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1. 发明申请

WO2017084766A1 COVER WITH MICRO-CONTAINER INTERFACE FOR COVERING A MICROFLUIDIC GAP 审中-公开
标题翻译：覆盖MICRO-CONID GAP的微型容器接口
公开(公告)号：WO2017084766A1
公开(公告)日：2017-05-26
申请号：PCT/EP2016/052860
申请日：2016-02-10
申请人： TECAN TRADING AG
发明人： PERROUD, Thomas , HOFFMEYER, Daniel , KOPF-SILL, Anne R. , SAGER, Adrian
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502792 , B01L3/563 , B01L2200/027 , B01L2200/028 , B01L2200/0689 , B01L2300/047 , B01L2300/0645 , B01L2300/123 , B01L2400/0427 , B01L2400/0478
摘要： A cover (10) for use in a digital microfluidics system (16) for manipulating samples in liquid portions or droplets is provided. The digital microfluidics system (16) com- prises a first substrate (18) with an array of electrodes (24) and a central control unit (20) for controlling the selection and for providing a number of said electrodes with voltage for manipulating liquid portions or droplets by electrowetting. A working gap (30) with a gap height is located parallel to the array of electrodes (24) and in-between first and second hydrophobic surfaces (26,28) that face each other at least during operation of the digital microfluidics system (16). The cover (10) comprises on one side the second hydrophobic surface (28) and on another side at least one micro-container interface (32), which comprises at least one cone (34). The inner surface of the cone (34) is formed to provide a sealing form fit contact with an outer surface of an inserted micro-container nozzle (36), by which a liquid is transferrable through a fluidic access hole (38) formed into the cover (10) and interconnecting each cone (34) and the gap (30). The cover (10) may be part of a disposable cartridge (14) or may be provided separately.
摘要翻译：提供了用于数字微流体系统（16）中用于操纵液体部分或液滴中的样品的盖（10）。数字微流体系统（16）包括具有电极阵列（24）和中央控制单元（20）的第一基板（18），用于控制选择并向多个所述电极提供用于操纵液体部分或通过电润湿的液滴。至少在数字微流体系统（16）的操作过程中，具有间隙高度的工作间隙（30）平行于电极阵列（24）定位并且位于彼此面对的第一和第二疏水表面（26,28）之间）。盖（10）在一侧包括第二疏水表面（28）并且在另一侧包括至少一个微容器接口（32），其包括至少一个锥体（34）。锥形体（34）的内表面形成为与插入的微容器喷嘴（36）的外表面形成配合接触的密封形式，液体可通过形成于其中的流体通路孔（38）盖（10）并且互连每个锥体（34）和间隙（30）。盖（10）可以是一次性盒（14）的一部分或可以单独提供。

2. 发明申请

WO2020259816A1 CARTRIDGE, ELECTROWETTING SAMPLE PROCESSING SYSTEM AND FEEDING THEREOF 审中-公开
公开(公告)号：WO2020259816A1
公开(公告)日：2020-12-30
申请号：PCT/EP2019/066935
申请日：2019-06-26
申请人： TECAN TRADING AG
发明人： KINNEY, Patrick , IYER, Sujata , HOFFMEYER, Daniel , DHINDSA, Manjeet , NGO, Tin , DING (LAY), Tiffany , BJÖRNSON, Torleif Ove
IPC分类号： B01L3/00 , G01N35/10
摘要： A cartridge (2) for use in an electrowetting sample processing system, the cartridge comprising one or more inlet ports (19') for introducing an input liquid into an internal gap (6) of the cartridge (2), which comprises at least one hydrophobic surface (17) for enabling an electrowetting induced movement of multiple microfluidic droplets (23) separated from the input liquid. The cartridge (2) further comprises at least one outlet port (80) that is operably connected to the inlet port (19') for providing a liquid flow through the cartridge (2), if a liquid driving force, in particular an electrowetting force or a pressure force, is applied to at least a part of the input liquid.

