专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1995033716A1 VITAMIN D3 DERIVATIVE AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：维生素D3衍生物及其制备方法
公开(公告)号：WO1995033716A1
公开(公告)日：1995-12-14
申请号：PCT/JP1995001145
申请日：1995-06-07
申请人： TEIJIN LIMITED , TABE, Masayasu , HAZATO, Atsuo , MANABE, Kenji , GAO, Qingzhi , TANAKA, Hiroko
发明人： TEIJIN LIMITED
IPC分类号： C07C401/00
CPC分类号： C07D307/33 , C07C69/675 , C07C69/716 , C07C69/732 , C07C401/00 , C07D307/58 , C07D317/34 , C07F7/1804
摘要： A vitamin D3 derivative represented by general formula (I), wherein Rs represent each independently hydrogen, tri(C1-C7 hydrocarbyl)silyl, C2-C8 acyl or a group forming an acetal bond with the oxygen atom of a hydroxyl group; A represents groups (a), (b) or (c) wherein R represents methyl or methylene, provided when R is methylene, the bond between it and the 3-position of the lactone ring it a double bond; R represents hydrogen or C1-C3 alkyl; and R represents hydrogen, or R and R may be combined together to represent an optionally substituted methylene group.
摘要翻译：由通式（I）表示的维生素D3衍生物，其中Rs各自独立地表示氢，三（C1-C7烃基）甲硅烷基，C2-C8酰基或与羟基的氧原子形成缩醛键的基团; A表示当R 1为亚甲基时，其中R 1表示甲基或亚甲基的基团（a），（b）或（c），其与内酯环的3-位上的键为双键 ; R 2表示氢或C 1 -C 3烷基; 并且R 3表示氢，或者R 2和R 3可以组合在一起以表示任选取代的亚甲基。

2. 发明申请

WO1994017806A1 DERMATOLOGIC PREPARATION COMPOSITION CONTAINING PROSTACYCLIN AS ACTIVE INGREDIENT 审中-公开
标题翻译：含有PROSTACYCLIN作为活性成分的精神制剂组合物
公开(公告)号：WO1994017806A1
公开(公告)日：1994-08-18
申请号：PCT/JP1994000164
申请日：1994-02-03
申请人： TEIJIN LIMITED , HAZATO, Atsuo , HANAJIMA, Nobuaki , MAKINO, Yuji , TAKEDA, Toshiaki , KOYAMA, Tamotsu
发明人： TEIJIN LIMITED
IPC分类号： A61K31/557
CPC分类号： A61K31/557
摘要： A dermatologic preparation composition containing as the active ingredient a prostacyclin represented by general formula (I) and/or an enantiomer thereof, wherein R represents hydrogen, C1-C10 linear or branched alkyl, or a monovalent cation; R represents -CH2-CH2-R (wherein R represents optionally substituted C1-C10 linear or branched alkyl, or optionally substituted C2-C10 linear or branched alkenyl or alkynyl) or optionally substituted C3-C10 cycloalkyl; and R and R represent each independently hydroxy or -OC( = O)R , wherein R represents C1-C5 linear or branched alkyl.
摘要翻译：一种皮肤病学制剂组合物，其含有作为活性成分的由通式（I）表示的前列环素和/或其对映异构体，其中R 1表示氢，C1-C10直链或支链烷基或一价阳离子; R 2表示-CH 2 -CH 2 -R 21（其中R 21表示任选取代的C 1 -C 10直链或支链烷基或任选取代的C 2 -C 10直链或支链烯基或炔基）或任选取代的C 3 -C 10 环烷基; R 3和R 4各自独立地表示羟基或-OC（= O）R 5，其中R 5表示C 1 -C 5直链或支链烷基。

