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1. 发明专利

JP2013038418A Method for inhibiting growth of intermetallic compound 有权
标题翻译：抑制络合物生长的方法
公开(公告)号：JP2013038418A
公开(公告)日：2013-02-21
申请号：JP2012163896
申请日：2012-07-24
申请人： National Chiao Tung University , ナショナルチャオツンユニヴァーシティー
发明人： CHI CHEN , KIM NING TSU , HSIAO HSIANG-YAO
IPC分类号： H01L21/60 , B23K1/00 , B23K1/20 , B23K101/40 , B23K103/12
CPC分类号： C23C28/021 , H01L24/03 , H01L24/05 , H01L24/11 , H01L24/13 , H01L2224/03849 , H01L2224/0401 , H01L2224/05147 , H01L2224/05611 , H01L2224/08503 , H01L2224/11849 , H01L2224/131 , H01L2924/01029 , H01L2924/01322 , H01L2924/01327 , H01L2924/10253 , H01L2924/3651 , H01L2924/00014 , H01L2924/01047 , H01L2924/00012 , H01L2924/00 , H01L2924/014
摘要： PROBLEM TO BE SOLVED: To provide a method for controlling the growth of an intermetallic compound formed by a rapid reaction of a solder and Cu prior to a bonding process and inhibiting the growth of the intermetallic compound after the bonding process.SOLUTION: A method for inhibiting the growth of an intermetallic compound includes: (i) a step of preparing a substrate element including a substrate including at least one layer of metal pad deposited thereon, in which at least one thin layer of solder is deposited onto the layer of a metal pad and then a reflow process is performed; and (ii) a step of further depositing a bump of solder with an appropriate thickness on the substrate element. In the method, a thin intermetallic compound is formed by the reaction of the thin solder layer and the metal in the metal pad after appropriate heat treatment to the thin solder layer. By the formation of a thin intermetallic compound, the growth of the intermetallic compound can be slowed and the transformation of the intermetallic compound can be prevented.
摘要翻译：要解决的问题：提供一种控制在焊接过程之前通过焊料和Cu的快速反应形成的金属间化合物的生长的方法，并且在接合工艺之后抑制金属间化合物的生长。解决方案：用于抑制金属间化合物生长的方法包括：（i）制备包括其上沉积有至少一层金属焊盘的衬底的衬底元件的步骤，其中至少一层焊料薄层沉积在金属焊盘的层上，然后进行回流处理; 和（ii）在衬底元件上进一步沉积具有适当厚度的焊料凸点的步骤。在该方法中，通过在对薄焊料层进行适当的热处理之后，通过薄焊料层和金属焊盘中的金属的反应形成薄的金属间化合物。通过形成薄的金属间化合物，可以减缓金属间化合物的生长，并且可以防止金属间化合物的转变。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2012104089A Method and system for human movement recognition 审中-公开
标题翻译：人体运动识别方法与系统
公开(公告)号：JP2012104089A
公开(公告)日：2012-05-31
申请号：JP2010287308
申请日：2010-12-24
申请人： Industrial Technology Research Inst , National Chiao Tung Univ , インダストリアルテクノロジーリサーチインスティテュートIndustrial Technology Research Institute , ナショナルチーアオトゥンユニヴァーシティーNational Chiao Tung University
发明人： LUO ZHI CHUN , WU TSUNG HENG , CHEN CHAO YU , LUN CHIA KUO , TSENG YU CHEE
IPC分类号： G06Q10/00
CPC分类号： A61B5/11
摘要： PROBLEM TO BE SOLVED: To provide a method and a system for human movement recognition actualized with an inertial measurement unit, to accomplish a purpose of being integrated with existing mobile devices.SOLUTION: The method comprises: a step 201 of retrieving successive measurement data for human movement recognition from an inertial measurement unit; a step 204 of dividing the successive measurement data to generate at least one human movement pattern waveform if the successive measurement data conforms to a specific human movement pattern (yes in a step 203); a step 205 of discretizing the at least one human movement pattern waveform to generate at least one human movement discrete number sequence; and a step 206 of determining a human movement corresponding to the measurements from the inertial measurement unit by comparing the at least one human movement discrete number sequence and reference humans' movement discrete number sequences.
摘要翻译：要解决的问题：提供用惯性测量单元实现的人体运动识别的方法和系统，以实现与现有移动设备集成的目的。解决方案：该方法包括：从惯性测量单元检索用于人体运动识别的连续测量数据的步骤201; 如果连续测量数据符合特定的人类运动模式（步骤203中为是），则将连续的测量数据分割以生成至少一个人体运动模式波形的步骤204。离散所述至少一个人运动模式波形以产生至少一个人运动离散数字序列的步骤205; 以及步骤206，通过比较至少一个人类运动离散数字序列和参考人类运动离散数字序列来确定与来自惯性测量单元的测量相对应的人类运动。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2013016494A Sample box for electron microscope 有权
标题翻译：电子显微镜样品盒
公开(公告)号：JP2013016494A
公开(公告)日：2013-01-24
申请号：JP2012151129
申请日：2012-07-05
申请人： National Chiao Tung University , ナショナルチャオツンユニヴァーシティー
发明人： CHI CHEN , KIM NING TSU
IPC分类号： H01J37/20
CPC分类号： H01J37/20 , H01J2237/2003
摘要： PROBLEM TO BE SOLVED: To provide a sample box for an electron microscope having guide holes and plugs capable of extending time to observe dynamic changes of a sample by introducing the required gas or liquid into the sample by reopening the sample box.SOLUTION: A sample box for an electron microscope includes a first substrate 11, a second substrate 12 and a metal adhesive layer 13. The first substrate 11 includes a first surface 111, a second surface 112, a first recessed groove 113 and at least one first guide hole 114. The first recessed groove 113 is provided on the second surface 112. On the first surface 111, a first thin film 115 corresponding to the first recessed groove 113 is formed. The first guide hole 114 is provided in the outer periphery of the first recessed groove 113 and bored in the first substrate 11. The second substrate 12 includes a third surface 121, a fourth surface 122, and a second recessed groove 123.
摘要翻译：要解决的问题：为了提供具有引导孔和插塞的电子显微镜的样品盒，其能够延长时间以通过重新打开样品箱将所需的气体或液体引入样品来观察样品的动态变化。解决方案：用于电子显微镜的样品盒包括第一基板11，第二基板12和金属粘合剂层13.第一基板11包括第一表面111，第二表面112，第一凹槽113和至少一个第一引导孔114.第一凹槽113设置在第二表面112上。在第一表面111上形成与第一凹槽113对应的第一薄膜115。第一引导孔114设置在第一凹槽113的外周中并且在第一基板11中钻孔。第二基板12包括第三表面121，第四表面122和第二凹槽123。版权所有（C）2013，JPO＆INPIT

