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1. 发明申请

WO1994007838A1 ISOCARBACYCLIN WITH MODIFIED 'alpha'-CHAIN AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：具有改性的α环的异柠檬酸和其生产方法
公开(公告)号：WO1994007838A1
公开(公告)日：1994-04-14
申请号：PCT/JP1993001407
申请日：1993-10-01
申请人： TEIJIN LIMITED , KOGA, Masahiro , TANAKA, Toshio , FUJII, Takao , MASEGI, Tsukio
发明人： TEIJIN LIMITED
IPC分类号： C07C61/35
CPC分类号： C07C65/19 , C07C69/76 , C07C405/0083
摘要： An isocarbacyclin with the alpha -chain modified with phenylene, cycloalkylene or thiophenediyl. It has the activity of inhibiting DNA synthesis of human smooth muscle cells and is expected to inhibit vascular hypertrophy.
摘要翻译：具有用亚苯基，亚环烷基或噻吩二基修饰的α-链的异卡巴环素。它具有抑制人平滑肌细胞DNA合成的活性，预计可抑制血管肥大。

2. 发明申请

WO1986004330A1 PROCESS FOR PREPARING 16-SUBSTITUTED PROSTAGLANDIN E'S 审中-公开
标题翻译：制备16替代的PROSTAGLANDIN E的方法
公开(公告)号：WO1986004330A1
公开(公告)日：1986-07-31
申请号：PCT/JP1986000034
申请日：1986-01-28
申请人： TEIJIN LIMITED , TANAKA, Toshio , HAZATO, Atsuo , KUROZUMI, Seizi , KOGA, Masahiro
发明人： TEIJIN LIMITED
IPC分类号： C07C177/00
CPC分类号： C07C405/0033 , C07C405/00
摘要： A process for preparing 16-substituted DELTA7-prostaglandin E's of the compounds represented by general formula (I), ADwherein R1 represents COOR2, CH2OR3 or COCH2OR3 (wherein R2 represents H, substituted or unsubstituted C1 - C10 alkyl, substituted or unsubstituted C3 - C10 cycloalkyl, or substituted or unsubstituted phenyl, and R3 represents H, tri-(C1 - C7hydrocarbyl)silyl, a group forming an acetal bond together with the oxygen atom of OH, or C2 - C7 acyl), R4 and R5 may be the same or different and each represents H, tri(C1 - C7hydrocarbyl)silyl, or a group forming an acetal bond together with the oxygen atom of OH, R6 represents H, C1 - C4 alkyl, or vinyl, R7 represents straight-chain or branched C3 - C8 alkyl group optionally containing oxygen, alkenyl, or alkynyl; optionally substituted phenyl, phenoxy or C3 - C10 cycloalkyl; or C1 - C6 alkoxy, optionally substituted phenyl, phenoxy, or C3 - C10 cycloalkyl-substituted straight-chain or branched C1 - C5 alkyl, and Y represents CH2X or XCH2 (wherein X represents ethylene, cis- or trans-vinylene, or ethynylene) BD, enantiomers thereof, or a mixture of optional proportion.

3. 发明申请

WO1996004903A1 VASCULAR SMOOTH MUSCLE CELL MIGRATION INHIBITOR 审中-公开
标题翻译：血管平滑肌细胞移植抑制剂
公开(公告)号：WO1996004903A1
公开(公告)日：1996-02-22
申请号：PCT/JP1995001492
申请日：1995-07-27
申请人： TEIJIN LIMITED , MASEGI, Tsukio , TOMIMORI, Koji , WATANABE, Kunihito
发明人： TEIJIN LIMITED
IPC分类号： A61K31/215
CPC分类号： A61K31/5575
摘要： A vascular smooth muscle cell migration inhibitor and a preventive or remedy for post-PTCA restenosis, each containing an isocarbacyclin represented by general formula (1) and/or an enantiomer thereof as the active ingredient, wherein W represents o-, m- or p-phenylene, C3-C7 cycloalkylene or thiophenediyl; R represents hydrogen, methyl, ethyl or vinyl; R represents optionally substituted linear or branched C3-C9 alkyl, alkenyl or alkynyl, or C3-C7 cycloalkyl; R represents hydrogen, C1-C10 alkyl, phenyl, naphthyl, benzyl or a mono-equivalent cation; Z and Z represent each independently hydrogen, tri(C1-C7 hydrocarbyl)silyl or a group that forms an acetal or ester linkage together with the oxygen atom to which it is bonded; n represents 0 or 1; and m represents an integer of 0 to 4.
摘要翻译：血管平滑肌细胞迁移抑制剂和用于PTCA后再狭窄的预防或治疗，每种含有由通式（1）表示的异卡巴环素和/或其对映异构体作为活性成分，其中W表示o-，m-或p 亚苯基，C3-C7亚环烷基或噻吩二基; R 1表示氢，甲基，乙基或乙烯基; R 2表示任选取代的直链或支链C 3 -C 9烷基，烯基或炔基或C 3 -C 7环烷基; R 30表示氢，C 1 -C 10烷基，苯基，萘基，苄基或单当量阳离子; Z 10和Z 20各自独立地表示氢，三（C 1 -C 7烃基）甲硅烷基或与其键合的氧原子一起形成缩醛或酯键的基团; n表示0或1; m表示0〜4的整数。