3. 发明申请

WO1991005766A1 2-SUBSTITUTED 2-CYCLOPENTENONE AND CARCINOSTATIC AGENT AND OSTEOGENESIS PROMOTER CONTAINING THE SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译： 2-取代的2-环烯酸和含有相同活性成分的致癌物质和促蛋白酶
公开(公告)号：WO1991005766A1
公开(公告)日：1991-05-02
申请号：PCT/JP1990001343
申请日：1990-10-18
申请人： TEIJIN LIMITED , SUGIURA, Satoshi , MINOSHIMA, Toru , HAZATO, Atsuo , KATO, Yoshinori
发明人： TEIJIN LIMITED
IPC分类号： C07C317/24
CPC分类号： C07D213/70 , C07C45/72 , C07C49/707 , C07C49/753 , C07C317/24 , C07C317/46 , C07C323/22 , C07C323/61 , C07C405/0033 , C07C2601/10 , C07C2601/14 , C07D233/84 , C07D239/38 , C07D257/04 , C07D263/58 , C07D277/16 , C07D277/74 , C07D303/40 , C07D307/38 , C07D307/46 , C07D405/12 , C07D473/38 , C07F7/1804 , C07H13/04
摘要： A 2-substituted 2-cyclopentenone of formula (I) and a carcinostatic agent and an osteogenesis promoter containing the same as the active ingredient.
摘要翻译：式（I）的2-取代的2-环戊烯酮和含有与活性成分相同的制癌剂和成骨促进剂。

4. 发明申请

WO1994005619A1 4-HYDROXY-2-CYCLOPENTENONE DERIVATIVE AND CARCINOSTATIC AND OSTEOGENESIS PROMOTER CONTAINING THE SAME 审中-公开
标题翻译： 4-羟基-2-环丙烯酮衍生物和含有它们的致癌和促蛋白酶促进剂
公开(公告)号：WO1994005619A1
公开(公告)日：1994-03-17
申请号：PCT/JP1993001266
申请日：1993-09-07
申请人： TEIJIN LIMITED , FURUYA, Minoru , SUGIURA, Satoshi , HAZATO, Atsuo
发明人： TEIJIN LIMITED
IPC分类号： C07C49/707
CPC分类号： C07H13/04 , C07C45/673 , C07C49/707 , C07C49/723 , C07C49/743 , C07C49/747 , C07C49/753 , C07C69/007 , C07C69/738 , C07C69/76 , C07C69/96 , C07C205/45 , C07C225/22 , C07C405/00 , C07C2601/10 , C07C2601/14 , C07D213/50 , C07D277/16 , C07D309/12 , C07D333/22 , C07F7/1804 , C07H13/06
摘要： An optically active compound represented by general formula (I), a mixture thereof, and a carcinostatic and osteogenesis promoter each containing the same as the active ingredient, wherein Y represents hydrogen or halogen; A represents hydroxy, C2-C7 acyloxy, C2-C5 alkoxycarbonyloxy or C1-C7 sulfonyloxy and B represents hydrogen, or alternatively A and B are combined together to represent a bond; R2 represents a C4-C10 alicyclic hydrocarbon, C6-C10 aromatic hydrocarbon or C1-C9 heterocyclic hydrocarbon group each of which may be substituted; R3 represents hydrogen or a C1-C10 aliphatic hydrocarbon, C4-C10 alicyclic hydrocarbon or C6-C10 aromatic hydrocarbon group each of which may be substituted; R4 represents hydrogen, C1-C4 alkyl, C2-C7 acyl, C2-C5 alkoxycarbonyl, tri(C1-C7 hydrocarbyl)silyl or a group which forms an acetal bond together with the oxygen atom to which the R4 is bonded; and R5 represents hydrogen or a C1-C10 aliphatic hydrocarbon or C4-C10 alicyclic hydrocarbon group each of which may be substituted.
摘要翻译：由通式（I）表示的光学活性化合物，其混合物，和各自含有与活性成分相同的制癌和成骨促进剂，其中Y表示氢或卤素; A表示羟基，C 2 -C 7酰氧基，C 2 -C 5烷氧基羰基氧基或C 1 -C 7磺酰氧基，B表示氢，或者A和B组合在一起表示键; R2表示可以被取代的C4-C10脂环族烃，C6-C10芳族烃或C1-C9杂环烃基; R 3表示氢或可以被取代的C 1 -C 10脂族烃，C 4 -C 10脂环烃或C 6 -C 10芳烃基; R4表示氢，C1-C4烷基，C2-C7酰基，C2-C5烷氧基羰基，三（C1-C7烃基）甲硅烷基或与R4键合的氧原子一起形成缩醛键的基团; 并且R 5表示氢或可以被取代的C 1 -C 10脂族烃或C 4 -C 10脂环族烃基。

