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1. 发明申请

WO2011109818A2 SYSTEM, METHODS AND COMPUTER- ACCESSIBLE MEDIUM WHICH PROVIDE MICOSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION 审中-公开
标题翻译：系统，方法和计算机可访问的介质，其在特定分辨率下提供至少一个解剖结构的微观图像
公开(公告)号：WO2011109818A2
公开(公告)日：2011-09-09
申请号：PCT/US2011/027421
申请日：2011-03-07
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E. , GARDECKI, Joseph, A. , LIU, Linbo , MCLEOD, Robert, R.
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E. , GARDECKI, Joseph, A. , LIU, Linbo , MCLEOD, Robert, R.
CPC分类号： A61B5/0066 , A61B5/0044 , A61B5/0075 , A61B5/0084 , G01B9/02091 , G02B6/32
摘要： Exemplary embodiments of apparatus, systems and methods can be provided for providing at least one electro-magnetic radiation to at least one sample. For example, a plurality of wave-guiding arrangements can be provided which are configured to (i) provide the electro-magnetic radiation(s), and (ii) at a point of emission of each of the wave guiding arrangements, cause a phase of each of the electro-magnetic radiation(s) to have a predetermined value. The exemplary apparatus can be part of a probe. Further the exemplary apparatus can include an interferometric arrangement provided in communication with the probe and/or be part of the probe.
摘要翻译：可以提供装置，系统和方法的示例性实施例，以向至少一个样品提供至少一个电磁辐射。例如，可以提供多个波导装置，其被配置为（i）提供电磁辐射，和（ii）在每个波导装置的发射点处，引起相位每个电磁辐射具有预定值。示例性装置可以是探针的一部分。此外，示例性装置可以包括与探针连接和/或成为探针的一部分提供的干涉装置。

2. 发明申请

WO2011109835A2 SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM WHICH PROVIDE MICROSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION 审中-公开
标题翻译：在特定分辨率下提供至少一个解剖结构的显微图像的系统，方法和计算机可访问介质
公开(公告)号：WO2011109835A2
公开(公告)日：2011-09-09
申请号：PCT/US2011/027450
申请日：2011-03-07
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E. , GARDECKI, Joseph, A. , LIU, Linbo
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E. , GARDECKI, Joseph, A. , LIU, Linbo
CPC分类号： A61B5/0066 , A61B5/0044 , A61B5/0075 , A61B5/0084 , G01B9/02091 , G02B6/32
摘要： Exemplary embodiments of probes, apparatus, systems and methods can be provided which provide at least one electro-magnetic radiation to at least one sample. For example, a plurality of axicon lenses can be provided which are configured to provide the electro-magnetic radiation(s) having at least partially annulus shape. In addition or alternatively, at least one optical arrangement can be provided which is configured to forward at least one radiation to the sample therethrough having at least partially circularly-symmetric pattern. For example, at least one first portion of the radiation transmitted through a circular section of the pattern can have an optical path-length that is different from an optical path- length of at least one second portion of the radiation transmitted through at least one other section of the pattern.
摘要翻译：可以提供探针，装置，系统和方法的示例性实施例，其向至少一个样本提供至少一个电磁辐射。例如，可以提供多个轴锥透镜，其被配置为提供具有至少部分环形形状的电磁辐射。附加地或替代地，可以提供至少一个光学装置，其被配置为将至少一个辐射传送到通过其中的具有至少部分圆形对称图案的样本。例如，通过图案的圆形部分透射的辐射的至少一个第一部分可以具有与通过至少一个其它透射部分透射的辐射的至少一个第二部分的光学路径长度不同的光学路径长度部分模式。

