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1. 发明申请

US20130209538A1 BIODEGRADABLE OCULAR IMPLANT 审中-公开
标题翻译：可生物降解的OCULAR IMPLANT
公开(公告)号：US20130209538A1
公开(公告)日：2013-08-15
申请号：US13816637
申请日：2011-08-12
申请人： Subramanian Venkatraman , Yin Chiang Freddy Boey , Tina Wong , Jodhbh Metha
发明人： Subramanian Venkatraman , Yin Chiang Freddy Boey , Tina Wong , Jodhbh Metha
IPC分类号： A61L31/14 , A61L31/12 , B05D5/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/1647 , A61K31/19 , A61K31/5575 , A61K31/573 , A61K47/34 , A61L27/18 , A61L27/54 , A61L27/58 , A61L31/125 , A61L31/148 , A61L2430/16 , B05D5/00 , B29C39/02 , B29C39/025 , B29D11/023 , B29K2067/04 , B29K2067/046 , B29K2105/0035 , B29K2105/0073 , B29K2995/0056 , B29K2995/006 , C08L67/04 , C08L69/005
摘要： The present invention relates to a biodegradable ocular implant for sustained drug delivery, comprising a first layer comprising a first biodegradable polymer, wherein the first layer contains a drug dispersed or dissolved therein. A multi-layered biodegradable ocular implant is also disclosed.
摘要翻译：本发明涉及用于持续药物递送的可生物降解的眼部植入物，其包含第一层，其包含第一可生物降解聚合物，其中第一层含有分散或溶解于其中的药物。还公开了一种多层可生物降解的眼部植入物。

2. 发明申请

US20130211314A1 GLAUCOMA VALVE, A CASING FOR CONTAINING A GLAUCOMA VALVE, AND A GLAUCOMA DRAINAGE DEVICE COMPRISING THE VALVE AND/OR THE CASING 审中-公开
标题翻译： GLAUCOMA阀，包含GLAUCOMA阀的壳体和包含阀门和/或壳体的GLAUCOMA排水装置
公开(公告)号：US20130211314A1
公开(公告)日：2013-08-15
申请号：US13816631
申请日：2011-08-12
申请人： Subramanian Venkatraman , Lei Shang , Yin Chiang Freddy Boey , Tina Wong
发明人： Subramanian Venkatraman , Lei Shang , Yin Chiang Freddy Boey , Tina Wong
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61F2210/0004
摘要： Various embodiments of the invention relate to a glaucoma valve, a casing for containing a glaucoma valve and a glaucoma drainage device comprising the glaucoma valve and/or the casing. The valve includes a flow channel having an inlet and an outlet and a valve member connected to the outlet of the flow channel. The valve member may be formed from a degradable polymer or a combination of degradable polymer and non-degradable polymer. Various embodiments of the invention relate to a glaucoma valve, the valve having a first flow channel. The interior of the first flow channel may be coated with a degradable polymer, such that in use, the polymer degrades to allow a greater flow of fluid through the flow channel. In some embodiments, the valve includes a second flow channel, which may be arranged in parallel to the first flow channel. The first flow channel may be completely sealed with the polymer such that in use, the polymer degrades to allow fluid to flow through the first flow channel. Various embodiments relate to a casing for containing a glaucoma valve. The casing may be formed from a degradable polymer, such as a biodegradable polymer.
摘要翻译：本发明的各种实施方案涉及青光眼瓣膜，用于容纳青光眼瓣膜的外壳和包括青光眼瓣膜和/或外壳的青光眼引流装置。阀包括具有入口和出口的流动通道和连接到流动通道的出口的阀构件。阀构件可以由可降解聚合物或可降解聚合物和不可降解聚合物的组合形成。本发明的各种实施例涉及青光眼瓣膜，该瓣膜具有第一流动通道。第一流动通道的内部可涂覆有可降解的聚合物，使得在使用中，聚合物降解以允许流体流过流动通道。在一些实施例中，阀包括可以与第一流动通道平行布置的第二流动通道。第一流动通道可以用聚合物完全密封，使得在使用中，聚合物降解以允许流体流过第一流动通道。各种实施方式涉及用于容纳青光眼阀的外壳。外壳可以由可降解的聚合物形成，例如可生物降解的聚合物。

