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1. 发明授权

US3759998A 2,2-bis (difluoramino)-5-fluoro-5,5-dinitro-1-pentanol 失效
标题翻译： 2,2-BIS（DIFLUORAMINO）-5-氟-5,5-脱氮-1-戊醇
公开(公告)号：US3759998A
公开(公告)日：1973-09-18
申请号：US3759998D
申请日：1969-10-10
申请人： US NAVY
发明人： COON C , HILL M , ROSS D
IPC分类号： C07C87/22 , C07C91/00
CPC分类号： C06B43/00
摘要： 2,2-bis (difluoramino)-5-fluoro-5,5-dinitro-1-pentanol having plasticizer properties for double-base propellants is synthesized by reacting 2,2-bis (difluoramino)-5-fluoro-5,5-dinitro-1-pentyl trifluoracetate with methanol.
摘要翻译：具有双基推进剂增塑剂性能的2,2-双（二氟氨基）-5-氟-5,5-二硝基-1-戊醇通过2,2-双（二氟氨基）-5-氟-5,5 二硝基-1-戊基三氟乙酸酯与甲醇。

2. 发明公开

EP0149480A3 Phosphonic-acid salts 失效
标题翻译：磷酸盐
公开(公告)号：EP0149480A3
公开(公告)日：1986-04-02
申请号：EP85100244
申请日：1985-01-11
申请人： CIBA-GEIGY AG
发明人： Clubley, Brian George , Dellar, Richard John, Dr. , Buszard, David Lewitt, Dr. , Richardson, Norman
IPC分类号： C07F09/40 , C07D213/74 , C07C87/00 , C07C91/00 , C07C93/04 , C08K05/53 , C08L75/04 , C08L79/04 , C08G18/38
CPC分类号： C07D213/74 , C07D295/027 , C07F9/4006 , C08K5/5317 , Y10S521/902

3. 发明公开

EP0036730A3 Bicyclooctane derivatives, processes for producing them, pharmaceutical compositions containing them, their use as pharmaceuticals and precursors thereof 失效
标题翻译：二氯化钛衍生物，生产它们的方法，含有它们的药物组合物，它们作为药物及其前体使用
公开(公告)号：EP0036730A3
公开(公告)日：1982-09-08
申请号：EP81301063
申请日：1981-03-13
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Ono, Keiichi , Sugie, Akihiko , Kawakami, Hajime , Sami, Shunsuke , Kojima, Atsuyuki , Katsube, Junki
IPC分类号： C07C43/18 , C07C59/00 , C07C69/66 , C07C91/00 , C07C93/00 , C07C47/00 , C07D211/14 , C07C121/75 , C07C103/30 , C07C177/00 , A61K31/00 , A61K31/557
CPC分类号： C07C255/00 , C07B2200/07 , C07B2200/09 , C07C29/095 , C07C29/1285 , C07C35/32 , C07C43/196 , C07C405/0083 , C07C2602/24 , C07D211/32 , Y10S514/925 , C07C29/143
摘要： Certain novel bicyclooctanes and their pharmaceutically acceptable salts are useful in the treatment of gastrointestinal ulcers. These compounds can be prepared by various methods and have the formula
wherein X 1 is a free or esterified carboxyl group, a hydroxymethyl group, a cyano group, a group of the formula:
(R a and R b are each independently a hydrogen atom, a C 1 -C 4 alkyl group, a C 3 -C 7 cycloalkyl group, a benzyl group, a phenyl group, a phenyl group substituted with a halogen atom or a C 1 -C 4 alkyl group, or, when taken together with the adjacent nitrogen atom to which they are attached, they represent a 5 to 7-membered saturated heterocyclic group) or a group of the formula:
(R a and R b are each as defined above), Y is an ethylene group or a vinylene group, R 1 is a hydrogen atom, a hydroxyl group or a protected hydroxyl group, R 2 is a hydrogen atom or R 1 and R 2 , when taken together, means a single linkage to form a double bond between the carbon atoms which they are linked, R 3 is a hydroxyl group or a protected hydroxyl group, R 4 is a hydrogen atom or a C 1 -C 4 alkyl group, R 5 is a hydrogen atom, a C 3 -C 8 alkenyl group, a C 3 -C 8 alkynyl group, a C 1 -C 8 alkyl group, a C 3 -C 7 cycloalkyl group or a group of the formula: -(CH 2 ) n- B (n is 1 or 2 and B is a C 1 -C 4 alkoxyl group, a C 3 -C 7 cycloalkyl group, or a phenyl or phenoxy group optionally substituted with a halogen atom, a C 1 -C 4 alkyl group, a trifluoromethyl group or a C 1 -C 4 alkoxyl group), A is a group of either one of the formulae: -CH=CH-,
(R 6 and R 7 are each independently a hydrogen atom or a C 1 -C 4 alkyl group) and m 1 is 1 or 2 and m 2 is 0, 1 or 2.
摘要翻译：某些新颖的双环辛烷及其药学上可接受的盐可用于治疗胃肠溃疡。这些化合物可以通过各种方法制备，并具有式... ...其中X 1是游离或酯化的羧基，羟甲基，氰基，下式的基团：... ...（ R a和R b各自独立地为氢原子，C 1 -C 4烷基，C 3 -C 7环烷基，苄基，苯基，被卤素原子取代的苯基或C1- C4烷基，或者当与它们所连接的相邻氮原子一起时，它们表示5至7元饱和杂环基团）或下式的基团：... ...（R a和 R b各自如上所定义），Y是亚乙基或亚乙烯基，R 1是氢原子，羟基或保护的羟基，R 2是氢原子或R 1和当R 2一起表示单键以在它们连接的碳原子之间形成双键时，R 3是羟基或被保护的羟基，R 4是氢原子或 C 1 -C 4烷基，R 5是氢原子，C 3 -C 8烯基，C 3 -C 8炔基，C 1 -C 8烷基，C 3 -C 7环烷基或下式的基团： - （CH 2）n B（n为1或2，B为C 1 -C 4烷氧基，C 3 -C 7环烷基或任选被卤素原子取代的苯基或苯氧基，C 1 -C 4烷基，基团或C 1 -C 4烷氧基），A是下式中的任何一个：-CH = CH-，... ...（R 6和R 7各自独立地是氢原子或 C1-C4烷基）和... ... m1为1或2，m2为0,1或2。

