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1. 发明授权

US06743795B1 3-nitropyridine derivaives and the pharmaceutical compositions containing said derivatives 失效
标题翻译： 3-硝基吡啶衍生物和含有所述衍生物的药物组合物
公开(公告)号：US06743795B1
公开(公告)日：2004-06-01
申请号：US10148227
申请日：2002-05-24
申请人： Sung June Yoon , Sang Wook Lee , Nam Doo Kim , Yong Kyun Park , Geun Hyung Lee , Jong Woo Kim , Sang Jin Park , Hee Jeoung Park , Dong Hyuk Shin
发明人： Sung June Yoon , Sang Wook Lee , Nam Doo Kim , Yong Kyun Park , Geun Hyung Lee , Jong Woo Kim , Sang Jin Park , Hee Jeoung Park , Dong Hyuk Shin
IPC分类号： A61K31496
CPC分类号： C07D401/12 , C07D403/12
摘要： The present invention relates to novel 3-nitropyridine derivatives, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the same as active ingredients. Methods of preparing the derivatives and pharmaceutical compositions containing the same are also disclosed. The 3-nitropyridine derivatives of the present invention, due to their inhibitory activity against the proliferation of human immunodeficiency virus (HIV) as well as hepatitis B virus (HBV), can be used as therapeutic agents as well as preventive agents for hepatitis B and acquired immune deficiency syndrome (AIDS).
摘要翻译：本发明涉及新的3-硝基吡啶衍生物，其药学上可接受的盐和含有它们作为活性成分的药物组合物。还公开了制备衍生物的方法和含有该衍生物的药物组合物。本发明的3-硝基吡啶衍生物由于其对人类免疫缺陷病毒（HIV）以及乙型肝炎病毒（HBV）的增殖的抑制活性可用作治疗剂以及用于乙型肝炎的预防剂获得性免疫缺陷综合征（AIDS）。

2. 发明申请

US20100317853A1 NOVEL IMATINIB CAMSYLATE AND METHOD FOR PREPARING THEREOF 审中-公开
标题翻译：新型樟脑磺酸钠及其制备方法
公开(公告)号：US20100317853A1
公开(公告)日：2010-12-16
申请号：US12525962
申请日：2008-02-01
申请人： Yoon Seok Oh , Jae Kyung Lim , Dong Hyuk Shin , Seung Kyoo Seong , Sang Ho Lee , Hak Soo Lee , Eun Hee Cho , Jei Man Ryu
发明人： Yoon Seok Oh , Jae Kyung Lim , Dong Hyuk Shin , Seung Kyoo Seong , Sang Ho Lee , Hak Soo Lee , Eun Hee Cho , Jei Man Ryu
IPC分类号： C07D401/14
CPC分类号： C07D401/04
摘要： The present invention relates to a novel imatinib camsylate and a method for preparing the same. Imatinib camsylate according to the present invention has a faster absorption rate and higher absorption concentration in terms of pharmacokinetics, and further has excellent water solubility, as compared to commercially available imatinib mesylate.
摘要翻译：本发明涉及新颖的伊马替尼樟脑磺酸盐及其制备方法。与市售的甲磺酸伊马替尼相比，本发明的伊马替尼樟脑磺酸盐在药代动力学方面具有更快的吸收速率和更高的吸收浓度，并且还具有优异的水溶性。

3. 发明授权

US07482747B2 Flexible EL device 有权
标题翻译：柔性EL器件
公开(公告)号：US07482747B2
公开(公告)日：2009-01-27
申请号：US11628642
申请日：2005-03-14
申请人： Dong Hyuk Shin , Kwang Hyuk Bae
发明人： Dong Hyuk Shin , Kwang Hyuk Bae
IPC分类号： H05B33/00
CPC分类号： H05B33/10 , H01L51/52 , H01L2251/5338 , H05B33/145 , H05B33/22 , H05B33/28 , Y10S428/917
摘要： A flexible EL device comprises a substrate, which is made of highly polymerized synthetic rubber, polyurethane, or silicon rubber, a conductive layer, a dielectric layer, a fluorescent layer, a transparent conductive layer, and a polymer protection film layer. Due to the high flexibility of the substrate, the flexibility of the flexible EL device according to the present invention is higher than the conventional EL device using PET, and therefore, the durability of the flexible EL device under mechanical impact is improved. As a result, the flexible EL device is not damaged when physical impacts are applied to the flexible EL device. Furthermore, noise is prevented or reduced by simply changing the structure of the flexible EL device and adding material layers, and therefore, electric and physical properties of the flexible EL device are improved. The flexible EL device is applicable to EL dome sheets or EL keypads.
摘要翻译：柔性EL器件包括由高分子合成橡胶，聚氨酯或硅橡胶，导电层，电介质层，荧光层，透明导电层和聚合物保护膜层制成的基片。由于基板的高灵活性，根据本发明的柔性EL器件的灵活性高于使用PET的常规EL器件，因此柔性EL器件在机械冲击下的耐久性得到改善。结果，当对柔性EL器件施加物理冲击时，柔性EL器件不会损坏。此外，通过简单地改变柔性EL器件的结构和添加材料层来防止或减少噪声，因此柔性EL器件的电学和物理特性得到改善。柔性EL器件适用于EL圆顶片或EL键盘。

