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1. 发明申请

WO2012054639A3 NMR SYSTEMS AND METHODS FOR THE RAPID DETECTION OF ANALYTES 审中-公开
标题翻译：用于快速检测分析物的NMR系统和方法
公开(公告)号：WO2012054639A3
公开(公告)日：2013-07-04
申请号：PCT/US2011056936
申请日：2011-10-19
申请人： T2 BIOSYSTEMS INC , LOWERY THOMAS JAY JR , AUDEH MARK JOHN , BLANCO MATTHEW , CHEPIN JAMES FRANKLIN , DEMAS VASILIKI , DHANDA RAHUL , FRITZEMEIER MARILYN LEE , KOH ISAAC , KUMAR SONIA , NEELY LORI ANNE , MOZELESKI BRIAN , PLOURDE DANIELLA LYNN , RITTERSHAUS CHARLES WILLIAM , WELLMAN PARRIS
发明人： LOWERY THOMAS JAY JR , AUDEH MARK JOHN , BLANCO MATTHEW , CHEPIN JAMES FRANKLIN , DEMAS VASILIKI , DHANDA RAHUL , FRITZEMEIER MARILYN LEE , KOH ISAAC , KUMAR SONIA , NEELY LORI ANNE , MOZELESKI BRIAN , PLOURDE DANIELLA LYNN , RITTERSHAUS CHARLES WILLIAM , WELLMAN PARRIS
IPC分类号： G01V3/00
CPC分类号： G01N33/54326 , B82Y25/00 , C12Q1/6825 , C12Q1/6827 , C12Q1/689 , C12Q1/6895 , C12Q1/70 , C12Q1/701 , G01N24/08 , G01N27/745 , G01N33/5434 , G01N33/9493 , G01R33/093 , G01R33/1269 , G01R33/281 , G01R33/302 , G01R33/448 , C12Q2563/143 , C12Q2565/633 , C12Q2563/149 , C12Q2565/113
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
摘要翻译：本发明的特征在于用于检测分析物的系统和方法及其在治疗和诊断疾病中的用途。

2. 发明申请

WO2012054638A3 NMR SYSTEMS AND METHODS FOR THE DETECTION OF ANALYTES 审中-公开
标题翻译： NMR系统和检测分析物的方法
公开(公告)号：WO2012054638A3
公开(公告)日：2012-07-05
申请号：PCT/US2011056933
申请日：2011-10-19
申请人： T2 BIOSYSTEMS INC , LOWERY THOMAS JAY , AUDEH MARK JOHN , BLANCO MATTHEW , CHEPIN JAMES FRANKLIN , DEMAS VASILIKI , DHANDA RAHUL , FRITZEMEIER MARILYN LEE , KOH ISAAC , KUMAR SONIA , NEELY LORI ANNE , MOZELESKI BRIAN , PLOURDE DANIELLA LYNN , RITTERSHAUS CHARLES WILLIAM , WELLMAN PARRIS
发明人： LOWERY THOMAS JAY , AUDEH MARK JOHN , BLANCO MATTHEW , CHEPIN JAMES FRANKLIN , DEMAS VASILIKI , DHANDA RAHUL , FRITZEMEIER MARILYN LEE , KOH ISAAC , KUMAR SONIA , NEELY LORI ANNE , MOZELESKI BRIAN , PLOURDE DANIELLA LYNN , RITTERSHAUS CHARLES WILLIAM , WELLMAN PARRIS
IPC分类号： C12Q1/68
CPC分类号： G01N33/54326 , B82Y25/00 , C12Q1/6825 , C12Q1/6827 , C12Q1/689 , C12Q1/6895 , C12Q1/70 , C12Q1/701 , G01N24/08 , G01N27/745 , G01N33/5434 , G01N33/9493 , G01R33/093 , G01R33/1269 , G01R33/281 , G01R33/302 , G01R33/448 , C12Q2563/143 , C12Q2565/633 , C12Q2563/149 , C12Q2565/113
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
摘要翻译：本发明描述了用于检测分析物的系统和方法，以及它们在疾病治疗和诊断中的用途。

3. 发明专利

AU2016204680A1 NMR systems and methods for the rapid detection of analytes 未知
公开(公告)号：AU2016204680A1
公开(公告)日：2016-07-21
申请号：AU2016204680
申请日：2016-07-06
申请人： T2 BIOSYSTEMS INC
发明人： LOWERY JR THOMAS JAY , AUDEH MARK JOHN , BLANCO MATTHEW , CHEPIN JAMES FRANKLIN , DEMAS VASILIKI , DHANDA RAHUL , FRITZEMEIER MARILYN LEE , KOH ISAAC , KUMAR SONIA , NEELY LORI ANNE , MOZELESKI BRIAN , PLOURDE DANIELLA LYNN , RITTERSHAUS CHARLES WILLIAM , WELLMAN PARRIS
IPC分类号： G01V3/00
摘要： NMR SYSTEMS AND METHODS FOR THE RAPID DETECTION OF ANALYTES Abstract This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.

