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1. 发明申请

WO2007084959A1 SYSTEMS AND METHODS FOR PROVIDING MIRROR TUNNEL MICROSCOPY 审中-公开
标题翻译：用于提供镜面隧道显微镜的系统和方法
公开(公告)号：WO2007084959A1
公开(公告)日：2007-07-26
申请号：PCT/US2007/060717
申请日：2007-01-18
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E. , OZCAN, Aydogan
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E. , OZCAN, Aydogan
IPC分类号： G02B27/46 , G02B27/08 , G02B21/36
CPC分类号： G02B27/08 , G01J3/36 , G02B17/006 , G02B21/00 , G02B21/367 , G02B27/46
摘要： Exemplary apparatus and method for obtaining information associated with at least one image of at least one portion of a sample can be provided. For example, at least one first electro¬ magnetic radiation can be provided from the at least one portion (e.g., using a first electro-magnetic radiation guiding arrangement which is configured to provide). A plurality of spatial frequency bands of the image associated with the first electro-magnetic radiation can be generated. Further, at least one second electro-magnetic radiation which is associated with the spatial frequency bands of the image can be received (e.g., using a second arrangement), and the image can be reconstructed based on the spatial frequency bands.
摘要翻译：可以提供用于获得与样品的至少一部分的至少一个图像相关联的信息的示例性装置和方法。例如，可以从至少一个部分（例如，使用配置为提供的第一电磁辐射引导装置）提供至少一个第一电磁辐射。可以产生与第一电磁辐射相关联的图像的多个空间频带。此外，可以接收与图像的空间频带相关联的至少一个第二电磁辐射（例如，使用第二布置），并且可以基于空间频带重建图像。

2. 发明申请

WO2011109818A2 SYSTEM, METHODS AND COMPUTER- ACCESSIBLE MEDIUM WHICH PROVIDE MICOSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION 审中-公开
标题翻译：系统，方法和计算机可访问的介质，其在特定分辨率下提供至少一个解剖结构的微观图像
公开(公告)号：WO2011109818A2
公开(公告)日：2011-09-09
申请号：PCT/US2011/027421
申请日：2011-03-07
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E. , GARDECKI, Joseph, A. , LIU, Linbo , MCLEOD, Robert, R.
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E. , GARDECKI, Joseph, A. , LIU, Linbo , MCLEOD, Robert, R.
CPC分类号： A61B5/0066 , A61B5/0044 , A61B5/0075 , A61B5/0084 , G01B9/02091 , G02B6/32
摘要： Exemplary embodiments of apparatus, systems and methods can be provided for providing at least one electro-magnetic radiation to at least one sample. For example, a plurality of wave-guiding arrangements can be provided which are configured to (i) provide the electro-magnetic radiation(s), and (ii) at a point of emission of each of the wave guiding arrangements, cause a phase of each of the electro-magnetic radiation(s) to have a predetermined value. The exemplary apparatus can be part of a probe. Further the exemplary apparatus can include an interferometric arrangement provided in communication with the probe and/or be part of the probe.
摘要翻译：可以提供装置，系统和方法的示例性实施例，以向至少一个样品提供至少一个电磁辐射。例如，可以提供多个波导装置，其被配置为（i）提供电磁辐射，和（ii）在每个波导装置的发射点处，引起相位每个电磁辐射具有预定值。示例性装置可以是探针的一部分。此外，示例性装置可以包括与探针连接和/或成为探针的一部分提供的干涉装置。

3. 发明申请

WO2008115965A1 APPARATUS AND METHOD FOR PROVIDING A NONINVASIVE DIAGNOSIS OF INTERNAL BLEEDING 审中-公开
标题翻译：提供非内在诊断的装置和方法
公开(公告)号：WO2008115965A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/057450
申请日：2008-03-19
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , VELMAHOS, George , BOUMA, Brett, E. , VAKOC, Benjamin, J.
发明人： TEARNEY, Guillermo, J. , VELMAHOS, George , BOUMA, Brett, E. , VAKOC, Benjamin, J.
IPC分类号： A61B5/00 , G01B9/02
CPC分类号： A61B5/0059 , A61B5/0066 , A61B5/0095 , A61B5/416
摘要： Exemplary apparatus and process can be provided for determining at least one characteristic of an anatomical structure. For example, it is possible to generate an acoustic wave in the anatomical structure using an opto-accoustic arrangement It is then possible to detect the acoustic wave and determine whether at least one blood pool is present at or in the anatomical structure as a function of at least one property of the acoustic wave. Further, it is possible to forward at least one first electro-magnetic radiation to at least one tissue of the anatomical structure, detect at least one second electro-magnetic radiation provided from the at least one tissue based on a motion of or within the at least one tissue to generate detection data, and determine the at least one characteristic of the at least one portion based on the detection data.
摘要翻译：可以提供示例性的装置和过程来确定解剖结构的至少一个特征。例如，可以使用光声布置在解剖结构中产生声波。然后可以检测声波并确定至少一个血液池是否存在于解剖结构中或解剖结构中，作为声波的至少一个属性。此外，可以将至少一个第一电磁辐射转发到解剖结构的至少一个组织，基于在所述至少一个组织中的运动或在所述至少一个组织内检测从所述至少一个组织提供的至少一个第二电磁辐射至少一个组织以产生检测数据，并且基于检测数据确定至少一个部分的至少一个特性。

