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1. 发明申请

WO2009149455A1 SUTURE BASED TISSUE REPAIR 审中-公开
标题翻译：基于组合的组织修复
公开(公告)号：WO2009149455A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/046624
申请日：2009-06-08
申请人： SYNTHES USA, LLC , SYNTHES GMBH , SINGHATAT, Wamis , TALBOT, James , KEANE, Michael , SCHMIDT, Brian , REICHEN, Marc
发明人： SINGHATAT, Wamis , TALBOT, James , KEANE, Michael , SCHMIDT, Brian , REICHEN, Marc
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B17/0057 , A61B17/0401 , A61B17/0466 , A61B17/0469 , A61B2017/00637 , A61B2017/00663 , A61B2017/0409 , A61B2017/0475 , A61B2017/081
摘要： The present invention provides an apparatus for suture-based tissue repair, preferably for the annulus of a spinal disc, that includes a suture loop preferably pre-tied with a sliding knot, a clasp-type component that captures the ends of the suture loop, and an optional plug member that fills the tissue defect. Also disclosed is a method that places the suture loop in a full-thickness stitch encircling the tissue defect, secures the ends of the suture loop to the clasp, and cinches the suture loop to approximate the tissue without the need to tie knots. Also disclosed is a suture passer that enables a suture strand or loop to be passed through the tissue wall, captured, and retrieved. The suture passer may optionally incorporate a clasp in such an arrangement that enables a suture loop passed through the tissue wall to be captured directly by the clasp.
摘要翻译：本发明提供了一种用于基于缝合的组织修复的装置，优选地用于脊椎盘的环，其包括优选地与滑结结合的缝合线环，捕获缝合线环的端部的扣环型部件，以及填充组织缺陷的可选插塞构件。还公开了一种将缝合线环放置在环绕组织缺损的全层缝合线上的方法，将缝合线环的端部固定到扣环上，并使缝合线环绕近距离组织而不需要扎结。还公开了一种能够使缝合线或环通过组织壁，被捕获和回收的缝合路人。缝合线路通道可以可选地并入一个这样一种布置的扣环，使得缝合线环可以通过组织壁直接由扣环抓住。

2. 发明申请

WO2009146331A1 PHASE TRANSITIONING HYDROGELS 审中-公开
标题翻译：相转移水凝胶
公开(公告)号：WO2009146331A1
公开(公告)日：2009-12-03
申请号：PCT/US2009/045328
申请日：2009-05-27
申请人： SYNTHES USA, LLC , SYNTHES GMBH , DREXEL UNIVERSITY , KITA, Kristin, B. , SMITH, Nigel, G. , LOWMAN, Anthony, M. , FUSSELL, Garland, W. , KEANE, Michael
发明人： KITA, Kristin, B. , SMITH, Nigel, G. , LOWMAN, Anthony, M. , FUSSELL, Garland, W. , KEANE, Michael
IPC分类号： C08L29/04 , A61L27/26 , A61L27/52 , C08L39/06 , C08L71/02 , C08K3/30
CPC分类号： C08L29/04 , A61L27/26 , A61L27/52 , A61L2400/06 , C08K3/30 , C08L39/06 , C08L71/02 , C08L2666/14 , C08L2666/02
摘要： A method of forming and the resulting hydrogel composition comprising poly( vinyl alcohol) at a final concentration of about 20% (w/w) to about 65% (w/w) and polyethylene glycol at a final concentration of about 2% (w/w) to about 20% (w/w), wherein the hydrogel composition has a total polymer content, above about 30% (w/w), higher than the total polymer content of a precursor polymer solution formulated prior to the formulation of the hydrogel composition. The hydrogel composition may further comprise poly( vinyl pyrrolidone) at a final concentration of about 0.10% (w/w) to about 0.75% (w/w).
摘要翻译：一种形成方法，所得到的水凝胶组合物包含最终浓度为约20％（w / w）至约65％（w / w）的聚乙烯醇和最终浓度为约2％的聚乙二醇（w / w）至约20％（w / w），其中所述水凝胶组合物的总聚合物含量高于约30％（w / w），高于在配制之前配制的前体聚合物溶液的总聚合物含量水凝胶组合物。水凝胶组合物还可以包含最终浓度为约0.10％（w / w）至约0.75％（w / w）的聚（乙烯基吡咯烷酮）。

