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1. 发明申请

WO2020259816A1 CARTRIDGE, ELECTROWETTING SAMPLE PROCESSING SYSTEM AND FEEDING THEREOF 审中-公开
公开(公告)号：WO2020259816A1
公开(公告)日：2020-12-30
申请号：PCT/EP2019/066935
申请日：2019-06-26
申请人： TECAN TRADING AG
发明人： KINNEY, Patrick , IYER, Sujata , HOFFMEYER, Daniel , DHINDSA, Manjeet , NGO, Tin , DING (LAY), Tiffany , BJÖRNSON, Torleif Ove
IPC分类号： B01L3/00 , G01N35/10
摘要： A cartridge (2) for use in an electrowetting sample processing system, the cartridge comprising one or more inlet ports (19') for introducing an input liquid into an internal gap (6) of the cartridge (2), which comprises at least one hydrophobic surface (17) for enabling an electrowetting induced movement of multiple microfluidic droplets (23) separated from the input liquid. The cartridge (2) further comprises at least one outlet port (80) that is operably connected to the inlet port (19') for providing a liquid flow through the cartridge (2), if a liquid driving force, in particular an electrowetting force or a pressure force, is applied to at least a part of the input liquid.

2. 发明申请

WO2020259817A1 CARTRIDGE AND ELECTROWETTING SAMPLE PROCESSING SYSTEM WITH DELIVERY ZONE 审中-公开
公开(公告)号：WO2020259817A1
公开(公告)日：2020-12-30
申请号：PCT/EP2019/066936
申请日：2019-06-26
申请人： TECAN TRADING AG
发明人： KINNEY, Patrick , DING (LAY), Tiffany , DHINDSA, Manjeet , TRAN, Daniel , JI, Jennifer , IYER, Sujata , NGO, Tin
IPC分类号： B01L3/00
摘要： A cartridge, in particular a disposable cartridge, for use in an electrowetting sample processing system. The cartridge comprises a liquid input port (19') for introducing an input liquid into an internal gap of the cartridge, the input liquid providing for at least one droplet (23), directly or via a liquid separation process within the internal gap, and the internal gap comprising at least one hydrophobic surface, at least one processing zone (78) for processing samples (80) located in the processing zone (78), and a delivery zone (74) for delivering the at least one droplet (23) from the liquid input port (19') to the at least one processing zone (78). The delivery zone (74) is configured to provide a repeating pattern of interacting electrowetting force for simultaneously transporting the at least one droplet (23) within the delivery zone (74).

3. 发明申请

WO2020259815A1 CARTRIDGE, ELECTROWETTING SAMPLE PROCESSING SYSTEM AND DROPLET FORMATION 审中-公开
公开(公告)号：WO2020259815A1
公开(公告)日：2020-12-30
申请号：PCT/EP2019/066934
申请日：2019-06-26
申请人： TECAN TRADING AG
发明人： KINNEY, Patrick , NGO, Tin , IYER, Sujata , HOFFMEYER, Daniel , DHINDSA, Manjeet , DING (LAY), Tiffany
IPC分类号： B01L3/00
摘要： A cartridge (2) for use in an electrowetting sample processing system, the cartridge (2) comprising at least one inlet port (19') for introducing an input liquid (60, 61) in an internal gap (6) of the cartridge (2), wherein the gap (6) comprises at least one hydrophobic surface (17) and is configured to provide an electrowetting induced movement of a microfluidic droplet (23) of input liquid (60, 61), wherein the input liquid (60, 61) comprises a carrier liquid (60) and a processing liquid (61) and the gap (6) comprises a capture zone that is configured to capture at least a part of the processing liquid (60,61) as a microfluidic droplet (23) by use of electrowetting force and the gap (6) further comprises a transfer zone that is configured to provide a passage for the carrier liquid (60) next to the microfluidic droplet (23), while processing liquid (61) is captured in the capture zone (62).