3. 发明申请

WO2020259815A1 CARTRIDGE, ELECTROWETTING SAMPLE PROCESSING SYSTEM AND DROPLET FORMATION 审中-公开
公开(公告)号：WO2020259815A1
公开(公告)日：2020-12-30
申请号：PCT/EP2019/066934
申请日：2019-06-26
申请人： TECAN TRADING AG
发明人： KINNEY, Patrick , NGO, Tin , IYER, Sujata , HOFFMEYER, Daniel , DHINDSA, Manjeet , DING (LAY), Tiffany
IPC分类号： B01L3/00
摘要： A cartridge (2) for use in an electrowetting sample processing system, the cartridge (2) comprising at least one inlet port (19') for introducing an input liquid (60, 61) in an internal gap (6) of the cartridge (2), wherein the gap (6) comprises at least one hydrophobic surface (17) and is configured to provide an electrowetting induced movement of a microfluidic droplet (23) of input liquid (60, 61), wherein the input liquid (60, 61) comprises a carrier liquid (60) and a processing liquid (61) and the gap (6) comprises a capture zone that is configured to capture at least a part of the processing liquid (60,61) as a microfluidic droplet (23) by use of electrowetting force and the gap (6) further comprises a transfer zone that is configured to provide a passage for the carrier liquid (60) next to the microfluidic droplet (23), while processing liquid (61) is captured in the capture zone (62).

4. 发明申请

WO2016011134A1 MICROFLUIDICS CARTRIDGE WITH PIPETTING GUIDE 审中-公开
标题翻译：具有导管指导的微流控盒
公开(公告)号：WO2016011134A1
公开(公告)日：2016-01-21
申请号：PCT/US2015/040534
申请日：2015-07-15
申请人： TECAN TRADING AG , LAY, Tiffany , HOFFMEYER, Daniel , KOPF-SILL, Anne, R. , PERROUD, Thomas
发明人： LAY, Tiffany , HOFFMEYER, Daniel , KOPF-SILL, Anne, R. , PERROUD, Thomas
IPC分类号： B01L3/02 , B81B1/00 , G01N27/447 , G01N27/453
CPC分类号： B01L3/502792 , B01L3/0275 , B01L3/50273 , B01L2200/027 , B01L2300/0816 , B01L2300/161 , B01L2400/0427
摘要： A disposable cartridge (1) is configured for use in a digital microfluidics system (3) for manipulating samples in liquid portions or droplets (4). The digital microfluidics system (3) comprises a cartridge accommodation site (2) and a central control unit (7) for controlling the selection of individual electrodes (8) of an electrode array (5) located at said cartridge accommodation site (2) and for providing a number of said electrodes (8) with individual voltage pulses for manipulating liquid portions or droplets (4) by electrowetting. The disposable cartridge (1) comprises a hydrophobic working surface (10) and a rigid cover (11 ) with a second hydrophobic surface (12), the hydrophobic surfaces (10,12) facing each other and being separated or being separable in essentially parallel planes by a gap (13) with a gap height (14).
摘要翻译：一次性盒（1）被配置用于数字微流体系统（3），用于操纵液体部分或液滴中的样品（4）。数字微流体系统（3）包括用于控制位于所述盒容纳位置（2）的电极阵列（5）的各个电极（8）的选择的盒容纳部位（2）和中央控制单元（7），以及用于通过电润湿来提供多个具有用于通过电润湿操纵液体部分或液滴（4）的各个电压脉冲的所述电极（8）。一次性药筒（1）包括具有第二疏水表面（12）的疏水性工作表面（10）和刚性覆盖物（11），所述疏水性表面（10,12）彼此面对并且基本平行地分离或可分离通过具有间隙高度（14）的间隙（13）。

