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1. 发明申请

US20140308701A1 Cellulolytic enzyme compositions and uses thereof 有权
标题翻译：纤维素分解酶组合物及其用途
公开(公告)号：US20140308701A1
公开(公告)日：2014-10-16
申请号：US14238431
申请日：2012-08-23
申请人： Jeffrey Shasky , Amanda Fischer , Suchindra Maiyuran
发明人： Jeffrey Shasky , Amanda Fischer , Suchindra Maiyuran
IPC分类号： C12N9/42 , C12P19/14 , C12P19/02
CPC分类号： C12P19/14 , C07K14/38 , C12N9/2437 , C12N9/2445 , C12P19/02 , C12Y302/01004 , C12Y302/01008 , C12Y302/01021 , C12Y302/01037 , C12Y302/01091 , C12Y302/01176 , Y02E50/16 , Y02P20/52
摘要： The present invention relates to recombinant filamentous fungal host cells producing cellulolytic enzyme compositions and methods of producing and using the compositions.
摘要翻译：本发明涉及产生纤维素分解酶组合物的重组丝状真菌宿主细胞和生产和使用该组合物的方法。

2. 发明授权

US08647856B2 Methods for producing polypeptides in enzyme-deficient mutants of Fusarium venenatum 失效
标题翻译：在镰孢镰刀菌酶缺陷突变体中产生多肽的方法
公开(公告)号：US08647856B2
公开(公告)日：2014-02-11
申请号：US13121254
申请日：2009-09-30
申请人： Jeffrey Shasky , Wendy Yoder
发明人： Jeffrey Shasky , Wendy Yoder
IPC分类号： C12N1/00 , C12N1/14
CPC分类号： C12P21/00 , C12N9/242 , C12N9/58 , C12N9/88 , C12N15/80 , C12P21/02 , C12Y302/01001 , C12Y401/01023 , Y02P20/52
摘要： The present invention relates to methods of producing a polypeptide, comprising: (a) cultivating a mutant of a parent Fusarium venenatum strain in a medium for the production of the polypeptide, wherein the mutant strain comprises a polynucleotide encoding the polypeptide and one or more (several) genes selected from the group consisting of pyrG, amyA, and alpA, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of orotidine-5′-monophosphate decarboxylase, alpha-amylase, and alkaline protease, respectively, compared to the parent Fusarium venenatum strain when cultivated under identical conditions; and (b) recovering the polypeptide from the cultivation medium. The present invention also relates to enzyme-deficient mutants of Fusarium venenatum strains and methods for producing such mutants.
摘要翻译：本发明涉及产生多肽的方法，其包括：（a）在用于产生多肽的培养基中培养亲本尖叶镰刀菌菌株的突变体，其中所述突变株包含编码多肽的多核苷酸和一个或多个（几种）选自pyrG，amyA和alpA的基因，其中所述一个或多个（若干）基因被修饰，使所述突变株缺乏产生选自下组的一种或多种（几种） -5'-单磷酸脱羧酶，α-淀粉酶和碱性蛋白酶，与相同条件下栽培的亲本镰刀菌镰孢菌株相比; 和（b）从培养基中回收多肽。本发明还涉及镰刀菌菌株的酶缺陷型突变体及其生产方法。

3. 发明申请

US20110236928A1 Methods for producing polypeptides in enzyme-deficient mutants of fusarium venenatum 失效
标题翻译：在镰孢镰刀菌酶缺陷突变体中产生多肽的方法
公开(公告)号：US20110236928A1
公开(公告)日：2011-09-29
申请号：US13121254
申请日：2009-09-30
申请人： Jeffrey Shasky , Wendy Yoder
发明人： Jeffrey Shasky , Wendy Yoder
IPC分类号： C12P21/00 , C12N1/15 , C12N15/80
CPC分类号： C12P21/00 , C12N9/242 , C12N9/58 , C12N9/88 , C12N15/80 , C12P21/02 , C12Y302/01001 , C12Y401/01023 , Y02P20/52
摘要： The present invention relates to methods of producing a polypeptide, comprising: (a) cultivating a mutant of a parent Fusarium venenatum strain in a medium for the production of the polypeptide, wherein the mutant strain comprises a polynucleotide encoding the polypeptide and one or more (several) genes selected from the group consisting of pyrG, amyA, and alpA, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of orotidine-5′-monophosphate decarboxylase, alpha-amylase, and alkaline protease, respectively, compared to the parent Fusarium venenatum strain when cultivated under identical conditions; and (b) recovering the polypeptide from the cultivation medium. The present invention also relates to enzyme-deficient mutants of Fusarium venenatum strains and methods for producing such mutants.
摘要翻译：本发明涉及产生多肽的方法，其包括：（a）在用于产生多肽的培养基中培养亲本尖叶镰刀菌菌株的突变体，其中所述突变株包含编码多肽的多核苷酸和一个或多个（几种）选自pyrG，amyA和alpA的基因，其中所述一个或多个（若干）基因被修饰，使所述突变株缺乏产生选自下组的一种或多种（几种） -5'-单磷酸脱羧酶，α-淀粉酶和碱性蛋白酶，与相同条件下栽培的亲本镰刀菌镰孢菌株相比; 和（b）从培养基中回收多肽。本发明还涉及镰刀菌菌株的酶缺陷型突变体及其生产方法。