3. 发明授权

US10548769B2 Glaucoma valve, a casing for containing a glaucoma valve, and a glaucoma drainage device comprising the valve and/or the casing 有权
公开(公告)号：US10548769B2
公开(公告)日：2020-02-04
申请号：US13816631
申请日：2011-08-12
申请人： Subramanian Venkatraman , Lei Shang , Yin Chiang Freddy Boey , Tina Wong
发明人： Subramanian Venkatraman , Lei Shang , Yin Chiang Freddy Boey , Tina Wong
IPC分类号： A61F9/007
摘要： Provided is a glaucoma valve, a casing for containing a glaucoma valve and a glaucoma drainage device including the glaucoma valve and/or the casing. The valve includes a flow channel having an inlet and an outlet and a valve member connected to the outlet of the flow channel. The valve member may be formed from a degradable polymer or a combination of degradable polymer and non-degradable polymer. The valve may have a first flow channel, the interior of which may be coated with a degradable polymer, such that in use, the polymer degrades to allow a greater flow of fluid through the flow channel. The valve may include a second flow channel, which may be arranged in parallel to the first flow channel. The casing may be formed from a degradable polymer, such as a biodegradable polymer.

4. 发明授权

US10272040B2 Liposomal formulation for ocular drug delivery 有权
公开(公告)号：US10272040B2
公开(公告)日：2019-04-30
申请号：US13816640
申请日：2011-08-12
申请人： Subramanian Venkatraman , Jayaganesh V. Natarajan , Tina Wong , Yin Chiang Freddy Boey
发明人： Subramanian Venkatraman , Jayaganesh V. Natarajan , Tina Wong , Yin Chiang Freddy Boey
IPC分类号： A61K9/127 , A61K31/5575 , A61K31/215 , A61K9/00
摘要： The present invention is directed to a liposomal formulation for ocular drug delivery comprising (i) liposomes comprising at least one lipid bilayer, and (ii) a prostaglandin drug and/or a prostaglandin derivative associated in the liposomes, wherein the liposomes have a mean diameter of less than 2μπι. The present invention is also directed to a pharmaceutical comprising the liposomal formulation and a method of producing the liposomal formulation for ocular drug delivery. Additionally, the present invention is directed to a method of treating or preventing an ocular disease, comprising administering the liposomal formulation or the pharmaceutical composition to a subject in need thereof.

5. 发明申请

US20130216606A1 LIPOSOMAL FORMULATION FOR OCULAR DRUG DELIVERY 审中-公开
标题翻译：用于药物输送的药物制剂
公开(公告)号：US20130216606A1
公开(公告)日：2013-08-22
申请号：US13816640
申请日：2011-08-12
申请人： Subramanian Venkatraman , Jayaganesh V. Natarajan , Tina Wong , Yin Chiang Freddy Boey
发明人： Subramanian Venkatraman , Jayaganesh V. Natarajan , Tina Wong , Yin Chiang Freddy Boey
IPC分类号： A61K9/127 , A61K31/215
CPC分类号： A61K9/127 , A61K9/0048 , A61K31/215 , A61K31/5575
摘要： The present invention is directed to a liposomal formulation for ocular drug delivery comprising (i) liposomes comprising at least one lipid bilayer, and (ii) a prostaglandin drug and/or a prostaglandin derivative associated in the liposomes, wherein the liposomes have a mean diameter of less than 2μπι. The present invention is also directed to a pharmaceutical comprising the liposomal formulation and a method of producing the liposomal formulation for ocular drug delivery. Additionally, the present invention is directed to a method of treating or preventing an ocular disease, comprising administering the liposomal formulation or the pharmaceutical composition to a subject in need thereof.
摘要翻译：本发明涉及一种用于眼药物递送的脂质体制剂，其包含（i）包含至少一种脂质双层的脂质体，和（ii）在脂质体中相关的前列腺素药物和/或前列腺素衍生物，其中所述脂质体具有平均直径小于2mupiiota。本发明还涉及包含脂质体制剂和生产用于眼药物递送的脂质体制剂的方法的药物。另外，本发明涉及治疗或预防眼部疾病的方法，包括将脂质体制剂或药物组合物施用于有需要的受试者。