5. 发明申请

WO2014108367A1 DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEMS 审中-公开
标题翻译：用于微流控系统的可替代墨盒
公开(公告)号：WO2014108367A1
公开(公告)日：2014-07-17
申请号：PCT/EP2014/050086
申请日：2014-01-06
申请人： TECAN TRADING AG
发明人： HOFFMEYER, Daniel , LAY, Tiffany , LEE, Travis , FEIGLIN, Marc, N. , HÄLG, Werner , KOPF-SILL, Anne, R.
IPC分类号： B01L3/00
CPC分类号： G01N27/44791 , B01L3/502715 , B01L3/502792 , B01L3/505 , B01L2200/027 , B01L2200/04 , B01L2300/044 , B01L2300/123 , B01L2400/0427 , B81B1/00 , G01N27/44756
摘要： A disposable cartridge (2) for use in a digital microfluidics system (1) comprises a bottom layer (3) with a first hydrophobic surface (17'), a rigid cover plate (12) with a second hydrophobic surface (17"), and a gap (6) there-between. The bottom layer (3) is a flexible film laid onto an uppermost surface (52) of a cartridge accommodation site (8) of a digital microfluidics system (1), attracted to and spread over the uppermost surface (52) by an underpressure in an evacuation space (46). The disposable cartridge (2) may be assembled at a cartridge accommodation site (8), a lower surface (48') of the rigid cover plate (12) and the flexible bottom layer (3) then are sealingly attached to each other by mutual contacting. The assembled disposable cartridge (2) is removed from the cartridge accommodation site (8) in one piece that comprises the bottom layer (3), the plane rigid cover plate (12), and the gap (6) that potentially comprises samples and processing fluids. The digital microfluidics system (1) comprises a base unit (7) and a cartridge accommodation site (8) with an electrode array (9) that comprises a number of individual electrodes (10). The digital microfluidics system (1) comprises a central control unit (14) for controlling the selection of the individual electrodes (10) and for providing these electrodes (10) with individual voltage pulses for manipulating liquid droplets within the gap (6) of the cartridge (2) by electrowetting.
摘要翻译：一种用于数字微流体系统（1）的一次性盒（2）包括具有第一疏水表面（17'）的底层（3），具有第二疏水表面（17“）的刚性盖板（12）底层（3）是布置在数字微流体系统（1）的盒容纳位置（8）的最上表面（52）上的柔性膜，被吸引并扩展一次性药筒（2）可以组装在药筒容纳部位（8），刚性盖板（12）的下表面（48'）上，并且柔性底层（3）然后通过相互接触彼此密封地连接。将组装的一次性盒（2）从包含底层（3）的一个部件中从盒容纳部位（8）移除，刚性盖板（12）和可能包含样品和加工流体的间隙（6）特征系统（1）包括具有包括多个单独电极（10）的电极阵列（9）的基座单元（7）和盒容纳部位（8）。数字微流体系统（1）包括一个中央控制单元（14），用于控制各个电极（10）的选择，并为这些电极（10）提供单独的电压脉冲，用于操纵液滴内部的液滴墨盒（2）通过电润湿。