5. 发明申请

WO1986004330A1 PROCESS FOR PREPARING 16-SUBSTITUTED PROSTAGLANDIN E'S 审中-公开
标题翻译：制备16替代的PROSTAGLANDIN E的方法
公开(公告)号：WO1986004330A1
公开(公告)日：1986-07-31
申请号：PCT/JP1986000034
申请日：1986-01-28
申请人： TEIJIN LIMITED , TANAKA, Toshio , HAZATO, Atsuo , KUROZUMI, Seizi , KOGA, Masahiro
发明人： TEIJIN LIMITED
IPC分类号： C07C177/00
CPC分类号： C07C405/0033 , C07C405/00
摘要： A process for preparing 16-substituted DELTA7-prostaglandin E's of the compounds represented by general formula (I), ADwherein R1 represents COOR2, CH2OR3 or COCH2OR3 (wherein R2 represents H, substituted or unsubstituted C1 - C10 alkyl, substituted or unsubstituted C3 - C10 cycloalkyl, or substituted or unsubstituted phenyl, and R3 represents H, tri-(C1 - C7hydrocarbyl)silyl, a group forming an acetal bond together with the oxygen atom of OH, or C2 - C7 acyl), R4 and R5 may be the same or different and each represents H, tri(C1 - C7hydrocarbyl)silyl, or a group forming an acetal bond together with the oxygen atom of OH, R6 represents H, C1 - C4 alkyl, or vinyl, R7 represents straight-chain or branched C3 - C8 alkyl group optionally containing oxygen, alkenyl, or alkynyl; optionally substituted phenyl, phenoxy or C3 - C10 cycloalkyl; or C1 - C6 alkoxy, optionally substituted phenyl, phenoxy, or C3 - C10 cycloalkyl-substituted straight-chain or branched C1 - C5 alkyl, and Y represents CH2X or XCH2 (wherein X represents ethylene, cis- or trans-vinylene, or ethynylene) BD, enantiomers thereof, or a mixture of optional proportion.

6. 发明申请

WO1985003936A1 7-THIAPROSTAGLANDIN E1'S AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译： 7-THIAPROSTAGLANDIN E1及其制备方法
公开(公告)号：WO1985003936A1
公开(公告)日：1985-09-12
申请号：PCT/JP1985000110
申请日：1985-03-05
申请人： TEIJIN LIMITED , TANAKA, Toshio , BANNAI, Kiyoshi , HAZATO, Atsuo , KUROZUMI, Seiji
发明人： TEIJIN LIMITED
IPC分类号： C07C177/00
CPC分类号： C07C405/0033
摘要： 7-thiaprostaglandin E1's represented by formula (I): (wherein R1 represents H, C1 to C10 alkyl, C2 to C20 alkenyl, substituted or unsubstituted phenyl, substituted or unsubstituted C3 to C10 cycloalkyl, substituted or unsubstituted phenyl(C1 to C2)alkyl, or mono-equivalent cation, R2 and R3, which may be the same or different, each represents H, tri(C1 to C7)-hydrocarbylsilyl or a group forming an acetal bond with the oxygen atom of the hydroxy group, R4 represents H, methyl or vinyl, R5 represents straight or branched C3 to C8 alkyl, straight or branched C3 to C8 alkenyl, straight or branched C3 to C8 alkynyl, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted C3 to C10 cycloalkyl, or straight or branched C1 to C5 alkyl substituted by C1 to C6 alkoxy, optionally substituted phenyl, optionally substituted phenoxy or optionally substituted C3 to C10 cycloalkyl, X represents ethylene, vinylene or ethynylene, n represents 0 or 1,$(1,6)$represents ethylene or vinylene, provided that, when n represents 0 and X represents ethylene, R5 does not represent straight or branched C3 to C8 alkyl, nor optionally substituted C3 to C10 cycloalkyl), enantiomers thereof, and mixtures thereof in arbitrary ratios are useful for treating and/or preventing diseases of digestive organs such as duodenum or stomach.

