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1. 发明申请

US20090274728A1 Mutant Viruses 有权
标题翻译：突变病毒
公开(公告)号：US20090274728A1
公开(公告)日：2009-11-05
申请号：US12436382
申请日：2009-05-06
申请人： Susanne Moira Brown , Bhuvanesh Singh , Ian Ganly , Paul Dunn
发明人： Susanne Moira Brown , Bhuvanesh Singh , Ian Ganly , Paul Dunn
IPC分类号： A61K39/245 , C12N7/01 , A61K35/76 , C12N15/66
CPC分类号： A61K38/00 , C12N15/1135 , C12N15/86 , C12N2710/16643 , C12N2840/203
摘要： An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding an antisense to the squamous cell carcinoma related oncogene (asSCCRO); and an herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a short interfering ribonucleic acid (siRNA) molecule that is capable of repressing or silencing expression of squamous cell carcinoma related oncogene (SCCRO) nucleic acid or polypeptide are disclosed together with methods for generation and applications of such viruses.
摘要翻译：单纯疱疹病毒，其中单纯疱疹病毒基因组包含编码与鳞状细胞癌相关致癌基因（asSCCRO）反义的核酸; 和单纯疱疹病毒，其中所述单纯疱疹病毒基因组包含编码能够抑制或沉默鳞状细胞癌相关致癌基因（SCCRO）核酸或多肽的表达的短干扰核糖核酸（siRNA）分子的核酸以及方法用于生成和应用此类病毒。

2. 发明授权

US08530437B2 Methods for treating cancer using herpes simplex virus expressing antisense to the squamous cell carcinoma related oncogene 有权
标题翻译：使用表达与鳞状细胞癌相关致癌基因反义的单纯疱疹病毒治疗癌症的方法
公开(公告)号：US08530437B2
公开(公告)日：2013-09-10
申请号：US12436382
申请日：2009-05-06
申请人： Susanne Moira Brown , Paul Dunn , Bhuvanesh Singh , Ian Ganly
发明人： Susanne Moira Brown , Paul Dunn , Bhuvanesh Singh , Ian Ganly
IPC分类号： C12N15/11 , A61K38/00 , C07H21/04 , C12Q1/68
CPC分类号： A61K38/00 , C12N15/1135 , C12N15/86 , C12N2710/16643 , C12N2840/203
摘要： An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding an antisense to the squamous cell carcinoma related oncogene (asSCCRO); and an herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a short interfering ribonucleic acid (siRNA) molecule that is capable of repressing or silencing expression of squamous cell carcinoma related oncogene (SCCRO) nucleic acid or polypeptide are disclosed together with methods for generation and applications of such viruses.
摘要翻译：单纯疱疹病毒，其中单纯疱疹病毒基因组包含编码与鳞状细胞癌相关致癌基因（asSCCRO）反义的核酸; 和单纯疱疹病毒，其中所述单纯疱疹病毒基因组包含编码能够抑制或沉默鳞状细胞癌相关致癌基因（SCCRO）核酸或多肽的表达的短干扰核糖核酸（siRNA）分子的核酸以及方法用于生成和应用此类病毒。

3. 发明申请

US20070003520A1 Mutant viruses 审中-公开
标题翻译：突变病毒
公开(公告)号：US20070003520A1
公开(公告)日：2007-01-04
申请号：US10579622
申请日：2004-11-17
申请人： Susanne Brown , Bhuvanesh Singh , Ian Ganly , Paul Dunn
发明人： Susanne Brown , Bhuvanesh Singh , Ian Ganly , Paul Dunn
IPC分类号： A61K48/00 , C12N7/00
CPC分类号： A61K38/00 , C12N15/1135 , C12N15/86 , C12N2710/16643 , C12N2840/203
摘要： An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding an antisense to the squamous cell carcinoma related oncogene (asSCCRO); and an herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a short interfering ribonucleic acid (siRNA) molecule that is capable of repressing or silencing expression of squamous cell carcinoma related oncogene (SCCRO) nucleic acid or polypeptide are disclosed together with methods for generation and applications of such viruses.
摘要翻译：单纯疱疹病毒，其中单纯疱疹病毒基因组包含编码与鳞状细胞癌相关致癌基因（asSCCRO）反义的核酸; 和单纯疱疹病毒，其中所述单纯疱疹病毒基因组包含编码能够抑制或沉默鳞状细胞癌相关致癌基因（SCCRO）核酸或多肽的表达的短干扰核糖核酸（siRNA）分子的核酸以及方法用于生成和应用此类病毒。