4. 发明申请

WO2007019479A3 MULTI-CHANNEL FLOW CELLS 审中-公开
标题翻译：多通道流动细胞
公开(公告)号：WO2007019479A3
公开(公告)日：2007-09-20
申请号：PCT/US2006030824
申请日：2006-08-04
申请人： HELICOS BIOSCIENCES CORP , LAWSON JOHN , WELLMAN PARRIS , KIANI SEPEHR
发明人： LAWSON JOHN , WELLMAN PARRIS , KIANI SEPEHR
IPC分类号： F15C1/06 , C12M1/36 , C12M3/00
CPC分类号： B01L3/502715 , B01J2219/00522 , B01J2219/00605 , B01J2219/00621 , B01L3/5025 , B01L3/502761 , B01L2200/027 , B01L2300/0636 , B01L2300/0816 , B01L2300/0829 , B01L2300/0877 , B01L2300/0887 , B01L2300/16 , B01L2300/163 , B01L2400/0406 , B01L2400/049 , G01N21/05 , G01N35/1095 , G01N2021/0346
摘要： A multi-channel flow cell can allow for reduced cross-contamination in sample loading and the ability to observe activity within the flow cell once the channels are loaded. A multi-channel flow cell includes a plurality of independently-addressable channels sandwiched between a two substrates. Each of the channels can be coated with a layer that facilitates support-binding of an analyte. Each of the channels terminates on one end in an inlet and on the other end in an outlet. A loading block having inlet ports that match the inlets of the channels can be mated to the inlets of the channels, and an outlet block can be mated to the outlets of the channels. Analytes can be introduced into the channels via the inlet ports of the loading block and are pulled through the channels by capillary action or by vacuum. Once analyte has been introduced into each of the channels, the loading and outlet blocks can be removed and the device turned over. Such a flow cell can be used for streamlining the process of reaction and interrogation of biochemical assays at the microfluidic level. Reagents can be introduced into each of the channels of the flow cell for chemical reactions therein, excess reagent being washed out through the channel outlets. Observation of optically-detectable moieties is then conducted. With such a flow cell optical labels associated with incorporation in a sequencing-by-synthesis reaction can be observed.
摘要翻译：多通道流通池可以允许在样品加载中减少交叉污染，并且一旦加载通道，就能够观察流动池内的活性。多通道流动池包括夹在两个基板之间的多个可独立寻址的通道。每个通道可以涂覆有促进分析物的支持结合的层。每个通道的一端在入口处终止，另一端在出口处终止。具有与通道的入口匹配的入口端口的装载块可以配合到通道的入口，并且出口块可以配合到通道的出口。分析物可以通过装载块的入口引入通道，并通过毛细作用或真空被吸引通过通道。一旦分析物被引入到每个通道中，则可以去除装载和出口块并且将装置翻转。这样的流动池可以用于在微流控水平下精简生物化学测定的反应和询问过程。可以将试剂引入流动池的每个通道中用于其中的化学反应，多余的试剂通过通道出口被洗出。然后进行光学可检测部分的观察。通过这样的流动池，可以观察到与逐步合成反应相结合的光学标记。

5. 发明专利

AU2018204483B2 NMR systems and methods for the rapid detection of analytes 未知
公开(公告)号：AU2018204483B2
公开(公告)日：2020-11-05
申请号：AU2018204483
申请日：2018-06-21
申请人： T2 BIOSYSTEMS INC
发明人： LOWERY JR THOMAS JAY , AUDEH MARK JOHN , BLANCO MATTHEW , CHEPIN JAMES FRANKLIN , DEMAS VASILIKI , DHANDA RAHUL , FRITZEMEIER MARILYN LEE , KOH ISAAC , KUMAR SONIA , NEELY LORI ANNE , MOZELESKI BRIAN , PLOURDE DANIELLA LYNN , RITTERSHAUS CHARLES WILLIAM , WELLMAN PARRIS
IPC分类号： G01N33/543 , G01V3/00
摘要： Abstract of the Disclosure This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease. 10382990_1 (GHMatters) P92976.AU.2

6. 发明专利

ZA201302022B NMR SYSTEMS AND METHODS FOR THE DETECTION OF ANALYTES 未知
公开(公告)号：ZA201302022B
公开(公告)日：2014-05-28
申请号：ZA201302022
申请日：2013-03-18
申请人： T2 BIOSYSTEMS INC
发明人： LOWERY THOMAS JAY , AUDEH MARK JOHN , BLANCO MATTHEW , CHEPIN JAMES FRANKLIN , DEMAS VASILIKI , DHANDA RAHUL , FRITZEMEIER MARLEYN LEE , KOH ISAAC , KUMAR SONIA , NEELY LORI ANNE , MOZELESKI BRIAN , PLOURDE DANIELLA LYNN , RITTERSHAUS CHARLES WILLIAM , WELLMAN PARRIS
IPC分类号： C12Q20060101
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.