4. 发明申请

WO2007109540A2 ARRANGEMENT, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR IDENTIFYING CHARACTERISTICS OF AT LEAST A PORTION OF A BLOOD VESSEL CONTAINED WITHIN A TISSUE USING SPECTRAL DOMAIN LOW COHERENCE INTERFEROMETRY 审中-公开
标题翻译：装置，方法和计算机可访问介质，用于识别使用光谱域低相干干涉的组织中包含的血管的一部分的特征
公开(公告)号：WO2007109540A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/064174
申请日：2007-03-16
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E.
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E.
CPC分类号： A61B5/489 , A61B5/0059 , A61B5/0062 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/103 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/6848 , A61B5/6852 , A61B10/0045 , A61B10/0283 , A61B2017/00022 , A61B2017/00061 , A61B2562/228 , G01N21/23 , G01N21/4795 , G01N2021/1787
摘要： An apparatus, method and computer-accessible medium for identifying characteristics of at least a portion of a blood vessel contained within a tissue can be provided. For example, it is possible to utilize a radiation source configured to provide a radiation to the tissue. In addition, a probe can be provided which may be adapted to receive the radiation returned from the tissue; Further, a system may be utilized which can be configured to process data relating to the tissue. The data can indicate whether the blood vessel is in a vicinity of an end portion of the probe.
摘要翻译：可以提供用于识别包含在组织内的血管的至少一部分的特征的装置，方法和计算机可访问介质。例如，可以利用被配置为向组织提供辐射的辐射源。此外，可以提供可以适于接收从组织返回的辐射的探针; 此外，可以使用可以被配置为处理与组织有关的数据的系统。数据可以指示血管是否在探针的端部附近。

5. 发明申请

WO2007084995A2 METHODS AND SYSTEMS FOR OPTICAL IMAGING OF EPITHELIAL LUMINAL ORGANS BY BEAM SCANNING THEREOF 审中-公开
标题翻译：通过光束扫描对上皮细胞的光学成像的方法和系统
公开(公告)号：WO2007084995A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/060787
申请日：2007-01-19
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , SHISHKOV, Milen , BOUMA, Brett, E. , VAKOC, Benjamin, J. , NISHIOKA, Norman, S.
发明人： TEARNEY, Guillermo, J. , SHISHKOV, Milen , BOUMA, Brett, E. , VAKOC, Benjamin, J. , NISHIOKA, Norman, S.
IPC分类号： A61B1/04 , A61B5/00 , A61B1/12
CPC分类号： A61B5/0084 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/6852 , A61B5/7271 , G06T7/0012 , G06T2207/10056 , G06T2207/10101
摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.
摘要翻译：提供了安排，装置，系统和系统以获得至少一个管腔或空心样品中的至少一个部分的数据。该装置，系统或装置可以（可经由患者的口或鼻中的至少一个插入），例如，第一光学装置可以被配置为收发至少一个电磁（例如，可视）第二布置可以至少部分地包围第一布置。此外，第三布置可被配置为被致动以将第一布置定位在管腔或中空样品内的预定位置处，第一布置可以是被配置为补偿由第二布置和/或第三布置引起的至少一个像差（例如，散光），第二布置可以包括使引导布置能够插入到其中的至少一个部分，可以提供另一种布置其被配置为测量所述至少一个部分内的压力，所述数据可以包括所述第一装置的位置和/或取向与r 对于管腔或空心样品。