3. 发明申请

WO2009036453A1 APPARATUS, COMPUTER-ACCESSIBLE MEDIUM AND METHOD FOR MEASURING CHEMICAL AND/OR MOLECULAR COMPOSITIONS OF CORONARY ATHEROSCLEROTIC PLAQUES IN ANATOMICAL STRUCTURES 审中-公开
标题翻译：装置，计算机可接受的介质和测量化学和/或分子结构的冠状动脉造影剂在解剖结构中的方法
公开(公告)号：WO2009036453A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/076447
申请日：2008-09-15
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E. , MOTZ, Jason, T. , GARDECKI, Joseph, A. , CHAU, Alexandra, H.
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E. , MOTZ, Jason, T. , GARDECKI, Joseph, A. , CHAU, Alexandra, H.
IPC分类号： A61B5/00 , A61B6/00 , G06F17/00
CPC分类号： A61B5/0075 , A61B5/0084 , A61B5/02007
摘要： Exemplary apparatus and method can be provided for controlling at least one electro-magnetic radiation. For example, it is possible to rotate and/or translate at least one optical waveguide. At least one of the optical waveguide(s) can receive a first radiation at a first wavelength and transmit the first radiation to at least one sample. Such optical waveguide and/or another optical waveguide may receive a second radiation at a second wavelength that is different from the first wavelength. For example, the second radiation may be produced based on an inelastic scattering of the first radiation. In addition, exemplary apparatus and method can be provided which can also be used to receive data associated with the second radiation, determine at least one characteristic of the at least one sample based on the data, and generate the image and/or the map of a portion of the arterial sample based on the at least one characteristic. Further, exemplary computer-accessible medium can be provided which includes a software arrangement thereon. When a processing arrangement executes the software arrangement, the processing arrangement is configured to modify at least one characteristic of an arrangement using certain procedures. These exemplary procedures include simulating at least one electro-magnetic radiation provided into and out of the arrangement, simulating an inelastic scattering radiation from at least one simulated sample, receiving the simulated inelastic scattering radiation into and out of the simulated arrangement, and determining a simulated characteristic of the simulated arrangement as a function of the simulated inelastic scattering radiation.
摘要翻译：可以提供示例性的装置和方法来控制至少一个电磁辐射。例如，可以旋转和/或平移至少一个光波导。至少一个光波导可以接收第一波长的第一辐射并将第一辐射传输到至少一个样本。这种光波导和/或另一光波导可以接收与第一波长不同的第二波长的第二辐射。例如，可以基于第一辐射的非弹性散射来产生第二辐射。此外，可以提供示例性的装置和方法，其还可以用于接收与第二辐射相关联的数据，基于数据确定至少一个样本的至少一个特征，并且生成图像和/或基于至少一个特征的动脉样本的一部分。此外，可以提供示例性的计算机可访问介质，其中包括其上的软件布置。当处理装置执行软件装置时，处理装置被配置为使用某些程序来修改装置的至少一个特性。这些示例性程序包括模拟提供入和排出的至少一个电磁辐射，模拟来自至少一个模拟样本的非弹性散射辐射，将模拟的非弹性散射辐射接收到模拟装置中和从模拟装置中取出，以及确定模拟作为模拟非弹性散射辐射的函数的模拟布置的特征。

4. 发明申请

WO2023028032A1 INTRAVASCULAR DUAL-MODALITY OCT AND MULTICHANNEL NIRF INFLAMMATION IMAGING 审中-公开
公开(公告)号：WO2023028032A1
公开(公告)日：2023-03-02
申请号：PCT/US2022/041171
申请日：2022-08-23
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： THRAPP, Andrew, D. , AHSEN, Osman, O. , TEARNEY, Guillermo, J. , JAFFER, Farouc, A. , GARDECKI, Joseph, A. , KASSAB, Mohamad, B. , MAUSKAPF, Adam
IPC分类号： A61B5/00 , A61B6/00 , G01N21/64
摘要： A method for detecting inflammatory activity, including: providing a catheter including a near-infrared fluorescence (NIRF) imaging system configured to perform NIRF imaging and an optical coherence tomography (OCT) imaging system configured to perform structural imaging; introducing a near-infrared fluorescent cathepsin-activatable imaging agent into a blood vessel; placing a distal end of the catheter within the blood vessel; obtaining, using the OCT imaging system, structural images of an atherosclerotic plaque within the blood vessel; obtaining, using the NIRF imaging system, NIRF images of the atherosclerotic plaque within the blood vessel; detecting the near-infrared fluorescent cathepsin-activatable imaging agent in the NIRF images; and identifying inflammation within the atherosclerotic plaque based on detecting the near- infrared fluorescent cathepsin-activatable imaging agent in the NIRF images.