7. 发明专利

AU2011317073A1 NMR systems and methods for the rapid detection of analytes 未知
公开(公告)号：AU2011317073A1
公开(公告)日：2013-05-02
申请号：AU2011317073
申请日：2011-10-19
申请人： T2 BIOSYSTEMS INC
发明人： LOWERY JR THOMAS JAY , AUDEH MARK JOHN , BLANCO MATTHEW , CHEPIN JAMES FRANKLIN , DEMAS VASILIKI , DHANDA RAHUL , FRITZEMEIER MARILYN LEE , KOH ISAAC , KUMAR SONIA , NEELY LORI ANNE , MOZELESKI BRIAN , PLOURDE DANIELLA LYNN , RITTERSHAUS CHARLES WILLIAM , WELLMAN PARRIS
IPC分类号： G01N33/553 , C12M1/34 , G01N33/566
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.

8. 发明申请

WO2005045378A2 SPACE-CREATING RETRACTOR WITH VESSEL MANIPULATOR 审中-公开
标题翻译：具有船舶操纵器的空间创建延迟器
公开(公告)号：WO2005045378A2
公开(公告)日：2005-05-19
申请号：PCT/US2004035776
申请日：2004-10-26
申请人： ETHICON INC , WELLMAN PARRIS , COHN SIMON , YOUNG JOHN , SWYST THOMAS , PELLETIER JAMES , LAPETINA JOHN , DEVLIN JOHN P
发明人： WELLMAN PARRIS , COHN SIMON , YOUNG JOHN , SWYST THOMAS
IPC分类号： A61B17/22 , A61B17/28 , A61B17/32 , G01J
CPC分类号： A61B17/29 , A61B17/22031 , A61B2017/320044
摘要： A retractor for manipulating a vessel in a patient includes a working head shaped to define a working space in the tissue of a patient and at least a first manipulator for manipulating a vessel located proximate the working space, the first manipulator having a retracted position and an extended position. The first manipulator if disposed at least partially within the working space when the first manipulator is in the retracted position.
摘要翻译：用于在患者中操纵血管的牵开器包括形成为在患者组织中限定工作空间的工作头和用于操纵位于工作空间附近的容器的至少第一操纵器，第一操纵器具有缩回位置和延长位置如果第一操纵器处于缩回位置，则第一操纵器至少部分地设置在工作空间内。

9. 发明专利

CA2815085C NMR SYSTEMS AND METHODS FOR THE RAPID DETECTION OF ANALYTES 未知
公开(公告)号：CA2815085C
公开(公告)日：2022-06-21
申请号：CA2815085
申请日：2011-10-19
申请人： T2 BIOSYSTEMS INC
发明人： LOWERY THOMAS JAY , AUDEH MARK JOHN , BLANCO MATTHEW , CHEPIN JAMES FRANKLIN , DEMAS VASILIKI , DHANDA RAHUL , FRITZEMEIER MARILYN LEE , KOH ISAAC , KUMAR SONIA , NEELY LORI ANNE , MOZELESKI BRIAN , PLOURDE DANIELLA LYNN , RITTERSHAUS CHARLES WILLIAM , WELLMAN PARRIS
IPC分类号： G01N33/543 , C12M1/34 , C12Q1/68 , C12Q1/6813 , C12Q1/6844 , C12Q1/6888 , C12Q1/689 , G01N33/569
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.

10. 发明专利

CA2815085A1 NMR SYSTEMS AND METHODS FOR THE RAPID DETECTION OF ANALYTES 未知
公开(公告)号：CA2815085A1
公开(公告)日：2012-04-26
申请号：CA2815085
申请日：2011-10-19
申请人： T2 BIOSYSTEMS INC
发明人： LOWERY THOMAS JAY JR , AUDEH MARK JOHN , BLANCO MATTHEW , CHEPIN JAMES FRANKLIN , DEMAS VASILIKI , DHANDA RAHUL , FRITZEMEIER MARILYN LEE , KOH ISAAC , KUMAR SONIA , NEELY LORI ANNE , MOZELESKI BRIAN , PLOURDE DANIELLA LYNN , RITTERSHAUS CHARLES WILLIAM , WELLMAN PARRIS
IPC分类号： G01N33/543 , C12M1/34 , C12Q1/68 , G01N33/569 , G01N33/68 , G01N33/70
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.

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