4. 发明授权

US09476036B2 Cellulolytic enzyme compositions and uses thereof 有权
标题翻译：纤维素分解酶组合物及其用途
公开(公告)号：US09476036B2
公开(公告)日：2016-10-25
申请号：US14238431
申请日：2012-08-23
申请人： Jeffrey Shasky , Amanda Fischer , Suchindra Maiyuran
发明人： Jeffrey Shasky , Amanda Fischer , Suchindra Maiyuran
IPC分类号： C12P7/10 , C12N9/42 , C07K14/38 , C12P19/14 , C12P19/02
CPC分类号： C12P19/14 , C07K14/38 , C12N9/2437 , C12N9/2445 , C12P19/02 , C12Y302/01004 , C12Y302/01008 , C12Y302/01021 , C12Y302/01037 , C12Y302/01091 , C12Y302/01176 , Y02E50/16 , Y02P20/52
摘要： The present invention relates to recombinant filamentous fungal host cells producing cellulolytic enzyme compositions and methods of producing and using the compositions.
摘要翻译：本发明涉及产生纤维素分解酶组合物的重组丝状真菌宿主细胞和生产和使用该组合物的方法。

5. 发明申请

US20120288892A1 Methods for Producing Polypeptidies in Protease-Deficient Mutants of Trichoderma 有权
标题翻译：在木霉的蛋白酶缺陷突变体中产生多肽的方法
公开(公告)号：US20120288892A1
公开(公告)日：2012-11-15
申请号：US13516433
申请日：2010-12-17
申请人： Suchindra Maiyuran , Abigail Jang , Kimberly Brown , Sandra Merino , Jeffrey Shasky , Eric Abbate
发明人： Suchindra Maiyuran , Abigail Jang , Kimberly Brown , Sandra Merino , Jeffrey Shasky , Eric Abbate
IPC分类号： C12N1/19 , C12N15/80 , C12P21/00
CPC分类号： C12P21/00 , C12N9/58 , C12N15/80 , C12P21/02
摘要： The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more (several) genes selected from the group consisting of a first subtilisin-like serine protease gene, a first aspartic protease gene, a trypsin-like serine protease gene, a second subtilisin-like serine protease gene, and a second aspartic pro-tease gene, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of a first subtilisin-like serine protease, a first aspartic protease, a trypsin-like serine protease, a second subtilisin-like serine protease, and a second aspartic protease, respectively, compared to the parent Trichoderma strain when cultivated under identical conditions. The present invention also relates to methods of producing a polypeptide in such mutants and methods for producing such mutants.
摘要翻译：本发明涉及母体木霉菌株的突变体，其包含编码多肽的多核苷酸和选自第一枯草杆菌蛋白酶样丝氨酸蛋白酶基因，第一天冬氨酸蛋白酶基因，胰蛋白酶抑制蛋白酶基因的一个或多个（若干）基因，如丝氨酸蛋白酶基因，第二枯草杆菌蛋白酶样丝氨酸蛋白酶基因和第二天冬氨酸蛋白酶基因，其中所述一个或多个（若干）基因被修饰，使得突变菌株缺乏产生一种或多种（多种）酶分别选自第一枯草杆菌蛋白酶样丝氨酸蛋白酶，第一天冬氨酸蛋白酶，胰蛋白酶样丝氨酸蛋白酶，第二枯草杆菌蛋白酶样丝氨酸蛋白酶和第二天冬氨酸蛋白酶，与培养时的母体木霉菌株相比在相同的条件下。本发明还涉及在这种突变体中产生多肽的方法和用于产生这种突变体的方法。

6. 发明申请

US20110223671A1 Methods for using positively and negatively selectable genes in a filamentous fungal cell 审中-公开
标题翻译：在丝状真菌细胞中使用正和负选择性基因的方法
公开(公告)号：US20110223671A1
公开(公告)日：2011-09-15
申请号：US13120102
申请日：2009-09-30
申请人： Wendy Yoder , Jeffrey Shasky
发明人： Wendy Yoder , Jeffrey Shasky
IPC分类号： C12N15/80 , C12N1/15 , C12N9/88 , C07H21/00 , C12N9/00
CPC分类号： C12N15/80 , C12N1/14 , C12N9/88
摘要： The present invention relates to methods for using positively and negatively selectable genes in a filamentous fungal cell to delete, disrupt, or insert a gene in a filamentous fungal cell.
摘要翻译：本发明涉及在丝状真菌细胞中使用正和负选择性基因以去除，破坏或插入丝状真菌细胞中的基因的方法。