6. 发明申请

WO2017040818A1 BEAD SEPARATION IN MICROFLUIDICS 审中-公开
标题翻译：微流控珠粒分离
公开(公告)号：WO2017040818A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/049952
申请日：2016-09-01
申请人： TECAN TRADING AG , PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
发明人： PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/502792 , B01L2200/0668 , B01L2300/0816 , B01L2300/123 , B01L2400/0427 , B01L2400/043
摘要： In a separation method, a digital microfluidics system (1) with electrodes (2) attached to a substrate or PCB (3), a control unit (7) for manipulating liquid droplets (8-1) by electrowetting, a cartridge accommodation site (18) for taking up a disposable cartridge (17) which comprises a working gap (4) in-between two hydrophobic surfaces (5,6), and a magnetic conduit (9)/backing magnet (10) combination is provided. A barrier element (40) is provided on an individual electrode (2) of the PCB (3) for narrowing the working gap (4). A disposable cartridge (17) is positioned at the cartridge accommodation site (18), its flexible working film (19) touching there and of the barrier element (40) an uppermost surface (22). In the working gap (4) and above a path of selected electrodes (2') a liquid portion (8-2) or liquid droplet (8- 1) with magnetically responsive beads (11) is provided and moved by electrowetting on the electrode path (2') until a magnetic field of the magnetic conduit (9) is reached. The backing magnet (10) is activated before and during moving by electrowetting the liquid portion (8-2) or liquid droplet (8- 1) with the magnetically responsive beads (11) over and/or around the barrier element (40), thereby attracting and substantially removing magnetically responsive beads (11) therefrom. A suspending method, a digital microfluidics system (1), and a disposable cartridge (17) are disclosed too.
摘要翻译：在分离方法中，具有连接到基板或PCB（3）上的电极（2）的数字微流体系统（1），用于通过电润湿来操纵液滴（8-1）的控制单元（7）提供了一种包括在两个疏水表面（5,6）之间的工作间隙（4）和一个磁性导管（9）/背衬磁体（10）组合）的一次性盒式存储器（17）。阻挡元件（40）设置在PCB（3）的单独电极（2）上，用于使工作间隙（4）变窄。一次性盒（17）定位在盒容纳位置（18）处，其柔性工作膜（19）接触其上和屏障元件（40）最上表面（22）。在工作间隙（4）及以上，提供具有磁响应珠（11）的液体部分（8-2）或液滴（8-1）的选定电极（2'）的路径，并通过电润湿移动到电极路径（2'），直到达到磁导管（9）的磁场。背衬磁体（10）在通过电磁润湿液体部分（8-2）或液滴（8-1）与磁性响应珠子（11）在屏障元件（40）之上和/或周围的移动之前和期间被激活，从而吸引并基本上去除其上的磁响应珠（11）。还公开了悬挂方法，数字微流体系统（1）和一次性盒（17）。

7. 发明申请

WO2017039654A1 MAGNETIC CONDUITS IN MICROFLUIDICS 审中-公开
标题翻译：微流控磁流体
公开(公告)号：WO2017039654A1
公开(公告)日：2017-03-09
申请号：PCT/US2015/048141
申请日：2015-09-02
申请人： TECAN TRADING AG , PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
发明人： PERROUD, Thomas , TRAN, Dan , HOFFMEYER, Daniel , LAY, Tiffany , DHINDSA, Manjeet
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/502792 , B01L2200/0668 , B01L2300/0816 , B01L2300/123 , B01L2400/0427 , B01L2400/043
摘要： A method comprises the steps of: providing a digital microfluidics system (1) with electrodes (2) attached to a substrate (3) and covered by a hydrophobic surface (5), and a control unit (7) for manipulating liquid droplets (8-1) by electrowetting; providing in close proximity to electrodes (2) a magnetic conduit (9) for directing a magnetic field of a backing magnet to the first hydrophobic surface (5); providing on the hydrophobic surface (5) a liquid droplet (8-1) that comprises magnetically responsive beads (11); moving by electrowetting the liquid droplet (8-1) with the magnetically responsive beads (11) until at least a part of which is placed atop of the magnetic conduit (9); actuating the backing magnet (10) of the magnetic conduit (9) and attracting/concentrating magnetically responsive beads (11); and while actuating the backing magnet (10), moving by electrowetting the liquid droplet (8-1)' with decreased number of magnetically responsive beads (11) away from the specific magnetic conduit (9). Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge (17) to carry out the methods therein.
摘要翻译：一种方法包括以下步骤：提供数字微流体系统（1），电极（2）连接到基底（3）并被疏水表面（5）覆盖;以及控制单元（7），用于操纵液滴 -1）通过电润湿; 提供靠近电极（2）的磁导管（9），用于将背衬磁体的磁场引导到第一疏水表面（5）; 在疏水表面（5）上提供包含磁响应珠（11）的液滴（8-1）; 通过用磁响应珠（11）电润湿液滴（8-1）直到其至少一部分放置在磁导管（9）的顶部来移动; 启动磁导管（9）的背衬磁体（10）并吸引/集中磁响应珠（11）; 并且在致动所述背衬磁体（10）时，通过以较少数量的磁响应珠（11）远离所述特定磁导管（9）的方式电润湿所述液滴（8-1）来移动。还公开了一种在数字微流体中的液体部分或液滴中悬浮磁响应珠的方法和用于执行其中的方法的一次性盒（17）。

