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1. 发明申请

WO2009149455A1 SUTURE BASED TISSUE REPAIR 审中-公开
标题翻译：基于组合的组织修复
公开(公告)号：WO2009149455A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/046624
申请日：2009-06-08
申请人： SYNTHES USA, LLC , SYNTHES GMBH , SINGHATAT, Wamis , TALBOT, James , KEANE, Michael , SCHMIDT, Brian , REICHEN, Marc
发明人： SINGHATAT, Wamis , TALBOT, James , KEANE, Michael , SCHMIDT, Brian , REICHEN, Marc
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B17/0057 , A61B17/0401 , A61B17/0466 , A61B17/0469 , A61B2017/00637 , A61B2017/00663 , A61B2017/0409 , A61B2017/0475 , A61B2017/081
摘要： The present invention provides an apparatus for suture-based tissue repair, preferably for the annulus of a spinal disc, that includes a suture loop preferably pre-tied with a sliding knot, a clasp-type component that captures the ends of the suture loop, and an optional plug member that fills the tissue defect. Also disclosed is a method that places the suture loop in a full-thickness stitch encircling the tissue defect, secures the ends of the suture loop to the clasp, and cinches the suture loop to approximate the tissue without the need to tie knots. Also disclosed is a suture passer that enables a suture strand or loop to be passed through the tissue wall, captured, and retrieved. The suture passer may optionally incorporate a clasp in such an arrangement that enables a suture loop passed through the tissue wall to be captured directly by the clasp.
摘要翻译：本发明提供了一种用于基于缝合的组织修复的装置，优选地用于脊椎盘的环，其包括优选地与滑结结合的缝合线环，捕获缝合线环的端部的扣环型部件，以及填充组织缺陷的可选插塞构件。还公开了一种将缝合线环放置在环绕组织缺损的全层缝合线上的方法，将缝合线环的端部固定到扣环上，并使缝合线环绕近距离组织而不需要扎结。还公开了一种能够使缝合线或环通过组织壁，被捕获和回收的缝合路人。缝合线路通道可以可选地并入一个这样一种布置的扣环，使得缝合线环可以通过组织壁直接由扣环抓住。

2. 发明申请

WO2010105046A1 THREADABLE KNOT SOFT TISSUE DEFECT REPAIR SYSTEM 审中-公开
标题翻译：可撕开软组织缺陷修复系统
公开(公告)号：WO2010105046A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/026969
申请日：2010-03-11
申请人： SYNTHES USA, LLC , SYNTHES GMBH , SINGHATAT, Wamis , MANOS, James , DELMARTER, Brian, Rick , MESSERLI, Dominique , SCHMIDT, Brian , MILLER, William , TALBOT, James , FUSSELL, Garland , SMITH, Nigel, G.
发明人： SINGHATAT, Wamis , MANOS, James , DELMARTER, Brian, Rick , MESSERLI, Dominique , SCHMIDT, Brian , MILLER, William , TALBOT, James , FUSSELL, Garland , SMITH, Nigel, G.
IPC分类号： A61B17/04
CPC分类号： A61B17/0485 , A61B17/00491 , A61B17/0057 , A61B17/0469 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/0477 , A61B2017/06052
摘要： A soft tissue defect repair system for approximating defects, such as defects in the annulus fibrosus of an intervertebral disc, includes a cannulated rod through which is disposed a suture retrieval device. A strand of suture includes a locking or ratcheting knot pre-tied around the outside of the cannulated rod and a free end that is guided in and out of the soft tissue. A knot pusher fits around the cannulated rod, which is used to push the knot off of the cannulated rod after the stitching of the tissue is accomplished. The defect is approximated by tensioning the free end. Various suturing methods or patterns are disclosed for defect approximation.
摘要翻译：用于近似缺陷的软组织缺损修复系统，例如椎间盘纤维环中的缺陷，包括插管杆，通过该插管杆设置缝合线取出装置。一股缝合线包括预先束缚在插管杆的外侧的锁定或棘轮结，以及引导进出软组织的自由端。一个结推动器围绕插管杆，用于在组织的缝合完成之后将结从推杆上推出。通过张紧自由端近似缺陷。公开了各种缝合方法或图案用于缺陷近似。