5. 发明申请

WO2014121186A1 APPARATUS AND METHOD WHICH CAN INCLUDE CENTER-WAVELENGTH SELECTABLE, BANDWIDTH ADJUSTABLE, SPECTRUM CUSTOMIZABLE, AND/OR MULTIPLEXABLE SWEPT-SOURCE LASER ARRANGEMENT 审中-公开
标题翻译：装置和方法，其中可以包括中心波长可选择，带宽可调，光谱自定义和/或多路复用切换源激光器布置
公开(公告)号：WO2014121186A1
公开(公告)日：2014-08-07
申请号：PCT/US2014/014413
申请日：2014-02-03
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： TEARNEY, Guillermo, J. , GARDECKI, Joseph, A. , JACQUES, Paulino, Vacas
IPC分类号： H01S3/10
CPC分类号： H01S3/105 , H01S3/083 , H01S3/1003 , H01S3/10053 , H01S5/06213 , H01S5/146
摘要： Systems, methods and computer-accessible mediums for providing a radiation(s) can be provided. For example, a hardware arrangement can be configured to provide the radiation(s) that can have a wavelength(s) that continuously changes over time and over a predetermined bandwidth with a predetermined envelope in a single sweep. The hardware arrangement can include a gain arrangement and a controller arrangement, and the controller arrangement can be configured to electronically control the gain arrangement such that the wavelength(s) provided by the hardware arrangement (i) spans a subset of the predetermined bandwidth, or (ii) changes a wavelength dependent distribution in the single sweep.
摘要翻译：可以提供用于提供辐射的系统，方法和计算机可访问介质。例如，硬件布置可以被配置为提供可以具有在一次扫描中具有预定包络的时间上和超过预定带宽连续变化的波长的辐射。硬件布置可以包括增益布置和控制器布置，并且控制器布置可以被配置为电子控制增益布置，使得由硬件布置（i）提供的波长跨越预定带宽的子集，或（ii）在单次扫描中改变波长相关分布。

6. 发明申请

WO2019140174A3 DEVICES, SYSTEMS, AND METHODS FOR ADVANCING AND POSITIONING TETHERED CAPSULE MICROENDOSCOPES 审中-公开
公开(公告)号：WO2019140174A3
公开(公告)日：2019-07-18
申请号：PCT/US2019/013172
申请日：2019-01-11
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： TEARNEY, Guillermo, J. , HYUN, Chulho, Daryl , GARDECKI, Joseph, A.
IPC分类号： A61B1/04 , A61B1/00 , A61B1/05 , A61B1/06 , A61B1/07 , A61B5/00
摘要： In some embodiments, devices, systems, and methods for advancing and positioning tethered capsule microendoscopes are provided. In some embodiments, a device for capsule endomicroscopy is provided, comprising: a tether having a proximal end and distal end; an optical fiber disposed within the tether; a tube enclosing at least a portion of the tether, the tube having a proximal end and a distal end, a diameter of the tube being larger than the diameter of the tether; a housing coupled to the distal end of the tether and the distal end of the tube; and an optical element disposed within the housing, the optical element being optically coupled to the distal end of the optical fiber and configured to direct light received from the optical fiber toward a periphery of the housing.

7. 发明申请

WO2019140174A2 DEVICES, SYSTEMS, AND METHODS FOR ADVANCING AND POSITIONING TETHERED CAPSULE MICROENDOSCOPES 审中-公开
公开(公告)号：WO2019140174A2
公开(公告)日：2019-07-18
申请号：PCT/US2019/013172
申请日：2019-01-11
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： TEARNEY, Guillermo, J. , HYUN, Chulho, Daryl , GARDECKI, Joseph, A.
IPC分类号： A61B1/02
摘要： In some embodiments, devices, systems, and methods for advancing and positioning tethered capsule microendoscopes are provided. In some embodiments, a device for capsule endomicroscopy is provided, comprising: a tether having a proximal end and distal end; an optical fiber disposed within the tether; a tube enclosing at least a portion of the tether, the tube having a proximal end and a distal end, a diameter of the tube being larger than the diameter of the tether; a housing coupled to the distal end of the tether and the distal end of the tube; and an optical element disposed within the housing, the optical element being optically coupled to the distal end of the optical fiber and configured to direct light received from the optical fiber toward a periphery of the housing.