3. 发明申请

WO2010077234A1 A METHOD OF FORMING AND THE RESULTING MEMBRANE COMPOSITION FOR SURGICAL SITE PRESERVATION 审中-公开
标题翻译：形成和形成外植体保护层的膜结构的方法
公开(公告)号：WO2010077234A1
公开(公告)日：2010-07-08
申请号：PCT/US2008/088444
申请日：2008-12-29
申请人： SYNTHES (U.S.A.) , SYNTHES GMBH , KEANE, Michael , MILLER, William , SMITH, Nigel
发明人： KEANE, Michael , MILLER, William , SMITH, Nigel
IPC分类号： A61L31/14 , A61L31/04 , A61L31/18
CPC分类号： A61L31/14 , A61L31/06 , A61L31/129 , A61L31/145 , A61L31/18 , C08L29/04 , C08L39/06
摘要： A method of forming and the resulting membrane composition for securement to a patient's bone or tissue to reduce the formation of tissue adhesions following a surgical procedure comprises a first component and a second component. The first component comprises a hydrogel including at least one crosslinked polymer. The second component comprises a textile component. The composition has a thickness between about two tenths of a millimeter (0.2 mm) to about six tenths of a millimeter (0.6 mm), a suture retention strength between about one Newton (1 N) to about thirteen Newtons (13 N), a static coefficient of friction between about one hundredth (0.01) and about one-half (0.5), a kinetic coefficient of friction between about one hundredth (0.01) and about one-half (0.5) and a flexibility of less than thirty millimeters (30 mm) bend length. A method of reducing the occurrence of tissue adhesions following surgery comprises applying the membrane composition to a surgical site.
摘要翻译：一种形成方法和所得的膜组合物用于固定到患者的骨骼或组织以减少外科手术后组织粘连的形成包括第一组分和第二组分。第一组分包含包含至少一种交联聚合物的水凝胶。第二部件包括纺织部件。该组合物具有约十分之二十毫米（0.2毫米）至约十六分之一毫米（0.6毫米）之间的厚度，约一牛顿（1N）至约十三牛顿（13N）之间的缝合线保持强度，一静态摩擦系数在约百分之一（0.01）至约一半（0.5）之间，摩擦系数约在百分之一（0.01）至约一半（0.5）之间，弹性小于三十毫米 mm）弯曲长度。减少手术后组织粘连发生的方法包括将膜组合物施用于手术部位。

4. 发明申请

WO2009086523A2 A TACK OR DRIVE SCREW FOR SECURING A PROSTHESIS TO BONE AND ASSOCIATED INSTRUMENTATION AND METHOD 审中-公开
标题翻译：用于保护骨骼和相关仪器和方法的插入或驱动螺丝
公开(公告)号：WO2009086523A2
公开(公告)日：2009-07-09
申请号：PCT/US2008/088462
申请日：2008-12-29
申请人： SYNTHES (U.S.A.) , SYNTHES GMBH , MORGAN, Mickey , PELOZA, John , LEE, Randall , KEANE, Michael , MILLER, William , TALBOT, James , VENNARD, Daniel , GABELBERGER, Josef
发明人： MORGAN, Mickey , PELOZA, John , LEE, Randall , KEANE, Michael , MILLER, William , TALBOT, James , VENNARD, Daniel , GABELBERGER, Josef
IPC分类号： A61B17/86
CPC分类号： A61B17/0401 , A61B17/0642 , A61B17/70 , A61B17/846 , A61B17/863 , A61B17/8685 , A61B17/8695 , A61B17/8872 , A61B17/92 , A61B2017/0414 , A61B2017/044 , A61B2017/0448 , A61B2017/0647 , A61B2017/0648 , A61B2090/08021 , A61B2090/3983
摘要： The present invention relates to a surgical method or procedure for securing a prosthesis to bone. More particularly, the present invention relates to (i) a surgical method or procedure for securing a low load bearing prosthesis such as, for example, an adhesion barrier, to a patient's bone, (ii) a tack or drive screw for securing the low load bearing prosthesis and (iii) associated instrumentation for driving the tack or drive screw into the patient's bone.
摘要翻译：本发明涉及一种将假体固定在骨上的手术方法或程序。更具体地，本发明涉及（i）用于将低负荷假体（例如粘合屏障）固定到患者骨骼的外科方法或程序，（ii）用于固定低位的固定或驱动螺钉承载假体和（iii）用于将钉头或驱动螺钉驱动到患者骨骼中的相关仪器。