3. 发明申请

WO2011088284A1 SYSTEM AND METHODS FOR MINIMALLY INVASIVE SPINE SURGERY 审中-公开
标题翻译：最小入侵脊柱手术的系统和方法
公开(公告)号：WO2011088284A1
公开(公告)日：2011-07-21
申请号：PCT/US2011/021238
申请日：2011-01-14
申请人： SYNTHES USA, LLC , SYNTHES GMBH , BANKOSKI, Brian , MASSON, Robert , ROSSNEY, Mark , SCHMIDT, Brian
发明人： BANKOSKI, Brian , MASSON, Robert , ROSSNEY, Mark , SCHMIDT, Brian
IPC分类号： A61B17/70
CPC分类号： A61B17/7079 , A61B17/1735 , A61B17/1757 , A61B17/7011 , A61B17/7037 , A61B17/7091 , A61B17/864 , A61B90/39 , A61B2017/0046 , A61B2090/037
摘要： Instruments and a method for minimally invasive surgery are disclosed. An implant manipulation instrument (20) comprises a driver (23) for locking a locking cap (19) against a spinal fixation rod (12) in a first spinal fixation device (11), and an actuator (22). The driver extends through the actuator and is rotatable with respect to it. An end (30) of the actuator is configured to fit over the rod, on which a second spinal fixation device (ll1) may be mounted. Pivoting (F) of the actuator with respect to the driver moves the second spinal fixation device closer to the first. An anchor delivery instrument (300) comprises a guide (302) including a cannulated body (303) to guide a surgical component (7), at least a first radio-opaque marker (313), and at least a second radio-opaque marker (330) distal to the first. A position of the first marker relative to the second on a radio image indicates whether the orientation of the guide is as desired.
摘要翻译：公开了用于微创手术的仪器和方法。植入物操纵仪器（20）包括用于在第一脊柱固定装置（11）中将锁定帽（19）锁定在脊柱固定杆（12）上的驱动器（23）和致动器（22）。驱动器延伸穿过致动器并且可相对于其旋转。致动器的端部（30）构造成配合在杆上，第二脊柱固定装置（111）可以安装在杆上。致动器相对于驾驶员的枢转（F）使第二脊柱固定装置更靠近第一脊柱固定装置。锚固器输送器具（300）包括导向器（302），该导向器（302）包括用于引导手术部件（7）的插管体（303），至少第一不透射线标记（313）和至少第二不透射线标记（330）远离第一个。在无线电图像上的第一标记相对于第二标记的位置指示引导件的取向是否如所期望的那样。

4. 发明申请

WO2015024003A3 INTEGRATED SYSTEM ARCHITECTURE AND METHODS FOR ADVERTISING INVENTORY ALLOCATIONS 审中-公开
公开(公告)号：WO2015024003A3
公开(公告)日：2015-02-19
申请号：PCT/US2014/051376
申请日：2014-08-15
申请人： OPENX TECHNOLOGIES, INC. , SAIFEE, Qasim , SHEN, Bin , SCHMIDT, Brian , ROBINSON, Jarriet , TANNENBAUM, David , TELYATNIKOV, Vadim , SOTELO, Caleb, Daniel , MOLINARO, Anthony
发明人： SAIFEE, Qasim , SHEN, Bin , SCHMIDT, Brian , ROBINSON, Jarriet , TANNENBAUM, David , TELYATNIKOV, Vadim , SOTELO, Caleb, Daniel , MOLINARO, Anthony
IPC分类号： G06F17/30 , G06Q30/02 , G06Q30/06
摘要： System architecture and methods for enabling a client-side real-time auction of advertising inventory that works in conjunction with ad serving technologies. Multiple parallel requests are sent from the end-user's browser client to multiple real-time bidders who respond with a bid & advertisement for each unit, the bids are compared within the end-user's browser and the winning bid is sent to an ad serving system to be compared with other statically priced advertisements and exchange demand to determine the winning advertisements that will be displayed to the end-user. In addition, the system architecture includes system and methods for online advertising placement that provide possibly defaulting advertisement tags the opportunity to serve an advertisement ahead of a lower value tag that is guaranteed to fill, resulting in higher CPMs (i.e., Cost Per Mille) for web publishers.