8. 发明申请

WO2014108366A1 DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEMS 审中-公开
标题翻译：用于微流控系统的可替代墨盒
公开(公告)号：WO2014108366A1
公开(公告)日：2014-07-17
申请号：PCT/EP2014/050085
申请日：2014-01-06
申请人： TECAN TRADING AG
发明人： HOFFMEYER, Daniel , LAY, Tiffany , LEE, Travis
IPC分类号： B01L3/00
CPC分类号： G01N27/44791 , B01L3/502715 , B01L3/502792 , B01L3/505 , B01L2200/027 , B01L2200/04 , B01L2300/044 , B01L2300/123 , B01L2400/0427 , B81B1/00 , G01N27/44756
摘要： Disclosed is an alternative digital microfluidics system (1) for manipulating samples in liquid droplets within a gap (6) between a first hydrophobic surface (17') of a bottom layer (3) and a second hydrophobic surface (17'') of at least one disposable cartridge (2). Also disclosed are a number of disposable cartridges (2) that comprise a body (47) and/or a rigid cover plate (12). The bottom layer (3) of each disposable cartridge (2) is a flexible film that is sealingly attached to the body (47) or rigid cover plate (12). The disposable cartridge (2) is devoid of a spacer (5) between the first hydrophobic surface (17') and the second hydrophobic surface (17''). When using these disposable cartridges (2), the bottom layer (3) that is configured as a working film for manipulating samples in liquid droplets (23) thereon is placed on an electrode array (9) of a cartridge accommodation site (8) of a digital microfluidics system (1). The electrode array (9) comprises a number of individual electrodes (10). The digital microfluidics system (1) also comprises a central control unit (14) for controlling the selection of the individual electrodes (10) of said electrode array (9) and for providing these electrodes (10) with individual voltage pulses for manipulating liquid droplets within the gap (6) of said cartridge (2) by electrowetting.
摘要翻译：公开了一种替代的数字微流体系统（1），用于在位于底层（3）的第一疏水表面（17'）和第二疏水表面（17“）之间的间隙（6）内的液滴中操作样品，至少一个一次性盒（2）。还公开了包括主体（47）和/或刚性盖板（12）的多个一次性盒（2）。每个一次性盒（2）的底层（3）是密封地附接到主体（47）或刚性盖板（12）的柔性膜。一次性药筒（2）在第一疏水表面（17'）和第二疏水表面（17“）之间没有隔离物（5）。当使用这些一次性盒（2）时，被配置为用于将其中的液滴（23）中的样品操作的工作薄膜的底层（3）放置在墨盒容纳部位（8）的电极阵列（9）上，数字微流体系统（1）。电极阵列（9）包括多个独立电极（10）。数字微流体系统（1）还包括一个中央控制单元（14），用于控制所述电极阵列（9）的各个电极（10）的选择，并为这些电极（10）提供用于操纵液滴的各个电压脉冲通过电润湿在所述盒（2）的间隙（6）内。

9. 发明授权

EP2773461B1 DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEMS 有权转让
标题翻译：有可更换的墨盒微型液体数制
公开(公告)号：EP2773461B1
公开(公告)日：2016-04-13
申请号：EP14700223.2
申请日：2014-01-06
申请人： Tecan Trading AG
发明人： HOFFMEYER, Daniel , LAY, Tiffany , LEE, Travis
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/502792 , B01L3/505 , B01L2200/027 , B01L2200/04 , B01L2300/044 , B01L2300/123 , B01L2400/0427

10. 发明授权

EP2945740B1 DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEMS 有权转让
公开(公告)号：EP2945740B1
公开(公告)日：2019-12-25
申请号：EP14700224.0
申请日：2014-01-06
申请人： Tecan Trading AG
发明人： HOFFMEYER, Daniel , LAY, Tiffany , LEE, Travis , FEIGLIN, Marc, N. , HÄLG, Werner , KOPF-SILL, Anne, R.
IPC分类号： B01L3/00

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