专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08596281B2 Devices, methods and compositions for presbyopia correction using ultrashort pulse laser 有权
标题翻译：使用超短脉冲激光器进行老花眼矫正的装置，方法和组成
公开(公告)号：US08596281B2
公开(公告)日：2013-12-03
申请号：US12087507
申请日：2007-03-05
申请人： Szymon Suckewer , Alexander Smits , Peter Hersh , Richard Register , Gary Kunkel , Anatoli Morozov
发明人： Szymon Suckewer , Alexander Smits , Peter Hersh , Richard Register , Gary Kunkel , Anatoli Morozov
IPC分类号： A61F9/008
CPC分类号： A61F9/00838 , A61B3/13 , A61F2009/0087 , A61F2009/00895
摘要： The invention relates to devices, compositions and methods used to improve vision and/or to treat an eye lens disease or condition. In some embodiments, the invention relates to altering or removing eye lens material for the treatment of presbyopia. In additional embodiments, the invention relates to placing compositions in a lens of an eye to improve elasticity of the lens both therapeutically by improving elasticity and/or improving refractive properties and/or prophylactically by preventing renewed stiffening and/or renewed deterioration of the lens refractive properties. In further embodiments, the invention relates to devices and methods of obtaining and analyzing data for use in altering the lens to optimize its elasticity and/or refractive properties.
摘要翻译：本发明涉及用于改善视力和/或治疗眼晶状体疾病或病症的装置，组合物和方法。在一些实施方案中，本发明涉及改变或去除用于治疗老花眼的眼晶状体材料。在另外的实施方案中，本发明涉及将组合物放置在眼睛的晶状体中，以通过改善弹性和/或改善屈光性能和/或通过防止透镜折射的新的加强和/或再次劣化来预防性地改善透镜的弹性属性。在另外的实施例中，本发明涉及获得和分析用于改变透镜以优化其弹性和/或折射性质的数据的装置和方法。

2. 发明申请

US20100076417A1 Devices, Methods and Compositions for Presbyopia Correction Using Ultrashort Pulse Laser 有权
标题翻译：使用超短脉冲激光器进行老花眼矫正的装置，方法和组成
公开(公告)号：US20100076417A1
公开(公告)日：2010-03-25
申请号：US12087507
申请日：2007-03-05
申请人： Szymon S. Suckewer , Alexander Smits , Peter Hersh , Richard Register , Gary Kunkel , Anatoli Morozov
发明人： Szymon S. Suckewer , Alexander Smits , Peter Hersh , Richard Register , Gary Kunkel , Anatoli Morozov
IPC分类号： A61F9/008 , A61B18/20
CPC分类号： A61F9/00838 , A61B3/13 , A61F2009/0087 , A61F2009/00895
摘要： The invention relates to devices, compositions and methods used to improve vision and/or to treat an eye lens disease or condition. In some embodiments, the invention relates to altering or removing eye lens material for the treatment of presbyopia. In additional embodiments, the invention relates to placing compositions in a lens of an eye to improve elasticity of the lens both therapeutically by improving elasticity and/or improving refractive properties and/or prophylactically by preventing renewed stiffening and/or renewed deterioration of the lens refractive properties. In further embodiments, the invention relates to devices and methods of obtaining and analyzing data for use in altering the lens to optimize its elasticity and/or refractive properties.
摘要翻译：本发明涉及用于改善视力和/或治疗眼晶状体疾病或病症的装置，组合物和方法。在一些实施方案中，本发明涉及改变或去除用于治疗老花眼的眼晶状体材料。在另外的实施方案中，本发明涉及将组合物放置在眼睛的晶状体中，以通过改善弹性和/或改善屈光性能和/或通过防止透镜折射的新的加强和/或再次劣化来预防性地改善透镜的弹性属性。在另外的实施例中，本发明涉及获得和分析用于改变透镜以优化其弹性和/或折射性质的数据的装置和方法。