7. 发明授权

US09663772B2 Aspergillus fumigatus cellulolytic enzyme compositions and uses thereof 有权
公开(公告)号：US09663772B2
公开(公告)日：2017-05-30
申请号：US14238688
申请日：2012-08-23
申请人： Jeffrey Shasky , Brett McBrayer
发明人： Jeffrey Shasky , Brett McBrayer
IPC分类号： C12N1/14 , C12N15/00 , C12N1/20 , C12N9/24 , C12N9/42 , C07H21/04 , C12P19/02 , C12P19/14 , C07K14/37
CPC分类号： C12N15/52 , C07K14/37 , C12N1/14 , C12N9/2402 , C12N9/2405 , C12N9/2437 , C12N9/2445 , C12N9/2471 , C12N9/248 , C12N9/2485 , C12N15/80 , C12P9/00 , C12P19/02 , C12P19/14 , C12P2203/00 , C12Y302/01091
摘要： The present invention relates to recombinant Trichoderma host cells producing Aspergillus fumigatus cellulolytic enzyme compositions and methods of producing and using the compositions.

8. 发明授权

US08986974B2 Methods for producing polypeptidies in protease-deficient mutants of trichoderma 有权
标题翻译：在木霉蛋白酶缺陷突变体中产生多肽的方法
公开(公告)号：US08986974B2
公开(公告)日：2015-03-24
申请号：US13516433
申请日：2010-12-17
申请人： Suchindra Maiyuran , Abigail Jang , Kimberly Brown , Sandra Merino , Jeffrey Shasky , Eric Abbate
发明人： Suchindra Maiyuran , Abigail Jang , Kimberly Brown , Sandra Merino , Jeffrey Shasky , Eric Abbate
IPC分类号： C12N1/15 , C12N9/58 , C12N15/80 , C12P21/02
CPC分类号： C12P21/00 , C12N9/58 , C12N15/80 , C12P21/02
摘要： The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more (several) genes selected from the group consisting of a first subtilisin-like serine protease gene, a first aspartic protease gene, a trypsin-like serine protease gene, a second subtilisin-like serine protease gene, and a second aspartic protease gene, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of a first subtilisin-like serine protease, a first aspartic protease, a trypsin-like serine protease, a second subtilisin-like serine protease, and a second aspartic protease, respectively, compared to the parent Trichoderma strain when cultivated under identical conditions. The present invention also relates to methods of producing a polypeptide in such mutants and methods for producing such mutants.
摘要翻译：本发明涉及母体木霉菌株的突变体，其包含编码多肽的多核苷酸和选自第一枯草杆菌蛋白酶样丝氨酸蛋白酶基因，第一天冬氨酸蛋白酶基因，胰蛋白酶抑制蛋白酶基因的一个或多个（若干）基因，如丝氨酸蛋白酶基因，第二枯草杆菌蛋白酶样丝氨酸蛋白酶基因和第二天冬氨酸蛋白酶基因，其中所述一个或多个（若干）基因被修饰，使得突变菌株缺乏产生一种或多种（若干）选自与母本木霉属菌株相比，分别在相同的条件下培养时由第一枯草杆菌蛋白酶样丝氨酸蛋白酶，第一天冬氨酸蛋白酶，胰蛋白酶样丝氨酸蛋白酶，第二枯草杆菌蛋白酶样丝氨酸蛋白酶和第二天冬氨酸蛋白酶组成的组条件。本发明还涉及在这种突变体中产生多肽的方法和用于产生这种突变体的方法。

9. 发明申请

US20140234914A1 Aspergillus Fumigatus Cellulolytic Enzyme Compositions and Uses Thereof 有权
标题翻译：曲霉菌纤维素分解酶组合物及其用途
公开(公告)号：US20140234914A1
公开(公告)日：2014-08-21
申请号：US14238688
申请日：2012-08-23
申请人： Jeffrey Shasky , Brett McBrayer
发明人： Jeffrey Shasky , Brett McBrayer
IPC分类号： C12N9/42 , C12P19/14 , C12P19/02 , C12N9/24
CPC分类号： C12N15/52 , C07K14/37 , C12N1/14 , C12N9/2402 , C12N9/2405 , C12N9/2437 , C12N9/2445 , C12N9/2471 , C12N9/248 , C12N9/2485 , C12N15/80 , C12P9/00 , C12P19/02 , C12P19/14 , C12P2203/00 , C12Y302/01091
摘要： The present invention relates to recombinant Trichoderma host cells producing Aspergillus fumigatus cellulolytic enzyme compositions and methods of producing and using the compositions.
摘要翻译：本发明涉及产生烟曲霉纤维素分解酶组合物的重组木霉属宿主细胞和生产和使用该组合物的方法。

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