4. 发明申请

WO1990003395A1 NOVEL PHYSIOLOGICALLY ACTIVE POLYPEPTIDE, RECOMBINANT PLASMID, RECOMBINANT MICROBIAL CELLS, MEDICINAL COMPOSITION, AND PROCESS FOR RECOVERING PURIFIED POLYPEPTIDE 审中-公开
标题翻译：新型生理活性多肽，重组质粒，重组微生物细胞，药物组合物和回收纯化多肽的方法
公开(公告)号：WO1990003395A1
公开(公告)日：1990-04-05
申请号：PCT/JP1989000966
申请日：1989-09-22
申请人： TEIJIN LIMITED , NAKAMURA, Satoshi , FUKUOKA, Masami , MASEGI, Tsukio , KITAI, Kazuo , KATO, Arata , ICHIKAWA, Yataro
发明人： TEIJIN LIMITED
IPC分类号： C07K13/00
CPC分类号： C07K14/525 , A61K38/00
摘要： The invention relates to novel physiologically active polypeptide of human tumor necrosis factor (human TNF) having modified terminal amino acids on both the amino terminal and carboxyl terminal, recombinant plasmid containing a DNA region coding said polypeptide, recombinant microbial cells transformed by said recombinant plasmid, a process for preparing said polypeptide by culturing said microbial cells, a medicinal composition containing said polypeptide and a process for purifying and recovering said polypeptide. This polypeptide has a better antitumor activity than the human TNF and can be utilized as an active ingredient of an antitumor composition.

5. 发明申请

WO1995022970A1 PATCH CONTAINING ISOSORBIDE DINITRATE AND PREPARED BY USING ADHESIVE MIXTURE 审中-公开
标题翻译：含有异氰酸酯的配方和使用粘合剂混合制备
公开(公告)号：WO1995022970A1
公开(公告)日：1995-08-31
申请号：PCT/JP1995000318
申请日：1995-02-28
申请人： TEIJIN LIMITED , TEYSAN PHARMACEUTICALS CO., LTD. , FUJII, Takao , IWATA, Makoto , FURUYA, Minoru , OHE, Michisuke
发明人： TEIJIN LIMITED , TEYSAN PHARMACEUTICALS CO., LTD.
IPC分类号： A61K31/34
CPC分类号： A61K9/7053 , A61K9/7069 , A61K31/34
摘要： A patch containing isosorbide dinitrate, which can reduce the occurence of a rash and is excellent in percutaneous absorbability and tack strength. It is produced by forming a tacky layer comprising a tacky composition containing a pressure-sensitive adhesive and isosorbide dinitrate on a flexible support. The pressure-sensitive adhesive is a mixture of a silicone adhesive (A) and a polyvinyl acetate adhesive (B) in a weight ratio (A/B) of from 85/15 to 15/85. The weight ratio of the mixture (A+B) to the dinitrate ranges from 90/10 to 60/40.
摘要翻译：含有硝酸异山梨酯的补片，其能够减少皮疹的发生，经皮吸收性和粘着强度优异。其通过在柔性载体上形成包含含有压敏粘合剂和硝酸异山梨酯的粘性组合物的粘性层来生产。压敏粘合剂是硅酮粘合剂（A）和聚乙酸乙烯酯粘合剂（B）的重量比（A / B）为85/15至15/85的混合物。混合物（A + B）与硝酸盐的重量比为90/10至60/40。