3. 发明授权

US08382744B2 Method and device for cornea reshaping by intrastromal tissue removal 有权
标题翻译：通过胸腔内组织去除角膜重塑的方法和装置
公开(公告)号：US08382744B2
公开(公告)日：2013-02-26
申请号：US11843498
申请日：2007-08-22
申请人： Szymon Suckewer , Peter Hersh , Alexander Smits , Anatoli Morozov
发明人： Szymon Suckewer , Peter Hersh , Alexander Smits , Anatoli Morozov
IPC分类号： A61F9/007
CPC分类号： A61F9/008 , A61F9/00827 , A61F2009/00872 , A61F2009/0088
摘要： A method and device for flapless, intrastromal keratomileusis for the correction of myopia, hyperopia and astigmatism, i.e., for vision correction by corneal reshaping without creating a flap. Ultra-short laser pulses are used to create a temporary micro-channel extending to an end point located within the cornea. A second series of ultra-short laser pulses are then delivered to photo-ablate material in the vicinity of the micro-channel end-point. The photo-ablated material may exit through the micro-channel used to deliver the laser pulses, or via a separate micro-channel. With the micro-channel oriented substantially normal to the optical axis of the cornea, and by continuing to supply the ultra-short laser pulses in the appropriate number while moving the point of ablation along the micro-channel, the photo-ablation of the intrastromal tissue may continue in a controlled fashion and the cornea reshaped in a predetermined manner without creating a flap.
摘要翻译：一种用于矫正近视，远视和散光的无瓣膜，基质内角膜磨镶术的方法和装置，即用于通过角膜重塑而不产生瓣片的视力矫正。使用超短激光脉冲来产生延伸到位于角膜内的终点的临时微通道。然后将第二系列的超短激光脉冲输送到微通道终点附近的光蚀刻材料。光消融材料可以通过用于传递激光脉冲的微通道，或通过单独的微通道离开。由于微通道取向为基本上垂直于角膜的光轴，并且通过在沿着微通道移动消融点的同时继续供应适当数量的超短激光脉冲，则基质内的光消融组织可以以受控的方式继续，并且角膜以预定方式重新成形，而不产生瓣。

4. 发明申请

US20080051772A1 Method and Device for Cornea Reshaping by Intrastromal Tissue Removal 有权
标题翻译：通过体内组织去除角膜重塑的方法和装置
公开(公告)号：US20080051772A1
公开(公告)日：2008-02-28
申请号：US11843498
申请日：2007-08-22
申请人： Szymon Suckewer , Peter Hersh , Alexander Smits , Anatoli Morozov
发明人： Szymon Suckewer , Peter Hersh , Alexander Smits , Anatoli Morozov
IPC分类号： A61B18/20
CPC分类号： A61F9/008 , A61F9/00827 , A61F2009/00872 , A61F2009/0088
摘要： A method and device for flapless, intrastromal keratomileusis for the correction of myopia, hyperopia and astigmatism, i.e., for vision correction by corneal reshaping without creating a flap. Ultra-short laser pulses are used to create a temporary micro-channel extending to an end point located within the cornea. A second series of ultra-short laser pulses are then delivered to photo-ablate material in the vicinity of the micro-channel end-point. The photo-ablated material may exit through the micro-channel used to deliver the laser pulses, or via a separate micro-channel. With the micro-channel oriented substantially normal to the optical axis of the cornea, and by continuing to supply the ultra-short laser pulses in the appropriate number while moving the point of ablation along the micro-channel, the photo-ablation of the intrastromal tissue may continue in a controlled fashion and the cornea reshaped in a predetermined manner without creating a flap.
摘要翻译：一种用于矫正近视，远视和散光的无瓣膜，基质内角膜磨镶术的方法和装置，即用于通过角膜重塑而不产生瓣片的视力矫正。使用超短激光脉冲来产生延伸到位于角膜内的终点的临时微通道。然后将第二系列的超短激光脉冲输送到微通道终点附近的光蚀刻材料。光消融材料可以通过用于传递激光脉冲的微通道，或通过单独的微通道离开。由于微通道取向为基本上垂直于角膜的光轴，并且通过在沿着微通道移动消融点的同时继续供应适当数量的超短激光脉冲，则基质内的光消融组织可以以受控的方式继续，并且角膜以预定方式重新成形，而不产生瓣。