4. 发明申请

US20090208460A1 Mutant Herpes Simplex Viruses Comprising Nucleic Acid Encoding A Nitroreductase 审中-公开
标题翻译：突变型单纯疱疹病毒包含编码硝基还原酶的核酸
公开(公告)号：US20090208460A1
公开(公告)日：2009-08-20
申请号：US12357123
申请日：2009-01-21
申请人： Susanne Moira Brown , Paul Dunn
发明人： Susanne Moira Brown , Paul Dunn
IPC分类号： A61K35/76 , C12N7/01 , C12P21/00
CPC分类号： C12N15/1135 , A01K2267/0331 , A61K35/13 , A61K48/00 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2710/16643 , C12N2840/203
摘要： An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a nitroreductase (NTR) is disclosed. Disclosed herpes simplex viruses are indicated to be useful in the treatment of cancer which may involve gene directed enzyme prodrug therapy.
摘要翻译：公开了一种单纯疱疹病毒，其中单纯疱疹病毒基因组包含编码硝基还原酶（NTR）的核酸。所公开的单纯疱疹病毒可用于治疗可能涉及基因定向酶前药治疗的癌症。

5. 发明授权

US07498161B2 Mutant herpes simplex viruses comprising nucleic acid encoding a nitroreductase 有权
标题翻译：包含编码硝基还原酶的核酸的突变单纯疱疹病毒
公开(公告)号：US07498161B2
公开(公告)日：2009-03-03
申请号：US10579606
申请日：2004-11-17
申请人： Susanne Moira Brown , Paul Dunn
发明人： Susanne Moira Brown , Paul Dunn
IPC分类号： C12N7/00
CPC分类号： C12N15/1135 , A01K2267/0331 , A61K35/13 , A61K48/00 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2710/16643 , C12N2840/203 , Y02A50/473
摘要： An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a nitroreductase (NTR) is disclosed. Disclosed herpes simplex viruses are indicated to be useful in the treatment of cancer which may involve gene directed enzyme prodrug therapy.
摘要翻译：公开了一种单纯疱疹病毒，其中单纯疱疹病毒基因组包含编码硝基还原酶（NTR）的核酸。所公开的单纯疱疹病毒可用于治疗可能涉及基因定向酶前药治疗的癌症。

6. 发明授权

US09025251B2 Optically variable devices, security device and article employing same, and associated method of creating same 有权
标题翻译：光学可变设备，安全设备和使用相同的文章，以及相关的创建方法
公开(公告)号：US09025251B2
公开(公告)日：2015-05-05
申请号：US12964897
申请日：2010-12-10
申请人： Paul Dunn , Robert Edward Renton , Donald William Tomkins
发明人： Paul Dunn , Robert Edward Renton , Donald William Tomkins
IPC分类号： G02B27/10 , G07D7/00 , G07D7/12
CPC分类号： G07D7/0006 , G07D7/0013 , G07D7/003 , G07D7/0032 , G07D7/124 , Y10T156/10
摘要： An optically variable device (“OVD”) with an integral image system that includes a focusing element and an array of micro-objects which, when viewed through the focusing element, changes in appearance depending on the relative location from which the OVD is observed. A security device including the OVD and methods for creating the OVD are also disclosed.
摘要翻译：具有整体图像系统的光学可变装置（“OVD”），其包括聚焦元件和当通过聚焦元件观察时根据观察到OVD的相对位置而改变外观的微物体阵列。还公开了包括OVD的安全设备和用于创建OVD的方法。

7. 发明申请

US20070098689A1 Mutant viruses 有权
标题翻译：突变病毒
公开(公告)号：US20070098689A1
公开(公告)日：2007-05-03
申请号：US10579606
申请日：2004-11-17
申请人： Susanne Brown , Paul Dunn
发明人： Susanne Brown , Paul Dunn
IPC分类号： A61K48/00 , C12N15/86 , C12N7/00
CPC分类号： C12N15/1135 , A01K2267/0331 , A61K35/13 , A61K48/00 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2710/16643 , C12N2840/203 , Y02A50/473
摘要： An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a nitroreductase (NTR) is disclosed. Disclosed herpes simplex viruses are indicated to be useful in the treatment of cancer which may involve gene directed enzyme prodrug therapy.
摘要翻译：公开了一种单纯疱疹病毒，其中单纯疱疹病毒基因组包含编码硝基还原酶（NTR）的核酸。所公开的单纯疱疹病毒可用于治疗可能涉及基因定向酶前药治疗的癌症。