4. 发明授权

US11613730B2 Method of culturing NK cells and kits containing medium additions 有权
公开(公告)号：US11613730B2
公开(公告)日：2023-03-28
申请号：US15998432
申请日：2018-08-15
申请人： Dong Hyuk Shin , NKCL BIO GROUP INC.
发明人： Dong Hyuk Shin
IPC分类号： C12N5/0783 , C07K16/28 , A61K35/17 , A61P35/00
摘要： The present invention relates to a method for culturing natural killer cells (NK cells) applied to immune therapy and, more particularly, to a medium addition kin for culturing NK cells with which lymphocytes derived from human peripheral blood can be cultured to effectively amplify and activate NK cells, which have an outstanding therapeutic effect on malignant tumors, while remarkably increasing the share of NK cells, and an NK cell culturing method using the kit.

5. 发明申请

US20080125596A1 Process For Preparing N-Hydroxy-4--Benzamidine 失效
标题翻译： N-羟基-4-苄脒的制备方法
公开(公告)号：US20080125596A1
公开(公告)日：2008-05-29
申请号：US11631829
申请日：2005-07-05
申请人： Jin Soo Lee , Seok Hoon Ahn , Young Goo Jin , Jae Hoon Park , Dong Hyuk Shin , Eun Hee Cho , Hwan Bong Chang , Young Ho Jung
发明人： Jin Soo Lee , Seok Hoon Ahn , Young Goo Jin , Jae Hoon Park , Dong Hyuk Shin , Eun Hee Cho , Hwan Bong Chang , Young Ho Jung
IPC分类号： C07D277/20
CPC分类号： C07D277/24
摘要： This invention relates to an improved method of preparing N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine.
摘要翻译：本发明涉及一种制备N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苄脒的改进方法。

6. 发明申请

US20090309889A1 Method and Apparatus for Contolling Writing of Data to Graphic Memory 有权
标题翻译：用于将数据写入图形存储器的方法和装置
公开(公告)号：US20090309889A1
公开(公告)日：2009-12-17
申请号：US12476905
申请日：2009-06-02
申请人： Jong Kon Bae , Sang-Hoon Lim , Kyu Young Chung , Won Sik Kang , Dong Hyuk Shin , Kyung Lip Park
发明人： Jong Kon Bae , Sang-Hoon Lim , Kyu Young Chung , Won Sik Kang , Dong Hyuk Shin , Kyung Lip Park
IPC分类号： G09G5/39
CPC分类号： G06T1/60 , G09G5/363 , G09G5/393 , G09G5/399 , G09G2360/12 , G09G2360/123
摘要： A method and apparatus for controlling writing of data to a graphic memory is provided. In the method and apparatus, a plurality of consecutively input data pieces are controlled to be not consecutively written to the same memory area in terms of time or space.
摘要翻译：提供了一种用于控制将数据写入图形存储器的方法和装置。在该方法和装置中，多个连续输入的数据被控制为在时间或空间方面不连续地写入相同的存储区域。

7. 发明授权

US07411143B2 Flexible EL dome sheet and flexible EL dome sheet keypad using the same 有权
标题翻译：柔性EL圆顶板和柔性EL圆顶板键盘使用相同
公开(公告)号：US07411143B2
公开(公告)日：2008-08-12
申请号：US11579003
申请日：2005-03-14
申请人： Dong Hyuk Shin , Kwang Hyuk Bae
发明人： Dong Hyuk Shin , Kwang Hyuk Bae
IPC分类号： H01H9/00
CPC分类号： H01H13/83 , H01H13/7006 , H01H2205/026 , H01H2219/018
摘要： A flexible EL dome sheet uses a polymer insulation layer having a thickness of 5 to 50 μm as a substrate, and therefore, the thickness of the flexible EL dome sheet is 50 to 150 μm. The flexible EL dome sheet comprises a flexible EL sheet having key patterns formed thereon and metal or poly domes attached to the EL sheet. Since the flexible EL sheet and the metal or poly domes are used, the flexible EL dome sheet has excellent flexibility and durability, and an additional process for silicon molding is not necessary. Furthermore, the tactile feel of the flexible EL dome sheet keypad is improved. Electric connection between an EL driver of a flexible printed circuit board and the flexible EL sheet is achieved using a contact pad terminal structure, whereby no additional connector is necessary, and therefore, an FPC connecting process is not required.
摘要翻译：柔性EL圆顶片使用厚度为5〜50μm的聚合物绝缘层作为基板，因此柔性EL圆顶片的厚度为50〜150μm。柔性EL圆顶片包括其上形成有键图案的柔性EL片和附着到EL片的金属或多晶圆顶。由于使用柔性EL片和金属或多晶圆顶，因此柔性EL圆顶片具有优异的柔性和耐久性，并且不需要额外的硅成型工艺。此外，改善了柔性EL圆顶板键盘的触感。柔性印刷电路板的EL驱动器与柔性EL片之间的电连接使用接触垫端子结构实现，由此不需要额外的连接器，因此不需要FPC连接工艺。