4. 发明专利

JP2013016490A Sample case for electron microscope 有权
标题翻译：电子显微镜样品
公开(公告)号：JP2013016490A
公开(公告)日：2013-01-24
申请号：JP2012149133
申请日：2012-07-03
申请人： National Chiao Tung University , ナショナルチャオツンユニヴァーシティー
发明人： CHI CHEN , KIM NING TSU
IPC分类号： H01J37/20
CPC分类号： H01J37/20 , H01J2237/2003
摘要： PROBLEM TO BE SOLVED: To provide a sample case for an electron microscope which includes through-holes and sealing caps, can be repeatedly opened and can extend dynamic state observation time of a sample by filling the required gas or liquid in the sample.SOLUTION: A sample case for an electron microscope includes a first substrate, a second substrate, one or more of photoelectric elements, and a metal adhesive layer. The first substrate includes a first surface, a second surface, a first recessed part, and one or more of first through-holes. The first through-holes penetrate through the first substrate. The second substrate includes a third surface, a fourth surface, and a second recessed part. The photoelectric elements are disposed between the first substrate and the second substrate. The metal adhesive layer is disposed between the first substrate and the second substrate to form a space, and a sample is housed in the space. Furthermore, this sample case includes one or more of sealing caps capable of sealing the first through-holes. In-situ-observation can be performed by the electron microscope by sealing the sample case.
摘要翻译：要解决的问题：为了提供一种包括通孔和密封盖的电子显微镜的样品盒，可以重复打开，并且可以通过在样品中填充所需的气体或液体来延长样品的动态观察时间。解决方案：用于电子显微镜的样品盒包括第一基板，第二基板，一个或多个光电元件和金属粘合剂层。第一基板包括第一表面，第二表面，第一凹部和一个或多个第一通孔。第一通孔贯穿第一基板。第二基板包括第三表面，第四表面和第二凹陷部分。光电元件设置在第一基板和第二基板之间。金属粘合剂层设置在第一基板和第二基板之间以形成空间，并且样品容纳在该空间中。此外，该样本壳体包括能够密封第一通孔的一个或多个密封盖。可以通过电子显微镜密封样品盒进行现场观察。版权所有（C）2013，JPO＆INPIT