7. 发明申请

WO1985003935A1 6-SUBSTITUTED PROSTAGLANDIN E1'S AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译： 6取代的PROSTAGLANDIN E1及其制备方法
公开(公告)号：WO1985003935A1
公开(公告)日：1985-09-12
申请号：PCT/JP1985000096
申请日：1985-02-28
申请人： TEIJIN LIMITED , TANAKA, Toshio , HAZATO, Atsuo , KUROZUMI, Seiji
发明人： TEIJIN LIMITED
IPC分类号： C07C177/00
CPC分类号： C07C405/0041 , C07C405/00 , C07F1/02 , C07F1/08
摘要： 6-substituted prostaglandin E1's represented by formula (I), (wherein R1 represents H, C1 to C10 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted C3 to C10 cycloalkyl, substituted or unsubstituted phenyl(C1 to C2) alkyl or mono-equivalent cation; R2 and R3, which may be the same or different, each represents H, tri(C1 to C7)hydrocarbylsilyl, or a group forming an acetal bond with the oxygen atom of the hydroxy group, R4 represents H, methyl or vinyl, R5 represents straight or branched C3 to C8 alkyl, straight or branched C3 to C8 alkenyl, straight or branched C3 to C8 alkynyl, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted C3 to C10 cycloalkyl or C1 to C6 alkoxy, straight or branched C1 to C5 alkyl substituted by optionally substituted phenyl, optionally substituted phenoxy or optionally substituted C3 to C10 cycloalkyl, and X represents H-NO2 or oxygen atom), enantiomers thereof, and mixtures thereof in arbritary ratios, are useful for treating and preventing diseases of digestive organs such as duodenum or stomach.

8. 发明申请

WO1994017805A1 DERMATOLOGIC PREPARATION COMPOSITION CONTAINING ISOCARBACYCLIN AS ACTIVE INGREDIENT 审中-公开
标题翻译：含有异柠檬酸作为活性成分的精神制剂组合物
公开(公告)号：WO1994017805A1
公开(公告)日：1994-08-18
申请号：PCT/JP1994000163
申请日：1994-02-03
申请人： TEIJIN LIMITED , FUJISAWA PHARMACEUTICAL CO., LTD. , HAZATO, Atsuo , HANAJIMA, Nobuaki , MAKINO, Yuji , TAKEDA, Toshiaki , KOYAMA, Tamotsu , HATA, Takehisa , KIMURA, Sumihisa , MURATA, Saburo
发明人： TEIJIN LIMITED , FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： A61K31/557
CPC分类号： A61K31/557 , Y10S514/824 , Y10S514/925 , Y10S514/928
摘要： A dermatologic preparation composition containing as the active ingredient an isocarbacyclin represented by general formula (I) and/or an enantiomer thereof, wherein R represents hydrogen, C1-C10 linear or branched alkyl, or a monovalent cation; R represents optionally substituted C1-C10 linear or branched alkyl, alkenyl or alkynyl; R represents C1-C5 linear alkyl; and R and R represent each independently hydroxy or -OC(=O)R , wherein R represents C1-C5 linear or branched alkyl.
摘要翻译：一种皮肤病学制剂组合物，含有作为活性成分的由通式（I）表示的异卡波环素和/或其对映异构体，其中R 1表示氢，C1-C10直链或支链烷基或一价阳离子; R 2表示任选取代的C 1 -C 10直链或支链烷基，烯基或炔基; R 3表示C 1 -C 5直链烷基; 和R 4和R 5各自独立地表示羟基或-OC（= O）R 6，其中R 6表示C 1 -C 5直链或支链烷基。