8. 发明授权

US08466923B2 Method and apparatus for contolling writing of data to graphic memory 有权
标题翻译：用于将数据写入图形存储器的方法和装置
公开(公告)号：US08466923B2
公开(公告)日：2013-06-18
申请号：US12476905
申请日：2009-06-02
申请人： Jong-Kon Bae , Sang-Hoon Lim , Kyu Young Chung , Won Sik Kang , Dong Hyuk Shin , Kyung Lip Park
发明人： Jong-Kon Bae , Sang-Hoon Lim , Kyu Young Chung , Won Sik Kang , Dong Hyuk Shin , Kyung Lip Park
IPC分类号： G09G5/39
CPC分类号： G06T1/60 , G09G5/363 , G09G5/393 , G09G5/399 , G09G2360/12 , G09G2360/123
摘要： A method and apparatus for controlling writing of data to a graphic memory is provided. In the method and apparatus, a plurality of consecutively input data pieces are controlled to be not consecutively written to the same memory area in terms of time or space.
摘要翻译：提供了一种用于控制将数据写入图形存储器的方法和装置。在该方法和装置中，多个连续输入的数据被控制为在时间或空间方面不连续地写入相同的存储区域。

9. 发明授权

US07585979B2 Process for preparing N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)-phenoxy]-pentoxy}-benzamidine 失效
标题翻译：制备N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基） - 苯氧基] - 苯氧基} - 苄脒的方法
公开(公告)号：US07585979B2
公开(公告)日：2009-09-08
申请号：US11631829
申请日：2005-07-05
申请人： Jin Soo Lee , Seok Hoon Ahn , Young Goo Jin , Jae Hoon Park , Dong Hyuk Shin , Eun Hee Cho , Hwan Bong Chang , Young Ho Jung
发明人： Jin Soo Lee , Seok Hoon Ahn , Young Goo Jin , Jae Hoon Park , Dong Hyuk Shin , Eun Hee Cho , Hwan Bong Chang , Young Ho Jung
IPC分类号： C07D277/20
CPC分类号： C07D277/24
摘要： This invention relates to an improved method of preparing N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine.
摘要翻译：本发明涉及一种制备N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苄脒的改进方法。

10. 发明申请

US20090176846A1 N-hydroxy-4- {5- [4- (5-isopropyl-2-methyl-1, 3-thiazol-4-yl) phenoxy] pentoxy} benzamidine 2 methanesulfonic acid salt 审中-公开
标题翻译： N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苄脒2甲磺酸盐
公开(公告)号：US20090176846A1
公开(公告)日：2009-07-09
申请号：US10584984
申请日：2005-11-22
申请人： Jei Man Ryu , Jin Soo Lee , Dong Hyuk Shin , Seung Kyoo Seong , Soon Ki Cho , Chan Seok Jeon , Young Goo Jin , Ki Young Lee , Se Hyun Jung , Eun Hee Cho , Seok Hoon Ahn
发明人： Jei Man Ryu , Jin Soo Lee , Dong Hyuk Shin , Seung Kyoo Seong , Soon Ki Cho , Chan Seok Jeon , Young Goo Jin , Ki Young Lee , Se Hyun Jung , Eun Hee Cho , Seok Hoon Ahn
IPC分类号： A61K31/426 , C07D277/28
CPC分类号： C07D277/24 , A61K9/143 , A61K31/426
摘要： Disclosed is an N-Hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy} benzamidine 2 methansulfonic acid salt, which has excellent bioavailability. Also disclosed are a method of preparing the compound and a pharmaceutical composition comprising the compound.
摘要翻译：公开了具有优异生物利用度的N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苄脒2甲磺酸盐。还公开了制备该化合物的方法和包含该化合物的药物组合物。

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