5. 发明专利

IL248567D0 Use of known compounds as d-amino acid oxidase inhibitors 未知
公开(公告)号：IL248567D0
公开(公告)日：2016-12-29
申请号：IL24856716
申请日：2016-10-27
申请人： NATIONAL TAIWAN UNIVERSITY , NATIONAL HEALTH RESEARCH INSTITUTES , NATIONAL CHIAO TUNG UNIVERSITY , YUFENG JANE TSENG
IPC分类号： C40B20060101
摘要： The invention utilizes virtual screening strategy to seek for current market drugs as anti-schizophrenia therapy-drug repurposing. Drug repurposing strategy finds new uses other than the original medical indications of existing drugs. Finding new indications for such drugs will benefit patients who are in needs for a potential new therapy sooner since known drugs are usually with acceptable safety and pharmacokinetic profiles. In this study, repurposing marketed drugs for DAAO inhibitor as new schizophrenia therapy was performed with virtual screening on marketed drugs and its metabolites. The identified and available drugs and compounds were further confirmed with in vitro DAAO enzymatic inhibitory assay.

6. 发明申请

WO2020117556A1 GAS SENSOR BASED ON THIOPHENE-BASED HIGH PERFORMANCE ORGANIC SEMICONDUCTING MATERIALS WITH LARGE SURFACE AREA VERTICAL DEVICE DESIGN 审中-公开
公开(公告)号：WO2020117556A1
公开(公告)日：2020-06-11
申请号：PCT/US2019/063218
申请日：2019-11-26
申请人： CORNING INCORPORATED , SPRING FOUNDATION OF NATIONAL CHIAO TUNG UNIVERSITY
发明人： HE, Mingqian , LI, Yang , LIU, Hung-Chuan , MEHROTRA, Karan , MENG, Hsin-Fei , ZAN, Hsiao-Wen
IPC分类号： H01L51/05 , G01N27/414
摘要： Described herein are ultrasensitive gas sensors based on a vertical-channel organic semiconductor (OSC) diode, along with methods for making such devices, and uses thereof. The organic sensing layer comprises a fused thiophene-based organic polymer that connects top and bottom electrodes to deliver a vertical current flow. The nano-porous top-electrode structure enables the contact between ambient gas molecules and the vertical organic channel. The device has high sensitivity, is easy to process, and has a long shelf life.

7. 发明申请

WO2020112394A1 HIGH CURRENT OTFT DEVICES WITH VERTICAL DESIGNED STRUCTURE AND DONOR-ACCEPTOR BASED ORGANIC SEMICONDUCTOR MATERIALS 审中-公开
公开(公告)号：WO2020112394A1
公开(公告)日：2020-06-04
申请号：PCT/US2019/061915
申请日：2019-11-18
申请人： CORNING INCORPORATED , NATIONAL CHIAO TUNG UNIVERSITY
发明人： HE, Mingqian , MANLEY, Robert George , MEHROTRA, Karan , MENG, Hsin-Fei , ZAN, Hsiao-Wen
IPC分类号： H01L51/10 , H01L51/30
摘要： Described herein are electronics that incorporate heterocyclic organic compounds. More specifically, described herein are organic electronics systems that are combined with donor-acceptor organic semiconductors, along with methods for making such devices, and uses thereof.

8. 发明申请

WO2018089545A1 SELECTIVE CHEMICAL BATH DEPOSITION OF IRIDIUM OXIDE ON THIN FILM FLEXIBLE SUBSTRATES 审中-公开
标题翻译：氧化铟在薄膜柔性衬底上的选择性化学浴沉积
公开(公告)号：WO2018089545A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060712
申请日：2017-11-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , NATIONAL CHIAO TUNG UNIVERSITY
发明人： LIU, Wentai , CHANG, Chih-Wei , WU, Pu-Wei , WU, Chung-Yu , CHEN, Pu-Chun , CHUNG, Tsai-Wei
IPC分类号： A61N1/05 , A61N1/00 , A61N1/02 , A61N1/04 , C23C22/00
摘要： A flexible thin film metal oxide electrode fabrication methods and devices are provided and illustrated with thin film polyimide electrode formation and IrOx chemical bath deposition. Growth factors of the deposited film such as film thickness, deposition rate and quality of crystallites can be controlled by varying the solution pH, temperature and component concentrations of the bath. The methods allow for selective deposition of IrOx on a flexible substrate (e.g. polyimide electrode) where the IrOx will only coat onto an exposed metal area but not the entire device surface. This feature enables the bath process to coat the IrOx onto every individual electrode in one batch, and to ensure electrical isolation between channels. The ability to perform selective deposition, pads for external connections will not have IrOx coverage that would otherwise interfere with a soldering/bumping process.
摘要翻译：提供了柔性薄膜金属氧化物电极制造方法和器件，并示出了薄膜聚酰亚胺电极形成和IrO x化学浴沉积。沉积膜的生长因子如膜厚度，沉积速率和微晶的质量可以通过改变溶液的pH值，温度和浴的组分浓度来控制。该方法允许在柔性衬底（例如聚酰亚胺电极）上选择性沉积IrOx，其中IrOx将仅涂布到暴露的金属区域而不是整个器件表面。该功能可以使镀浴过程将IrOx涂覆到每批单个电极上，并确保通道之间的电气隔离。执行选择性沉积的能力，用于外部连接的焊盘将不具有IrOx覆盖范围，否则会干扰焊接/撞击过程。