8. 发明申请

US20050039153A1 Macro design techniques to accommodate chip level wiring and circuit placement across the macro 有权
标题翻译：宏观设计技术，以适应芯片级布线和电路布局
公开(公告)号：US20050039153A1
公开(公告)日：2005-02-17
申请号：US10946552
申请日：2004-09-21
申请人： Thomas Bednar , Paul Dunn , Scott Gould , Jeannie Panner , Paul Zuchowski
发明人： Thomas Bednar , Paul Dunn , Scott Gould , Jeannie Panner , Paul Zuchowski
IPC分类号： G06F17/50 , H01L21/82 , H01L21/822 , H01L27/04
CPC分类号： G06F17/5068 , Y10S707/99931
摘要： Macro design techniques are disclosed for facilitating subsequent stage wiring across the macro. Whitespace areas within the macro are rearranged to accommodate the wiring. The rearrangement may take the form of physical rearrangement of the whitespace areas into routing tracks extending from one side of the macro to another; shielding using, for example, macro power bussing and/or macro wiring; routing power busses to the rearranged whitespace; and/or inserting active circuits with pins accessible to the wiring. In a preferred embodiment, active circuits are placed into rearranged macro whitespace during the design of subsequent stages. The rearrangement of the whitespace facilitates the wiring across the macro so that slew rate and path delay requirements of the subsequent stage wiring can be maintained, without excessive buffering or rerouting of wiring.
摘要翻译：公开了宏观设计技术，以便于跨宏观的后续布线。重新布置宏中的空白区域以适应布线。重新布置可以采取将空白区域的物理重新布置成从宏的一侧延伸到另一侧的路由轨道的形式; 使用例如宏功率总线和/或宏布线进行屏蔽; 路由功率总线到重新排列的空格; 和/或插入具有可接线的引脚的有源电路。在优选实施例中，在后续阶段的设计期间，将有源电路放置在重排的宏空白中。空白的重新排列有助于宏观上的布线，使得可以保持后续级布线的压摆率和路径延迟要求，而不会过度缓冲或重新布线。

9. 发明申请

US20060274856A1 System and method for communicating confidential messages 有权
标题翻译：用于传达机密信息的系统和方法
公开(公告)号：US20060274856A1
公开(公告)日：2006-12-07
申请号：US11143240
申请日：2005-06-01
申请人： Paul Dunn , Aaron Belcher , Alan Gatzke
发明人： Paul Dunn , Aaron Belcher , Alan Gatzke
IPC分类号： H04L27/22
CPC分类号： H04L63/045 , H04K1/00 , H04L9/0825 , H04L2209/60 , H04M3/533
摘要： A method of recording messages includes recording audio data in a first file structured in accordance with a file format that defines a first portion and a second portion. The audio data is recorded in the first portion of the first file. The method also includes encrypting the audio data stored in the first portion of the first file and generating a second file structured according to the file format. The second file includes decoy audio data in the first portion of the second file and the encrypted audio data in the second portion of the second file. The decoy audio data indicates a confidential status of the second file or serves as a red herring to distract from the encrypted audio data in the second portion of the second file.
摘要翻译：记录消息的方法包括：将音频数据记录在根据定义第一部分和第二部分的文件格式构成的第一文件中。音频数据被记录在第一文件的第一部分中。该方法还包括加密存储在第一文件的第一部分中的音频数据并产生根据文件格式构造的第二文件。第二文件包括第二文件的第一部分中的诱饵音频数据和第二文件的第二部分中的加密音频数据。诱饵音频数据指示第二文件的机密状态，或者用作红色鲱鱼，以分散第二文件的第二部分中的加密音频数据。

10. 发明申请

US20070100593A1 Method for constructing a geologic model of a subsurface reservoir 有权
标题翻译：构造地下储层地质模型的方法
公开(公告)号：US20070100593A1
公开(公告)日：2007-05-03
申请号：US10586373
申请日：2005-02-22
申请人： Max Deffenbaugh , Paul Dunn
发明人： Max Deffenbaugh , Paul Dunn
IPC分类号： G06G7/48
CPC分类号： E21B49/00 , G01V1/301
摘要： The present invention is a method for constructing a geologic model of a subsurface reservoir which is a composite sedimentary body (30) composed of many smaller fundamental sedimentary bodies (32). In one embodiment, the fundamental sedimentary bodies (32) within the composite body (30) are specified by the properties of the flow which built them, including the flow properties that existed at the local inlet (36) of each fundamental body (32). The statistical distribution of these local inlet properties is characterized throughout the composite sedimentary body (30) using either outline forms of some of the fundamental sedimentary bodies (32) or a well penetration which samples the composite sedimentary body (30). The geologic model is constructed by placing an appropriate statistical distribution of the fundamental sedimentary bodies (32) into the outline form of the composite sedimentary body (30) so that the grain size distribution and/or other geologic properties are specified at each point within the composite sedimentary body (30).
摘要翻译：本发明是一种构造地下储层的地质模型的方法，该地下储层是由许多较小的基底沉积体组成的复合沉积体（30）（32）。在一个实施例中，复合体（30）内的基础沉积体（32）由构成它们的流动特性来确定，包括存在于每个基体（32）的局部入口（36）处的流动性质，。这些局部入口性质的统计分布在整个复合沉积体（30）中的特征是使用一些基本沉积体（32）的轮廓形式或对复合沉积体（30）进行取样的井渗透。地质模型是通过将基础沉积体（32）的适当统计分布放置在复合沉积体（30）的轮廓形式中构成的，以使得粒度分布和/或其他地质特性在复合沉积体（30）。

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