4. 发明公开

EP0192601A3 Flame-retardant for polyurethanes 失效
标题翻译：聚氨酯阻燃剂
公开(公告)号：EP0192601A3
公开(公告)日：1988-02-10
申请号：EP86810026
申请日：1986-01-20
申请人： CIBA-GEIGY AG
发明人： Richardson, Norman , Clubley, Brian George , Dellar, Richard John, Dr.
IPC分类号： C08K05/53 , C08G18/38 , C08G18/14 , C07F09/38 , C07F09/40 , C07C91/00
CPC分类号： C07F9/4006 , C07C279/24 , C07C279/28 , C07F9/3808 , C08G18/388 , C08G18/3889 , C08K5/5317 , C08L75/04

5. 发明公开

EP0149480A2 Phosphonsäuresalze 失效
标题翻译： Phosphonsäuresalze。
公开(公告)号：EP0149480A2
公开(公告)日：1985-07-24
申请号：EP85100244.4
申请日：1985-01-11
申请人： CIBA-GEIGY AG
发明人： Clubley, Brian George , Dellar, Richard John, Dr. , Buszard, David Lewitt, Dr. , Richardson, Norman
IPC分类号： C07F9/40 , C07D213/74 , C07C87/00 , C07C91/00 , C07C93/04 , C08K5/53 , C08L75/04 , C08L79/04 , C08G18/38
CPC分类号： C07D213/74 , C07D295/027 , C07F9/4006 , C08K5/5317 , Y10S521/902
摘要： Gegenstand der Erfindung sind Salze der Methylphosphonsäure bzw. deren Mono- oder Dimethylester mit bestimmten Aminen. Die Salze sind nützliche flammhemmende Zusätze für Polyurethane und Polyisocyanate.
摘要翻译：本发明涉及甲基膦酸或与某些胺它们的单或二酯的盐。盐是聚氨酯和聚异氰酸酯有用的阻燃添加剂。

6. 发明授权

EP0149480B1 Phosphonsäuresalze 失效
标题翻译：磷酸盐
公开(公告)号：EP0149480B1
公开(公告)日：1989-04-19
申请号：EP85100244.4
申请日：1985-01-11
申请人： CIBA-GEIGY AG
发明人： Clubley, Brian George , Dellar, Richard John, Dr. , Buszard, David Lewitt, Dr. , Richardson, Norman
IPC分类号： C07F9/40 , C07D213/74 , C07C87/00 , C07C91/00 , C07C93/04 , C08K5/53 , C08L75/04 , C08L79/04 , C08G18/38
CPC分类号： C07D213/74 , C07D295/027 , C07F9/4006 , C08K5/5317 , Y10S521/902

7. 发明公开

EP0255756A3 Method for producing high purity quaternary ammonium hydroxides 失效
标题翻译：生产高纯度季铵氢氧化物的方法
公开(公告)号：EP0255756A3
公开(公告)日：1988-08-17
申请号：EP87305482
申请日：1987-06-19
申请人： Southwestern Analytical Chemicals, Inc.
发明人： Hale, Cecil H. , Tanner, Alan R. , Hale, Bryan M.
IPC分类号： C25B03/00 , B01D57/02 , C07C87/00 , C07C91/00 , C07C93/00
CPC分类号： B01D61/44 , C07C209/84 , C25B3/00
摘要： A process is described for improving the purity of aqueous quaternary ammonium hydroxides, the process comprising:
(a) heating the aqueous quaternary ammonium hydroxide solution at an elevated temperature of from about 50°C to about 200°C for a period of at least about 0.1 hour; (b) charging the thus treated aqueous solution to the anolyte compartment an electrolysis cell comprising an anolyte compartment and a catholyte compartment separated from each other by a cation-exchange membrane and containing water as the catholyte; (c) passing a direct current through the electrolysis cell to produce a high purity quaternary ammonium hydroxide in the catholyte compartment; and (d) recovering the high purity quaternary ammonium hydroxide from the catholyte compartment. The process significantly reduces the amount of halogen (both ionic and latent), carbonates and/or metals present in the quaternary ammonium hydroxide and improves the colour.

