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1. 发明授权

US3876645A Pyridine thioacetamide derivatives 失效
标题翻译：吡啶硫酮酰胺衍生物
公开(公告)号：US3876645A
公开(公告)日：1975-04-08
申请号：US32543873
申请日：1973-01-22
申请人： TAKEDA CHEMICAL INDUSTRIES LTD
发明人： KANAI YOSHIO , NOHARA AKIRA , HONDA HARUOMI , KANNO MORIO , SANNO YASUSHI
IPC分类号： C07D213/59 , C07D213/68 , C07D215/12 , C07D31/50
CPC分类号： C07D213/68 , C07D213/59 , C07D215/12 , Y10S514/926 , Y10S514/927
摘要： Compounds of the formula

Wherein R.sub.1 is hydrogen, lower alkyl, lower alkoxy or halogen and n is an integer of 1 to 4, or wherein (R.sub.1).sub.n is a divalent straight chain hydrocarbon radical having 4 carbon atoms which is attached to the 5th and 6th positions of the pyridine ring, each of R.sub.2 and R.sub.3 independently represents hydrogen, lower alkyl, aralkyl or aryl, or R.sub.2 and R.sub.3 together with the nitrogen atom to which they are attached form a heterocyclic ring with a proviso that at least one of R.sub.1, R.sub.2 and R.sub.3 is other than hydrogen and a pharmaceutically acceptable salt thereof with acids.

2. 发明专利

DE2536509A1 未知
公开(公告)号：DE2536509A1
公开(公告)日：1976-03-18
申请号：DE2536509
申请日：1975-08-16
申请人： TAKEDA CHEMICAL INDUSTRIES LTD
发明人： OKA YOSHIKAZU , HASHIMOTO NAOTO , KANNO MORIO , SUITA OSAKA , NISHIKAWA MASAO
IPC分类号： A61K31/135 , C07C20060101 , C07D319/08 , C07F7/18 , C07F9/32 , C07F9/40 , C07C93/14

3. 发明专利

AU8402275A BENZOCYCLOHEPTENE DERIVATIVES 未知
公开(公告)号：AU8402275A
公开(公告)日：1977-02-17
申请号：AU8402275
申请日：1975-08-15
申请人： TAKEDA CHEMICAL INDUSTRIES LTD
发明人： OKA YOSHIKAZU , HASHIMOTO NAOTO , KANNO MORIO , NISHIKAWA MASAO
IPC分类号： A61K31/135 , C07C20060101 , C07D319/08 , C07F7/18 , C07F9/32 , C07F9/40 , C07C91/42 , C07C83/04 , C07C91/00 , C07C93/14 , C07C93/26 , C07C97/07 , C07C103/38 , C07C103/42 , C07C103/44 , C07C103/82 , C07C125/04 , C07C125/06 , C07C127/19 , C07C143/68 , C07C143/76

4. 发明专利

CA939347A PYRIDINE THIOACETAMIDE DERIVATIVES 未知
公开(公告)号：CA939347A
公开(公告)日：1974-01-01
申请号：CA87627
申请日：1970-07-08
申请人： TAKEDA CHEMICAL INDUSTRIES LTD
发明人： KANAI YOSHIO , KANNO MORIO , SANNO YASUSHI , NOHARA AKIRA , HONDA HARUOMI
IPC分类号： C07D213/59 , C07D213/68 , C07D215/12
摘要： 1285302 Thioacetamides TAKEDA YAKUHIN KOGYO KK 7 July 1970 [8 July 1969 27 Sept 1969] 32790/70 Heading C2C Novel compounds I (including salts thereof) where R 1 is H, alkyl, alkoxy or halogen, n is 1 to 4, including the case where (R 1 ) n signifies a divalent straight-chain hydrocarbon radical of 4C which is attached to the 5th and 6th positions of the pyridine ring, R 2 and R 3 are H, alkyl, aralkyl or aryl or together with the adjacent N comprise a heterocycle, and with the proviso that R 1 , R 2 and R 3 are not simultaneously H, are made: (a) by reacting a corresponding -CH 2 CONR 2 R 3 compound with a phosphorus sulphide, or with a halogenating agent and then reacting the product so obtained with hydrogen sulphide; (b) by reacting NHR 1 2 R 1 3 with a compound I containing the 2-CH 2 CSNH 2 group, to afford a corresponding I containing a 2-CH 2 CSNR 1 2 R 1 3 group (R 1 2 and R 1 3 are the same as R 2 and R 3 but are not simultaneously H); and (c) by reacting a corresponding compound with hydrogen sulphide, RCSNH 2 (R is alkyl, aryl or aralkyl) or (R 1 O) 2 P(:S)SH, to afford I containing the 2-CH 2 CS.NH 2 group, or with R 2 NH 2 followed by reaction of the product so obtained with hydrogen sulphide to afford a corresponding I containing a group (R 1 is alkyl). Pharmaceutical preparations useful in treating and/or preventing gastric diseases contain I as active ingredient; suitable forms for administration are, e.g. powders, granules and tablets, and solutions for injection.

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