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1. 发明申请

US20120288892A1 Methods for Producing Polypeptidies in Protease-Deficient Mutants of Trichoderma 有权
标题翻译：在木霉的蛋白酶缺陷突变体中产生多肽的方法
公开(公告)号：US20120288892A1
公开(公告)日：2012-11-15
申请号：US13516433
申请日：2010-12-17
申请人： Suchindra Maiyuran , Abigail Jang , Kimberly Brown , Sandra Merino , Jeffrey Shasky , Eric Abbate
发明人： Suchindra Maiyuran , Abigail Jang , Kimberly Brown , Sandra Merino , Jeffrey Shasky , Eric Abbate
IPC分类号： C12N1/19 , C12N15/80 , C12P21/00
CPC分类号： C12P21/00 , C12N9/58 , C12N15/80 , C12P21/02
摘要： The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more (several) genes selected from the group consisting of a first subtilisin-like serine protease gene, a first aspartic protease gene, a trypsin-like serine protease gene, a second subtilisin-like serine protease gene, and a second aspartic pro-tease gene, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of a first subtilisin-like serine protease, a first aspartic protease, a trypsin-like serine protease, a second subtilisin-like serine protease, and a second aspartic protease, respectively, compared to the parent Trichoderma strain when cultivated under identical conditions. The present invention also relates to methods of producing a polypeptide in such mutants and methods for producing such mutants.
摘要翻译：本发明涉及母体木霉菌株的突变体，其包含编码多肽的多核苷酸和选自第一枯草杆菌蛋白酶样丝氨酸蛋白酶基因，第一天冬氨酸蛋白酶基因，胰蛋白酶抑制蛋白酶基因的一个或多个（若干）基因，如丝氨酸蛋白酶基因，第二枯草杆菌蛋白酶样丝氨酸蛋白酶基因和第二天冬氨酸蛋白酶基因，其中所述一个或多个（若干）基因被修饰，使得突变菌株缺乏产生一种或多种（多种）酶分别选自第一枯草杆菌蛋白酶样丝氨酸蛋白酶，第一天冬氨酸蛋白酶，胰蛋白酶样丝氨酸蛋白酶，第二枯草杆菌蛋白酶样丝氨酸蛋白酶和第二天冬氨酸蛋白酶，与培养时的母体木霉菌株相比在相同的条件下。本发明还涉及在这种突变体中产生多肽的方法和用于产生这种突变体的方法。

2. 发明授权

US08986974B2 Methods for producing polypeptidies in protease-deficient mutants of trichoderma 有权
标题翻译：在木霉蛋白酶缺陷突变体中产生多肽的方法
公开(公告)号：US08986974B2
公开(公告)日：2015-03-24
申请号：US13516433
申请日：2010-12-17
申请人： Suchindra Maiyuran , Abigail Jang , Kimberly Brown , Sandra Merino , Jeffrey Shasky , Eric Abbate
发明人： Suchindra Maiyuran , Abigail Jang , Kimberly Brown , Sandra Merino , Jeffrey Shasky , Eric Abbate
IPC分类号： C12N1/15 , C12N9/58 , C12N15/80 , C12P21/02
CPC分类号： C12P21/00 , C12N9/58 , C12N15/80 , C12P21/02
摘要： The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more (several) genes selected from the group consisting of a first subtilisin-like serine protease gene, a first aspartic protease gene, a trypsin-like serine protease gene, a second subtilisin-like serine protease gene, and a second aspartic protease gene, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of a first subtilisin-like serine protease, a first aspartic protease, a trypsin-like serine protease, a second subtilisin-like serine protease, and a second aspartic protease, respectively, compared to the parent Trichoderma strain when cultivated under identical conditions. The present invention also relates to methods of producing a polypeptide in such mutants and methods for producing such mutants.
摘要翻译：本发明涉及母体木霉菌株的突变体，其包含编码多肽的多核苷酸和选自第一枯草杆菌蛋白酶样丝氨酸蛋白酶基因，第一天冬氨酸蛋白酶基因，胰蛋白酶抑制蛋白酶基因的一个或多个（若干）基因，如丝氨酸蛋白酶基因，第二枯草杆菌蛋白酶样丝氨酸蛋白酶基因和第二天冬氨酸蛋白酶基因，其中所述一个或多个（若干）基因被修饰，使得突变菌株缺乏产生一种或多种（若干）选自与母本木霉属菌株相比，分别在相同的条件下培养时由第一枯草杆菌蛋白酶样丝氨酸蛋白酶，第一天冬氨酸蛋白酶，胰蛋白酶样丝氨酸蛋白酶，第二枯草杆菌蛋白酶样丝氨酸蛋白酶和第二天冬氨酸蛋白酶组成的组条件。本发明还涉及在这种突变体中产生多肽的方法和用于产生这种突变体的方法。

3. 发明申请

US20100299788A1 Polypeptides having Cellulolytic Enhancing Activity and Polynucleotides Encoding Same 失效
标题翻译：具有纤维素分解增强活性的多肽和编码相同的多核苷酸
公开(公告)号：US20100299788A1
公开(公告)日：2010-11-25
申请号：US12746022
申请日：2008-12-17
申请人： Paul Harris , Suchindra Maiyuran , Kimberly Brown
发明人： Paul Harris , Suchindra Maiyuran , Kimberly Brown
IPC分类号： A01H5/00 , C12N9/42 , C07H21/04 , C12N15/63 , C12N1/00 , C12N5/10 , C12P21/00 , C12P19/00
CPC分类号： C12N9/2434 , C07K14/37 , C11D3/38645
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有纤维素分解增强活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