5. 发明授权

US09351826B2 Cataract removal using ultra-short pulse lasers 有权
标题翻译：使用超短脉冲激光去除白内障
公开(公告)号：US09351826B2
公开(公告)日：2016-05-31
申请号：US14269170
申请日：2014-05-04
申请人： Szymon Suckewer , Peter Hersh , Alexander Smits , Richard Register
发明人： Szymon Suckewer , Peter Hersh , Alexander Smits , Richard Register
IPC分类号： A61B18/20 , A61F2/16 , A61F9/008
CPC分类号： A61F2/1613 , A61F9/00834 , A61F2009/0087 , A61F2009/0088 , A61F2009/00887
摘要： A system and method of replacing a lens to treat a cataract is disclosed. Cataractous tissue is ablated via a multi-photon process using focused, ultra-short laser pulses. Multi-photon ablation requires an energy intensity between 1013 to 1015 W/cm2. Using lasers having femto-second duration pulses, this intensity is achieved with 50 micro-Joules of energy, allowing material disruption with very little heating or shock. The multi-photon ablated material is removed through a micro-channel that leads from the multi-photon ablated region to at least the surface of the eye. Once the material is removed a pre-polymer fluid is injected in to fill the void. This polymerizes into a gel once inside the lens. The polymerized, transformed material matches both the transparency to visible light and the Young's modulus of healthy lens.
摘要翻译：公开了一种更换镜片以治疗白内障的系统和方法。白内障组织通过使用聚焦的超短激光脉冲的多光子过程消融。多光子消融需要1013〜1015W / cm2的能量强度。使用具有毫微微秒持续时间脉冲的激光器，以强度为50微焦的能量实现该强度，从而允许材料中断，非常少的加热或冲击。通过从多光子烧蚀区域引导至至少眼睛表面的微通道去除多光子消融材料。一旦去除材料，就注入预聚物流体以填充空隙。透镜内聚合成凝胶。聚合的转化材料与透明度与可见光和健康透镜的杨氏模量相匹配。

6. 发明申请

US20150290030A1 Cataract Removal using Ultra-Short Pulse Lasers 有权
标题翻译：使用超短脉冲激光去除白内障
公开(公告)号：US20150290030A1
公开(公告)日：2015-10-15
申请号：US14269170
申请日：2014-05-04
申请人： Szymon Suckewer , Peter Hersh , Alexander Smits , Richard Register
发明人： Szymon Suckewer , Peter Hersh , Alexander Smits , Richard Register
IPC分类号： A61F9/008 , A61F2/16
CPC分类号： A61F2/1613 , A61F9/00834 , A61F2009/0087 , A61F2009/0088 , A61F2009/00887
摘要： A system and method of replacing a lens to treat a cataract is disclosed. Cataractous tissue is ablated via a multi-photon process using focused, ultra-short laser pulses. Multi-photon ablation requires an energy intensity between 1013 to 1015 W/cm2. Using lasers having femto-second duration pulses, this intensity is achieved with 50 micro-Joules of energy, allowing material disruption with very little heating or shock. The multi-photon ablated material is removed through a micro-channel that leads from the multi-photon ablated region to at least the surface of the eye. Once the material is removed a pre-polymer fluid is injected in to fill the void. This polymerizes into a gel once inside the lens. The polymerized, transformed material matches both the transparency to visible light and the Young's modulus of healthy lens.
摘要翻译：公开了一种更换镜片以治疗白内障的系统和方法。白内障组织通过使用聚焦的超短激光脉冲的多光子过程消融。多光子消融需要1013〜1015W / cm2的能量强度。使用具有毫微微秒持续时间脉冲的激光器，以强度为50微焦的能量实现该强度，从而允许材料中断，非常少的加热或冲击。通过从多光子烧蚀区域引导至至少眼睛表面的微通道去除多光子消融材料。一旦去除材料，就注入预聚物流体以填充空隙。透镜内聚合成凝胶。聚合的转化材料与透明度与可见光和健康透镜的杨氏模量相匹配。