6. 发明申请

WO2006024014A2 PROCESS, SYSTEM AND SOFTWARE ARRANGEMENT FOR MEASURING A MECHANICAL STRAIN AND ELASTIC PROPERTIES OF A SAMPLE 审中-公开
标题翻译：用于测量机械应变和样品的弹性特性的过程，系统和软件安排
公开(公告)号：WO2006024014A2
公开(公告)日：2006-03-02
申请号：PCT/US2005/030294
申请日：2005-08-24
申请人： THE GENERAL HOSPITAL CORPORATION , BOUMA, Brett, E. , CHAN, Raymond, C. , TEARNEY, Guillermo, J.
发明人： BOUMA, Brett, E. , CHAN, Raymond, C. , TEARNEY, Guillermo, J.
IPC分类号： A61B5/00
CPC分类号： A61B5/0066 , A61B5/0059 , A61B5/02007
摘要： A system, process and software arrangement are provided to determining data associated with at least one structural change of tissue. In particular, a first optical coherence tomography ("OCT”) signal which contains first information regarding the tissue at a first stress level, and a second OCT signal which contains second information regarding the tissue at a second stress level are received. The first and second information are compared to produce comparison information. The data associated with the at least one structural change is determined as a function of the comparison information and further information associated with (i) at least one known characteristics of the tissue and/or (ii) characteristics of an OCT system. Further, at least one optical coherence tomography ("OCT”) signal which contains information regarding the tissue can be received, and the modulus of the tissue may be determined as a function of the received at least one OCT signal.
摘要翻译：提供系统，过程和软件布置以确定与组织的至少一个结构变化相关联的数据。特别地，接收包含关于第一应力水平的组织的第一信息的第一光学相干断层摄影（“OCT”）信号和包含关于第二应力水平的组织的第二信息的第二OCT信号。比较第一和第二信息以产生比较信息。与至少一个结构变化相关联的数据被确定为比较信息和与（i）组织的至少一个已知特征和/或（ii）OCT系统的特征相关联的进一步信息的函数。此外，可以接收包含关于组织的信息的至少一个光学相干断层摄影（“OCT”）信号，并且可以根据所接收的至少一个OCT信号来确定组织的模量。

7. 发明申请

WO2011153434A2 APPARATUS AND METHOD FOR DEVICES FOR IMAGING STRUCTURES IN OR AT ONE OR MORE LUMINAL ORGANS 审中-公开
标题翻译：用于在一个或更多个LUMINAL器官上形成结构的设备的装置和方法
公开(公告)号：WO2011153434A2
公开(公告)日：2011-12-08
申请号：PCT/US2011/039066
申请日：2011-06-03
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E. , GORA, Michalina , SUTER, Melissa , YOO, Hongki , SHISHKOV, Milen
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E. , GORA, Michalina , SUTER, Melissa , YOO, Hongki , SHISHKOV, Milen
IPC分类号： A61B1/227 , A61B1/24 , G01B9/02
CPC分类号： A61B1/00082 , A61B1/00165 , A61B1/00179
摘要： In accordance with exemplary embodiments of the present disclosure, device and method can be provided which can facilitate imaging of biological tissues, e.g., luminal organs in vivo, using optical techniques. The exemplary device can include different designs an features of one or more catheters, which can illuminate the tissues, and collect signals from the inside of the lumen. In another exemplary embodiment according to the present disclosure, a balloon-catheter can be provided with the flexible neck, which can absorb most of the bending. According to still another exemplary embodiments of the present disclosure, a balloon-catheter tethered capsule can be provided, and according a yet further exemplary embodiment, a structured balloon design can be provided with one or more protuberances, thus enabling imaging of the structures in close contact, e.g., without compressing of the tissue.
摘要翻译：根据本公开的示例性实施例，可以提供可以使用光学技术来促进生物组织例如体内器官的成像的装置和方法。示例性装置可以包括不同的设计，一个或多个导管的特征可以照亮组织，并从内腔收集信号。在根据本公开的另一示例性实施例中，球囊导管可以设置有柔性颈部，其可以吸收大部分的弯曲。根据本公开的另一示例性实施例，可以提供球囊 - 导管系留胶囊，并且根据另外的示例性实施例，结构化球囊设计可以设置有一个或多个突起，从而能够使结构在近距离成像接触，例如，不压缩组织。