9. 发明申请

WO1990012001A1 THIONAPHTHALENE DERIVATIVES, METHOD OF PRODUCING THE SAME, AND ANTIALLERGIC AGENT CONTAINING THE SAME 审中-公开
标题翻译：衍生物及其制备方法和含有该衍生物的抗微生物剂
公开(公告)号：WO1990012001A1
公开(公告)日：1990-10-18
申请号：PCT/JP1990000441
申请日：1990-03-30
申请人： TEIJIN LIMITED , HAZATO, Atsuo , KATO, Yoshinori , KUROZUMI, Seizi , OHMORI, Hitoshi , MINOSHIMA, Toru , OSADA, Yoshio , NAGATA, Ikuo , KOMORIYA, Keiji
发明人： TEIJIN LIMITED
IPC分类号： C07C317/22
CPC分类号： C07D207/333 , C07C317/22 , C07C317/44 , C07C323/21 , C07C323/22 , C07C323/52 , C07C323/60 , C07D213/32 , C07D213/50 , C07D241/12 , C07D257/04 , C07D277/26 , C07D333/22
摘要： Thionaphthalene derivatives represented by formula (I) and nontoxic salts thereof, wherein R represents hydrogen, (un)substituted C1 to C5 alkyl, (un)substituted aryl, heterocyclic group, R4CO- (wherein R4 represents (un)substituted C¿1? to C5 alkyl, (un)substituted aryl, or heterocyclic group), R?5¿OCO- (wherein R5 represents hydrogen, (un)substituted C¿1? to C10 alkyl, (un)substituted C3 to C10 alkenyl, or (un)substituted C5 to C7 cycloalkyl), R?6¿NHCO- (wherein R6 represents (un)substituted C¿1? to C5 alkyl, (un)substituted aryl, or heterocyclic group), or cyano; R?1 and R2¿ represent each independently hydrogen, C¿1? to C5 alkyl, or phenyl; R?3¿ represents hydrogen, C¿1? to C5 alkyl, or R?7¿CO- (wherein R7 represents -OR?81, -R82¿, or -NR¿2??83, and R81, R82 and R83¿ represent each C¿1? to C4 alkyl); and n represents an integer of 0 to 2.

10. 发明申请

WO1995019340A1 7-THIAPROSTAGLANDINS AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译： 7-THIAPROSTAGLANDINS及其生产方法
公开(公告)号：WO1995019340A1
公开(公告)日：1995-07-20
申请号：PCT/JP1995000042
申请日：1995-01-18
申请人： TEIJIN LIMITED , MINOSHIMA, Toru , KATAOKA, Kenichiro , TANAKA, Hiroko , ISHII, Koji , ENDO, Noriaka
发明人： TEIJIN LIMITED
IPC分类号： C07C405/00
CPC分类号： C07C405/0033
摘要： 7-Thiaprostaglandins represented by general formula (I), enantiomers thereof, and mixtures thereof, inhibiting cell migration caused by chemokives such as monocyte migration factor MCP-1/MCAF and serving as a remedy for arteriosclerosis, diabetic angiopathy, and the like.
摘要翻译：由通式（I）表示的7-硫代前列腺素，其对映异构体及其混合物，抑制由诸如单核细胞迁移因子MCP-1 / MCAF的化学试剂引起的细胞迁移并用作动脉硬化，糖尿病性血管病等的补救剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式