8. 发明授权

US4362892A Hypolipidaemic compounds 失效
标题翻译：降血脂化合物
公开(公告)号：US4362892A
公开(公告)日：1982-12-07
申请号：US859379
申请日：1977-12-12
申请人： Richard M. Hindley , Keith H. Baggaley
发明人： Richard M. Hindley , Keith H. Baggaley
IPC分类号： A61K31/135 , A61K20060101 , A61K31/04 , A61K31/16 , A61K31/165 , A61K31/185 , A61K31/19 , A61K31/195 , A61K31/21 , A61K31/215 , A61K31/24 , A61K31/275 , A61K31/36 , A61P3/06 , C07C20060101 , C07C67/00 , C07C209/00 , C07C209/10 , C07C209/18 , C07C209/50 , C07C209/52 , C07C211/44 , C07C213/00 , C07C215/68 , C07C225/22 , C07C227/00 , C07C227/04 , C07C227/16 , C07C227/18 , C07C229/42 , C07C229/60 , C07C231/00 , C07C231/12 , C07C253/00 , C07C255/42 , C07D317/30 , C07C87/28 , C07C91/00
CPC分类号： A61K31/04 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/185 , A61K31/19 , A61K31/195 , A61K31/21 , A61K31/215 , A61K31/24 , A61K31/275 , A61K31/36 , C07C1/00 , C07C209/00 , C07C209/10 , C07C209/18 , C07C209/50 , C07C209/52 , C07C211/44 , C07C213/00 , C07C215/68 , C07C225/22 , C07C227/00 , C07C227/04 , C07C227/16 , C07C227/18 , C07C229/42 , C07C229/60 , C07C231/00 , C07C231/12 , C07C253/00 , C07C255/42 , C07C67/00 , C07D317/30
摘要： Certain substituted aralkylanilines in which the aromatic aniline ring carries, at the para position to the amino function, a substituent which comprises a carboxylic acid, salt or ester, an alkyl, hydroxyalkyl, cyano or acyl group, have hypolipidaemic activity.
摘要翻译：其中芳香族苯胺环在氨基官能的对位具有含羧酸，盐或酯，烷基，羟基烷基，氰基或酰基的取代基的某些取代的芳烷基苯胺具有降血脂活性。

9. 发明授权

US3900515A 2-aryl-3-isopropylamino-1-butanols 失效
标题翻译： 2-ARYL-3-ISOPROPYLAMINO-1-DUTANOLS
公开(公告)号：US3900515A
公开(公告)日：1975-08-19
申请号：US25103772
申请日：1972-05-08
申请人： LEPETIT SPA
发明人： BELLASIO ELVIO , CRISTIANI FRANCO
IPC分类号： C07C20060101 , C07C91/00
CPC分类号： C07C51/353 , Y10S514/821
摘要： and their pharmaceutically acceptable acid salts. The compounds of the invention are crystalline solids or liquids which, having two asymmetric centers, can be obtained in their stereoisomeric forms as racemic mixtures or in optically active form. The compounds exhibit Beta -receptor activity as Beta -blocking agents and are therefore useful in the treatment of heart diseases such as angina pectoris and cardiac arrhythmias. The compounds are prepared by reacting a lower alkyl 2-aryl-3isopropylamino-butyrate with acetone to form a Schiff base which is subsequently hydrogenated to the corresponding 2-aryl-3isopropylamino-1-butanol.
2-Aryl-3-isopropylamino-1-butanols corresponding to the formula

10. 发明授权

US3778467A Aminoalkyl-ethanoanthracenes 失效
标题翻译：氨基烷基 - 乙烷基
公开(公告)号：US3778467A
公开(公告)日：1973-12-11
申请号：US3778467D
申请日：1969-04-29
申请人： CIBA GEIGY CORP
发明人： WILHELM M , RIESS W
IPC分类号： A61K31/13 , A23K1/16 , A61K31/135 , A61P25/00 , C07C15/28 , C07C215/42 , C07D211/08 , C07D265/12 , C07D295/08 , C07D295/22 , C07C91/00 , C07C93/00 , C07C97/10
CPC分类号： C07D295/08 , C07D211/08 , C07D265/12 , C07D295/22 , Y10S514/96
摘要： IN WHICH PH AND PH'' ARE OPTIONALLY SUBSTITUTED O-PHENYLENE RADICALS ALK STANDS FOR LOWER ALKYLENE R STANDS FOR AN OPTONALLY SUBSTITUTED AMINO GROUP RO REPRESENTS HYDROGEN OR LOWER ALKYL R''X REPRESENTS HYDROGEN OR LOWER ALKYL RA REPRESENTS HYDROGEN OR ACYL ARE USEFUL AS PSYCHOPHARMACEUTICALS.

BOTH CH''S ARE JOINED

AND PH
PH
COMPOUNDS OF THE FORMULA

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