8. 发明申请

WO2010091190A3 APPARATUS AND METHOD FOR UTILIZATION OF A HIGH-SPEED OPTICAL WAVELENGTH TUNING SOURCE 审中-公开
公开(公告)号：WO2010091190A3
公开(公告)日：2010-08-12
申请号：PCT/US2010/023215
申请日：2010-02-04
申请人： THE GENERAL HOSPITAL CORPORATION , OH, Wang-Yuhl , VAKOC, Benjamin, J. , TEARNEY, Guillermo, J. , BOUMA, Brett, E.
发明人： OH, Wang-Yuhl , VAKOC, Benjamin, J. , TEARNEY, Guillermo, J. , BOUMA, Brett, E.
IPC分类号： H01S3/10 , H01S3/00
摘要： Exemplary embodiments of apparatus, source arrangement and method for, e.g., providing high-speed wavelength tuning can be provided. According to one exemplary embodiment, at least one arrangement can be provided which is configured to emit an electromagnetic radiation that (i) has a spectrum whose mean frequency changes at an absolute rate that is greater than about 6000 (or 2000) terahertz per millisecond, (ii) whose mean frequency changes over a range that is greater than about 10 terahertz, and/or (iii) has an instantaneous line width that is less than about 15 gigahertz. According to another exemplary embodiment, at least one arrangement can be provided configured to, periodically and as a function of time, select at least one first electro-magnetic radiation based on a mean frequency of the at least one first electro-magnetic radiation, with the periodic selection being performed at a first characteristic period. The mean frequency can vary linearly over time, wherein the apparatus can emit at least one second electromagnetic radiation that has a spectrum whose mean frequency changes periodically as a function of time with a second characteristic period. Further, the first characteristic period can be greater than the second characteristic period.

9. 发明申请

WO2009137701A3 SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR TRACKING VESSEL MOTION DURING THREE-DIMENSIONAL CORONARY ARTERY MICROSCOPY 审中-公开
公开(公告)号：WO2009137701A3
公开(公告)日：2009-11-12
申请号：PCT/US2009/043178
申请日：2009-05-07
申请人： THE GENERAL HOSPITAL CORPORATION , COLICE, Christopher, Max , BOUMA, Brett, E. , TEARNEY, Guillermo, J. , HA, Jinyong , SHISHKOV, Milen
发明人： COLICE, Christopher, Max , BOUMA, Brett, E. , TEARNEY, Guillermo, J. , HA, Jinyong , SHISHKOV, Milen
IPC分类号： G01B11/24 , G01B11/25 , G01B7/28 , G01B17/06 , G06F17/00 , G01P3/00
摘要： Exemplary embodiments of apparatus, method and computer accessible medium can be provided which can facilitate a determination of at least one characteristic of a structure. For example, it is possible to use at least one first arrangement which can be structured to provide at least one first transmitted radiation along a first axis and at least one second transmitted radiation along a second axis. The first and second transmitted radiations can impact the structure and generate respective first and second returned radiation. The first and second axis can be provided at a predetermined angle with respect with one another which is greater than 0. Further, at least one second arrangement can be provided which can be configured to receive data associated with the first and second returned radiations, and determine at least one relative velocity between the structure and the first arrangement along the first and second axes.

10. 发明申请

WO2008049118A2 APPARATUS AND METHOD FOR OBTAINING AND PROVIDING IMAGING INFORMATION ASSOCIATED WITH AT LEAST ONE PORTION OF A SAMPLE AND EFFECTING SUCH PORTION(S) 审中-公开
标题翻译：用于获取和提供与样品的至少一部分相关联的成像信息并使该部分有效的装置和方法，
公开(公告)号：WO2008049118A2
公开(公告)日：2008-04-24
申请号：PCT/US2007/081982
申请日：2007-10-19
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E. , YELIN, Dvir
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E. , YELIN, Dvir
CPC分类号： A61B1/07 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B18/22 , A61B2017/00061
摘要： Exemplary apparatus and process can be provided for imaging information associated with at least one portion of a sample. For example, (i) at least two first different wavelengths of at least one first electro-magnetic radiation can be provided within a first wavelength range provided on the portion of the sample so as to determine at least one first transverse location of the portion, and (ii) at least two second different wavelengths of at least one second electro-magnetic radiation are provided within a second wavelength range provided on the portion so as to determine at least one second transverse location of the portion. The first and second ranges can east partially overlap on the portion. Further, a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference can be obtained to determine a relative depth location of the portion. First information of the portion based on the first transverse location and the relative depth location, and second information of the portion based on the second transverse location and the relative depth location can be obtained. The imaging information may include the first and second information.
摘要翻译：可以提供示例性的设备和过程用于与样本的至少一部分相关联的成像信息。例如，（i）至少一个第一电磁辐射的至少两个第一不同波长可以设置在样本的该部分上提供的第一波长范围内，以便确定该部分的至少一个第一横向位置，（ii）至少一个第二电磁辐射的至少两个第二不同波长被提供在设置在该部分上的第二波长范围内，以便确定该部分的至少一个第二横向位置。第一和第二范围可以在该部分上向东部分重叠。此外，可以获得从样本返回的至少一个第三电磁辐射电磁辐射与从参考返回的至少一个第四电磁辐射之间的相对相位，以确定该部分的相对深度位置。可以获得基于第一横向位置和相对深度位置的部分的第一信息以及基于第二横向位置和相对深度位置的部分的第二信息。成像信息可以包括第一和第二信息。

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