6. 发明申请

WO1997004826A1 POWDERY MEDICINE DOSING DEVICE 审中-公开
标题翻译：粉末药物剂量设备
公开(公告)号：WO1997004826A1
公开(公告)日：1997-02-13
申请号：PCT/JP1996002097
申请日：1996-07-25
申请人： TEIJIN LIMITED , MATSUGI, Hideo , KAWABE, Hiroyuki , MAKINO, Yuji , SUZUKI, Yoshiki , FUJII, Takao
发明人： TEIJIN LIMITED
IPC分类号： A61M13/00
CPC分类号： A61M15/0028 , A61M11/00 , A61M2202/06 , A61M2202/064
摘要： A powdery medicine dosing device which achieves portability, simplicity and rapidity of operation, simplicity of a manufacturing process, rigidity of construction, and economy such as minimization of the number of parts and low costing. The device comprises a medicine holding section, which defines therein a powder medicine storing space doubling as an air reservoir and of which at least a portion of a wall is flexible, and a medicine leading-out section which allows an inner space of the medicine holding section to communicate with the outside. The inner space of the medicine holding section communicates with the outside only through the medicine leading-out section, and the medicine leading-out section is of a tubular construction which includes at one end thereof a medicine spraying port disposed outside of the medicine holding section and at the other end thereof a medicine suction port disposed in the inner space of the medicine holding section. Disposed substantially immediately below the medicine suction port of the medicine leading-out section is a bottom of the inner space of the medicine holding section, and disposed close to the bottom is the medicine suction port, so that a powder medicine is jetted outside through the medicine leading-out section by pressing and loosening the flexible wall portion of the medicine holding section.
摘要翻译：实现便携性，操作简单性和快速性，制造过程简单，结构刚性和经济性的粉末药物计量装置，例如零件数量的最小化和低成本。该装置包括：药剂保持部，其在其中限定作为空气储存器加倍的粉末药物储存空间，壁的至少一部分是柔性的;以及药物引出部，其允许药剂保持的内部空间部分与外界沟通。药剂保持部的内部空间仅通过药物引出部与外部连通，药物导出部为管状结构，其一端包括设置在药剂保持部的外侧的药剂喷出口另一端设置在药剂保持部的内部空间中的吸药口。在药物引出部的药液吸入口的下方大致立即设置在药剂保持部的内部空间的底部，并且靠近底部设置有药物吸入口，从而将粉末药物通过通过按压和松开药物保持部的柔性壁部来进行药物导出部。

7. 发明申请

WO1997031626A1 POWDERY COMPOSITION FOR NASAL ADMINISTRATION 审中-公开
标题翻译：粉末成分为NASAL管理
公开(公告)号：WO1997031626A1
公开(公告)日：1997-09-04
申请号：PCT/JP1997000541
申请日：1997-02-26
申请人： TEIJIN LIMITED , DOHI, Masahiko , NISHIBE, Yoshihisa , MAKINO, Yuji , FUJII, Takao
发明人： TEIJIN LIMITED
IPC分类号： A61K09/14
CPC分类号： A61K9/0043
摘要： A powdery composition for nasal administration wherein: (1) the composition comprises (i) a medicament, (ii) a water-absorbent, gel-forming base such as hydroxypropylcellulose or hydroxypropylmethylcellulose, and (iii) a water-absorbent, sparingly water-soluble base such as crystalline cellulose or alpha -cellulose; (2) the amount of the water-absorbent, gel-forming base is about 5 to 40 % by weight of the sum of the amounts of the water-absorbent, gel-forming base and the water-absorbent, sparingly water-soluble base; and (3) the medicament is unevenly dispersed in the water-absorbent, sparingly water-soluble base rather than in the water-absorbent, gel-forming base. The composition is advantageous in that an excellent absorption via the nasal cavity can be offered even in the case of a highly water-soluble medicament, a highly liposoluble medicament, and a high-molecular weight peptide or protein medicament and the maximum blood level is much larger than that for the conventional compositions for nasal administration.
摘要翻译：一种用于鼻内给药的粉末状组合物，其中：（1）组合物包含（i）药物，（ii）吸水性凝胶形成碱如羟丙基纤维素或羟丙基甲基纤维素，和（iii）吸水性，可溶性碱如结晶纤维素或α-纤维素; （2）吸水性凝胶形成基质的量为吸水性凝胶形成基质和吸水性微溶水性基质的总量的5〜40重量％ ; 和（3）药物不均匀地分散在吸水性微水溶性基质中而不是在吸水凝胶形成基质中。该组合物的优点在于，即使在高度水溶性药物，高度脂溶性药物和高分子量肽或蛋白质药物的情况下也可以提供通过鼻腔的优异吸收，并且最大血液水平是多大于用于鼻腔给药的常规组合物。

