61K31/09 , A61K31/44 , A61K45/06 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions comprising derivatives of NDGA, including M4N (tetra-O-methyl nordihydroguaiaretic acid) and sorafenib and their use in the inhibition and treatment of neoplastic diseases, such as liver cancer, colon cancer, breast cancer, brain cancers and ovarian cancers, for example, in a subject. Compositions comprising derivatives of NDGA, including M4N, sorafenib and additional therapeutic agents are also provided.

5. 发明申请

WO2022109602A1 USE OF CRASSOCEPHALUM RABENS EXTRACT IN THE PREVENTION AND/OR TREATMENT OF FATIGUE AND/OR DEPRESSION 审中-公开
公开(公告)号：WO2022109602A1
公开(公告)日：2022-05-27
申请号：PCT/US2021/072518
申请日：2021-11-19
申请人： ACADEMIA SINICA , SHIH, Ming-Che
发明人： SHYUR, Lie-Fen , LIANG, Yu-Chuan , CHEN, Yu-Hsin , LIN, Chuan-Ju , CHANG, Meng-Ting , YANG, Chung-Chih
IPC分类号： A61P25/00 , A61P25/28 , A61P43/00
摘要： The present disclosure provides a method for preventing and/or treating fatigue and/or depression in a subject in need of such prevention and/or treatment, comprising administering to said subject an effective amount of Crassocephalum rabens plant or extract and optionally a pharmaceutically acceptable carrier or excipient. The present disclosure also provides a method for increasing skeletal muscle lactate dehydrogenase and/or malate dehydrogenase.

6. 发明申请

WO2021113391A1 ARTIFICIAL INTELLIGENT SYSTEM FOR MANAGING A POULTRY HOUSE 审中-公开
公开(公告)号：WO2021113391A1
公开(公告)日：2021-06-10
申请号：PCT/US2020/062932
申请日：2020-12-02
申请人： ACADEMIA SINICA , SHIH, Ming-Che
发明人： YANG, Wen-Chin , LEE, Yang-Han , LIANG, Yu-Chuan , PHOA, Frederick Kin Hing , CHANG, Lee-Tian , HSU, Cheng-Chih , CHEN, Jia-Kun , LIN, Shau-Ping , HSIAO, Chiao-LING
IPC分类号： A01K31/00 , G16H40/67 , C12Q1/04
摘要： A system for use in a poultry house includes a control server, a network gateway disposed in the poultry house and equipping with a wireless communication capability; a movable sensor module disposed in the poultry house, wherein the movable sensor module is movable within the poultry house for obtaining a plurality of environmental parameters associated with specific locations within the poultry house, and a sampling machine disposed in the poultry house for obtaining a sample of poultry waste on the ground of the poultry house. The movable sensor module transmits the environmental parameters to the network gateway, and the network gateway transmits the environmental parameters to the control server for processing the environmental parameters.

7. 发明申请

WO2020198093A1 BIDENS PILOSA AND ITS PHYTOCHEMICALS FOR USE IN PREVENTION AND TREATMENT OF DIARRHEA 审中-公开
公开(公告)号：WO2020198093A1
公开(公告)日：2020-10-01
申请号：PCT/US2020/024106
申请日：2020-03-22
申请人： ACADEMIA SINICA , SHIH, Ming-Che
发明人： YANG, Wen-Chin , LIANG, Yu-Chuan
IPC分类号： A23K10/30 , A23K50/75 , A61K9/14 , A61K31/00 , A61K31/7012 , A61K31/7028
摘要： A composition comprising Bidem pilosa or an active compound isolated from the Bidem pilosa for use in treating, inhibiting and/or decreasing the presence of pathogenic gut microbiota in an animal in need thereof is disclosed. The pathogenic gut microbiota are at least one selected from the group consisting of Brachyspira , porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis coronavirus (TGEV) and Rotavirus (RV). The composition is also for use in treating, inhibiting and/or decreasing occurrence of swine diarrhea, swine dysentery, swine viral infection and increasing the percentage of swine carcass and bone weight, in one embodiment, the composition is for use in treating, inhibiting and/or decreasing occurrence of s wine dysentery associated with Brachyspira.

8. 发明申请

WO2017127272A1 BENEFICIAL EFFECT OF BIDENS PILOSA ON FAT DECREASE AND MUSCLE INCREASE 审中-公开
标题翻译： Pilosa对减肥和肌肉增加的有益作用
公开(公告)号：WO2017127272A1
公开(公告)日：2017-07-27
申请号：PCT/US2017/013073
申请日：2017-01-11
申请人： ACADEMIA SINICA , LIANG, Chi-Ming
发明人： YANG, Wen-Chin , CHANG, Lee-Tian , LIANG, Yu-Chuan
IPC分类号： A61K31/7028 , A61K36/28 , A61P3/04
CPC分类号： A61K31/7028 , A61K36/28
摘要： A composition comprising a therapeutically effective amount of Bidens pilosa extract, or an active compound isolated from the Bidens pilosa extract for use in treating obesity, reducing body weight or body weight gain, and/or gaining muscle mass or muscle content in a subject in need thereof is disclosed. The composition is useful for reducing fat cell size and/or fat accumulation in the fat cell in a subject in need thereof. The composition may further comprises an animal feed. A polyacetylenic compound for use in treating obesity, gaining muscle mass or muscle content, and/or increasing lean tissue protein content in a subject in need thereof is also disclosed. In one embodiment, the polyacetylenic compound is cytopiloyne.
摘要翻译：包含治疗有效量的Bidens pilosa提取物或从Bidens pilosa提取物分离的用于治疗肥胖症的活性化合物的组合物，公开了减轻体重或体重增加，和/或获得有此需要的受试者的肌肉质量或肌肉含量。该组合物可用于减少有此需要的受试者中的脂肪细胞的脂肪细胞大小和/或脂肪细胞积累。该组合物可以进一步包含动物饲料。还公开了用于治疗有需要的受试者的肥胖症，获得肌肉量或肌肉含量和/或增加瘦组织蛋白质含量的聚乙炔化合物。在一个实施方案中，聚乙炔化合物是细胞鞘素。

9. 发明公开

EP3945846A1 BIDENS PILOSA AND ITS PHYTOCHEMICALS FOR USE IN PREVENTION AND TREATMENT OF DIARRHEA 审中-公开
公开(公告)号：EP3945846A1
公开(公告)日：2022-02-09
申请号：EP20779648.3
申请日：2020-03-22
申请人： Academia Sinica
发明人： YANG, Wen-Chin , LIANG, Yu-Chuan
IPC分类号： A23K10/30 , A23K50/75 , A61K9/14 , A61K31/00 , A61K31/7012 , A61K31/7028

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