4. 发明申请

WO2017040818A1 BEAD SEPARATION IN MICROFLUIDICS 审中-公开
标题翻译：微流控珠粒分离
公开(公告)号：WO2017040818A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/049952
申请日：2016-09-01
申请人： TECAN TRADING AG , PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
发明人： PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/502792 , B01L2200/0668 , B01L2300/0816 , B01L2300/123 , B01L2400/0427 , B01L2400/043
摘要： In a separation method, a digital microfluidics system (1) with electrodes (2) attached to a substrate or PCB (3), a control unit (7) for manipulating liquid droplets (8-1) by electrowetting, a cartridge accommodation site (18) for taking up a disposable cartridge (17) which comprises a working gap (4) in-between two hydrophobic surfaces (5,6), and a magnetic conduit (9)/backing magnet (10) combination is provided. A barrier element (40) is provided on an individual electrode (2) of the PCB (3) for narrowing the working gap (4). A disposable cartridge (17) is positioned at the cartridge accommodation site (18), its flexible working film (19) touching there and of the barrier element (40) an uppermost surface (22). In the working gap (4) and above a path of selected electrodes (2') a liquid portion (8-2) or liquid droplet (8- 1) with magnetically responsive beads (11) is provided and moved by electrowetting on the electrode path (2') until a magnetic field of the magnetic conduit (9) is reached. The backing magnet (10) is activated before and during moving by electrowetting the liquid portion (8-2) or liquid droplet (8- 1) with the magnetically responsive beads (11) over and/or around the barrier element (40), thereby attracting and substantially removing magnetically responsive beads (11) therefrom. A suspending method, a digital microfluidics system (1), and a disposable cartridge (17) are disclosed too.
摘要翻译：在分离方法中，具有连接到基板或PCB（3）上的电极（2）的数字微流体系统（1），用于通过电润湿来操纵液滴（8-1）的控制单元（7）提供了一种包括在两个疏水表面（5,6）之间的工作间隙（4）和一个磁性导管（9）/背衬磁体（10）组合）的一次性盒式存储器（17）。阻挡元件（40）设置在PCB（3）的单独电极（2）上，用于使工作间隙（4）变窄。一次性盒（17）定位在盒容纳位置（18）处，其柔性工作膜（19）接触其上和屏障元件（40）最上表面（22）。在工作间隙（4）及以上，提供具有磁响应珠（11）的液体部分（8-2）或液滴（8-1）的选定电极（2'）的路径，并通过电润湿移动到电极路径（2'），直到达到磁导管（9）的磁场。背衬磁体（10）在通过电磁润湿液体部分（8-2）或液滴（8-1）与磁性响应珠子（11）在屏障元件（40）之上和/或周围的移动之前和期间被激活，从而吸引并基本上去除其上的磁响应珠（11）。还公开了悬挂方法，数字微流体系统（1）和一次性盒（17）。

5. 发明申请

WO2017039654A1 MAGNETIC CONDUITS IN MICROFLUIDICS 审中-公开
标题翻译：微流控磁流体
公开(公告)号：WO2017039654A1
公开(公告)日：2017-03-09
申请号：PCT/US2015/048141
申请日：2015-09-02
申请人： TECAN TRADING AG , PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
发明人： PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/502792 , B01L2200/0668 , B01L2300/0816 , B01L2300/123 , B01L2400/0427 , B01L2400/043
摘要： A method comprises the steps of: providing a digital microfluidics system (1) with electrodes (2) attached to a substrate (3) and covered by a hydrophobic surface (5), and a control unit (7) for manipulating liquid droplets (8-1) by electrowetting; providing in close proximity to electrodes (2) a magnetic conduit (9) for directing a magnetic field of a backing magnet to the first hydrophobic surface (5); providing on the hydrophobic surface (5) a liquid droplet (8-1) that comprises magnetically responsive beads (11); moving by electrowetting the liquid droplet (8-1) with the magnetically responsive beads (11) until at least a part of which is placed atop of the magnetic conduit (9); actuating the backing magnet (10) of the magnetic conduit (9) and attracting/concentrating magnetically responsive beads (11); and while actuating the backing magnet (10), moving by electrowetting the liquid droplet (8-1)' with decreased number of magnetically responsive beads (11) away from the specific magnetic conduit (9). Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge (17) to carry out the methods therein.
摘要翻译：一种方法包括以下步骤：提供数字微流体系统（1），电极（2）连接到基底（3）并被疏水表面（5）覆盖;以及控制单元（7），用于操纵液滴 -1）通过电润湿; 提供靠近电极（2）的磁导管（9），用于将背衬磁体的磁场引导到第一疏水表面（5）; 在疏水表面（5）上提供包含磁响应珠（11）的液滴（8-1）; 通过用磁响应珠（11）电润湿液滴（8-1）直到其至少一部分放置在磁导管（9）的顶部来移动; 启动磁导管（9）的背衬磁体（10）并吸引/集中磁响应珠（11）; 并且在致动所述背衬磁体（10）时，通过以较少数量的磁响应珠（11）远离所述特定磁导管（9）的方式电润湿所述液滴（8-1）来移动。还公开了一种在数字微流体中的液体部分或液滴中悬浮磁响应珠的方法和用于执行其中的方法的一次性盒（17）。