6. 发明授权

US10905405B2 Occlusion device for closing anatomical defects 有权
公开(公告)号：US10905405B2
公开(公告)日：2021-02-02
申请号：US13516065
申请日：2010-12-17
申请人： Subramanian Venkatraman , Yin Chiang Freddy Boey , Wei Wu , Yong-dan Tang , Wei Luen James Yip , Hong Duc Duong
发明人： Subramanian Venkatraman , Yin Chiang Freddy Boey , Wei Wu , Yong-dan Tang , Wei Luen James Yip , Hong Duc Duong
IPC分类号： A61B17/00 , A61B90/00
摘要： The present invention generally relates to the field of transcatheter device closure techniques for closing an opening in a tissue and more particularly, to occlusion devices for closing anatomical defects in tissue such as defects consisting of an opening connecting a front side and a back side of a tissue. More particularly the present invention relates to occlusion devices for closing septal abnormalities such as atrial septal defects and patent foramen ovale, delivering systems for such occlusion devices, kits comprising the occlusion devices and the delivering systems and to methods of closing an anatomical defect in a tissue consisting of an opening connecting a front side and a back side of a tissue.

7. 发明申请

US20140072610A1 BIOABSORBABLE TRACHEAL STENT, AND METHOD OF MANUFACTURING THEREOF 审中-公开
标题翻译：生物吸收性斜管及其制造方法
公开(公告)号：US20140072610A1
公开(公告)日：2014-03-13
申请号：US14003738
申请日：2012-03-21
申请人： Subramanian Venkatraman , Herr Cheun Anthony Ng , Yin Chiang Freddy Boey , Hsueh Yee Lynne Lim
发明人： Subramanian Venkatraman , Herr Cheun Anthony Ng , Yin Chiang Freddy Boey , Hsueh Yee Lynne Lim
IPC分类号： A61F2/04 , A61K31/407 , A61K47/32
CPC分类号： A61F2/04 , A61F2/82 , A61F2002/046 , A61K31/407 , A61K47/32 , A61L31/06 , A61L31/16 , A61L2300/00 , C08L67/04
摘要： A bioabsorbable tracheal stent is provided. The bioabsorbable stent comprises a biodegradable polymer, wherein the “ biodegradable polymer comprises about 0 to 30 wt % glycerol, polyethylene glycol, triethyl citrate, or mixture thereof. A drug is dispersed within or dissolved in the biodegradable polymer. In a second and third aspect, the invention relates to methods of manufacturing a bioabsorbable tracheal stent. The first method includes forming a solution comprising a biodegradable polymer and a drug, the biodegradable polymer comprising about 0 to 30 wt % glycerol, polyethylene glycol, triethyl citrate, or mixture thereof. The method further comprises casting the solution to form the bioabsorbable tracheal stent. The second method includes forming a polymeric stent, and dip casting the polymeric stent in a solution comprising a biodegradable polymer and a drug to form a coating on the polymeric stent, wherein the biodegradable polymer comprises about 0 to 30 wt % glycerol, polyethylene glycol, triethyl citrate, or mixture thereof.
摘要翻译：提供生物吸收性气管支架。生物可吸收性支架包括可生物降解的聚合物，其中“可生物降解的聚合物包含约0至30重量％的甘油，聚乙二醇，柠檬酸三乙酯或其混合物”，药物分散在生物可降解的聚合物中或溶于可生物降解的聚合物中，在第二和第三方面本发明涉及制造生物可吸收气管支架的方法，第一种方法包括形成包含可生物降解的聚合物和药物的溶液，所述可生物降解聚合物包含约0至30重量％的甘油，聚乙二醇，柠檬酸三乙酯或其混合物。该方法还包括浇铸该溶液以形成生物可吸收气管支架，第二种方法包括形成聚合物支架，并将聚合物支架浸入包含可生物降解聚合物和药物的溶液中以在聚合物支架上形成涂层，其中可生物降解的聚合物包含约0至30重量％的甘油，聚乙二醇，柠檬酸三乙酯或混合物t 这里。