5. 发明授权

EP2282679B1 SUTURE BASED TISSUE REPAIR 有权
公开(公告)号：EP2282679B1
公开(公告)日：2018-11-21
申请号：EP09759613.4
申请日：2009-06-08
申请人： Synthes GmbH
发明人： SINGHATAT, Wamis , TALBOT, James , KEANE, Michael , SCHMIDT, Brian , REICHEN, Marc
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B17/0057 , A61B17/0401 , A61B17/0466 , A61B17/0469 , A61B2017/00637 , A61B2017/00663 , A61B2017/0409 , A61B2017/0475 , A61B2017/081
摘要： The present invention provides an apparatus for suture-based tissue repair, preferably for the annulus of a spinal disc, that includes a suture loop preferably pre-tied with a sliding knot, a clasp-type component that captures the ends of the suture loop, and an optional plug member that fills the tissue defect. Also disclosed is a method that places the suture loop in a full-thickness stitch encircling the tissue defect, secures the ends of the suture loop to the clasp, and cinches the suture loop to approximate the tissue without the need to tie knots. Also disclosed is a suture passer that enables a suture strand or loop to be passed through the tissue wall, captured, and retrieved. The suture passer may optionally incorporate a clasp in such an arrangement that enables a suture loop passed through the tissue wall to be captured directly by the clasp.

6. 发明授权

EP2285899B1 METHOD TO PREPARE PHASE TRANSITIONING HYDROGELS 有权
标题翻译：制备相变水凝胶的方法
公开(公告)号：EP2285899B1
公开(公告)日：2017-03-22
申请号：EP09755692.2
申请日：2009-05-27
申请人： Synthes GmbH , Drexel University
发明人： KITA, Kristin, B. , SMITH, Nigel, G. , LOWMAN, Anthony, M. , FUSSELL, Garland, W. , KEANE, Michael
IPC分类号： C08L29/04 , C08K3/30 , A61L27/26 , A61L27/52 , C08L71/02 , C08L39/06
CPC分类号： C08L29/04 , A61L27/26 , A61L27/52 , A61L2400/06 , C08K3/30 , C08L39/06 , C08L71/02 , C08L2666/14 , C08L2666/02

7. 发明公开

EP2282679A1 SUTURE BASED TISSUE REPAIR 有权
标题翻译：焊接基底的组织修复
公开(公告)号：EP2282679A1
公开(公告)日：2011-02-16
申请号：EP09759613.4
申请日：2009-06-08
申请人： Synthes GmbH
发明人： SINGHATAT, Wamis , TALBOT, James , KEANE, Michael , SCHMIDT, Brian , REICHEN, Marc
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B17/0057 , A61B17/0401 , A61B17/0466 , A61B17/0469 , A61B2017/00637 , A61B2017/00663 , A61B2017/0409 , A61B2017/0475 , A61B2017/081
摘要： The present invention provides an apparatus for suture-based tissue repair, preferably for the annulus of a spinal disc, that includes a suture loop preferably pre-tied with a sliding knot, a clasp-type component that captures the ends of the suture loop, and an optional plug member that fills the tissue defect. Also disclosed is a method that places the suture loop in a full-thickness stitch encircling the tissue defect, secures the ends of the suture loop to the clasp, and cinches the suture loop to approximate the tissue without the need to tie knots. Also disclosed is a suture passer that enables a suture strand or loop to be passed through the tissue wall, captured, and retrieved. The suture passer may optionally incorporate a clasp in such an arrangement that enables a suture loop passed through the tissue wall to be captured directly by the clasp.