7. 发明申请

US20160120700A1 Intrastromal Corneal Reshaping Method and Apparatus for Correction of Refractive Errors Using Ultra-Short and Ultra-Intensive Laser Pulses 审中-公开
$Intrastromal Corneal Reshaping Method and Apparatus for Correction of Refractive Errors Using Ultra-Short and Ultra-Intensive Laser Pulses$
标题翻译：使用超短和超强激光脉冲校正折射误差的内膜角膜重塑方法和装置
公开(公告)号：US20160120700A1
公开(公告)日：2016-05-05
申请号：US14874407
申请日：2015-10-03
申请人： Taehee Han , Szymon Suckewer , Peter Hersh
发明人： Taehee Han , Szymon Suckewer , Peter Hersh
IPC分类号： A61F9/013 , A61F9/008
CPC分类号： A61F9/013 , A61F9/00827 , A61F2009/00872 , A61F2009/00897
摘要： Ultra-short, ultra-intense laser pulses from a first laser beam are applied to a patient's cornea, creating a temporary micro-channel extending from the cornea surface to an end-point within it. Further ultra-short ultra-intense laser pulses from a second laser beam, are then delivered to the endpoint along with further pulses from the first beam, but delayed by a few nanoseconds. The micro-channel acts as a light-guide for these pulses. At the end point, they are focused to sufficient intensity to multiphoton ablate surrounding stromal tissue. With a few small entrance holes and without the lamellar flap necessary in LASIK procedures, the cornea is reshaped by rotating the direction of the laser beam. The vertical location of ablation is adjusted precisely using an applanator on the corneal surface. The multiphoton ablated tissue is ejected via the micro-channels, allowing the cornea surface to collapse after the procedure, changing its refractive power.
摘要翻译：将来自第一激光束的超短激光脉冲施加到患者的角膜，从而产生从角膜表面延伸到其中的终点的临时微通道。然后，来自第二激光束的另外的超短超强激光脉冲随着来自第一光束的进一步脉冲传送到端点，但延迟几纳秒。微通道用作这些脉冲的光导。在终点，他们集中在足够的强度，以遍布基质组织的多孔烧蚀。在LASIK手术中需要几个小入口孔和无层片瓣，通过旋转激光束的方向重新形成角膜。使用角膜表面上的压扁镜精确调整消融的垂直位置。通过微通道喷射多光子消融组织，允许角膜表面在手术后塌陷，改变其屈光力。

8. 发明申请

US20120289886A1 CONTROLLED APPLICATION OF CROSS-LINKING AGENT 审中-公开
标题翻译：交联剂的控制应用
公开(公告)号：US20120289886A1
公开(公告)日：2012-11-15
申请号：US13475175
申请日：2012-05-18
申请人： David Muller , John Marshall , Stephen L. Trokel , Peter Hersh , Pavel Kamaev
发明人： David Muller , John Marshall , Stephen L. Trokel , Peter Hersh , Pavel Kamaev
IPC分类号： A61M37/00
CPC分类号： A61K31/525 , A61F9/0079 , A61F9/008 , A61F9/00804 , A61F2009/00844 , A61F2009/00851 , A61F2009/00853 , A61F2009/00857 , A61F2009/00872
摘要： Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.
摘要翻译：激活眼睛的至少一个眼睛部件内的交联的装置和方法，以稳定和加强眼睛的角膜组织或其他组织。通过将交联剂输送到至少一种眼睛部件的区域，然后通过将起始元件递送至至少一种眼睛部件来激活交联剂，在至少一种眼睛部件内激活交联。本文公开的方法允许通过将交联剂输送到至少一种眼睛部件的区域来精确地控制强化组织的三维区域。方法允许将交联剂输送到角膜表面下方的深度，使得交联在角膜表面下被激活。

9. 发明申请

US20110288466A1 SYSTEMS AND METHODS FOR ACTIVATING CROSS-LINKING IN AN EYE 审中-公开
标题翻译：用于在眼睛中进行交叉连接的系统和方法
公开(公告)号：US20110288466A1
公开(公告)日：2011-11-24
申请号：US13086019
申请日：2011-04-13
申请人： David Muller , John Marshall , Stephen L. Trokel , Peter Hersh , Pavel Kamaev
发明人： David Muller , John Marshall , Stephen L. Trokel , Peter Hersh , Pavel Kamaev
IPC分类号： A61M37/00
CPC分类号： A61K31/525 , A61F9/008 , A61F2009/00844 , A61F2009/00857 , A61F2009/00872 , A61N5/062
摘要： Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.
摘要翻译：激活眼睛的至少一个眼睛部件内的交联的装置和方法，以稳定和加强眼睛的角膜组织或其他组织。通过将交联剂输送到至少一种眼睛部件的区域，然后通过将起始元件递送至至少一种眼睛部件来激活交联剂，在至少一种眼睛部件内激活交联。本文公开的方法允许通过将交联剂输送到至少一种眼睛部件的区域来精确地控制强化组织的三维区域。方法允许将交联剂输送到角膜表面下方的深度，使得交联在角膜表面下被激活。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式