8. 发明申请

US20130046254A1 OCCLUSION DEVICE FOR CLOSING ANATOMICAL DEFECTS 审中-公开
标题翻译：闭合解剖缺陷的闭塞装置
公开(公告)号：US20130046254A1
公开(公告)日：2013-02-21
申请号：US13516065
申请日：2010-12-17
申请人： Subramanian Venkatraman , Yin Chiang Freddy Boey , Wei Wu , Yong-dan Tang , Wei Luen James Yip , Hong Duc Duong
发明人： Subramanian Venkatraman , Yin Chiang Freddy Boey , Wei Wu , Yong-dan Tang , Wei Luen James Yip , Hong Duc Duong
IPC分类号： A61B17/03 , A61M25/00
CPC分类号： A61B17/0057 , A61B2017/00243 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623 , A61B2090/3966
摘要： The present invention generally relates to the field of transcatheter device closure techniques for closing an opening in a tissue and more particularly, to occlusion devices for closing anatomical defects in tissue such as defects consisting of an opening connecting a front side and a back side of a tissue. More particularly the present invention relates to occlusion devices for closing septal abnormalities such as atrial septal defects and patent foramen ovale, delivering systems for such occlusion devices, kits comprising the occlusion devices and the delivering systems and to methods of closing an anatomical defect in a tissue consisting of an opening connecting a front side and a back side of a tissue.
摘要翻译：本发明总体上涉及用于封闭组织中的开口的经导管装置闭合技术的领域，更具体地说，涉及用于封闭组织中的解剖缺陷的闭塞装置，例如由连接前侧和后侧的开口构成的缺陷组织。更具体地，本发明涉及用于闭合中隔异常的闭塞装置，例如房间隔缺损和卵圆孔卵孔，输送用于这种闭塞装置的系统，包括闭塞装置和递送系统的套件以及关闭组织中的解剖缺陷的方法由连接组织的前侧和背面的开口组成。

9. 发明申请

US20130281977A1 DEVICE FOR CONTROLLED RELEASE OF A BIOACTIVE AGENT 有权
标题翻译：用于控制释放生物剂的装置
公开(公告)号：US20130281977A1
公开(公告)日：2013-10-24
申请号：US13977332
申请日：2011-12-29
申请人： Terry W.J. Steele , Say Chye Joachim Loo , Subramanian Venkatraman , Yin Chiang Freddy Boey
发明人： Terry W.J. Steele , Say Chye Joachim Loo , Subramanian Venkatraman , Yin Chiang Freddy Boey
IPC分类号： A61K9/70
CPC分类号： A61K9/7007 , A61F2250/0067 , A61K9/5153 , A61M2025/105
摘要： Present invention relates to a device for controlled release of a bioactive agent. The device comprises a thin film located on the surface of the device, wherein said thin film comprises a bioactive agent-containing layer comprising a polymeric matrix and at least one bioactive agent.
摘要翻译：本发明涉及用于控制释放生物活性剂的装置。该装置包括位于装置表面上的薄膜，其中所述薄膜包括含有聚合物基质和至少一种生物活性剂的含生物活性剂的层。

10. 发明申请

US20140296798A1 OCCLUSION DEVICE FOR CLOSING ANATOMICAL DEFECTS 审中-公开
标题翻译：闭合解剖缺陷的闭塞装置
公开(公告)号：US20140296798A1
公开(公告)日：2014-10-02
申请号：US14233132
申请日：2012-07-16
申请人： Subramanian Venkatraman , Yin Chiang Freddy Boey , Laximikant Khanolkar , Prasada Rao
发明人： Subramanian Venkatraman , Yin Chiang Freddy Boey , Laximikant Khanolkar , Prasada Rao
IPC分类号： A61B17/00 , A61L31/16
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00623 , A61L31/16
摘要： An occlusion device for closing an anatomical defect in tissue comprising a conduit connecting an opening on a first tissue and an opening on a second tissue is provided. The occlusion device comprises a scaffold comprising a) a proximal support structure comprising at least two arms; b) a distal support structure comprising at least two arms, wherein the arms are adapted to provide anchorage for the device in the tissue; and c) a waist portion adapted for extending through the opening on the first tissue and connecting the proximal support structure with the distal support structure, wherein the scaffold consists essentially of a biodegradable polymer, wherein the proximal support structure and the distal support structure comprise or consist of polycaprolactone (PCL), poly-(D,L-lactide-co-caprolactone) (PLC), or a mixture thereof. A method of closing an anatomical defect using the occlusion device is also provided.
摘要翻译：提供了用于封闭组织中的解剖缺陷的闭塞装置，其包括连接第一组织上的开口和连接在第二组织上的开口的导管。闭塞装置包括支架，其包括a）包括至少两个臂的近端支撑结构; b）包括至少两个臂的远端支撑结构，其中所述臂适于为所述组织中的装置提供锚固; 以及c）适于延伸通过所述第一组织上的所述开口并且将所述近端支撑结构与所述远端支撑结构连接的腰部，其中所述支架基本上由可生物降解的聚合物组成，其中所述近端支撑结构和所述远侧支撑结构包括或由聚己内酯（PCL），聚（D，L-丙交酯 - 共 - 己内酯）（PLC）或其混合物组成。还提供了使用遮挡装置来闭合解剖缺陷的方法。

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