8. 发明公开

EP2285899A1 PHASE TRANSITIONING HYDROGELS 有权
标题翻译：相变水凝胶
公开(公告)号：EP2285899A1
公开(公告)日：2011-02-23
申请号：EP09755692.2
申请日：2009-05-27
申请人： Synthes GmbH , Drexel University
发明人： KITA, Kristin, B. , SMITH, Nigel, G. , LOWMAN, Anthony, M. , FUSSELL, Garland, W. , KEANE, Michael
IPC分类号： C08L29/04 , A61L27/26 , A61L27/52 , C08L39/06 , C08L71/02 , C08K3/30
CPC分类号： C08L29/04 , A61L27/26 , A61L27/52 , A61L2400/06 , C08K3/30 , C08L39/06 , C08L71/02 , C08L2666/14 , C08L2666/02
摘要： A method of forming and the resulting hydrogel composition comprising poly( vinyl alcohol) at a final concentration of about 20% (w/w) to about 65% (w/w) and polyethylene glycol at a final concentration of about 2% (w/w) to about 20% (w/w), wherein the hydrogel composition has a total polymer content, above about 30% (w/w), higher than the total polymer content of a precursor polymer solution formulated prior to the formulation of the hydrogel composition. The hydrogel composition may further comprise poly( vinyl pyrrolidone) at a final concentration of about 0.10% (w/w) to about 0.75% (w/w).
摘要翻译：形成最终浓度为约20％（w / w）至约65％（w / w）的聚（乙烯醇）和最终浓度为约2％的聚乙二醇（w / w）至约20％（w / w），其中所述水凝胶组合物具有高于约30％（w / w）的总聚合物含量，高于配制前配制的前体聚合物溶液的总聚合物含量该水凝胶组合物。水凝胶组合物可进一步包含最终浓度为约0.10％（w / w）至约0.75％（w / w）的聚（乙烯基吡咯烷酮）。

9. 发明公开

EP2224870A1 A TACK OR DRIVE SCREW FOR SECURING A PROSTHESIS TO BONE AND ASSOCIATED INSTRUMENTATION AND METHOD 有权
标题翻译：主食或ANTRRIEBSSCHRAUBE用于固定假体骨和相应的仪器
公开(公告)号：EP2224870A1
公开(公告)日：2010-09-08
申请号：EP08866342.2
申请日：2008-12-29
申请人： Synthes GmbH
发明人： MORGAN, Mickey , PELOZA, John , LEE, Randall , KEANE, Michael , MILLER, William , TALBOT, James , VENNARD, Daniel , GABELBERGER, Josef
IPC分类号： A61B17/86
CPC分类号： A61B17/0401 , A61B17/0642 , A61B17/70 , A61B17/846 , A61B17/863 , A61B17/8685 , A61B17/8695 , A61B17/8872 , A61B17/92 , A61B2017/0414 , A61B2017/044 , A61B2017/0448 , A61B2017/0647 , A61B2017/0648 , A61B2090/08021 , A61B2090/3983
摘要： The present invention relates to a surgical method or procedure for securing a prosthesis to bone. More particularly, the present invention relates to (i) a surgical method or procedure for securing a low load bearing prosthesis such as, for example, an adhesion barrier, to a patient's bone, (ii) a tack or drive screw for securing the low load bearing prosthesis and (iii) associated instrumentation for driving the tack or drive screw into the patient's bone.

10. 发明授权

EP2381974B1 A METHOD OF FORMING AND THE RESULTING MEMBRANE COMPOSITION FOR SURGICAL SITE PRESERVATION 有权
标题翻译：形成方法及所得的膜组成进行保存操作SITUS的
公开(公告)号：EP2381974B1
公开(公告)日：2014-12-17
申请号：EP08876533.4
申请日：2008-12-29
申请人： Synthes GmbH
发明人： KEANE, Michael , MILLER, William , SMITH, Nigel
IPC分类号： A61L31/12 , A61L31/14 , A61L31/18
CPC分类号： A61L31/14 , A61L31/06 , A61L31/129 , A61L31/145 , A61L31/18 , C08L29/04 , C08L39/06

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