8. 发明申请

WO1990007335A1 USE OF ISOCARBACYCLINS FOR PREVENTING OR TREATING ORGAN DISEASES 审中-公开
标题翻译：异烟肼用于预防或治疗器官疾病的使用
公开(公告)号：WO1990007335A1
公开(公告)日：1990-07-12
申请号：PCT/JP1989001287
申请日：1989-12-21
申请人： TEIJIN LIMITED , BANNAI, Kiyoshi , TANAKA, Toshio , KATO, Yoshinori , KOYAMA, Tamotsu , ASANO, Satoshi , OHTSU, Akira , KUROZUMI, Seizi , OGAWA, Makoto , MORI, Yoshio
发明人： TEIJIN LIMITED
IPC分类号： A61K31/557
CPC分类号： A61K31/557
摘要： Isocarbacyclins, 4-heteroisocarbacyclins, 3-heteroisocarbacyclins and enantiomers thereof are effective in preventing or treating diseases of the organs such as liver or kidney. These compounds are remarkably characteristic in that they have a high selectivity in the abovementioned actions.
摘要翻译：异卡多环素，4-杂异环碳酰胆碱，3-杂异碳环胆素及其对映异构体在预防或治疗诸如肝脏或肾脏的器官疾病方面是有效的。这些化合物是显着的特征，因为它们在上述作用中具有高选择性。

9. 发明申请

WO1985003936A1 7-THIAPROSTAGLANDIN E1'S AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译： 7-THIAPROSTAGLANDIN E1及其制备方法
公开(公告)号：WO1985003936A1
公开(公告)日：1985-09-12
申请号：PCT/JP1985000110
申请日：1985-03-05
申请人： TEIJIN LIMITED , TANAKA, Toshio , BANNAI, Kiyoshi , HAZATO, Atsuo , KUROZUMI, Seiji
发明人： TEIJIN LIMITED
IPC分类号： C07C177/00
CPC分类号： C07C405/0033
摘要： 7-thiaprostaglandin E1's represented by formula (I): (wherein R1 represents H, C1 to C10 alkyl, C2 to C20 alkenyl, substituted or unsubstituted phenyl, substituted or unsubstituted C3 to C10 cycloalkyl, substituted or unsubstituted phenyl(C1 to C2)alkyl, or mono-equivalent cation, R2 and R3, which may be the same or different, each represents H, tri(C1 to C7)-hydrocarbylsilyl or a group forming an acetal bond with the oxygen atom of the hydroxy group, R4 represents H, methyl or vinyl, R5 represents straight or branched C3 to C8 alkyl, straight or branched C3 to C8 alkenyl, straight or branched C3 to C8 alkynyl, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted C3 to C10 cycloalkyl, or straight or branched C1 to C5 alkyl substituted by C1 to C6 alkoxy, optionally substituted phenyl, optionally substituted phenoxy or optionally substituted C3 to C10 cycloalkyl, X represents ethylene, vinylene or ethynylene, n represents 0 or 1,$(1,6)$represents ethylene or vinylene, provided that, when n represents 0 and X represents ethylene, R5 does not represent straight or branched C3 to C8 alkyl, nor optionally substituted C3 to C10 cycloalkyl), enantiomers thereof, and mixtures thereof in arbitrary ratios are useful for treating and/or preventing diseases of digestive organs such as duodenum or stomach.

10. 发明申请

WO1985003935A1 6-SUBSTITUTED PROSTAGLANDIN E1'S AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译： 6取代的PROSTAGLANDIN E1及其制备方法
公开(公告)号：WO1985003935A1
公开(公告)日：1985-09-12
申请号：PCT/JP1985000096
申请日：1985-02-28
申请人： TEIJIN LIMITED , TANAKA, Toshio , HAZATO, Atsuo , KUROZUMI, Seiji
发明人： TEIJIN LIMITED
IPC分类号： C07C177/00
CPC分类号： C07C405/0041 , C07C405/00 , C07F1/02 , C07F1/08
摘要： 6-substituted prostaglandin E1's represented by formula (I), (wherein R1 represents H, C1 to C10 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted C3 to C10 cycloalkyl, substituted or unsubstituted phenyl(C1 to C2) alkyl or mono-equivalent cation; R2 and R3, which may be the same or different, each represents H, tri(C1 to C7)hydrocarbylsilyl, or a group forming an acetal bond with the oxygen atom of the hydroxy group, R4 represents H, methyl or vinyl, R5 represents straight or branched C3 to C8 alkyl, straight or branched C3 to C8 alkenyl, straight or branched C3 to C8 alkynyl, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted C3 to C10 cycloalkyl or C1 to C6 alkoxy, straight or branched C1 to C5 alkyl substituted by optionally substituted phenyl, optionally substituted phenoxy or optionally substituted C3 to C10 cycloalkyl, and X represents H-NO2 or oxygen atom), enantiomers thereof, and mixtures thereof in arbritary ratios, are useful for treating and preventing diseases of digestive organs such as duodenum or stomach.

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