6. 发明公开

EP3334532A1 BEAD SEPARATION IN MICROFLUIDICS 有权
公开(公告)号：EP3334532A1
公开(公告)日：2018-06-20
申请号：EP16770817.1
申请日：2016-09-01
申请人： Tecan Trading AG
发明人： PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
IPC分类号： B01L3/00
CPC分类号： C02F1/484 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502792 , B01L3/508 , B01L2200/025 , B01L2200/0668 , B01L2300/0816 , B01L2300/123 , B01L2400/0427 , B01L2400/043
摘要： A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface, and a control unit for manipulating liquid droplets by electrowetting; providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface; providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads; moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit; actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads; and while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit. Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge to carry out the methods.

7. 发明授权

EP3344388B1 MAGNETIC CONDUITS IN MICROFLUIDICS 有权
公开(公告)号：EP3344388B1
公开(公告)日：2020-11-11
申请号：EP15766294.1
申请日：2015-09-02
申请人： Tecan Trading AG
发明人： PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
IPC分类号： B01L3/00

8. 发明公开

EP3990178A1 CARTRIDGE, ELECTROWETTING SAMPLE PROCESSING SYSTEM AND FEEDING THEREOF 审中-实审
公开(公告)号：EP3990178A1
公开(公告)日：2022-05-04
申请号：EP19742527.5
申请日：2019-06-26
申请人： TECAN Trading AG
发明人： KINNEY, Patrick , IYER, Sujata , HOFFMEYER, Daniel , DHINDSA, Manjeet , NGO, Tin , DING (LAY), Tiffany , BJÖRNSON, Torleif Ove
IPC分类号： B01L3/00 , G01N35/10

9. 发明公开

EP3990177A1 CARTRIDGE AND ELECTROWETTING SAMPLE PROCESSING SYSTEM WITH DELIVERY ZONE 审中-实审
公开(公告)号：EP3990177A1
公开(公告)日：2022-05-04
申请号：EP19735515.9
申请日：2019-06-26
申请人： TECAN Trading AG
发明人： KINNEY, Patrick , DING (LAY), Tiffany , DHINDSA, Manjeet , TRAN, Daniel , JI, Jennifer , IYER, Sujata , NGO, Tin
IPC分类号： B01L3/00

10. 发明公开

EP3956061A1 CARTRIDGE, ELECTROWETTING SAMPLE PROCESSING SYSTEM AND DROPLET FORMATION 审中-实审
公开(公告)号：EP3956061A1
公开(公告)日：2022-02-23
申请号：EP19742526.7
申请日：2019-06-26
申请人： TECAN Trading AG
发明人： KINNEY, Patrick , NGO, Tin , IYER, Sujata , HOFFMEYER, Daniel , DHINDSA, Manjeet , DING (LAY), Tiffany
IPC分类号： B01L3/00

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