5. 发明申请

WO2011084412A1 DETERGENT COMPOSITIONS CONTAINING THERMOBIFIDA FUSCA LIPASE AND METHODS OF USE THEREOF 审中-公开
标题翻译：含有THERMOBIFIDA FUSCA脂质的洗涤剂组合物及其使用方法
公开(公告)号：WO2011084412A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/060253
申请日：2010-12-14
申请人： DANISCO US INC. , ADAMS, Christian , SCHMIDT, Brian
发明人： ADAMS, Christian , SCHMIDT, Brian
IPC分类号： C11D3/386 , C12N9/20 , C12N9/18
CPC分类号： C12N9/20 , C11D3/38627 , C12N9/18
摘要： The present compositions and methods relate to a lipase cloned from Thermobifida fusca, polynucleotides encoding the lipase, and methods of use thereof. The compositions and methods have particular application in detergent cleaning compositions and methods.
摘要翻译：本发明的组合物和方法涉及从Thermobifida fusca克隆的脂肪酶，编码脂肪酶的多核苷酸及其使用方法。组合物和方法在洗涤剂清洁组合物和方法中具有特别的应用。

6. 发明申请

WO2005047302A1 EXPRESSION IN FILAMENTOUS FUNGI OF PROTEASE INHIBITORS AND VARIANTS THEREOF 审中-公开
标题翻译：蛋白酶抑制剂及其变体的真菌真菌中的表达
公开(公告)号：WO2005047302A1
公开(公告)日：2005-05-26
申请号：PCT/US2004/035278
申请日：2004-10-22
申请人： GENENCOR INTERNATIONAL, INC. , DE NOBEL, Hans , ESTELL, David, A. , LIU, Wei , POWER, Scott, D. , SCHMIDT, Brian , WANG, Huaming
发明人： DE NOBEL, Hans , ESTELL, David, A. , LIU, Wei , POWER, Scott, D. , SCHMIDT, Brian , WANG, Huaming
IPC分类号： C07H21/04
CPC分类号： C12N15/80 , C07K14/811
摘要： Described herein are protease inhibitors, variants thereof and methods for their production.
摘要翻译：本文描述的是蛋白酶抑制剂，其变体及其生产方法。

7. 发明申请

WO2011084417A1 DETERGENT COMPOSITIONS CONTAINING GEOBACILLUS STEAROTHERMOPHILUS LIPASE AND METHODS OF USE THEREOF 审中-公开
标题翻译：含有GEOBACILLUS STEAROTHERMOPHILUS LIPASE的洗涤剂组合物及其使用方法
公开(公告)号：WO2011084417A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/060268
申请日：2010-12-14
申请人： DANISCO US INC. , ADAMS, Christian , SCHMIDT, Brian
发明人： ADAMS, Christian , SCHMIDT, Brian
IPC分类号： C11D3/386 , C12N9/20 , C12N9/18
CPC分类号： C11D3/38627 , C12N9/20
摘要： The present compositions and methods relate to a lipase cloned from Geobacillus stearothermophilus, polynucleotides encoding the lipase, and methods of use thereof. The compositions and methods have particular application in detergent cleaning compositions and methods.
摘要翻译：本发明的组合物和方法涉及从嗜热脂肪芽孢杆菌克隆的脂肪酶，编码脂肪酶的多核苷酸及其使用方法。组合物和方法在洗涤剂清洁组合物和方法中具有特别的应用。