4. 发明授权

US08575426B2 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same 失效
公开(公告)号：US08575426B2
公开(公告)日：2013-11-05
申请号：US12746003
申请日：2008-12-17
申请人： Paul Harris , Suchindra Maiyuran , Kimberly Brown
发明人： Paul Harris , Suchindra Maiyuran , Kimberly Brown
IPC分类号： C12P21/02 , C12N15/56 , C12N15/82 , C12N9/42 , A01N63/00
CPC分类号： C12N9/2434 , C07K14/37 , C12P19/14
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

5. 发明申请

US20120156755A1 POLYPEPTIDES HAVING CELLOBIOHYDROLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 有权
标题翻译：具有环糊精活性的多肽和编码其的多核苷酸
公开(公告)号：US20120156755A1
公开(公告)日：2012-06-21
申请号：US13405988
申请日：2012-02-27
申请人： Suchindra Maiyuran , Paul Harris , Hanshu Ding , Kimberly Brown
发明人： Suchindra Maiyuran , Paul Harris , Hanshu Ding , Kimberly Brown
IPC分类号： C12N9/42 , C12N15/63 , C12N1/19 , C12N5/10 , C12N1/21 , C12N1/15 , C12N15/56 , A01H5/00
CPC分类号： C12N9/2437 , C11D3/38645 , C12Y302/01091
摘要： The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有纤维二糖水解酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

6. 发明申请

US20120276640A1 Polypeptides Having Cellobiohydrolase Activity And Polynucleotides Encoding Same 有权
标题翻译：具有纤维二糖水解酶活性的多肽和编码相同的多核苷酸
公开(公告)号：US20120276640A1
公开(公告)日：2012-11-01
申请号：US13548706
申请日：2012-07-13
申请人： Suchindra Maiyuran , Paul Harris , Hanshu Ding , Kimberly Brown
发明人： Suchindra Maiyuran , Paul Harris , Hanshu Ding , Kimberly Brown
IPC分类号： C12N9/42 , C12N1/15 , C12N15/80 , C12N1/21 , C12N15/63 , C12N15/70
CPC分类号： C12N9/2437 , C11D3/38645 , C12Y302/01091
摘要： The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有纤维二糖水解酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

7. 发明授权

US08377693B2 Polypeptides having cellobiohydrolase activity and polynucleotides encoding same 有权
公开(公告)号：US08377693B2
公开(公告)日：2013-02-19
申请号：US13548706
申请日：2012-07-13
申请人： Suchindra Maiyuran , Paul Harris , Hanshu Ding , Kimberly Brown
发明人： Suchindra Maiyuran , Paul Harris , Hanshu Ding , Kimberly Brown
IPC分类号： C12N1/00 , C12N15/79
CPC分类号： C12N9/2437 , C11D3/38645 , C12Y302/01091
摘要： The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

8. 发明授权

US08227667B2 Polypeptides having cellobiohydrolase activity and polynucleotides encoding same 有权
标题翻译：具有纤维二糖水解酶活性的多肽和编码该多肽的多核苷酸
公开(公告)号：US08227667B2
公开(公告)日：2012-07-24
申请号：US13405988
申请日：2012-02-27
申请人： Suchindra Maiyuran , Paul Harris , Hanshu Ding , Kimberly Brown
发明人： Suchindra Maiyuran , Paul Harris , Hanshu Ding , Kimberly Brown
IPC分类号： A01H9/00 , C12N9/26 , C12N5/00 , C12N1/20 , C07H21/04
CPC分类号： C12N9/2437 , C11D3/38645 , C12Y302/01091
摘要： The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有纤维二糖水解酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

9. 发明申请

US20100306881A1 Polypeptides having Cellulolytic Enhancing Activity and Polynucleotides Encoding Same 审中-公开
公开(公告)号：US20100306881A1
公开(公告)日：2010-12-02
申请号：US12745993
申请日：2008-12-17
申请人： Paul Harris , Suchindra Maiyuran , Kimberly Brown
发明人： Paul Harris , Suchindra Maiyuran , Kimberly Brown
IPC分类号： A01H5/00 , C07K14/39 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/02 , C12N15/01 , C07H21/02 , C12N5/00 , C12P7/40 , C12P7/04 , C12P7/26
CPC分类号： C07K14/37 , C12N9/2434
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

10. 发明申请

US20100304434A1 Polypeptides having Cellulolytic Enhancing Activity and Polynucleotides Encoding Same 失效
公开(公告)号：US20100304434A1
公开(公告)日：2010-12-02
申请号：US12745985
申请日：2008-12-18
申请人： Paul Harris , Suchindra Maiyuran , Kimberly Brown
发明人： Paul Harris , Suchindra Maiyuran , Kimberly Brown
IPC分类号： C12P21/02 , C07K14/37 , C07H21/04 , C12N15/63 , C12N1/15 , C12N15/01 , A01H5/00 , C12N5/10 , C12P19/00 , C12N5/02 , C12P1/02 , C12P1/04
CPC分类号： C12N9/2437 , C12N9/2434 , C12P19/14 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

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