8. 发明申请

WO2019084316A1 SYSTEMS AND METHODS FOR IMAGING AND THERAPY SUITABLE FOR USE IN THE CARDIOVASCULAR SYSTEM 审中-公开
公开(公告)号：WO2019084316A1
公开(公告)日：2019-05-02
申请号：PCT/US2018/057584
申请日：2018-10-25
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： MELNITOCHOUK, Serguei , TEARNEY, Guillermo, J. , BALDWIN, Grace, E. , GARDECKI, Joseph, A.
IPC分类号： H01F3/10
CPC分类号： A61B5/0066 , A61B5/0075 , A61B5/0084
摘要： Probes, catheters, systems, methods, and ferrofluids are provides for acquiring direct visualization medical images of internal structures. The probes can include a channel, an optical waveguide, and a ferrofluid attractor. The ferrofluid attractor can be configured to magnetically attract the ferrofluid when exiting a distal port of the channel. The medical image can be acquired through the ferrofluid, which is excluding blood from the area that the ferrofluid is occupying. The ferrofluid has a lower optical absorbance than blood, so the acquiring the image through the ferrofluid rather than through blood provides improved images.

9. 发明申请

WO2014120791A1 APPARATUS, SYSTEMS AND METHODS FOR PROVIDING INFORMATION REGARDING THE AORTIC VALVE 审中-公开
标题翻译：装置，系统和方法提供关于动力阀的信息
公开(公告)号：WO2014120791A1
公开(公告)日：2014-08-07
申请号：PCT/US2014/013628
申请日：2014-01-29
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： TEARNEY, Guillermo, J. , WARGER, II, William, C. , GARDECKI, Joseph, A. , GALLAGHER, Kevin , GUERRERO, Jose, L. , JAFFER, Farouc
IPC分类号： A61B1/00 , A61B6/00 , A61B1/07
CPC分类号： A61B5/0066 , A61B5/0084 , A61B8/12 , A61M25/04
摘要： An apparatus according to an exemplary embodiment of the present disclosure can include a first section(s) and a second section(s) which can have a cross-section that can be smaller than that of the first section. The first and second sections can be a particular section and can include memory-forming characteristics. An imaging arrangement can be in communication with the first section or the second section. The particular section can have a first shape when the particular section can be constrained, and the particular section can have a second shape when the particular section can be unconstrained. The second shape can be more curved than the first shape.
摘要翻译：根据本公开的示例性实施例的装置可以包括可以具有小于第一部分的横截面的第一部分和第二部分。第一和第二部分可以是特定部分，并且可以包括记忆形成特征。成像装置可以与第一部分或第二部分连通。当特定部分可以被约束时，特定部分可以具有第一形状，并且当特定部分可以是不受约束时，特定部分可以具有第二形状。第二形状可以比第一形状更弯曲。

10. 发明公开

EP2542154A2 SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM WHICH PROVIDE MICROSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION 有权
标题翻译：系统，方法和每台计算机可访问介质，用于提供显微图像最不解剖结构与特定的解决方案
公开(公告)号：EP2542154A2
公开(公告)日：2013-01-09
申请号：EP11751520.5
申请日：2011-03-07
申请人： The General Hospital Corporation
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E. , GARDECKI, Joseph, A. , LIU, Linbo
IPC分类号： A61B5/05 , A61B1/00 , G01B9/02
摘要： Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from the portion which is based on the first radiation. Based on an interaction between the optical arrangement and the first radiation and/or the second radiation, the optical arrangement can have a first transfer function. Further, it is possible to forward at least one third radiation to the portion through such optical arrangement (or through another optical arrangement), and receive at least one fourth radiation from the portion which is based on the third radiation. Based on an interaction between the optical arrangement (or the other optical arrangement) and the third radiation and/or the fourth radiation, the optical arrangement (or the other optical arrangement) can have a second transfer function. The first transfer function can be at least partially different from the second transfer function. The data can be generated based on the second and fourth radiations.

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