8. 发明申请

WO2009023271A2 KAPPA-CARRAGEENASE AND KAPPA-CARRAGEENASE-CONTAINING COMPOSITIONS 审中-公开
标题翻译： KAPPA-CARRAGEENASE和含KAPPA-CARRAGEENASE的组合物
公开(公告)号：WO2009023271A2
公开(公告)日：2009-02-19
申请号：PCT/US2008/009789
申请日：2008-08-15
申请人： DANISCO US INC., GENENCOR DIVISION , MCDONALD, Hugh, C. , SCHMIDT, Brian
发明人： MCDONALD, Hugh, C. , SCHMIDT, Brian
IPC分类号： C07K14/43
CPC分类号： C12Y302/01083 , C11D3/38636 , C12N9/2402
摘要： The present invention provides cleaning compositions comprising at least one carrageenase enzyme, methods for producing carrageenase enzymes in host cells, host cells comprising recombinant polynucleotides encoding at least one carrageenase, and recombinant polynucleotides encoding carrageenase.
摘要翻译：本发明提供了包含至少一种角叉菜
酶的清洁组合物，在宿主细胞中产生角叉菜
聚酶的方法，包含编码至少一种角叉菜
胶的重组多核苷酸的宿主细胞和编码角叉菜
酶的重组多核苷酸。

9. 发明申请

WO2006121610A2 PERSONAL CARE COMPOSITIONS AND METHODS FOR THEIR USE 审中-公开
标题翻译：个人护理组合物及其使用方法
公开(公告)号：WO2006121610A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/015711
申请日：2006-04-25
申请人： GENENCOR INTERNATIONAL, INC. , COLLIER, Katherine, D. , DAY, Anthony , DE NOBEL, Hans , ESTELL, David, A. , GANSHAW, Grant, C. , KOLKMAN, Marc , LAD, Raj , MILLER, Jeffrey, V. , MURRAY, Christopher, J. , POWER, Scott, D. , SCHMIDT, Brian , VAN KIMMENADE, Anita , VOGTENTANZ, Gudrun
发明人： COLLIER, Katherine, D. , DAY, Anthony , DE NOBEL, Hans , ESTELL, David, A. , GANSHAW, Grant, C. , KOLKMAN, Marc , LAD, Raj , MILLER, Jeffrey, V. , MURRAY, Christopher, J. , POWER, Scott, D. , SCHMIDT, Brian , VAN KIMMENADE, Anita , VOGTENTANZ, Gudrun
CPC分类号： A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
摘要： The present invention provides peptides and supported peptides for treating various diseases and conditions. In particularly preferred embodiments, the present invention provides compositions and methods for personal care. In some embodiments, the present invention provides compositions for use in skin and/or hair care, as well as cosmetic compositions. In alternative particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein comprises BBI.
摘要翻译：本发明提供用于治疗各种疾病和病症的肽和负载肽。在特别优选的实施方案中，本发明提供用于个人护理的组合物和方法。在一些实施方案中，本发明提供用于皮肤和/或头发护理以及化妆品组合物的组合物。在替代的特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载的肽，例如红斑痤疮。在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。在一些最优选的实施方案中，支架蛋白包含BBI。

10. 发明申请

WO2011084599A1 DETERGENT COMPOSITIONS CONTAINING BACILLUS SUBTILIS LIPASE AND METHODS OF USE THEREOF 审中-公开
标题翻译：含有BACILLUS SUBTILIS LIPASE的洗涤剂组合物及其使用方法
公开(公告)号：WO2011084599A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/060768
申请日：2010-12-16
申请人： DANISCO US INC. , ADAMS, Christian , SCHMIDT, Brian
发明人： ADAMS, Christian , SCHMIDT, Brian
IPC分类号： C11D3/386
CPC分类号： C11D3/38627 , C07K2319/20 , C12N9/20 , C12N9/2437 , C12Y302/01004
摘要： The present compositions and methods relate to a lipase cloned from Bacillus subtilis, polynucleotides encoding the lipase, and methods of use thereof. The compositions and methods have particular application in detergent cleaning compositions and methods.
摘要翻译：本发明的组合物和方法涉及从枯草芽孢杆菌克隆的脂肪酶，编码脂肪酶的多核苷酸及其使用方法。组合物和方法在洗涤剂清洁组合物和方法中具有特别的应用。

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