9. 发明申请

WO2017173022A1 IN VIVO AMELIORATION OF ENDOGENOUS ANTI-TUMOR AUTOANTIBODIES TARGETING SURFACE TUMOR ANTIGENS VIA LOW-DOSE P4N 审中-公开
标题翻译：通过低剂量P4N体内诱导表达肿瘤抗原的内源性抗肿瘤自体抗体
公开(公告)号：WO2017173022A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/024905
申请日：2017-03-30
申请人： THE JOHNS HOPKINS UNIVERSITY , NATIONAL CHIAO TUNG UNIVERSITY
发明人： HUANG, Ru Chih C. , MOLD, David , JACKSON, Tiffany , LIN, Yu-Ling , LIAO, Kuang-Wen
IPC分类号： A61K31/435 , A61P35/00
摘要： In accordance with the present invention, the immunoregulatory activity of low doses of P 4 N was investigated. Unlike previously described antitumor drugs, low dose P 4 N, in doses of about 1 to 10 mg/kg, or at concentrations of about 10 to 100 nM, was surprisingly found to contribute to humoral immunity by raising the titers and activities of autoantibodies against GRP78 and F1F0 ATP synthase on the surface of CT26 cells, and inducing B cell proliferation and differentiation of plasma cells. Methods for inducing endogenous antitumor autoantibodies (EAA) in a subject having a neoplasia comprising administering to the subject an effective amount of the nordihydroguaiaretic acid (NDGA) derivative P4N, or salts, solvates and stereoisomers thereof, as well as methods for inducing B cell proliferation, inducing BAFF stimulated B cell proliferation, and suppressing or inhibition growth of a neoplasia are also provided.
摘要翻译：根据本发明，研究了低剂量的P N 4 N的免疫调节活性。与先前描述的抗肿瘤药物不同，以约1至10mg / kg的剂量或以约10至100nM的浓度的低剂量P 4 N令人惊讶地发现通过提高 CT26细胞表面抗GRP78和F1F0 ATP合酶自身抗体的滴度和活性，诱导B细胞增殖和分化浆细胞。在具有瘤形成的受试者中诱导内源性抗肿瘤自身抗体（EAA）的方法，包括给受试者施用有效量的去甲二氢愈创木酸（NDGA）衍生物P4N或其盐，溶剂化物和立体异构体，以及诱导B细胞增殖，诱导BAFF刺激的B细胞增殖，并且还提供了抑制或抑制瘤形成的生长。

10. 发明申请

WO2021108601A1 FORMULATIONS OF TERAMEPROCOL AND TEMOZOLOMIDE AND THEIR USE IN STIMULATION OF HUMORAL IMMUNITY IN TUMORS 审中-公开
公开(公告)号：WO2021108601A1
公开(公告)日：2021-06-03
申请号：PCT/US2020/062288
申请日：2020-11-25
申请人： THE JOHNS HOPKINS UNIVERSITY , ACADEMIA SINICA , NATIONAL CHIAO TUNG UNIVERSITY
发明人： HUANG, Ru Chih C. , CHUN, Jong Ho , LIN, Yu-Ling , LIANG, Yu-Chuan , LIAO, Kunag-Wen , JACKSON, Tiffany , MOLD, David
IPC分类号： A61K31/4188 , A61K31/495 , A61K47/02
摘要： The present invention provides novel pharmaceutical formulations comprising derivatives of NDGA, including M4N (tetra-0-methyl nordihydroguaiaretic acid) and temozolomide and their use in the inhibition and treatment of neoplastic diseases, including glioblastoma multiforme, lung and other cancers.

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