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    • 2. 发明申请
    • 7-THIAPROSTAGLANDIN E1'S AND PROCESS FOR THEIR PREPARATION
    • 7-THIAPROSTAGLANDIN E1及其制备方法
    • WO1985003936A1
    • 1985-09-12
    • PCT/JP1985000110
    • 1985-03-05
    • TEIJIN LIMITEDTANAKA, ToshioBANNAI, KiyoshiHAZATO, AtsuoKUROZUMI, Seiji
    • TEIJIN LIMITED
    • C07C177/00
    • C07C405/0033
    • 7-thiaprostaglandin E1's represented by formula (I): (wherein R1 represents H, C1 to C10 alkyl, C2 to C20 alkenyl, substituted or unsubstituted phenyl, substituted or unsubstituted C3 to C10 cycloalkyl, substituted or unsubstituted phenyl(C1 to C2)alkyl, or mono-equivalent cation, R2 and R3, which may be the same or different, each represents H, tri(C1 to C7)-hydrocarbylsilyl or a group forming an acetal bond with the oxygen atom of the hydroxy group, R4 represents H, methyl or vinyl, R5 represents straight or branched C3 to C8 alkyl, straight or branched C3 to C8 alkenyl, straight or branched C3 to C8 alkynyl, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted C3 to C10 cycloalkyl, or straight or branched C1 to C5 alkyl substituted by C1 to C6 alkoxy, optionally substituted phenyl, optionally substituted phenoxy or optionally substituted C3 to C10 cycloalkyl, X represents ethylene, vinylene or ethynylene, n represents 0 or 1,$(1,6)$represents ethylene or vinylene, provided that, when n represents 0 and X represents ethylene, R5 does not represent straight or branched C3 to C8 alkyl, nor optionally substituted C3 to C10 cycloalkyl), enantiomers thereof, and mixtures thereof in arbitrary ratios are useful for treating and/or preventing diseases of digestive organs such as duodenum or stomach.